Detailed information for compound 1838999

Basic information

Technical information
  • TDR Targets ID: 1838999
  • Name: (3R,3aS,6aR,8R,9aR,9bS)-8-hydroxy-3-(hydroxym ethyl)-6,9-dimethylidene-3a,4,5,6a,7,8,9a,9b- octahydro-3H-azuleno[5,4-d]furan-2-one
  • MW: 264.317 | Formula: C15H20O4
  • H donors: 2 H acceptors: 3 LogP: 0.76 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@@H]1C(=O)O[C@H]2[C@H]1CCC(=C)[C@H]1[C@@H]2C(=C)[C@@H](C1)O
  • InChi: 1S/C15H20O4/c1-7-3-4-9-11(6-16)15(18)19-14(9)13-8(2)12(17)5-10(7)13/h9-14,16-17H,1-6H2/t9-,10-,11-,12+,13-,14-/m0/s1
  • InChiKey: LVEDRXPCZZIZMQ-GAURVVSWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3R,3aS,6aR,8R,9aR,9bS)-8-hydroxy-3-(hydroxymethyl)-6,9-dimethylene-3a,4,5,6a,7,8,9a,9b-octahydro-3H-azuleno[5,4-d]furan-2-one
  • (3R,3aS,6aR,8R,9aR,9bS)-8-hydroxy-6,9-dimethylene-3-methylol-3a,4,5,6a,7,8,9a,9b-octahydro-3H-azuleno[5,4-d]furan-2-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Onchocerca volvulus 0.0038 0.0099 0.0238
Echinococcus granulosus tm gpcr rhodopsin 0.0278 0.1889 0.3437
Loa Loa (eye worm) hypothetical protein 0.0035 0.0076 0.0401
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0278 0.1889 0.3437
Schistosoma mansoni neuropeptide F-like receptor 0.0278 0.1889 1
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0038 0.0099 1
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0038 0.0099 0.0058
Schistosoma mansoni opsin-like receptor 0.0278 0.1889 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.0291
Loa Loa (eye worm) hypothetical protein 0.0035 0.0076 0.0401
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0278 0.1889 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0038 0.0099 0.0058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0278 0.1889 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0076 0.0401
Schistosoma mansoni biogenic amine receptor 0.0278 0.1889 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0278 0.1889 1
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0038 0.0099 0.0058
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0038 0.0099 0.0058
Schistosoma mansoni amine GPCR 0.0278 0.1889 1
Onchocerca volvulus 0.0278 0.1889 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0278 0.1889 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0076 0.7675
Onchocerca volvulus 0.0035 0.0076 0.0113
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0099 0.0058
Plasmodium vivax enoyl-acyl carrier protein reductase 0.056 0.3998 1
Echinococcus granulosus somatostatin receptor 0.0278 0.1889 0.3437
Echinococcus granulosus neuropeptides capa receptor 0.0278 0.1889 0.3437
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0076 0.0401
Echinococcus multilocularis rhodopsin orphan GPCR 0.0278 0.1889 0.327
Leishmania major hypothetical protein, conserved 0.0035 0.0076 0.7675
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0038 0.0099 0.0058
Schistosoma mansoni hypothetical protein 0.0164 0.1041 0.5375
Echinococcus granulosus neuropeptide receptor 0.0278 0.1889 0.3437
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0038 0.0099 0.0058
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0038 0.0099 0.0099
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0278 0.1889 0.1889
Echinococcus granulosus rhodopsin orphan GPCR 0.0278 0.1889 0.3437
Schistosoma mansoni biogenic amine receptor 0.0278 0.1889 1
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.0291
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0099 0.0058
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Echinococcus granulosus neuropeptide Y receptor 0.0278 0.1889 0.3437
Echinococcus granulosus G protein coupled receptor 139 0.0278 0.1889 0.3437
Echinococcus granulosus geminin 0.0164 0.1041 0.1847
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0038 0.0099 0.0058
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0278 0.1889 0.327
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0278 0.1889 0.3437
Loa Loa (eye worm) plexin A 0.0091 0.0494 0.2614
Schistosoma mansoni neuropeptide receptor 0.0278 0.1889 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0278 0.1889 0.3437
Brugia malayi Serotonin receptor 0.0278 0.1889 0.1889
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0278 0.1889 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0278 0.1889 0.327
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0278 0.1889 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0038 0.0099 0.0058
Echinococcus multilocularis g protein coupled receptor 0.0278 0.1889 0.327
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0038 0.0099 0.0058
Brugia malayi putative neuropeptide receptor 0.0278 0.1889 0.1889
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0278 0.1889 1
