Detailed information for compound 1837567

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 586.655 | Formula: C32H30N2O7S
  • H donors: 2 H acceptors: 5 LogP: 5.59 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(=O)Oc1cc(/C=C/C(=O)Nc2cccc3c2cccc3S(=O)(=O)Nc2ccc(cc2)C(C)C)ccc1OC(=O)C
  • InChi: 1S/C32H30N2O7S/c1-20(2)24-13-15-25(16-14-24)34-42(38,39)31-10-6-7-26-27(31)8-5-9-28(26)33-32(37)18-12-23-11-17-29(40-21(3)35)30(19-23)41-22(4)36/h5-20,34H,1-4H3,(H,33,37)/b18-12+
  • InChiKey: YPOVDWRRXZVWEW-LDADJPATSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.083 0.5638 1
Echinococcus granulosus cGMP dependent protein kinase 0.0009 0.0004 0.0004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.058 0.3924 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0008
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0052 0.0052
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0196 0.1286 0.3048
Echinococcus granulosus cpg binding protein 0.0031 0.0154 0.0154
Echinococcus granulosus thymidylate synthase 0.0215 0.142 0.142
Schistosoma mansoni hypothetical protein 0.0016 0.0052 0.0052
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0148 0.0148
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0039 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0148 0.0148
Schistosoma mansoni serine/threonine protein kinase 0.0623 0.4217 0.4217
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0148 0.0148
Entamoeba histolytica hypothetical protein 0.0071 0.0432 0.1025
Plasmodium vivax basic transcription factor 3b, putative 0.0036 0.0186 0.0317
Echinococcus multilocularis phd:f box containing protein 0.001 0.0008 0.0008
Schistosoma mansoni cpg binding protein 0.0031 0.0154 0.0154
Schistosoma mansoni phd/f-box containing protein 0.001 0.0008 0.0008
Schistosoma mansoni cpg binding protein 0.0029 0.0142 0.0142
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0052 0.0052
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0004 0.0004
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0095 0.0592 0.0592
Echinococcus granulosus FTZ F1 alpha 0.003 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.003 0.0148 0.0148
Brugia malayi AF-10 protein 0.001 0.0009 0.0009
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0051
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.058 0.3924 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.003 0.0148 0.0148
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0225 0.0225
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0215 0.142 0.1356
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0039
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0073 0.0073
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0148 0.0148
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0148 0.0148
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0196 0.1286 0.1286
Brugia malayi jmjC domain containing protein 0.001 0.0008 0.0008
Schistosoma mansoni dep domain containing protein 0.0009 0.0004 0.0004
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0148 0.017
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0095 0.0592 0.1051
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0073 0.0187
Brugia malayi tailless protein 0.0014 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.003 0.0148 0.0148
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.083 0.5638 1
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0103 0.065 0.1148
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0183 0.1201 0.1413
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.001 0.0008 0.0008
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0004 0.0004
Brugia malayi PHD-finger family protein 0.003 0.0145 0.0145
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0073 0.0187
Brugia malayi hypothetical protein 0.0071 0.0432 0.0432
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0775 0.0775
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0215 0.142 0.142
Echinococcus granulosus lysine specific demethylase 6a 0.001 0.0008 0.0008
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0095 0.0592 0.1051
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0073 0.0187
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.083 0.5638 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0145 0.0145
Plasmodium falciparum JmjC domain-containing protein, putative 0.001 0.0008 0.0007
Brugia malayi nuclear receptor RXR 0.0014 0.0039 0.0039
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0095 0.0592 0.0592
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0148 0.0148
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0004 0.0004
Loa Loa (eye worm) AGC/PKG protein kinase 0.0009 0.0004 0.0004
Leishmania major protein kinase, putative 0.0009 0.0004 0.0007
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0051 0.0051
Brugia malayi conserved hypotetical protein 0.0014 0.0039 0.0039
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0196 0.1286 0.1286
Schistosoma mansoni protein phosphatase 2C 0.001 0.0008 0.0008
Schistosoma mansoni nuclear receptor 0.0014 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.045 0.3031 0.3031
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0186 0.0474
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0073 0.0073
Toxoplasma gondii histone lysine demethylase JMJD6a 0.001 0.0008 0.0007
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0033 0.0168 0.0095
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0102 0.0645 0.1144
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0148 0.0148
Brugia malayi MH2 domain containing protein 0.0121 0.0775 0.0775
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0039 0.0039
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0148 0.0148
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0148 0.0148
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0009 0.0015
Echinococcus granulosus GPCR family 2 0.0016 0.0052 0.0052
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0073 0.0187
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0432 0.0432
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0004
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0148 0.0148
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0283 0.1887 0.1887
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0073 0.0073
Schistosoma mansoni hypothetical protein 0.0035 0.018 0.018
Onchocerca volvulus 0.0245 0.1621 0.1908
Echinococcus granulosus jumonji domain containing 1A 0.001 0.0008 0.0008
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0073 0.013
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0148 0.0148
Echinococcus multilocularis expressed conserved protein 0.0009 0.0004 0.0004
