Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (ADMET) | = 3.43 mg kg-1 | Toxicity in ip dosed CD-1 mouse assessed as incidence of tremor measured every 10 to 15 mins for 8 hrs up to day 14 | ChEMBL. | 24211635 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.