TDR Targets

Basic information

Technical information

TDR Targets ID: 1838004
Name: ethyl 4-(2-methoxyphenyl)-6-methyl-2-sulfanyl idene-3,4-dihydro-1H-pyrimidine-5-carboxylate
MW: 306.38 | Formula: C15H18N2O3S
H donors: 2 H acceptors: 1 LogP: 1.95 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)C1=C(C)NC(=S)NC1c1ccccc1OC
InChi: 1S/C15H18N2O3S/c1-4-20-14(18)12-9(2)16-15(21)17-13(12)10-7-5-6-8-11(10)19-3/h5-8,13H,4H2,1-3H3,(H2,16,17,21)
InChiKey: JARBZPDXVYXTSA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 4-(2-methoxyphenyl)-6-methyl-2-thioxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
4-(2-methoxyphenyl)-6-methyl-2-thioxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid ethyl ester
Oprea1_044774
EU-0001851
ST5269796
AG-690/36532019
BAS 03148546

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	dihydrofolate reductase	Starlite/ChEMBL	No references
Cryptosporidium parvum	dihydrofolate reductase-thymidylate synthase	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Candida albicans	dihydrofolate reductase	Get druggable targets OG5_128410	All targets in OG5_128410
Loa Loa (eye worm)	dihydrofolate reductase	Get druggable targets OG5_128410	All targets in OG5_128410
Brugia malayi	Dihydrofolate reductase	Get druggable targets OG5_128410	All targets in OG5_128410
Schistosoma japonicum	ko:K00560 thymidylate synthase [EC2.1.1.45], putative	Get druggable targets OG5_127385	All targets in OG5_127385
Echinococcus multilocularis	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Candida albicans	dihydrofolate reductase	Get druggable targets OG5_128410	All targets in OG5_128410
Onchocerca volvulus		Get druggable targets OG5_127385	All targets in OG5_127385
Babesia bovis	dihydrofolate reductase/thymidilate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Cryptosporidium parvum	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Chlamydia trachomatis	dihydrofolate reductase	Get druggable targets OG5_128410	All targets in OG5_128410
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Echinococcus granulosus	dihydrofolate reductase	Get druggable targets OG5_128410	All targets in OG5_128410
Echinococcus granulosus	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Leishmania mexicana	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Brugia malayi	dihydrofolate reductase family protein	Get druggable targets OG5_128410	All targets in OG5_128410
Plasmodium knowlesi	bifunctional dihydrofolate reductase-thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	Get druggable targets OG5_127385	All targets in OG5_127385
Candida albicans	Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C)	Get druggable targets OG5_127385	All targets in OG5_127385
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	Get druggable targets OG5_128410	All targets in OG5_128410
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	Get druggable targets OG5_127385	All targets in OG5_127385
Plasmodium yoelii	thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Plasmodium berghei	bifunctional dihydrofolate reductase-thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Cryptosporidium hominis	chain A, crystal structure of Dhfr	Get druggable targets OG5_127385	All targets in OG5_127385
Loa Loa (eye worm)	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Echinococcus multilocularis	dihydrofolate reductase	Get druggable targets OG5_128410	All targets in OG5_128410
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	Get druggable targets OG5_128410	All targets in OG5_128410
Trypanosoma brucei gambiense	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Neospora caninum	Bifunctional dihydrofolate reductase-thymidylate synthase, related	Get druggable targets OG5_127385	All targets in OG5_127385
Leishmania infantum	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Leishmania braziliensis	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Candida albicans	hypothetical protein	Get druggable targets OG5_128410	All targets in OG5_128410
Leishmania donovani	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Mycobacterium ulcerans	dihydrofolate reductase DfrA	Get druggable targets OG5_128410	All targets in OG5_128410
Leishmania major	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Schistosoma japonicum	ko:K00287 dihydrofolate reductase [EC1.5.1.3], putative	Get druggable targets OG5_128410	All targets in OG5_128410
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127385	All targets in OG5_127385
Mycobacterium ulcerans	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Candida albicans	Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C)	Get druggable targets OG5_127385	All targets in OG5_127385
Theileria parva	dihydrofolate reductase-thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Schistosoma mansoni	dihydrofolate reductase	Get druggable targets OG5_128410	All targets in OG5_128410

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	dihydrofolate reductase	187 aa	202 aa	29.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0433	0.8599	1
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0433	0.8599	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0433	0.8599	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0433	0.8599	1
Brugia malayi	Raf kinase	0.0433	0.8599	1
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Echinococcus granulosus	epidermal growth factor receptor	0.0433	0.8599	1
Schistosoma mansoni	serine/threonine protein kinase	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0433	0.8599	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0433	0.8599	1
Loa Loa (eye worm)	hypothetical protein	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0433	0.8599	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0433	0.8599	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0433	0.8599	1
