Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 14 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 14 | 360 aa | 336 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 0.7712 | 0.7712 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 0.7712 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0152 | 0.7712 | 0.7712 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0071 | 0.0071 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 0.7712 | 0.7712 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.3413 | 0.4373 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 0.7712 | 0.7712 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.202 | 0.2262 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 0.7712 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.1091 | 0.1091 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0968 | 0.1174 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1412 | 0.1755 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1254 | 0.1549 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.0198 | 0.0198 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0067 | 0.2677 | 0.2677 |
Schistosoma mansoni | bromodomain containing protein | 0.0071 | 0.2916 | 0.2916 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0152 | 0.7712 | 0.7712 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0968 | 0.0968 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0968 | 0.0831 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.1091 | 0.1091 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.202 | 0.2551 |
Brugia malayi | Bromodomain containing protein | 0.0043 | 0.1249 | 0.1214 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0198 | 0.0198 |
Brugia malayi | P38 map kinase family protein 2 | 0.0152 | 0.7712 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.202 | 0.2262 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0152 | 0.7712 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.0198 | 0.0198 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.202 | 0.2551 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 0.7712 | 0.7712 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0152 | 0.7712 | 0.5 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0152 | 0.7712 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0084 | 0.3698 | 0.4543 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0067 | 0.2677 | 0.2677 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1539 | 0.1922 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.146 uM | Competitive inhibition of p38alpha MAP kinase (unknown origin) in presence of 100 uM ATP | ChEMBL. | 24131218 |
IC50 (binding) | = 0.684 uM | Inhibition of p38alpha MAP kinase in human whole blood assessed as inhibition of LPS-induced TNFalpha release by ELISA | ChEMBL. | 24131218 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.