Echinococcus granulosus neuropeptide Y receptor 0.0278 0.1889 0.3437
Schistosoma mansoni amine GPCR 0.0278 0.1889 1
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0099 0.0058
Brugia malayi hypothetical protein 0.0032 0.0055 0.0055
Mycobacterium tuberculosis Possible oxidoreductase 0.0038 0.0099 0.0058
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0038 0.0099 0.0247
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Brugia malayi hypothetical protein 0.0278 0.1889 0.1889
Leishmania major pteridine reductase 1 0.0038 0.0099 1
Onchocerca volvulus 0.0278 0.1889 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0278 0.1889 0.327
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Schistosoma mansoni amine GPCR 0.0278 0.1889 1
Echinococcus multilocularis fmrfamide receptor 0.0278 0.1889 0.327
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0278 0.1889 0.3437
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0076 0.0039
Brugia malayi hypothetical protein 0.0278 0.1889 0.1889
Schistosoma mansoni histamine h1 receptor 0.0278 0.1889 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0149 0.079
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0038 0.0099 0.0247
Loa Loa (eye worm) neuropeptide F receptor 0.0278 0.1889 1
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0099 0.0058
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0038 0.0099 0.0058
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0278 0.1889 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0038 0.0099 0.0058
Brugia malayi AKH receptor 0.0278 0.1889 0.1889
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0038 0.0099 0.0058
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0278 0.1889 0.327
Brugia malayi Dopamine receptor 0.0278 0.1889 0.1889
Brugia malayi MH2 domain containing protein 0.012 0.0712 0.0712
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.5663 1
Onchocerca volvulus 0.0278 0.1889 1
Schistosoma mansoni amine GPCR 0.0278 0.1889 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0038 0.0099 1
Echinococcus granulosus g protein coupled receptor 0.0278 0.1889 0.3437
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0038 0.0099 1
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0038 0.0099 0.0058
Echinococcus granulosus biogenic amine 5HT receptor 0.0278 0.1889 0.3437
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0278 0.1889 1
Loa Loa (eye worm) oxidoreductase 0.0038 0.0099 0.0522
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0038 0.0099 0.0078
Schistosoma mansoni hypothetical protein 0.0278 0.1889 1
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0038 0.0099 1
Schistosoma mansoni hypothetical protein 0.0164 0.1041 0.5375
Brugia malayi hypothetical protein 0.0278 0.1889 0.1889
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0278 0.1889 0.3437
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.0291
Onchocerca volvulus 0.0278 0.1889 1
Echinococcus granulosus neuropeptide receptor 0.0278 0.1889 0.3437
Echinococcus multilocularis G protein coupled receptor 139 0.0278 0.1889 0.327
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0076 0.0113
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.056 0.3998 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0038 0.0099 0.0099
Echinococcus multilocularis neuropeptide Y receptor 0.0278 0.1889 0.327
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0278 0.1889 0.3437
Echinococcus granulosus tachykinin peptides receptor 99D 0.0278 0.1889 0.3437
Echinococcus multilocularis neuropeptides capa receptor 0.0278 0.1889 0.327
Schistosoma mansoni neuropeptide receptor 0.0278 0.1889 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0076 0.7675
Schistosoma mansoni neuropeptide F-like receptor 0.0278 0.1889 1
Loa Loa (eye worm) beta-lactamase 0.0035 0.0076 0.0401
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0278 0.1889 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0278 0.1889 0.1889
Echinococcus multilocularis neuropeptides capa receptor 0.0278 0.1889 0.327
Echinococcus granulosus rhodopsin orphan GPCR 0.0278 0.1889 0.3437
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0278 0.1889 1
Echinococcus multilocularis serotonin receptor 0.0278 0.1889 0.327
Schistosoma mansoni alpha-1 adrenergic receptor 0.0278 0.1889 1
Brugia malayi Plexin repeat family protein 0.0077 0.0389 0.0389
Echinococcus granulosus dro:myosuppressin receptor 0.0278 0.1889 0.3437
Schistosoma mansoni adenoreceptor 0.0278 0.1889 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0278 0.1889 0.327
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0278 0.1889 1
Schistosoma mansoni plexin 0.0045 0.0149 0.0514
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0099 0.0058