Onchocerca volvulus		0.0433	0.8599	1
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0433	0.8599	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0433	0.8599	1
Echinococcus multilocularis	tyrosine protein kinase	0.0433	0.8599	1
Leishmania major	hypothetical protein, conserved	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Brugia malayi	Guanylyl cyclase protein 23	0.0433	0.8599	1
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0433	0.8599	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0433	0.8599	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0433	0.8599	1
Brugia malayi	protein-tyrosine kinase	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0433	0.8599	0.5
Loa Loa (eye worm)	TK/FAK protein kinase	0.0433	0.8599	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Schistosoma mansoni	ephrin receptor	0.0433	0.8599	1
Echinococcus multilocularis	insulin receptor	0.0433	0.8599	1
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Loa Loa (eye worm)	hypothetical protein	0.0433	0.8599	1
Echinococcus multilocularis	tyrosine kinase	0.0433	0.8599	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0433	0.8599	1
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Loa Loa (eye worm)	TK protein kinase	0.0433	0.8599	1
Schistosoma mansoni	dihydrofolate reductase	0.026	0.371	0.4315
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0433	0.8599	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.0433	0.8599	1
Loa Loa (eye worm)	hypothetical protein	0.0433	0.8599	1
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0433	0.8599	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0433	0.8599	1
Schistosoma mansoni	serine/threonine protein kinase	0.0433	0.8599	1
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0433	0.8599	1
Brugia malayi	integrin-linked kinase	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Echinococcus granulosus	tyrosine kinase	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Brugia malayi	Receptor family ligand binding region containing protein	0.0433	0.8599	1
Toxoplasma gondii	protein kinase	0.0433	0.8599	1
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0433	0.8599	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.0433	0.8599	1
Trichomonas vaginalis	conserved hypothetical protein	0.0433	0.8599	0.5
Trichomonas vaginalis	TK family protein kinase	0.0433	0.8599	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Echinococcus multilocularis	tyrosine kinase	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Echinococcus granulosus	integrin linked protein kinase	0.0433	0.8599	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0433	0.8599	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0433	0.8599	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0433	0.8599	1
Schistosoma mansoni	protein kinase	0.0433	0.8599	1
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Echinococcus multilocularis	dihydrofolate reductase	0.026	0.371	0.4315
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0433	0.8599	1
Plasmodium falciparum	protein kinase, putative	0.0433	0.8599	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0433	0.8599	1
Loa Loa (eye worm)	hypothetical protein	0.0433	0.8599	1
Giardia lamblia	Protein 21.1	0.0433	0.8599	0.5
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0433	0.8599	1
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Schistosoma mansoni	tyrosine protein kinase	0.0433	0.8599	1
Loa Loa (eye worm)	TK protein kinase	0.0433	0.8599	1
Trichomonas vaginalis	conserved hypothetical protein	0.0433	0.8599	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0433	0.8599	0.5
Onchocerca volvulus		0.0433	0.8599	1
Trichomonas vaginalis	conserved hypothetical protein	0.0433	0.8599	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0433	0.8599	1
Brugia malayi	SRC-1	0.0433	0.8599	1
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0433	0.8599	1
Echinococcus granulosus	kinase suppressor of Ras 1	0.0433	0.8599	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0433	0.8599	1
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Trichomonas vaginalis	conserved hypothetical protein	0.0433	0.8599	0.5
Onchocerca volvulus		0.0433	0.8599	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0433	0.8599	1
Onchocerca volvulus		0.0433	0.8599	1
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Brugia malayi	SH2 domain containing protein	0.0433	0.8599	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0433	0.8599	1
Echinococcus granulosus	tyrosine protein kinase shark	0.0433	0.8599	1
Echinococcus granulosus	dihydrofolate reductase	0.026	0.371	0.4315
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0433	0.8599	1
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Echinococcus multilocularis	FL cytokine receptor	0.0433	0.8599	1
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0433	0.8599	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0433	0.8599	1
Brugia malayi	Dihydrofolate reductase	0.026	0.371	0.4315
Loa Loa (eye worm)	TK/FER protein kinase	0.0433	0.8599	1
Echinococcus multilocularis	heat shock protein 70	0.0433	0.8599	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0433	0.8599	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0433	0.8599	1
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0433	0.8599	1
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0433	0.8599	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0433	0.8599	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0433	0.8599	1
Loa Loa (eye worm)	TK protein kinase	0.0433	0.8599	1
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Brugia malayi	SH2 domain containing protein	0.0433	0.8599	1
