Detailed information for compound 1838027

Basic information

Technical information
  • TDR Targets ID: 1838027
  • Name: AIDS157597
  • MW: 237.339 | Formula: C17H19N
  • H donors: 1 H acceptors: 0 LogP: 2.86 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC1C2C3C4C1(c1ccccc1)C1C2CC3C1C4
  • InChi: 1S/C17H19N/c18-16-14-11-6-9-10-7-12(13(9)14)17(16,15(10)11)8-4-2-1-3-5-8/h1-5,9-16H,6-7,18H2
  • InChiKey: OPWWFTVBORMGFH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • NSC646114 (HYDROCHLORIDE SALT)
  • 1,3,5-Methenocyclopenta[cd]pentalen-2-amine, decahydro-1-phenyl-
  • AIDS-157597

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) acetyltransferase 0.0445 0.4622 0.4604
Echinococcus granulosus cpg binding protein 0.0067 0.0516 0.0484
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.005 0.0017
Echinococcus multilocularis nAChR subunit 0.0029 0.0104 0.0071
Loa Loa (eye worm) hypothetical protein 0.0029 0.0104 0.0071
Brugia malayi hypothetical protein 0.0025 0.0059 0.0044
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0055 0.0378 0.0601
Brugia malayi MH2 domain containing protein 0.0358 0.3677 0.6362
Loa Loa (eye worm) hypothetical protein 0.0075 0.0603 0.0572
Echinococcus multilocularis smad 0.0024 0.005 0.0017
Schistosoma mansoni neurotransmitter gated ion channel 0.0025 0.0059 0.0025
Echinococcus granulosus histone lysine methyltransferase setb 0.0085 0.0704 0.0673
Echinococcus multilocularis importin subunit beta 1 0.0088 0.0742 0.0711
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0055 0.0378 0.0345
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0313 0.0797
Echinococcus multilocularis glycine receptor subunit beta 0.0055 0.0378 0.0345
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0473 0.0441
Echinococcus granulosus glycine receptor subunit beta 0.0055 0.0378 0.0345
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0055 0.0378 0.0345
Loa Loa (eye worm) hypothetical protein 0.0025 0.0059 0.0025
Mycobacterium tuberculosis Conserved protein 0.0075 0.0603 0.0754
Loa Loa (eye worm) hypothetical protein 0.0075 0.0603 0.0572
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0055 0.0378 0.0601
Schistosoma mansoni acetylcholine receptor subunit beta 0.0025 0.0059 0.0025
Brugia malayi Importin beta-1 subunit 0.0088 0.0742 0.1237
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0055 0.0378 0.0345
Entamoeba histolytica hypothetical protein 0.0069 0.0533 0.4449
Onchocerca volvulus 0.0055 0.0378 0.0744
Echinococcus granulosus glycine receptor subunit alpha 1 0.0055 0.0378 0.0345
Brugia malayi acetyltransferase, GNAT family protein 0.0445 0.4622 0.8013
Schistosoma mansoni neurotransmitter gated ion channel 0.0029 0.0104 0.0071
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0183 0.0261
Onchocerca volvulus 0.0055 0.0378 0.0744
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0055 0.0378 0.0345
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0711 0.751 0.7501
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0065 0.049 0.1626
Echinococcus granulosus importin subunit beta 1 0.0088 0.0742 0.0711
Echinococcus multilocularis glycine receptor subunit beta 0.0055 0.0378 0.0345
Echinococcus granulosus Smad4 0.0024 0.005 0.0017
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.005 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0119 0.0086
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0378 0.3894 0.3873
Onchocerca volvulus 0.0055 0.0378 0.0744
Entamoeba histolytica hypothetical protein 0.0069 0.0533 0.4449
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0025 0.0059 0.0025
Trichomonas vaginalis importin beta-1, putative 0.0071 0.0561 0.2402
Loa Loa (eye worm) RNA binding protein 0.0063 0.0473 0.0441
Loa Loa (eye worm) hypothetical protein 0.0055 0.0378 0.0345
Schistosoma mansoni nAChR subunit 0.0055 0.0378 0.0345
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0345 0.3536 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.005 0.0017
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0603 0.2583
Plasmodium falciparum importin beta, putative 0.0088 0.0742 0.2964
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0603 0.0572
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0055 0.0378 0.0345
Brugia malayi hypothetical protein 0.0025 0.0059 0.0044
Schistosoma mansoni neurotransmitter gated ion channel 0.0025 0.0059 0.0025
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0055 0.0378 0.0345
Loa Loa (eye worm) hypothetical protein 0.0025 0.0059 0.0025