Brugia malayi beta-lactamase family protein 0.0035 0.0076 0.0076
Schistosoma mansoni plexin 0.0077 0.0389 0.182
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0278 0.1889 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0278 0.1889 1
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.056 0.3998 1
Onchocerca volvulus 0.0035 0.0076 0.0113
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0038 0.0099 0.0247
Echinococcus multilocularis g protein coupled receptor 0.0278 0.1889 0.327
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Brugia malayi hypothetical protein 0.0278 0.1889 0.1889
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Mycobacterium ulcerans oxidoreductase 0.0038 0.0099 0.0058
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0038 0.0099 1
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0099 0.0058
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Schistosoma mansoni hypothetical protein 0.0278 0.1889 1
Plasmodium falciparum enoyl-acyl carrier reductase 0.056 0.3998 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0278 0.1889 0.327
Schistosoma mansoni neuropeptide receptor 0.0278 0.1889 1
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0099 0.0058
Brugia malayi hypothetical protein 0.0278 0.1889 0.1889
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.0291
Echinococcus granulosus serotonin receptor 0.0278 0.1889 0.3437
Echinococcus multilocularis neuropeptide receptor 0.0278 0.1889 0.327
Loa Loa (eye worm) hypothetical protein 0.0077 0.0389 0.2058
Echinococcus granulosus hypothetical protein 0.0278 0.1889 0.3437
Schistosoma mansoni amine GPCR 0.0278 0.1889 1
Schistosoma mansoni dihydropteridine reductase 0.0038 0.0099 0.0238
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0076 0.0037
Echinococcus granulosus allatostatin A receptor 0.0278 0.1889 0.3437
Echinococcus multilocularis plexin a4 0.0091 0.0494 0.0782
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0038 0.0099 0.0058
Brugia malayi G-protein coupled receptor 0.0278 0.1889 0.1889
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0038 0.0099 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0278 0.1889 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0278 0.1889 1
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0278 0.1889 0.327
Loa Loa (eye worm) G-protein coupled receptor 0.0278 0.1889 1
Onchocerca volvulus 0.0038 0.0099 0.0238
Loa Loa (eye worm) G-protein coupled receptor 0.0278 0.1889 1
Brugia malayi G protein-coupled receptor 0.0278 0.1889 0.1889
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0038 0.0099 1
Onchocerca volvulus 0.0278 0.1889 1
Schistosoma mansoni hypothetical protein 0.0278 0.1889 1
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0099 0.0058
Brugia malayi putative neuropeptide receptor NPR1 0.0278 0.1889 0.1889
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Echinococcus granulosus sex peptide receptor 0.0278 0.1889 0.3437
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.056 0.3998 1
Echinococcus multilocularis somatostatin receptor 0.0278 0.1889 0.327
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0099 0.0058
Echinococcus granulosus rhodopsin orphan GPCR 0.0278 0.1889 0.3437
Mycobacterium tuberculosis Probable oxidoreductase 0.0038 0.0099 0.0058
Echinococcus multilocularis geminin 0.0164 0.1041 0.1757
Echinococcus granulosus g-protein coupled receptor 0.0278 0.1889 0.3437
Brugia malayi Sema domain containing protein 0.0032 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.0278 0.1889 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0038 0.0099 0.0058
Echinococcus multilocularis neuropeptide receptor 0.0278 0.1889 0.327
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0038 0.0099 0.0058
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.1479 0.3577
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0278 0.1889 1
Brugia malayi neuropeptide F receptor 0.0278 0.1889 0.1889
Brugia malayi hypothetical protein 0.0032 0.0055 0.0055
Trypanosoma brucei pteridine reductase 1 0.0038 0.0099 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0278 0.1889 1
Loa Loa (eye worm) TYRA-2 protein 0.0278 0.1889 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0278 0.1889 0.327
Echinococcus multilocularis neuropeptide Y receptor 0.0278 0.1889 0.327
Onchocerca volvulus 0.0278 0.1889 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0278 0.1889 1
Brugia malayi Dopamine receptor protein 1 0.0278 0.1889 0.1889
Echinococcus multilocularis neuropeptide receptor A26 0.0747 0.5391 0.9514
Brugia malayi ORL1-like opioid receptor 0.0278 0.1889 0.1889
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.0712 0.3771
Echinococcus granulosus 7TM GPCR rhodopsin 0.0278 0.1889 0.3437
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0038 0.0099 0.0238
