Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0516 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0027 | 0.0516 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.0126 | 0.139 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3096 | 0.3096 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.195 | 0.195 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0027 | 0.0516 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1315 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.0126 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0027 | 0.0516 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0516 | 1 |
Brugia malayi | TAR-binding protein | 0.0072 | 0.3096 | 1 |
Brugia malayi | hypothetical protein | 0.0041 | 0.1315 | 0.4247 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.2218 | 0.7163 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1315 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0516 | 0.1668 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0516 | 0.1668 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1315 | 0.1315 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.195 | 0.195 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.1191 | 0.3848 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3096 | 0.3096 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0516 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.195 | 0.195 |
Brugia malayi | RNA binding protein | 0.0072 | 0.3096 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.002 | 0.0126 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0027 | 0.0516 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.2218 | 0.7163 |
Echinococcus multilocularis | tar DNA binding protein | 0.0072 | 0.3096 | 0.3096 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0027 | 0.0516 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0126 | 0.0408 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0516 | 0.1668 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0126 | 0.0408 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0516 | 0.1668 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.1315 | 0.1315 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1191 | 0.3848 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0126 | 0.0408 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3096 | 0.3096 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.2218 | 0.7163 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.1315 | 0.1315 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.195 | 0.63 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.1315 | 0.1315 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0072 | 0.3096 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0516 | 0.1668 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0516 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0516 | 0.1668 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.195 | 0.63 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0126 | 0.0408 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.195 | 0.195 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.195 | 0.195 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.195 | 0.195 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0027 | 0.0516 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0072 | 0.3096 | 1 |
Onchocerca volvulus | 0.0027 | 0.0516 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1315 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.002 | 0.0126 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0072 | 0.3096 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1315 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3096 | 0.3096 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0516 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3096 | 0.3096 |
Echinococcus granulosus | tar DNA binding protein | 0.0072 | 0.3096 | 0.3096 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.195 | 0.195 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0516 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0516 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.0516 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0126 | 0.0408 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.2218 | 0.7163 |
Loa Loa (eye worm) | TAR-binding protein | 0.0072 | 0.3096 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.1191 | 0.1191 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0516 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 500 ug ml-1 | Antibacterial activity against Escherichia coli after 18 hrs by turbidity assay | ChEMBL. | 24168147 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.