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0004 0.0004
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0148 0.0148
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0095 0.0592 0.151
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0432 0.0432
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0148 0.0148
Mycobacterium tuberculosis Hypothetical protein 0.0102 0.0645 0.0576
Loa Loa (eye worm) hypothetical protein 0.003 0.0148 0.0148
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0623 0.4217 0.4217
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.058 0.3924 1
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0004 0.0004
Brugia malayi Bromodomain containing protein 0.003 0.0145 0.0145
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.058 0.3924 1
Echinococcus granulosus peregrin 0.003 0.0145 0.0145
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0004 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0148 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0186 0.0474
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.083 0.5638 1
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0148 0.0148
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0103 0.065 0.1657
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0148 0.0148
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0196 0.1286 0.228
Brugia malayi nuclear receptor NHR-88 0.0014 0.0039 0.0039
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0623 0.4215 0.4215
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0004
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0039 0.0039
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0145 0.0145
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0004 0.0004
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0004 0.0004
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0051 0.0051
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.029 0.029
Brugia malayi glucose-6-phosphate dehydrogenase 0.0095 0.0592 0.0592
Entamoeba histolytica hypothetical protein 0.0071 0.0432 0.1025
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0039 0.0039
Schistosoma mansoni ap endonuclease 0.0019 0.0073 0.0073
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0148 0.0148
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0031 0.0158 0.028
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.0608 0.0608
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0052
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0292 0.1949 0.1949
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0186 0.033
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0283 0.1887 0.1827
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0004 0.0004
Schistosoma mansoni coup transcription factor 0.003 0.0148 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0148 0.0148
Loa Loa (eye worm) runx1 0.0056 0.033 0.033
Brugia malayi hypothetical protein 0.045 0.3031 0.3031
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0039
Brugia malayi jmjC domain containing protein 0.0038 0.02 0.02
Leishmania major basic transcription factor 3a, putative 0.0036 0.0186 0.033
Brugia malayi beta-NAC-like protein 0.0036 0.0186 0.0186
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0051 0.0051
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0095 0.0592 0.0592
Brugia malayi hypothetical protein 0.0016 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0183 0.1201 0.1201
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.0608 0.0608
Schistosoma mansoni hypothetical protein 0.0016 0.0052 0.0052
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.003 0.0148 0.0148
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0004 0.0004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0148 0.0148
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0145 0.0145
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0148 0.017
Echinococcus multilocularis jumonji domain containing 1A 0.001 0.0008 0.0008
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0148 0.0148
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0103 0.065 0.1148
Onchocerca volvulus 0.1244 0.8477 1
Entamoeba histolytica hypothetical protein 0.0036 0.0186 0.0441
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0004 0.0004
Entamoeba histolytica hypothetical protein 0.0071 0.0432 0.1025
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0148 0.0148
Treponema pallidum fructose-bisphosphate aldolase 0.058 0.3924 1
Onchocerca volvulus 0.003 0.0148 0.017
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0073 0.0116
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0008 0.0008
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0051
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0148 0.0148
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0148 0.0148
Echinococcus granulosus nuclear factor of activated T cells 5 0.0292 0.1949 0.1949
Loa Loa (eye worm) hypothetical protein 0.0051 0.029 0.029
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0039 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0148 0.0148
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0322 0.0564
Schistosoma mansoni ap endonuclease 0.0019 0.0073 0.0073
Echinococcus multilocularis lysine specific demethylase 6a 0.001 0.0008 0.0008
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0775 0.0775
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0052 0.0052
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0103 0.065 0.1141
Echinococcus multilocularis JmjC domain containing protein 4 0.001 0.0008 0.0008
Loa Loa (eye worm) ICD-1 protein 0.0036 0.0186 0.0186
Brugia malayi nuclear hormone receptor 0.0014 0.0039 0.0039
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0004 0.0004
Schistosoma mansoni phosphatidylserine receptor 0.001 0.0008 0.0008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.058 0.3924 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0148 0.0148
Schistosoma mansoni lozenge 0.0056 0.033 0.033
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.02 0.02
Brugia malayi DIX domain containing protein 0.0009 0.0004 0.0004
Onchocerca volvulus 0.045 0.3031 0.3573
Plasmodium falciparum basic transcription factor 3b, putative 0.0036 0.0186 0.0323
Schistosoma mansoni zinc finger protein 0.0014 0.0039 0.0039
Brugia malayi hypothetical protein 0.0016 0.0051 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0148 0.0148
Onchocerca volvulus 0.0029 0.0142 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0186 0.0474
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.007 0.007
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0052 0.0052
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0039