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0038 0.0099 0.0247
Echinococcus granulosus g protein coupled receptor 0.0278 0.1889 0.3437
Leishmania major oxidoreductase-like protein 0.0038 0.0099 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0278 0.1889 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0278 0.1889 0.327
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0278 0.1889 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0278 0.1889 0.327
Onchocerca volvulus 0.0278 0.1889 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0278 0.1889 0.1889
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0278 0.1889 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0278 0.1889 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.0291
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0038 0.0099 0.0058
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0038 0.0099 0.0058
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.056 0.3998 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0076 0.0401
Brugia malayi Melatonin receptor type 1A 0.0278 0.1889 0.1889
Echinococcus granulosus g protein coupled receptor 0.0278 0.1889 0.3437
Brugia malayi G protein-coupled receptor F59B2.13 0.0278 0.1889 0.1889
Loa Loa (eye worm) retinol dehydrogenase 12 0.0038 0.0099 0.0522
Brugia malayi Sema domain containing protein 0.0032 0.0055 0.0055
Schistosoma mansoni opsin-like receptor 0.0278 0.1889 1
Loa Loa (eye worm) sema domain-containing protein 0.0032 0.0055 0.0291
Echinococcus granulosus orexin receptor type 2 0.0278 0.1889 0.3437
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0278 0.1889 0.327
Schistosoma mansoni hypothetical protein 0.0045 0.0149 0.0514
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0278 0.1889 0.327
Trypanosoma brucei oxidoreductase-like protein 0.0038 0.0099 1
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0076 0.7675
Onchocerca volvulus 0.0278 0.1889 1
Onchocerca volvulus 0.0278 0.1889 1
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.0712 0.3771
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0278 0.1889 0.1889
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0099 0.0058
Echinococcus multilocularis neuropeptide s receptor 0.0747 0.5391 0.9514
Echinococcus multilocularis orexin receptor type 2 0.0278 0.1889 0.327
Onchocerca volvulus 0.0278 0.1889 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0278 0.1889 0.327
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0278 0.1889 1
Brugia malayi hypothetical protein 0.0278 0.1889 0.1889
Brugia malayi Serotonin receptor 0.0278 0.1889 0.1889
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Brugia malayi sulfakinin receptor protein 0.0278 0.1889 0.1889
Brugia malayi hypothetical protein 0.0278 0.1889 0.1889
Brugia malayi Tachykinin-like peptides receptor 99D 0.0278 0.1889 0.1889
Toxoplasma gondii ABC1 family protein 0.0035 0.0076 0.0189
Echinococcus multilocularis g protein coupled receptor 0.0278 0.1889 0.327
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Onchocerca volvulus 0.0035 0.0076 0.0113
Brugia malayi Dopamine receptor protein 2 0.0278 0.1889 0.1889
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.056 0.3998 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0038 0.0099 0.0058
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0278 0.1889 0.3437
Echinococcus multilocularis rhodopsin orphan GPCR 0.0278 0.1889 0.327
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Trichomonas vaginalis hypothetical protein 0.056 0.3998 1
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0038 0.0099 0.0247
Schistosoma mansoni biogenic amine (5HT) receptor 0.0278 0.1889 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0278 0.1889 0.327
Onchocerca volvulus 0.0278 0.1889 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0038 0.0099 0.0058
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0038 0.0099 0.0058
Echinococcus granulosus biogenic amine 5HT receptor 0.0278 0.1889 0.3437
Brugia malayi beta-lactamase 0.0035 0.0076 0.0076
Brugia malayi G-protein coupled receptor 0.0278 0.1889 0.1889
Echinococcus multilocularis g-protein coupled receptor 0.0278 0.1889 0.327
Echinococcus multilocularis sex peptide receptor 0.0278 0.1889 0.327
Brugia malayi larval opioid receptor 0.0278 0.1889 0.1889
Onchocerca volvulus 0.0278 0.1889 1
Echinococcus granulosus neuropeptide receptor A26 0.0747 0.5391 1
Loa Loa (eye worm) sema domain-containing protein 0.0032 0.0055 0.0291
Echinococcus multilocularis allatostatin A receptor 0.0278 0.1889 0.327
Onchocerca volvulus 0.0077 0.0389 0.182
Loa Loa (eye worm) hypothetical protein 0.0035 0.0076 0.0401
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Brugia malayi hypothetical protein 0.0278 0.1889 0.1889