Trypanosoma brucei importin beta-1 subunit, putative 0.0088 0.0742 0.2023
Echinococcus granulosus insulin growth factor 1 receptor beta 0.003 0.0107 0.0073
Loa Loa (eye worm) hypothetical protein 0.0149 0.1402 0.1373
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0055 0.0378 0.0601
Schistosoma mansoni ap endonuclease 0.0037 0.0183 0.015
Brugia malayi hypothetical protein 0.0158 0.1505 0.257
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0603 0.0754
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0055 0.0378 0.0345
Trypanosoma cruzi ISWI complex protein 0.0048 0.0311 0.0791
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0055 0.0378 0.0601
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0136 0.1265 0.5876
Toxoplasma gondii HEAT repeat-containing protein 0.0088 0.0742 0.3195
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0473 0.0441
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0025 0.0059 0.0025
Schistosoma mansoni lozenge 0.0056 0.0397 0.0364
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0345 0.3536 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0358 0.3677 0.3655
Echinococcus granulosus zinc finger protein 0.0076 0.061 0.0578
Loa Loa (eye worm) hypothetical protein 0.0075 0.0603 0.0572
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0085 0.0704 0.0673
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0313 0.0797
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0378 0.3894 0.3873
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0055 0.0378 0.0601
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0055 0.0378 0.0345
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.1265 0.1236
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0163 0.156 0.4359
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0136 0.1265 0.5876
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0603 0.0572
Loa Loa (eye worm) LGC-31 protein 0.0055 0.0378 0.0345
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0029 0.0104 0.0124
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0071 0.0561 0.2402
Entamoeba histolytica hypothetical protein 0.0071 0.0561 0.4744
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0055 0.0378 0.0345
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0603 0.0572
Schistosoma mansoni transcription factor LCR-F1 0.0069 0.0533 0.0501
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0055 0.0378 0.0601
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0603 0.0995
Onchocerca volvulus 0.0075 0.0603 0.1232
Brugia malayi dihydrofolate reductase family protein 0.055 0.576 1
Leishmania major importin beta-1 subunit, putative 0.0071 0.0561 0.1507
Echinococcus multilocularis muscleblind protein 0.0149 0.1406 0.1378
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0075 0.0595 0.0564
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0183 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.013 0.1194 0.3313
Loa Loa (eye worm) hypothetical protein 0.0025 0.0059 0.0025
Loa Loa (eye worm) hypothetical protein 0.0025 0.0059 0.0025
Loa Loa (eye worm) hypothetical protein 0.0029 0.0104 0.0071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0378 0.3894 0.3873
Chlamydia trachomatis dihydrofolate reductase 0.055 0.576 0.5
Brugia malayi F/Y-rich N-terminus family protein 0.0025 0.0055 0.0037
Mycobacterium ulcerans lipase LipD 0.0075 0.0603 0.0754
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0143 0.1339 0.131
Schistosoma mansoni cpg binding protein 0.0067 0.0516 0.0484
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.005 0.0017
Onchocerca volvulus 0.0029 0.0104 0.0153
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0473 0.0767
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0378 0.3894 0.3873
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0603 0.0754
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0025 0.0059 0.0044
Brugia malayi Pre-SET motif family protein 0.0207 0.2028 0.3483
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0065 0.049 0.1302
Echinococcus granulosus dihydrofolate reductase 0.055 0.576 0.5746
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0473 0.0441
Loa Loa (eye worm) hypothetical protein 0.0143 0.1339 0.131
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0603 0.1627
Loa Loa (eye worm) bromodomain containing protein 0.0067 0.0508 0.0477
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0069 0.0533 0.0501
Schistosoma mansoni nAChR subunit 0.0055 0.0378 0.0345