Echinococcus multilocularis Protein lozenge 0.0056 0.033 0.033
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0052 0.0052
Entamoeba histolytica transcription factor BTF3, putative 0.0036 0.0186 0.0441
Giardia lamblia Fructose-bisphosphate aldolase 0.058 0.3924 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0073 0.013
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0039
Toxoplasma gondii exonuclease III APE 0.0019 0.0073 0.0123
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0225 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.1244 0.8477 0.8477
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0142 0.0142
Brugia malayi hypothetical protein 0.0014 0.0039 0.0039
Leishmania major protein kinase, putative 0.0009 0.0004 0.0007
Brugia malayi jmjC domain containing protein 0.001 0.0008 0.0008
Brugia malayi hypothetical protein 0.0009 0.0004 0.0004
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0004 0.0004
Schistosoma mansoni jumonji domain containing protein 0.001 0.0008 0.0008
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0004 0.0004
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.001 0.0008 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0148 0.0148
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0095 0.0592 0.0592
Brugia malayi solute carrier family 40, member 1 0.1244 0.8477 0.8477
Brugia malayi nuclear hormone receptor 0.003 0.0148 0.0148
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0196 0.1286 0.228
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.001 0.0008 0.0014
Echinococcus multilocularis transcription factor Dp 1 0.0113 0.072 0.072
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0004 0.0004
Onchocerca volvulus 0.0215 0.142 0.1671
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.018 0.018
Schistosoma mansoni hypothetical protein 0.003 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.003 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0039
Brugia malayi jmjC domain containing protein 0.0097 0.0608 0.0608
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0039 0.0039
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0148 0.0148
Leishmania major hypothetical protein, conserved 0.001 0.0008 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.058 0.3924 1
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0148 0.0148
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0039 0.0039
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.058 0.3924 0.9305
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0004
Brugia malayi jmjC domain containing protein 0.001 0.0008 0.0008
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0039 0.0039
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0148 0.0148
Brugia malayi hypothetical protein 0.0014 0.0039 0.0039
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0039 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.003 0.0145 0.0145
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0073 0.013
Brugia malayi nuclear receptor RXR 0.0016 0.0051 0.0051
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0004 0.0004
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0004 0.0004
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0188 0.0188
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0004 0.0004
Entamoeba histolytica protein kinase, putative 0.0623 0.4217 1
Schistosoma mansoni thyroid hormone receptor 0.003 0.0148 0.0148
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.02 0.02
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0051 0.0051
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.058 0.3924 0.9305
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0362 0.0362
Echinococcus granulosus cGMP dependent protein kinase 1 0.0009 0.0004 0.0004
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0039 0.0039
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0039 0.0039
Brugia malayi Pax transcription factor protein 2 0.0245 0.1621 0.1621
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0039 0.0039
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0103 0.065 0.1657
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0073 0.0123
Brugia malayi jmjC domain containing protein 0.001 0.0008 0.0008
Plasmodium falciparum phd finger protein, putative 0.003 0.0145 0.0251
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.0645 0.1644
Entamoeba histolytica hypothetical protein 0.0071 0.0432 0.1025
Schistosoma mansoni hypothetical protein 0.001 0.0009 0.0009
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0009 0.0015
Brugia malayi thymidylate synthase 0.0215 0.142 0.142
Echinococcus granulosus transcription factor Dp 1 0.0113 0.072 0.072
Brugia malayi steroid hormone receptor 0.003 0.0148 0.0148
Mycobacterium ulcerans thymidylate synthase 0.0215 0.142 0.142
Entamoeba histolytica protein kinase, putative 0.0623 0.4217 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0051
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0039
Leishmania major dihydrofolate reductase-thymidylate synthase 0.083 0.5638 1
Onchocerca volvulus 0.0014 0.0039 0.0041
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0471 0.0471
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0039 0.0039
Onchocerca volvulus Alhambra homolog 0.003 0.0145 0.0167
Echinococcus multilocularis peregrin 0.003 0.0145 0.0145
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0052 0.0052
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0148 0.017
Loa Loa (eye worm) hypothetical protein 0.0035 0.018 0.018
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0004 0.0004
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0039 0.0039
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0148 0.0148
Schistosoma mansoni hypothetical protein 0.0016 0.0052 0.0052
Echinococcus multilocularis transcription factor btf3 0.0036 0.0186 0.0186
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0432 0.0432
Brugia malayi nuclear receptor NHR-88 0.003 0.0148 0.0148
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0039 0.0039
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.02 0.02
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0062 0.0367 0.0367
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.001 0.0008 0.0007
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0145 0.0251
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0051 0.0051
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0004 0.0004
Echinococcus granulosus JmjC domain containing protein 4 0.001 0.0008 0.0008
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0095 0.0592 0.0592
Loa Loa (eye worm) hypothetical protein 0.0051 0.0291 0.0291
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0009 0.0004 0.0004