Loa Loa (eye worm)	TK protein kinase	0.0433	0.8599	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0433	0.8599	1
Chlamydia trachomatis	dihydrofolate reductase	0.026	0.371	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Echinococcus granulosus	tyrosine kinase	0.0433	0.8599	1
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0433	0.8599	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0433	0.8599	1
Onchocerca volvulus		0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0433	0.8599	1
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Trichomonas vaginalis	conserved hypothetical protein	0.0433	0.8599	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0433	0.8599	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0433	0.8599	1
Brugia malayi	dihydrofolate reductase family protein	0.026	0.371	0.4315
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0433	0.8599	1
Schistosoma mansoni	protein kinase	0.0433	0.8599	1
Echinococcus granulosus	raf serine:threonine protein kinase	0.0433	0.8599	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0433	0.8599	1
Giardia lamblia	Kinase	0.0433	0.8599	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0433	0.8599	1
Echinococcus granulosus	receptor type guanylyl cyclase	0.0433	0.8599	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0433	0.8599	1
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0433	0.8599	1
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.026	0.371	1
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0433	0.8599	1
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Schistosoma mansoni	protein kinase	0.0433	0.8599	1
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0433	0.8599	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0433	0.8599	1
Toxoplasma gondii	STE kinase	0.0433	0.8599	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0433	0.8599	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0433	0.8599	1
Onchocerca volvulus		0.0433	0.8599	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0433	0.8599	1
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Echinococcus multilocularis	protein kinase	0.0433	0.8599	1
Echinococcus multilocularis	transfer RNA-Thr	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Echinococcus granulosus	tyrosine protein kinase	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Loa Loa (eye worm)	dihydrofolate reductase	0.026	0.371	0.4315
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0433	0.8599	1
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0433	0.8599	1
Echinococcus granulosus	c src tyrosine kinase	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Onchocerca volvulus		0.0433	0.8599	1
Echinococcus granulosus	activin receptor type	0.0433	0.8599	1
Giardia lamblia	Kinase, NEK	0.0433	0.8599	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Schistosoma mansoni	protein kinase	0.0433	0.8599	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0433	0.8599	1
Loa Loa (eye worm)	TK protein kinase	0.0433	0.8599	1
Onchocerca volvulus		0.0433	0.8599	1
Loa Loa (eye worm)	hypothetical protein	0.0433	0.8599	1
Schistosoma mansoni	serine/threonine RGC	0.0433	0.8599	1
Loa Loa (eye worm)	TK protein kinase	0.0433	0.8599	1
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.026	0.371	1
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Plasmodium vivax	protein kinase, putative	0.0433	0.8599	1
Schistosoma mansoni	serine/threonine protein kinase	0.0433	0.8599	1
Loa Loa (eye worm)	TK protein kinase	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Onchocerca volvulus		0.0433	0.8599	1
Onchocerca volvulus		0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0433	0.8599	1
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0433	0.8599	1
Echinococcus multilocularis	protein kinase	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Brugia malayi	hypothetical protein	0.0433	0.8599	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0433	0.8599	1
Plasmodium falciparum	protein kinase, putative	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0433	0.8599	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0433	0.8599	1
Loa Loa (eye worm)	hypothetical protein	0.0433	0.8599	1
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Schistosoma mansoni	protein tyrosine kinase	0.0433	0.8599	1
Giardia lamblia	Kinase, NEK	0.0433	0.8599	0.5
Onchocerca volvulus		0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Schistosoma mansoni	protein kinase	0.0433	0.8599	1
Loa Loa (eye worm)	hypothetical protein	0.0433	0.8599	1
Brugia malayi	C-terminal src kinase protein 1	0.0433	0.8599	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0433	0.8599	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0433	0.8599	1
Echinococcus granulosus	ephrin type A receptor 4 A	0.0433	0.8599	1
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0433	0.8599	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0433	0.8599	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.0433	0.8599	1
Trypanosoma brucei	protein kinase, putative	0.0433	0.8599	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0433	0.8599	1
Leishmania major	protein kinase, putative	0.0433	0.8599	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.0433	0.8599	1
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0433	0.8599	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0433	0.8599	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0433	0.8599	1
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Trypanosoma cruzi	protein kinase, putative	0.0433	0.8599	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0433	0.8599	1
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0433	0.8599	1
Loa Loa (eye worm)	hypothetical protein	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0433	0.8599	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0433	0.8599	1