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0029 0.0104 0.0124
Loa Loa (eye worm) hypothetical protein 0.0449 0.4658 0.464
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0055 0.0378 0.0345
Loa Loa (eye worm) hypothetical protein 0.0025 0.0059 0.0025
Loa Loa (eye worm) hypothetical protein 0.0055 0.0378 0.0345
Loa Loa (eye worm) hypothetical protein 0.0025 0.0059 0.0025
Loa Loa (eye worm) hypothetical protein 0.0025 0.0059 0.0025
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0055 0.0378 0.0345
Loa Loa (eye worm) hypothetical protein 0.0121 0.1103 0.1073
Brugia malayi hypothetical protein 0.013 0.1194 0.2026
Loa Loa (eye worm) hypothetical protein 0.0088 0.0742 0.0711
Loa Loa (eye worm) hypothetical protein 0.0075 0.0603 0.0572
Schistosoma mansoni acetylcholine receptor-related 0.0025 0.0059 0.0025
Brugia malayi beta-lactamase 0.0075 0.0603 0.0995
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0055 0.0378 0.0345
Loa Loa (eye worm) hypothetical protein 0.014 0.1301 0.1271
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0183 0.0426
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0603 0.2583
Trypanosoma cruzi importin beta-1 subunit, putative 0.0071 0.0561 0.1507
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0025 0.0059 0.0025
Brugia malayi MH1 domain containing protein 0.0024 0.005 0.003
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0603 0.0754
Echinococcus granulosus glycine receptor subunit beta 0.0055 0.0378 0.0345
Onchocerca volvulus 0.0158 0.1505 0.3183
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0055 0.0378 0.0345
Loa Loa (eye worm) hypothetical protein 0.0055 0.0378 0.0345
Mycobacterium ulcerans hypothetical protein 0.0075 0.0603 0.0754
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.005 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0119 0.0086
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0345 0.3536 1
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0473 0.0441
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0029 0.0104 0.0124
Toxoplasma gondii histone lysine methyltransferase SET1 0.0129 0.1187 0.5476
Brugia malayi Cation transporter family protein 0.0055 0.0378 0.0601
Schistosoma mansoni ap endonuclease 0.0037 0.0183 0.015
Onchocerca volvulus 0.0055 0.0378 0.0744
Onchocerca volvulus 0.0075 0.0603 0.1232
Onchocerca volvulus 0.0235 0.2336 0.4979
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0025 0.0059 0.0044
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0065 0.049 0.3468
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0055 0.0378 0.0345
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0055 0.0378 0.0345
Trypanosoma cruzi PAB1-binding protein , putative 0.013 0.1194 0.3313
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0114 0.1019 0.0989
Onchocerca volvulus 0.0025 0.0059 0.0054
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0603 0.0754
Schistosoma mansoni bromodomain containing protein 0.0214 0.2111 0.2084
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0183 0.0814
Loa Loa (eye worm) hypothetical protein 0.0158 0.1505 0.1477
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.1132 0.1102
Loa Loa (eye worm) hypothetical protein 0.0055 0.0378 0.0345
Loa Loa (eye worm) hypothetical protein 0.0055 0.0378 0.0345
Brugia malayi Bromodomain containing protein 0.0132 0.1217 0.2067
Echinococcus multilocularis Protein lozenge 0.0056 0.0397 0.0364
Plasmodium vivax ataxin-2 like protein, putative 0.013 0.1194 0.5749
Schistosoma mansoni nAChR subunit 0.0055 0.0378 0.0345
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0183 0.0782
Echinococcus granulosus tar DNA binding protein 0.0063 0.0473 0.0441
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.055 0.576 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0093 0.006
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0059 0.0044
Brugia malayi MH2 domain containing protein 0.0024 0.005 0.003
Brugia malayi excitatory GABA receptor EXP-1A 0.0055 0.0378 0.0601
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.2028 0.2001
Echinococcus granulosus nAChR subunit 0.0029 0.0104 0.0071
Loa Loa (eye worm) hypothetical protein 0.0055 0.0378 0.0345
Schistosoma mansoni zinc finger protein 0.0076 0.061 0.0578
Loa Loa (eye worm) hypothetical protein 0.0029 0.0104 0.0071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0378 0.3894 0.3873
Loa Loa (eye worm) latrophilin receptor protein 2 0.0045 0.0277 0.0244
Echinococcus granulosus nAChR subunit 0.0055 0.0378 0.0345