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0073 0.5
Echinococcus granulosus transcription factor btf3 0.0036 0.0186 0.0186
Echinococcus granulosus cGMP dependent protein kinase 1 0.0009 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0016 0.0052 0.0052
Brugia malayi hypothetical protein 0.0102 0.0645 0.0645
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0196 0.1286 0.228
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0148 0.0148
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0009 0.0004 0.0004
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0196 0.1286 0.1286
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0039 0.0039
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0062 0.0367 0.0644
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0148 0.0148
Brugia malayi PHD-finger family protein 0.0011 0.002 0.002
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0004 0.0004
Plasmodium vivax hypothetical protein, conserved 0.003 0.0145 0.0245
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.058 0.3924 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0073 0.0073
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0004 0.0004
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0011 0.0021 0.003
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0095 0.0592 0.0592
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0196 0.1286 0.228
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0145 0.0251
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0039 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0148 0.0148
Onchocerca volvulus 0.0014 0.0039 0.0041
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0051
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0073 0.0174
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0073 0.013
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.045 0.3031 0.3031
Loa Loa (eye worm) hypothetical protein 0.003 0.0148 0.0148
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0021 0.0023
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0145 0.0145
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0039 0.0039
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0039 0.0039
Brugia malayi hypothetical protein 0.0009 0.0004 0.0004
Schistosoma mansoni nuclear hormone receptor 0.003 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0008
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0148 0.0148
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0148 0.0148
Echinococcus multilocularis thymidylate synthase 0.0215 0.142 0.142
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0623 0.4215 0.4215
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.058 0.3924 1
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.083 0.5638 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0148 0.0148
Echinococcus multilocularis cpg binding protein 0.0031 0.0154 0.0154
Trypanosoma brucei transcription factor BTF3, putative 0.0036 0.0186 0.033
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0058 0.0058
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0196 0.1286 0.1286
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0051 0.0051
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0052 0.0052
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0148 0.0148
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0623 0.4217 0.4217
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0004 0.0004
Loa Loa (eye worm) thymidylate synthase 0.0215 0.142 0.142
Brugia malayi nuclear receptor NHR-67 0.0014 0.0039 0.0039
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0073 0.0073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0148 0.0148
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0103 0.065 0.1657
Schistosoma mansoni dishevelled 0.0009 0.0004 0.0004
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0196 0.1286 0.1286
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.001 0.0008 0.0014
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0367 0.0367
Schistosoma mansoni thyroid hormone receptor 0.003 0.0148 0.0148
Schistosoma mansoni hypothetical protein 0.0071 0.0432 0.0432
Echinococcus multilocularis GPCR, family 2 0.0016 0.0052 0.0052
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0039 0.0039
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0095 0.0592 0.1051
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0103 0.065 0.1657
Brugia malayi ecdysone receptor 0.0014 0.0039 0.0039
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0039 0.0039
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0039
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0148 0.0148
Schistosoma mansoni cpg binding protein 0.0031 0.0154 0.0154
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0039
Brugia malayi ecdysteroid receptor 0.003 0.0148 0.0148
Toxoplasma gondii PHD-finger domain-containing protein 0.001 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0148 0.0148
Brugia malayi N-terminal motif family protein 0.0183 0.1201 0.1201
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0008 0.0008
Schistosoma mansoni dishevelled 0.0009 0.0004 0.0004
Schistosoma mansoni transcription factor btf3 0.0036 0.0186 0.0186
Brugia malayi CXXC zinc finger family protein 0.0029 0.0142 0.0142
Toxoplasma gondii NAC domain-containing protein 0.0036 0.0186 0.0323
Loa Loa (eye worm) DR-78 0.0014 0.0039 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0148 0.0148
Loa Loa (eye worm) pax transcription factor protein 2 0.0245 0.1621 0.1621
Giardia lamblia PHD finger protein 15 0.003 0.0145 0.0371
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0148 0.0148
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0039 0.0039
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0051 0.0051
Brugia malayi Egg laying defective protein 4 0.0009 0.0004 0.0004
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0039 0.0039
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.029 0.029
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.001 0.0009 0.0008
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.003 0.0151 0.0268
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0215 0.142 0.142
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.02 0.02
Schistosoma mansoni nuclear receptor 0.0014 0.0039 0.0039
Echinococcus granulosus phd:f box containing protein 0.001 0.0008 0.0008
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0148 0.0148
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0283 0.1887 0.1887
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0186 0.033
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0039 0.0041

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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