Detailed information for compound 183883

Basic information

Technical information
  • TDR Targets ID: 183883
  • Name: 6-(2,6-dichlorophenyl)-8-methyl-2-(pyridin-3- ylmethylamino)pyrido[2,3-d]pyrimidin-7-one
  • MW: 412.272 | Formula: C20H15Cl2N5O
  • H donors: 1 H acceptors: 4 LogP: 3.76 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1c1cc2cnc(nc2n(c1=O)C)NCc1cccnc1)Cl
  • InChi: 1S/C20H15Cl2N5O/c1-27-18-13(8-14(19(27)28)17-15(21)5-2-6-16(17)22)11-25-20(26-18)24-10-12-4-3-7-23-9-12/h2-9,11H,10H2,1H3,(H,24,25,26)
  • InChiKey: XHGSDPKRXJOFGF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-(2,6-dichlorophenyl)-8-methyl-2-(3-pyridylmethylamino)pyrido[2,3-d]pyrimidin-7-one
  • 6-(2,6-dichlorophenyl)-8-methyl-2-(3-pyridylmethylamino)-7-pyrido[2,3-d]pyrimidinone
  • 6-(2,6-dichlorophenyl)-8-methyl-2-(pyridin-3-ylmethylamino)pyrido[6,5-d]pyrimidin-7-one
  • 6-(2,6-dichlorophenyl)-8-methyl-2-(3-pyridylmethylamino)pyrido[6,5-d]pyrimidin-7-one
  • 6-(2,6-dichlorophenyl)-8-methyl-2-(3-pyridylmethylamino)-7-pyrido[6,5-d]pyrimidinone
  • 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 35