Loa Loa (eye worm) hypothetical protein 0.0025 0.0059 0.0025
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0055 0.0378 0.0345
Loa Loa (eye worm) hypothetical protein 0.0055 0.0378 0.0345
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0378 0.3894 0.3873
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0045 0.0277 0.0425
Mycobacterium ulcerans beta-lactamase 0.0075 0.0603 0.0754
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0313 0.0797
Schistosoma mansoni ran 0.0065 0.049 0.0458
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.005 0.0017
Loa Loa (eye worm) hypothetical protein 0.0055 0.0378 0.0345
Leishmania major hypothetical protein, conserved 0.0048 0.0311 0.0791
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0085 0.0704 0.0673
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.021 0.207 1
Schistosoma mansoni hypothetical protein 0.0045 0.0277 0.0244
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0473 0.0441
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0203 0.1988 0.1961
Mycobacterium tuberculosis Conserved protein 0.0075 0.0603 0.0754
Loa Loa (eye worm) hypothetical protein 0.0029 0.0104 0.0071
Schistosoma mansoni methyl-cpg binding protein mbd 0.0054 0.0371 0.0338
Loa Loa (eye worm) hypothetical protein 0.0055 0.0378 0.0345
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0136 0.1265 0.5415
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0143 0.1339 0.228
Loa Loa (eye worm) dihydrofolate reductase 0.055 0.576 0.5746
Entamoeba histolytica hypothetical protein 0.0069 0.0533 0.4449
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0065 0.049 0.1302
Onchocerca volvulus 0.0025 0.0059 0.0054
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0163 0.156 0.4359
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.003 0.0107 0.0073
Schistosoma mansoni ephrin receptor 0.003 0.0107 0.0073
Echinococcus granulosus histone acetyltransferase KAT2B 0.0426 0.4408 0.4389
Schistosoma mansoni dihydrofolate reductase 0.055 0.576 0.5746
Schistosoma mansoni smad1 5 8 and 0.0024 0.005 0.0017
Loa Loa (eye worm) hypothetical protein 0.0025 0.0059 0.0025
Mycobacterium tuberculosis Conserved hypothetical protein 0.0182 0.1761 0.2829
Brugia malayi MH1 domain containing protein 0.0024 0.005 0.003
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0055 0.0378 0.0345
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0603 0.0754
Loa Loa (eye worm) hypothetical protein 0.0055 0.0378 0.0345
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.021 0.207 0.5814
Loa Loa (eye worm) hypothetical protein 0.0075 0.0603 0.0572
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0065 0.049 0.19
Brugia malayi Cation transporter family protein 0.0055 0.0378 0.0601
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0603 0.1627
Plasmodium falciparum histone acetyltransferase GCN5 0.0118 0.1067 0.4688
Entamoeba histolytica hypothetical protein 0.0069 0.0533 0.4449
Schistosoma mansoni smad1 5 8 and 0.0024 0.005 0.0017
Loa Loa (eye worm) hypothetical protein 0.0449 0.4658 0.464
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0183 0.0426
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0055 0.0378 0.0345
Toxoplasma gondii exonuclease III APE 0.0037 0.0183 0.0328
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0603 0.0572
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0029 0.0104 0.0124
Loa Loa (eye worm) hypothetical protein 0.013 0.1194 0.1164
Loa Loa (eye worm) hypothetical protein 0.0025 0.0059 0.0025
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0055 0.0378 0.0345
Loa Loa (eye worm) GABA receptor subunit 0.0029 0.0104 0.0071
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0065 0.049 0.0458
Brugia malayi beta-lactamase family protein 0.0075 0.0603 0.0995
Brugia malayi beta-lactamase family protein 0.0075 0.0603 0.0995
Brugia malayi Bromodomain containing protein 0.0251 0.2513 0.433
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0071 0.0561 0.2402
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0059 0.0428 0.1126
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0055 0.0378 0.0601
Brugia malayi MH2 domain containing protein 0.0024 0.005 0.003
Loa Loa (eye worm) hypothetical protein 0.0055 0.0378 0.0345
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0055 0.0378 0.0601
Schistosoma mansoni importin beta-1 0.0088 0.0742 0.0711
Plasmodium vivax SET domain protein, putative 0.0031 0.0119 0.0535
Loa Loa (eye worm) hypothetical protein 0.0028 0.0085 0.0051