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0433	0.8599	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0433	0.8599	0.5
Echinococcus granulosus	activated cdc42 kinase 1	0.0433	0.8599	1
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Echinococcus granulosus	epidermal growth factor receptor	0.0433	0.8599	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0433	0.8599	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0433	0.8599	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Trichomonas vaginalis	STE family protein kinase	0.0433	0.8599	0.5
Onchocerca volvulus		0.0433	0.8599	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0433	0.8599	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0433	0.8599	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0433	0.8599	1
Echinococcus granulosus	insulin receptor	0.0433	0.8599	1
Loa Loa (eye worm)	TK/Met protein kinase	0.0433	0.8599	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.0433	0.8599	1
Echinococcus granulosus	protein tyrosine kinase	0.0433	0.8599	1
Loa Loa (eye worm)	TK/CSK protein kinase	0.0433	0.8599	1
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0433	0.8599	1
Loa Loa (eye worm)	hypothetical protein	0.0433	0.8599	1
Schistosoma mansoni	protein kinase	0.0433	0.8599	1
Schistosoma mansoni	protein kinase	0.0433	0.8599	1
Brugia malayi	Tyrosine-protein kinase PR2	0.0433	0.8599	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0433	0.8599	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0433	0.8599	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0433	0.8599	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0433	0.8599	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0433	0.8599	1
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0433	0.8599	1
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Trypanosoma cruzi	protein kinase, putative	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Schistosoma mansoni	ephrin receptor	0.0433	0.8599	1
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0433	0.8599	1
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.0433	0.8599	1
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0433	0.8599	1
Trichomonas vaginalis	AGC family protein kinase	0.0433	0.8599	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0433	0.8599	1
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0433	0.8599	1
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Brugia malayi	hypothetical protein	0.0433	0.8599	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Loa Loa (eye worm)	hypothetical protein	0.0433	0.8599	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0433	0.8599	1
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Loa Loa (eye worm)	TK protein kinase	0.0433	0.8599	1
Leishmania major	protein kinase, putative	0.0433	0.8599	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0433	0.8599	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0433	0.8599	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0433	0.8599	1
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0433	0.8599	1
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0433	0.8599	1
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0433	0.8599	1
Plasmodium falciparum	protein kinase, putative	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0433	0.8599	1
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0433	0.8599	1
Brugia malayi	hypothetical protein	0.0433	0.8599	1
Schistosoma mansoni	protein kinase	0.0433	0.8599	1
Echinococcus multilocularis	activated cdc42 kinase 1	0.0433	0.8599	1
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Echinococcus granulosus	tyrosine kinase	0.0433	0.8599	1
Onchocerca volvulus	Tyrosine kinase homolog	0.0433	0.8599	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0433	0.8599	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0433	0.8599	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0433	0.8599	1
Brugia malayi	Furin-like cysteine rich region family protein	0.0433	0.8599	1
Onchocerca volvulus		0.0433	0.8599	1
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Loa Loa (eye worm)	TK protein kinase	0.0433	0.8599	1
Echinococcus multilocularis	integrin linked protein kinase	0.0433	0.8599	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0433	0.8599	1
Schistosoma mansoni	hypothetical protein	0.0433	0.8599	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Onchocerca volvulus		0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Schistosoma mansoni	protein kinase	0.0433	0.8599	1
Loa Loa (eye worm)	hypothetical protein	0.0433	0.8599	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0433	0.8599	1
Schistosoma mansoni	protein kinase	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0433	0.8599	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0433	0.8599	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0433	0.8599	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0433	0.8599	1
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0433	0.8599	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0433	0.8599	1
Trypanosoma brucei	Pseudokinase, putative	0.0433	0.8599	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.0433	0.8599	1
Loa Loa (eye worm)	hypothetical protein	0.0433	0.8599	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.0433	0.8599	1
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0433	0.8599	1
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0433	0.8599	1
Echinococcus granulosus	protein kinase	0.0433	0.8599	1
Echinococcus multilocularis	activin receptor type	0.0433	0.8599	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0433	0.8599	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0433	0.8599	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0433	0.8599	0.5
