Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Integrase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0128 | 0.6678 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 0.6495 | 0.6495 |
Plasmodium vivax | thioredoxin reductase, putative | 0.005 | 0.1811 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0128 | 0.6678 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0125 | 0.6495 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0127 | 0.6644 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0127 | 0.6644 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.005 | 0.1811 | 0.2725 |
Brugia malayi | Thioredoxin reductase | 0.005 | 0.1811 | 0.2725 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 0.2887 | 0.4346 |
Brugia malayi | MH2 domain containing protein | 0.0127 | 0.6644 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.005 | 0.1811 | 0.1811 |
Mycobacterium tuberculosis | Probable reductase | 0.0115 | 0.5871 | 0.8342 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0128 | 0.6678 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.2887 | 0.2887 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0115 | 0.5871 | 0.8342 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0115 | 0.5871 | 0.8342 |
Brugia malayi | TAR-binding protein | 0.0068 | 0.2887 | 0.4346 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0115 | 0.5871 | 0.8342 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.005 | 0.1811 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0068 | 0.2887 | 0.2887 |
Loa Loa (eye worm) | thioredoxin reductase | 0.005 | 0.1811 | 0.2725 |
Plasmodium vivax | glutathione reductase, putative | 0.005 | 0.1811 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.2887 | 0.2887 |
Toxoplasma gondii | thioredoxin reductase | 0.005 | 0.1811 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 0.2887 | 0.4346 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0128 | 0.6678 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0115 | 0.5871 | 0.8342 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.2887 | 0.2887 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0068 | 0.2887 | 0.4346 |
Echinococcus granulosus | tar DNA binding protein | 0.0068 | 0.2887 | 0.2887 |
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 0.2887 | 0.4346 |
Brugia malayi | glutathione reductase | 0.005 | 0.1811 | 0.2725 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.2887 | 0.2887 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.005 | 0.1811 | 0.1811 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.2887 | 0.2887 |
Brugia malayi | RNA binding protein | 0.0068 | 0.2887 | 0.4346 |
Plasmodium falciparum | glutathione reductase | 0.005 | 0.1811 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0115 | 0.5871 | 0.8342 |
Leishmania major | trypanothione reductase | 0.005 | 0.1811 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.005 | 0.1811 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | > 50 uM | Cytotoxicity against human HeLa cells expressing CD4 after 24 hrs by beta-galactosidase reporter gene assay | ChEMBL. | 24124919 |
IC50 (binding) | = 12 uM | Inhibition of strand transfer activity of recombinant HIV1 integrase using 5'-end-labeled 21-mer double-stranded DNA as substrate after 60 mins by electrochemiluminescent plate-based assay | ChEMBL. | 24124919 |
IC50 (binding) | > 100 uM | Inhibition of RNase H activity of recombinant HIV1 reverse transcriptase using poly(dC)-[3H]poly(rG) as substrate | ChEMBL. | 24124919 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.