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0055 0.0378 0.0601
Loa Loa (eye worm) hypothetical protein 0.0085 0.0704 0.0673
Leishmania major dihydrofolate reductase-thymidylate synthase 0.021 0.207 0.5814
Onchocerca volvulus 0.0058 0.0415 0.0824
Leishmania major mitochondrial DNA polymerase beta 0.0345 0.3536 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0415 0.0382
Schistosoma mansoni zinc finger protein 0.0048 0.0311 0.0278
Echinococcus granulosus GPCR family 2 0.0045 0.0277 0.0244
Schistosoma mansoni nAChR subunit 0.0055 0.0378 0.0345
Echinococcus multilocularis zinc finger protein 0.0076 0.061 0.0578
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0055 0.0378 0.0601
Entamoeba histolytica acetyltransferase, GNAT family 0.0118 0.1067 1
Schistosoma mansoni cpg binding protein 0.0058 0.0415 0.0382
Brugia malayi Muscleblind-like protein 0.0149 0.1406 0.2398
Schistosoma mansoni nAChR subunit 0.0055 0.0378 0.0345
Plasmodium falciparum ataxin-2 like protein, putative 0.013 0.1194 0.5357
Echinococcus granulosus methyl CpG binding domain protein 2 0.0054 0.0371 0.0338
Schistosoma mansoni methyl-cpg binding protein mbd 0.0054 0.0371 0.0338
Loa Loa (eye worm) Smad1 0.0024 0.005 0.0017
Loa Loa (eye worm) hypothetical protein 0.0045 0.0277 0.0244
Echinococcus granulosus glycine receptor subunit alpha 1 0.0055 0.0378 0.0345
Plasmodium vivax importin-beta 2, putative 0.0088 0.0742 0.3559
Mycobacterium tuberculosis Conserved protein 0.0075 0.0603 0.0754
Echinococcus granulosus GTP binding nuclear protein Ran 0.0065 0.049 0.0458
Schistosoma mansoni hypothetical protein 0.0045 0.0277 0.0244
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0183 0.015
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0058 0.0417 0.0385
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0055 0.0378 0.0601
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0163 0.156 0.4359
Trichomonas vaginalis ran, putative 0.0065 0.049 0.2095
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0059 0.0044
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0603 0.1627
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0603 0.0754
Loa Loa (eye worm) hypothetical protein 0.0025 0.0059 0.0025
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0183 0.0426
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0055 0.0378 0.0345
Brugia malayi Pre-SET motif family protein 0.0031 0.0119 0.0149
Brugia malayi RNA binding protein 0.0063 0.0473 0.0767
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0059 0.0044
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0055 0.0378 0.0345
Schistosoma mansoni hypothetical protein 0.0048 0.0311 0.0278
Loa Loa (eye worm) PHD-finger family protein 0.0065 0.0494 0.0462
Brugia malayi Dihydrofolate reductase 0.055 0.576 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0445 0.4622 0.4604
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0065 0.049 0.0458
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0481 0.5012 0.8658
Loa Loa (eye worm) hypothetical protein 0.0224 0.2214 0.2188
Toxoplasma gondii ABC1 family protein 0.0075 0.0603 0.2484
Echinococcus granulosus fetal alzheimer antigen falz 0.0075 0.0595 0.0564
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0603 0.0754
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0025 0.0059 0.0025
Loa Loa (eye worm) hypothetical protein 0.0055 0.0378 0.0345
Echinococcus granulosus geminin 0.0166 0.1587 0.1558
Brugia malayi hypothetical protein 0.0449 0.4658 0.8076
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0603 0.0754
Loa Loa (eye worm) hypothetical protein 0.0055 0.0378 0.0345
Loa Loa (eye worm) hypothetical protein 0.0055 0.0378 0.0345
Trichomonas vaginalis set domain proteins, putative 0.0235 0.2336 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0029 0.0104 0.0071
Loa Loa (eye worm) hypothetical protein 0.0149 0.1406 0.1378
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0603 0.0754
Echinococcus granulosus glycine receptor subunit alpha 1 0.0055 0.0378 0.0345
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0055 0.0378 0.0345
Loa Loa (eye worm) hypothetical protein 0.0098 0.0847 0.0817
Schistosoma mansoni hypothetical protein 0.0045 0.0277 0.0244
Loa Loa (eye worm) hypothetical protein 0.0025 0.0059 0.0025
Schistosoma mansoni hypothetical protein 0.0166 0.1587 0.1558
Echinococcus multilocularis GPCR, family 2 0.0045 0.0277 0.0244
Toxoplasma gondii hypothetical protein 0.0056 0.039 0.1391
