Activity (functional)
|
|
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as decrease in host lung congestion at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control
|
ChEMBL.
|
No reference
|
Activity (functional)
|
|
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as decrease in Toxoplasma antigen in host serum at 0.25 mg, po administered 48 hr post-infection measured after 3 days by Co-A test relative to control
|
ChEMBL.
|
No reference
|
Activity (functional)
|
|
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as epethelioid granuloma in host spleen at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control
|
ChEMBL.
|
No reference
|
Activity (functional)
|
|
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as decrease in host spleen white pulp at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control
|
ChEMBL.
|
No reference
|
Activity (functional)
|
|
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as decrease in host liver necrosis at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control
|
ChEMBL.
|
No reference
|
Activity (functional)
|
|
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as decrease in interstitial pneumonia at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control
|
ChEMBL.
|
No reference
|
Activity (functional)
|
|
Antiparasitic activity against Toxoplasma gondii RH infected Swiss albino mouse assessed as decrease in tachozyte count in liver at 0.25 mg, po administered 48 hr post-infection measured after 3 days by Geimsa staining relative to control
|
ChEMBL.
|
No reference
|
Activity (functional)
|
|
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as clear lymphocytes in host liver focal granuloma at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control
|
ChEMBL.
|
No reference
|
Activity (functional)
|
|
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as megakaryocytes in host spleen at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control
|
ChEMBL.
|
No reference
|
Activity (functional)
|
|
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as parasite deformity in host peritoneal exudate at 0.25 mg, po administered 48 hr post-infection measured after 3 days by light microscopic analysis
|
ChEMBL.
|
No reference
|
Activity (functional)
|
|
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as extramedullary hematopoiesis in host spleen at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control
|
ChEMBL.
|
No reference
|
Activity (functional)
|
|
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as clear mononuclear cells in host liver focal granuloma at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control
|
ChEMBL.
|
No reference
|
Activity (functional)
|
|
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as increase in host spleen red pulp at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control
|
ChEMBL.
|
No reference
|
Activity (functional)
|
|
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as decrease in host spleen necrosis at 0.25 mg, po administered 48 hr post-infection measured after 3 days by haematoxylin and eosin staining relative to control
|
ChEMBL.
|
No reference
|
Activity (functional)
|
|
Antiparasitic activity against Toxoplasma gondii RH infected Swiss albino mouse assessed as decrease in tachozyte count in spleen at 0.25 mg, po administered 48 hr post-infection measured after 3 days by Geimsa staining relative to control
|
ChEMBL.
|
No reference
|
Activity (functional)
|
|
Antiparasitic activity Toxoplasma gondii RH infected Swiss albino mouse assessed as decreased parasite movement in host peritoneal exudate at 0.25 mg, po administered 48 hr post-infection measured after 3 days by light microscopic analysis
|
ChEMBL.
|
No reference
|
IC50 (binding)
|
= 2.1 uM
|
Inhibition of Cryptosporidium parvum recombinant DHFR using dihydrofolate as substrate incubated for 5 min prior to substrate addition by spectrophotometric assay
|
ChEMBL.
|
No reference
|
IC50 (binding)
|
= 2.9 uM
|
Inhibition of Homo sapiens (human) dihydrofolate reductase using dihydrofolate as substrate incubated for 5 min prior to substrate addition by spectrophotometric assay
|
ChEMBL.
|
No reference
|