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens epidermal growth factor receptor Starlite/ChEMBL References
Homo sapiens fibroblast growth factor receptor 1 Starlite/ChEMBL References
Mus musculus platelet derived growth factor receptor, beta polypeptide Starlite/ChEMBL References
Gallus gallus Tyrosine-protein kinase SRC Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus fibroblast growth factor receptor 4 Get druggable targets OG5_128769 All targets in OG5_128769
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128769 All targets in OG5_128769
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-2 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis fibroblast growth factor receptor 4 Get druggable targets OG5_128769 All targets in OG5_128769
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus basic fibroblast growth factor receptor 1 A Get druggable targets OG5_128769 All targets in OG5_128769
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-4 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Fibroblast growth factor receptor precursor, putative Get druggable targets OG5_128769 All targets in OG5_128769
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K05085 receptor tyrosine-protein kinase erbB-4, putative Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi Furin-like cysteine rich region family protein Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR002048,Calcium-binding EF-hand;IPR001245,Tyrosine protein kinase;IPR000719,Protein kinase;IPR011009,Protein kinase-like,domai Get druggable targets OG5_128769 All targets in OG5_128769
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus melanoma receptor tyrosine protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum expressed protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Tyrosine-protein kinase transforming protein erbB, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK/EGFR protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A Get druggable targets OG5_128769 All targets in OG5_128769
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_128769 All targets in OG5_128769
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_128769 All targets in OG5_128769
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis tyrosine protein kinase Btk29A Tyrosine-protein kinase SRC   533 aa 500 aa 35.0 %
Schistosoma mansoni serine/threonine protein kinase Tyrosine-protein kinase SRC   533 aa 473 aa 24.5 %
Schistosoma mansoni tyrosine kinase Tyrosine-protein kinase SRC   533 aa 501 aa 35.3 %
Onchocerca volvulus Tyrosine-protein kinase SRC   533 aa 435 aa 27.4 %
Echinococcus multilocularis tyrosine protein kinase Abl Tyrosine-protein kinase SRC   533 aa 506 aa 36.6 %
Onchocerca volvulus Cyclin-H homolog Tyrosine-protein kinase SRC   533 aa 453 aa 44.8 %
Brugia malayi Tyrosine-protein kinase abl-1 Tyrosine-protein kinase SRC   533 aa 455 aa 44.4 %
Echinococcus granulosus tyrosine protein kinase ABL1 Tyrosine-protein kinase SRC   533 aa 473 aa 39.5 %
Echinococcus granulosus c src tyrosine kinase Tyrosine-protein kinase SRC   533 aa 513 aa 33.7 %
Echinococcus granulosus tyrosine protein kinase Btk29A Tyrosine-protein kinase SRC   533 aa 500 aa 35.0 %
Echinococcus multilocularis c src tyrosine kinase Tyrosine-protein kinase SRC   533 aa 513 aa 33.9 %
Echinococcus multilocularis tyrosine protein kinase ABL1 Tyrosine-protein kinase SRC   533 aa 473 aa 39.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0154 0.0154
Schistosoma mansoni nephrin 0.0032 0.0033 0.0033
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0134 0.0985 0.5
Echinococcus granulosus roundabout 2 0.0036 0.0076 0.0076
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0124 0.0892 0.0892
Schistosoma mansoni isocitrate dehydrogenase 0.0134 0.0985 0.0985
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0049 0.0195 0.0195
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0101 0.0675 0.0675
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.1103 1 0.5
Schistosoma mansoni tyrosine kinase 0.0096 0.063 0.063
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0134 0.0985 0.5
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.1103 1 0.5
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0038 0.0088 0.0088
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0049 0.0195 0.0195
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0049 0.0195 0.0195
Schistosoma mansoni tyrosine kinase 0.0184 0.145 0.145
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.0109 0.0109
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0033 0.0043 0.0043
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0134 0.0985 0.0985
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0134 0.0985 0.0985
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.0088 0.0088
Loa Loa (eye worm) TK/INSR protein kinase 0.0061 0.031 0.031
Echinococcus granulosus tyrosine protein kinase Fyn 0.0049 0.0195 0.0195
Echinococcus multilocularis neuroglian 0.0032 0.0033 0.0033
Schistosoma mansoni tyrosine kinase 0.0124 0.0892 0.0892
Brugia malayi protein-tyrosine kinase 0.0045 0.0154 0.0154
Schistosoma mansoni cell adhesion molecule 0.0033 0.0043 0.0043
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.1103 1 1
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0134 0.0985 0.0985
Brugia malayi Protein kinase domain containing protein 0.0061 0.031 0.031
Schistosoma mansoni tyrosine kinase 0.0061 0.031 0.031
Loa Loa (eye worm) SRC-1 0.0049 0.0195 0.0195
Echinococcus multilocularis tyrosine protein kinase Blk 0.0045 0.0154 0.0154
Echinococcus multilocularis tyrosine protein kinase HCK 0.004 0.0111 0.0111
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0134 0.0985 0.0985
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0061 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.0134 0.0985 0.0985
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.0109 0.0109
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0049 0.0195 0.0195
Schistosoma mansoni tyrosine kinase 0.0049 0.0195 0.0195
