Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0516 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.195 | 0.195 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.2218 | 0.7163 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3096 | 0.3096 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0516 | 0.1668 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.1191 | 0.1191 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0516 | 0.1668 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0126 | 0.0408 |
Loa Loa (eye worm) | TAR-binding protein | 0.0072 | 0.3096 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3096 | 0.3096 |
Plasmodium falciparum | acyl-CoA synthetase | 0.002 | 0.0126 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0072 | 0.3096 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.195 | 0.195 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1191 | 0.3848 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.1315 | 0.1315 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0516 | 0.1668 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0072 | 0.3096 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.195 | 0.195 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.195 | 0.195 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0126 | 0.0408 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0027 | 0.0516 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0516 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.1315 | 0.1315 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0027 | 0.0516 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0516 | 0.1668 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.0126 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.2218 | 0.7163 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.2218 | 0.7163 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1315 | 0.1315 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.195 | 0.63 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0516 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.195 | 0.195 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1315 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3096 | 0.3096 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.195 | 0.195 |
Loa Loa (eye worm) | RNA binding protein | 0.0072 | 0.3096 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.2218 | 0.7163 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0516 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0072 | 0.3096 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0027 | 0.0516 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0516 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0072 | 0.3096 | 0.3096 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0027 | 0.0516 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0027 | 0.0516 | 1 |
Onchocerca volvulus | 0.0027 | 0.0516 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1315 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3096 | 0.3096 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.1191 | 0.3848 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0516 | 0.1668 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.195 | 0.63 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0516 | 0.5 |
Brugia malayi | hypothetical protein | 0.0041 | 0.1315 | 0.4247 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0516 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.195 | 0.195 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.0126 | 0.139 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1315 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3096 | 0.3096 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0516 | 0.1668 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.002 | 0.0126 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0126 | 0.0408 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0126 | 0.0408 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.0516 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0516 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1315 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0126 | 0.0408 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.1315 | 0.1315 |
Echinococcus multilocularis | tar DNA binding protein | 0.0072 | 0.3096 | 0.3096 |
Brugia malayi | RNA binding protein | 0.0072 | 0.3096 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0027 | 0.0516 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 500 ug ml-1 | Antibacterial activity against Escherichia coli after 18 hrs by turbidity assay | ChEMBL. | 24168147 |
MIC (functional) | > 500 ug ml-1 | Antibacterial activity against Escherichia coli after 18 hrs by turbidity assay | ChEMBL. | 24168147 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.