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0038 0.0099 0.0058
Brugia malayi beta-lactamase family protein 0.0035 0.0076 0.0076
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0038 0.0099 0.0058
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0278 0.1889 1
Brugia malayi plexin A 0.0091 0.0494 0.0494
Schistosoma mansoni biogenic amine receptor 0.0278 0.1889 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0076 0.0189
Echinococcus multilocularis G-protein coupled receptor, putative 0.0278 0.1889 0.327
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0278 0.1889 0.327
Echinococcus granulosus rhodopsin orphan GPCR 0.0278 0.1889 0.3437
Onchocerca volvulus 0.0278 0.1889 1
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0038 0.0099 0.0082
Echinococcus granulosus rhodopsin orphan GPCR 0.0278 0.1889 0.3437
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0038 0.0099 0.0058
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0278 0.1889 0.327
Loa Loa (eye worm) hypothetical protein 0.0038 0.0099 0.0522
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0038 0.0099 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0278 0.1889 0.3437
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0038 0.0099 0.0058
Loa Loa (eye worm) neuropeptide F receptor 0.0278 0.1889 1
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0278 0.1889 0.327
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.056 0.3998 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0278 0.1889 0.1889
Brugia malayi hypothetical protein 0.0278 0.1889 0.1889
Echinococcus granulosus tm gpcr rhodopsin 0.0278 0.1889 0.3437
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Echinococcus granulosus plexin a4 0.0091 0.0494 0.0822
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.0291
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Schistosoma mansoni myosin xvIII 0.0278 0.1889 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0278 0.1889 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0278 0.1889 0.327
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0278 0.1889 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0076 0.0401
Echinococcus granulosus neuropeptide s receptor 0.0747 0.5391 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0278 0.1889 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0278 0.1889 0.327
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0099 0.0058
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0278 0.1889 0.327
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0038 0.0099 0.0058
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0278 0.1889 0.3437
Echinococcus multilocularis fmrfamide receptor 0.0278 0.1889 0.327
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Schistosoma mansoni opsin-like receptor 0.0278 0.1889 1
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Onchocerca volvulus 0.0278 0.1889 1
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0278 0.1889 0.3437
Echinococcus granulosus rhodopsin orphan GPCR 0.0278 0.1889 0.3437
Loa Loa (eye worm) melatonin receptor type 1A 0.0278 0.1889 1
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0278 0.1889 0.3437
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0278 0.1889 0.327
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Onchocerca volvulus 0.0278 0.1889 1
Echinococcus granulosus fmrfamide receptor 0.0278 0.1889 0.3437
Echinococcus granulosus 7tm_1 domain containing protein 0.0278 0.1889 0.3437
Echinococcus multilocularis serotonin receptor 0.0278 0.1889 0.327
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0076 0.0113
Schistosoma mansoni neuropeptide receptor 0.0278 0.1889 1
Loa Loa (eye worm) hypothetical protein 0.0278 0.1889 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0038 0.0099 0.0522
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0076 0.0076
Onchocerca volvulus 0.0278 0.1889 1
Onchocerca volvulus 0.0278 0.1889 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0278 0.1889 0.327
Brugia malayi RE15519p 0.0278 0.1889 0.1889
Brugia malayi neuropeptide F receptor 0.0278 0.1889 0.1889
Schistosoma mansoni neuropeptide f receptor 76f 0.0278 0.1889 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0278 0.1889 1
Echinococcus granulosus neuropeptides capa receptor 0.0278 0.1889 0.3437
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0278 0.1889 1
Brugia malayi hypothetical protein 0.0278 0.1889 0.1889
Brugia malayi follicle stimulating hormone receptor 0.0278 0.1889 0.1889
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0099 0.0058
Onchocerca volvulus Neuropeptide F receptor homolog 0.0278 0.1889 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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