Brugia malayi latrophilin 2 splice variant baaae 0.0098 0.0847 0.1421
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0055 0.0378 0.0345
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0378 0.3894 0.6741
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0065 0.049 0.1302
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0025 0.0059 0.0025
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0473 0.0441
Mycobacterium ulcerans hypothetical protein 0.0182 0.1761 0.2829
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0045 0.0277 0.0244
Trypanosoma brucei PAB1-binding protein , putative 0.013 0.1194 0.3313
Loa Loa (eye worm) hypothetical protein 0.0029 0.0104 0.0071
Onchocerca volvulus 0.0055 0.0378 0.0744
Schistosoma mansoni nAChR subunit 0.0055 0.0378 0.0345
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0603 0.2583
Trypanosoma cruzi ISWI complex protein 0.0048 0.0311 0.0791
Loa Loa (eye worm) hypothetical protein 0.0055 0.0378 0.0345
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0055 0.0378 0.0345
Schistosoma mansoni Smad4 0.0024 0.005 0.0017
Trichomonas vaginalis esterase, putative 0.0075 0.0603 0.2583
Onchocerca volvulus 0.0055 0.0378 0.0744
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0313 0.0797
Loa Loa (eye worm) transcription factor SMAD2 0.0358 0.3677 0.3655
Echinococcus multilocularis cpg binding protein 0.0067 0.0516 0.0484
Schistosoma mansoni cpg binding protein 0.0067 0.0516 0.0484
Schistosoma mansoni hypothetical protein 0.0045 0.0277 0.0244
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0055 0.0378 0.0345
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0114 0.1019 0.0989
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0473 0.0441
Leishmania major hypothetical protein, conserved 0.0075 0.0603 0.1627
Leishmania major GTP-binding protein, putative 0.0065 0.049 0.1302
Schistosoma mansoni hypothetical protein 0.0098 0.0847 0.0817
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0183 0.0782
Brugia malayi hypothetical protein 0.0084 0.0695 0.1154
Plasmodium falciparum ataxin-2 like protein, putative 0.013 0.1194 0.5357
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0045 0.0277 0.0244
Loa Loa (eye worm) hypothetical protein 0.0055 0.0378 0.0345
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0025 0.0059 0.0025
Echinococcus multilocularis nAChR subunit 0.0055 0.0378 0.0345
Loa Loa (eye worm) hypothetical protein 0.0025 0.0059 0.0025
Trypanosoma brucei importin beta-1 subunit, putative 0.0088 0.0742 0.2023
Loa Loa (eye worm) ACC-1 protein 0.0055 0.0378 0.0345
Trichomonas vaginalis bromodomain-containing protein, putative 0.0136 0.1265 0.5415
Loa Loa (eye worm) hypothetical protein 0.0025 0.0059 0.0025
Onchocerca volvulus 0.0025 0.0059 0.0054
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0075 0.0595 0.0564
Echinococcus multilocularis geminin 0.0166 0.1587 0.1558
Loa Loa (eye worm) hypothetical protein 0.0025 0.0059 0.0025
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0603 0.2583
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0203 0.1988 0.1961
Schistosoma mansoni smad1 5 8 and 0.0024 0.005 0.0017
Brugia malayi CXXC zinc finger family protein 0.0058 0.0415 0.0666
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0119 0.0086
Loa Loa (eye worm) hypothetical protein 0.0055 0.0378 0.0345
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.021 0.207 0.5814
Echinococcus granulosus muscleblind protein 0.0149 0.1406 0.1378
Brugia malayi TAR-binding protein 0.0063 0.0473 0.0767
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0045 0.0277 0.0244
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0183 0.0845
Giardia lamblia Histone acetyltransferase GCN5 0.0118 0.1067 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0143 0.1339 0.228
Echinococcus multilocularis dihydrofolate reductase 0.055 0.576 0.5746
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.021 0.207 1
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0055 0.0378 0.0345
Loa Loa (eye worm) hypothetical protein 0.0029 0.0104 0.0071
Loa Loa (eye worm) hypothetical protein 0.0055 0.0378 0.0345
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0055 0.0378 0.0601
Echinococcus multilocularis Smad4 0.0024 0.005 0.0017
Schistosoma mansoni nAChR subunit 0.0025 0.0059 0.0025
Entamoeba histolytica Ran family GTPase 0.0065 0.049 0.4
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0603 0.2885
Loa Loa (eye worm) beta-lactamase 0.0075 0.0603 0.0572
