Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate (NMDA) receptor subunit zeta 1 | Starlite/ChEMBL | References |
Rattus norvegicus | Glutamate receptor ionotropic, AMPA | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glutamate receptor NMDA | 0.0145 | 0.8103 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0107 | 0.4862 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0052 | 0.018 | 0.5 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0107 | 0.4862 | 0.4862 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0107 | 0.4862 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0107 | 0.4862 | 0.4862 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0095 | 0.3882 | 0.3882 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0052 | 0.018 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0107 | 0.4862 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0107 | 0.4862 | 0.4862 |
Brugia malayi | isocitrate dehydrogenase | 0.0107 | 0.4862 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0106 | 0.4762 | 0.4762 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0107 | 0.4862 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0052 | 0.018 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0107 | 0.4862 | 0.5 |
Chlamydia trachomatis | glutamine binding protein | 0.0052 | 0.018 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0095 | 0.3882 | 0.3882 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0107 | 0.4862 | 0.4862 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0072 | 0.1897 | 0.1897 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0107 | 0.4862 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0107 | 0.4862 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0167 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0107 | 0.4862 | 0.4862 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0107 | 0.4862 | 0.5 |
Brugia malayi | Isocitrate dehydrogenase | 0.0107 | 0.4862 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0052 | 0.018 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0107 | 0.4862 | 0.4862 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0106 | 0.4762 | 0.4762 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0107 | 0.4862 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0107 | 0.4862 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0107 | 0.4862 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 10 uM | Displacement of [3H]-AMPA from Ionotropic glutamate receptor AMPA. | ChEMBL. | 1382133 |
Ki (binding) | > 10 uM | Displacement of [3H]-glycine from glycine site on the NMDA receptor. | ChEMBL. | 1382133 |
Ki (binding) | > 10 uM | Displacement of [3H]-AMPA from Ionotropic glutamate receptor AMPA. | ChEMBL. | 1382133 |
Ki (binding) | > 10 uM | Displacement of [3H]-glycine from glycine site on the NMDA receptor. | ChEMBL. | 1382133 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.