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0433	0.8599	1
Loa Loa (eye worm)	hypothetical protein	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0433	0.8599	1
Loa Loa (eye worm)	SRC-1	0.0433	0.8599	1
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Brugia malayi	ephrin receptor 1 precursor	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Loa Loa (eye worm)	TK/INSR protein kinase	0.0433	0.8599	1
Onchocerca volvulus		0.0433	0.8599	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.0433	0.8599	1
Schistosoma mansoni	protein kinase	0.0433	0.8599	1
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.026	0.371	1
Echinococcus multilocularis	protein tyrosine kinase	0.0433	0.8599	1
Trichomonas vaginalis	protein kinase atn1, putative	0.0433	0.8599	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0433	0.8599	1
Trichomonas vaginalis	conserved hypothetical protein	0.0433	0.8599	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0433	0.8599	1
Echinococcus multilocularis	c src tyrosine kinase	0.0433	0.8599	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0433	0.8599	1
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0433	0.8599	1
Loa Loa (eye worm)	TK protein kinase	0.0433	0.8599	1
Trichomonas vaginalis	TKL family protein kinase	0.0433	0.8599	0.5
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0433	0.8599	1
Brugia malayi	Protein kinase domain containing protein	0.0433	0.8599	1
Schistosoma mansoni	tyrosine kinase	0.0433	0.8599	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0433	0.8599	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0433	0.8599	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)		Antiparasitic activity against Toxoplasma gondii RH infected Swiss albino mouse assessed as decrease in tachozyte count in spleen at 0.25 mg, po administered 48 hr post-infection measured after 3 days by Geimsa staining relative to control	ChEMBL.	No reference
Activity (functional)		Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as decreased parasite movement in host peritoneal exudate at 0.25 mg, po administered 48 hr post-infection measured after 3 days by light microscopic analysis	ChEMBL.	No reference
Activity (functional)		Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as decrease in host spleen necrosis at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control	ChEMBL.	No reference
Activity (functional)		Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as increase in host spleen red pulp at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control	ChEMBL.	No reference
Activity (functional)		Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as clear mononuclear cells in host liver focal granuloma at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control	ChEMBL.	No reference
Activity (functional)		Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as parasite deformity in host peritoneal exudate at 0.25 mg, po administered 48 hr post-infection measured after 3 days by light microscopic analysis	ChEMBL.	No reference
Activity (functional)		Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as megakaryocytes in host spleen at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control	ChEMBL.	No reference
Activity (functional)		Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as extramedullary hematopoiesis in host spleen at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control	ChEMBL.	No reference
Activity (functional)		Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as clear lymphocytes in host liver focal granuloma at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control	ChEMBL.	No reference
Activity (functional)		Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as decrease in host liver necrosis at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control	ChEMBL.	No reference
Activity (functional)		Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as decrease in interstitial pneumonia at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control	ChEMBL.	No reference
Activity (functional)		Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as decrease in host spleen white pulp at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control	ChEMBL.	No reference
Activity (functional)		Antiparasitic activity against Toxoplasma gondii RH infected Swiss albino mouse assessed as decrease in tachozyte count in liver at 0.25 mg, po administered 48 hr post-infection measured after 3 days by Geimsa staining relative to control	ChEMBL.	No reference
Activity (functional)		Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as epethelioid granuloma in host spleen at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control	ChEMBL.	No reference
Activity (functional)		Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as decrease in Toxoplasma antigen in host serum at 0.25 mg, po administered 48 hr post-infection measured after 3 days by Co-A test relative to control	ChEMBL.	No reference
Activity (functional)		Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as decrease in host lung congestion at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control	ChEMBL.	No reference
IC50 (binding)	= 1.9 uM	Inhibition of Homo sapiens (human) dihydrofolate reductase using dihydrofolate as substrate incubated for 5 min prior to substrate addition by spectrophotometric assay	ChEMBL.	No reference
IC50 (binding)	= 2.4 uM	Inhibition of Cryptosporidium parvum recombinant DHFR using dihydrofolate as substrate incubated for 5 min prior to substrate addition by spectrophotometric assay	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2261698

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1838004