Brugia malayi Cation transporter family protein 0.0055 0.0378 0.0601
Toxoplasma gondii LsmAD domain-containing protein 0.013 0.1194 0.5509
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.055 0.576 1
Trypanosoma brucei ISWI complex protein 0.0048 0.0311 0.0791
Loa Loa (eye worm) hypothetical protein 0.0075 0.0603 0.0572
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0069 0.0533 0.0501
Loa Loa (eye worm) ACC-1 protein 0.0055 0.0378 0.0345
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0055 0.0378 0.0601
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0055 0.0378 0.0345
Schistosoma mansoni hypothetical protein 0.0069 0.0533 0.0501
Schistosoma mansoni nAChR subunit 0.0025 0.0059 0.0025
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0025 0.0059 0.0025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0378 0.3894 0.3873
Loa Loa (eye worm) hypothetical protein 0.0029 0.0104 0.0071
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0045 0.0277 0.0244
Schistosoma mansoni hypothetical protein 0.0058 0.0417 0.0385
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0054 0.0371 0.0338
Onchocerca volvulus 0.0031 0.0119 0.0184
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0055 0.0378 0.0345
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0065 0.049 0.2333
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0029 0.0104 0.0071
Onchocerca volvulus 0.0075 0.0603 0.1232
Onchocerca volvulus Putative nachr subunit 0.0055 0.0378 0.0744
Loa Loa (eye worm) hypothetical protein 0.0029 0.0104 0.0071
Loa Loa (eye worm) hypothetical protein 0.0055 0.0378 0.0345
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0055 0.0378 0.0601
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0058 0.0417 0.0385
Schistosoma mansoni hypothetical protein 0.0065 0.0494 0.0462
Onchocerca volvulus 0.0449 0.4658 1
Loa Loa (eye worm) acetylcholine receptor protein 0.0025 0.0059 0.0025
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0603 0.0572
Brugia malayi PHD-finger family protein 0.0093 0.0793 0.1326
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.005 0.0017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0378 0.3894 0.3873
Brugia malayi hypothetical protein 0.0025 0.0059 0.0044
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0055 0.0378 0.0345
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0085 0.0704 0.0673
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0055 0.0378 0.0601
Schistosoma mansoni bromodomain containing protein 0.0028 0.0085 0.0051
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0055 0.0378 0.0601
Loa Loa (eye worm) hypothetical protein 0.0149 0.1406 0.1378
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0055 0.0378 0.0345
Brugia malayi RNA, U transporter 1 0.0251 0.2506 0.4318
Schistosoma mansoni smad 0.0024 0.005 0.0017
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0025 0.0059 0.0044
Brugia malayi hypothetical protein 0.0025 0.0059 0.0044
Loa Loa (eye worm) hypothetical protein 0.0029 0.0104 0.0071
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0183 0.0426
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0183 0.015
Brugia malayi hypothetical protein 0.0025 0.0059 0.0044
Echinococcus granulosus smad 0.0024 0.005 0.0017
Leishmania major hypothetical protein, conserved 0.013 0.1194 0.3313
Schistosoma mansoni ran 0.0065 0.049 0.0458
Brugia malayi Smad1 0.0024 0.005 0.003
Schistosoma mansoni hypothetical protein 0.0166 0.1587 0.1558
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.055 0.576 1
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0473 0.0441
Brugia malayi hypothetical protein 0.0069 0.0533 0.0872
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0065 0.049 0.0796
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0603 0.2583
Onchocerca volvulus 0.0029 0.0104 0.0153
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.021 0.207 1
Echinococcus multilocularis muscleblind protein 1 0.0149 0.1406 0.1378
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0183 0.5
Brugia malayi Latrophilin receptor protein 2 0.0045 0.0277 0.0425
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0136 0.1265 0.6096
Schistosoma mansoni nAChR subunit 0.0055 0.0378 0.0345
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0183 0.015
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0445 0.4622 0.4604
Loa Loa (eye worm) runx1 0.0056 0.0397 0.0364

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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