Echinococcus multilocularis 0.0056 0.0257 0.0257
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0049 0.0195 0.0195
Loa Loa (eye worm) TK protein kinase 0.0127 0.0925 0.0925
Echinococcus granulosus tyrosine protein kinase Fyn 0.0049 0.0195 0.0195
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.1103 1 1
Brugia malayi Isocitrate dehydrogenase 0.1103 1 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0127 0.0925 0.0925
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0134 0.0985 0.0985
Echinococcus granulosus tyrosine protein kinase Blk 0.0045 0.0154 0.0154
Echinococcus granulosus twitchin 0.0032 0.0033 0.0033
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.1103 1 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.1103 1 0.5
Loa Loa (eye worm) TK/EGFR protein kinase 0.0184 0.145 0.145
Echinococcus granulosus tyrosine protein kinase Src42A 0.0049 0.0195 0.0195
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0134 0.0985 0.0985
Loa Loa (eye worm) hypothetical protein 0.0036 0.0076 0.0076
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0049 0.0195 0.0195
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0049 0.0195 0.0195
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0049 0.0195 0.0195
Loa Loa (eye worm) isocitrate dehydrogenase 0.1103 1 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.1103 1 1
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0134 0.0985 0.0985
Echinococcus granulosus insulin receptor 0.0061 0.031 0.031
Loa Loa (eye worm) TK protein kinase 0.0045 0.0154 0.0154
Brugia malayi SRC-1 0.0049 0.0195 0.0195
Echinococcus multilocularis roundabout 2 0.0036 0.0076 0.0076
Schistosoma mansoni tyrosine kinase 0.0096 0.063 0.063
Entamoeba histolytica tartrate dehydrogenase, putative 0.0134 0.0985 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0049 0.0195 0.0195
Echinococcus granulosus epidermal growth factor receptor 0.0184 0.145 0.145
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.1103 1 0.5
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0134 0.0985 0.0985
Toxoplasma gondii isocitrate dehydrogenase 0.1103 1 0.5
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.1103 1 0.5
Schistosoma mansoni unc-13 (munc13) 0.0134 0.0985 0.0985
Brugia malayi Probable isocitrate dehydrogenase 0.0134 0.0985 0.0985
Loa Loa (eye worm) hypothetical protein 0.0033 0.0043 0.0043
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0134 0.0985 0.5
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0124 0.0892 0.0892
Schistosoma mansoni tyrosine kinase 0.0101 0.0675 0.0675
Schistosoma mansoni tyrosine kinase 0.0061 0.031 0.031
Echinococcus granulosus tyrosine protein kinase Lyn 0.0049 0.0195 0.0195
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0061 0.031 0.031
Schistosoma mansoni tyrosine kinase 0.0049 0.0195 0.0195
Loa Loa (eye worm) TK protein kinase 0.004 0.0111 0.0111
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.1103 1 1
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0124 0.0892 0.0892
Echinococcus granulosus tyrosine protein kinase HCK 0.004 0.0111 0.0111
Echinococcus multilocularis insulin receptor 0.0061 0.031 0.031
Echinococcus multilocularis tyrosine protein kinase Srms 0.0045 0.0154 0.0154
Echinococcus granulosus neuroglian 0.0032 0.0033 0.0033
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0045 0.0154 0.0154
Brugia malayi Probable isocitrate dehydrogenase 0.0134 0.0985 0.0985
Echinococcus granulosus tyrosine protein kinase Fyn 0.0049 0.0195 0.0195
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.1103 1 1
Brugia malayi Furin-like cysteine rich region family protein 0.0184 0.145 0.145
Loa Loa (eye worm) hypothetical protein 0.0036 0.0076 0.0076
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0049 0.0195 0.0195
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.1103 1 0.5
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0134 0.0985 0.0985
Echinococcus multilocularis isocitrate dehydrogenase 0.1103 1 1
Echinococcus multilocularis epidermal growth factor receptor 0.0184 0.145 0.145
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0134 0.0985 0.5
Echinococcus granulosus epidermal growth factor receptor 0.0101 0.0675 0.0675
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0049 0.0195 0.0195
Echinococcus granulosus fibroblast growth factor receptor 4 0.0124 0.0892 0.0892
Toxoplasma gondii isocitrate dehydrogenase 0.1103 1 0.5
Echinococcus granulosus tyrosine kinase 0.0045 0.0154 0.0154
Echinococcus granulosus tyrosine protein kinase Src64B 0.0049 0.0195 0.0195
Schistosoma mansoni tyrosine kinase 0.0101 0.0675 0.0675
Echinococcus multilocularis epidermal growth factor receptor 0.0101 0.0675 0.0675
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.1103 1 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.1103 1 1
Schistosoma mansoni tyrosine kinase 0.0096 0.063 0.063

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3.15 uM Inhibitory concentration evaluated against fibroblast growth factor receptor 1. ChEMBL. 9703473
IC50 (binding) = 3.15 uM Inhibitory concentration evaluated against fibroblast growth factor receptor 1. ChEMBL. 9703473
IC50 (binding) = 3.2 uM Inhibition of avian c-Src tyrosine kinase ChEMBL. 9703473
IC50 (binding) = 3.2 uM Inhibition of avian c-Src tyrosine kinase ChEMBL. 9703473
IC50 (binding) > 5 uM Inhibitory concentration was evaluated against epidermal growth factor receptor (EGFr) tyrosine kinase ChEMBL. 9703473
IC50 (binding) > 5 uM Inhibitory concentration was evaluated against epidermal growth factor receptor (EGFr) tyrosine kinase ChEMBL. 9703473
IC50 (binding) = 6.6 uM Inhibitory concentration of the compound was evaluated against Platelet-derived growth factor receptor beta (PDGFr) tyrosine kinase ChEMBL. 9703473
IC50 (binding) = 6.6 uM Inhibitory concentration of the compound was evaluated against Platelet-derived growth factor receptor beta (PDGFr) tyrosine kinase ChEMBL. 9703473

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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