Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0296 | 0.5058 | 0.4525 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.4465 | 0.4373 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.4465 | 0.4373 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0264 | 0.4465 | 0.3869 |
Onchocerca volvulus | 0.0264 | 0.4465 | 0.4128 | |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0264 | 0.4465 | 0.3869 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0264 | 0.4465 | 0.4373 |
Brugia malayi | nuclear receptor NHR-67 | 0.0264 | 0.4465 | 0.3869 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.007 | 0.0827 | 1 |
Brugia malayi | conserved hypotetical protein | 0.0264 | 0.4465 | 0.3869 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.007 | 0.0827 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0264 | 0.4465 | 0.3869 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0264 | 0.4465 | 0.4373 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0264 | 0.4465 | 0.3869 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0264 | 0.4465 | 0.4128 |
Brugia malayi | hypothetical protein | 0.0296 | 0.5058 | 0.4525 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0264 | 0.4465 | 0.3869 |
Schistosoma mansoni | nuclear receptor | 0.0264 | 0.4465 | 0.3869 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.4465 | 0.4373 |
Brugia malayi | nuclear hormone receptor | 0.0264 | 0.4465 | 0.3869 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.4465 | 0.4373 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.4465 | 0.4373 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0296 | 0.5058 | 0.4525 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0496 | 0.0337 |
Brugia malayi | nuclear receptor RXR | 0.0296 | 0.5058 | 0.4525 |
Brugia malayi | ecdysone receptor | 0.0264 | 0.4465 | 0.3869 |
Loa Loa (eye worm) | hypothetical protein | 0.0296 | 0.5058 | 0.4976 |
Loa Loa (eye worm) | hypothetical protein | 0.0296 | 0.5058 | 0.4976 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0264 | 0.4465 | 0.3869 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0264 | 0.4465 | 0.4373 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0264 | 0.4465 | 0.3869 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.4465 | 0.4373 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0296 | 0.5058 | 0.4525 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0296 | 0.5058 | 0.4525 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.4465 | 0.4373 |
Onchocerca volvulus | 0.0264 | 0.4465 | 0.4128 | |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0264 | 0.4465 | 0.3869 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0042 | 0.031 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.4465 | 0.4373 |
Brugia malayi | hypothetical protein | 0.0296 | 0.5058 | 0.4525 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0496 | 0.0337 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0264 | 0.4465 | 0.3869 |
Brugia malayi | nuclear receptor RXR | 0.0264 | 0.4465 | 0.3869 |
Brugia malayi | hypothetical protein | 0.0264 | 0.4465 | 0.3869 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0264 | 0.4465 | 0.3869 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.007 | 0.0827 | 1 |
Brugia malayi | hypothetical protein | 0.0264 | 0.4465 | 0.3869 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.4465 | 0.4373 |
Loa Loa (eye worm) | hypothetical protein | 0.0296 | 0.5058 | 0.4976 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.4465 | 0.4373 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0264 | 0.4465 | 0.3869 |
Leishmania major | DNA topoisomerase ii | 0.007 | 0.0827 | 1 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0264 | 0.4465 | 0.4128 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0296 | 0.5058 | 0.4525 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0264 | 0.4465 | 0.3869 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0264 | 0.4465 | 0.3869 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0264 | 0.4465 | 0.3869 |
Giardia lamblia | DNA topoisomerase II | 0.0074 | 0.0909 | 0.5 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0078 | 0.0973 | 0.0822 |
Loa Loa (eye worm) | DR-78 | 0.0264 | 0.4465 | 0.4373 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0078 | 0.0973 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0078 | 0.0973 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0264 | 0.4465 | 0.3869 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.007 | 0.0827 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.4465 | 0.4373 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0264 | 0.4465 | 0.3869 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0078 | 0.0973 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.4465 | 0.4373 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0296 | 0.5058 | 0.4976 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0078 | 0.0973 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0078 | 0.0973 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0296 | 0.5058 | 0.4525 |
Loa Loa (eye worm) | hypothetical protein | 0.0296 | 0.5058 | 0.4976 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0264 | 0.4465 | 0.3869 |
Schistosoma mansoni | nuclear hormone receptor | 0.0264 | 0.4465 | 0.3869 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0264 | 0.4465 | 0.3869 |
Schistosoma mansoni | nuclear hormone receptor | 0.0264 | 0.4465 | 0.3869 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.4465 | 0.4373 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0264 | 0.4465 | 0.3869 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0264 | 0.4465 | 0.3869 |
Loa Loa (eye worm) | hypothetical protein | 0.0296 | 0.5058 | 0.4976 |
Schistosoma mansoni | nuclear receptor | 0.0264 | 0.4465 | 0.3869 |
Schistosoma mansoni | zinc finger protein | 0.0264 | 0.4465 | 0.3869 |
Brugia malayi | tailless protein | 0.0264 | 0.4465 | 0.3869 |
Brugia malayi | nuclear receptor NHR-88 | 0.0264 | 0.4465 | 0.3869 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0264 | 0.4465 | 0.3869 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of Homo sapiens (human) topoisomerase 1 assessed as production of nicked DNA up to 25 uM by agarose gel electrophoresis | ChEMBL. | No reference | |
Inhibition (binding) | Inhibition of Homo sapiens (human) topoisomerase 1 assessed as relaxation of supercoiled DNA up to 25 uM by agarose gel electrophoresis | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.