Detailed information for compound 1839278

Basic information

Technical information
  • TDR Targets ID: 1839278
  • Name: (3E,3aR,5S,8bS)-5-hydroxy-8,8-dimethyl-3-[[(2 R)-4-methyl-5-oxo-2H-furan-2-yl]oxymethyliden e]-3a,4,5,6,7,8b-hexahydroindeno[2,1-d]furan- 2-one
  • MW: 346.374 | Formula: C19H22O6
  • H donors: 1 H acceptors: 3 LogP: 1.26 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1O[C@H]2[C@@H](/C/1=C\O[C@@H]1OC(=O)C(=C1)C)CC1=C2C(C)(C)CC[C@@H]1O
  • InChi: 1S/C19H22O6/c1-9-6-14(24-17(9)21)23-8-12-10-7-11-13(20)4-5-19(2,3)15(11)16(10)25-18(12)22/h6,8,10,13-14,16,20H,4-5,7H2,1-3H3/b12-8+/t10-,13+,14-,16+/m1/s1
  • InChiKey: VOFXXOPWCBSPAA-KCNJUGRMSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (3E,3aR,5S,8bS)-5-hydroxy-8,8-dimethyl-3-[[(2R)-4-methyl-5-oxo-2H-furan-2-yl]oxymethylene]-3a,4,5,6,7,8b-hexahydroindeno[2,1-d]furan-2-one
  • (3E,3aR,5S,8bS)-5-hydroxy-3-[[(2R)-5-keto-4-methyl-2H-furan-2-yl]oxymethylene]-8,8-dimethyl-3a,4,5,6,7,8b-hexahydroindeno[2,1-d]furan-2-one
  • 11017-56-4
  • C09190
  • Strigol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni lamin 0.0028 0.0338 0.0685
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0052 0.0036
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0291 0.0369
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0052 0.0036
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0582 0.0548
Echinococcus granulosus lamin dm0 0.0028 0.0338 0.0303
Brugia malayi hypothetical protein 0.0017 0.0049 0.0111
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0338 0.076
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0845 0.0812
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.0994 0.2616
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0845 0.0812
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0049 0.0912 0.0879
Trichomonas vaginalis galactokinase, putative 0.0051 0.0958 0.2126
Brugia malayi mevalonate kinase family protein 0.0121 0.279 0.6275
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0291 0.0275
Trypanosoma cruzi fucose kinase, putative 0.007 0.1442 0.1428
Loa Loa (eye worm) hypothetical protein 0.0051 0.0958 0.2155
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.2848 0.281
Trichomonas vaginalis galactokinase, putative 0.0184 0.4447 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0052 0.0036
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0118 0.0102
Echinococcus granulosus lamin 0.0028 0.0338 0.0303
Trypanosoma cruzi galactokinase, putative 0.0344 0.8652 0.8649
Brugia malayi galactokinase family protein 0.0184 0.4447 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.1722 0.1692
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.2834 0.6373
Echinococcus granulosus Mevalonate galactokinase 0.0121 0.279 0.2765
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0118 0.0392
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0956 0.215
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0845 0.1835
Mycobacterium ulcerans homoserine kinase 0.0121 0.279 0.2752
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0052 0.0036
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0052 0.0017
Loa Loa (eye worm) hypothetical protein 0.0051 0.0956 0.215
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0956 0.215
Brugia malayi diphosphomevalonate decarboxylase family protein 0.0051 0.0958 0.2155
Leishmania major fucose kinase, putative 0.0051 0.0958 0.0911
Leishmania major trypanothione reductase 0.0049 0.0887 0.0839
Schistosoma mansoni hypothetical protein 0.0037 0.0582 0.1237
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0049 0.0912 0.5148
Leishmania major hypothetical protein, conserved 0.0026 0.0291 0.0239
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0052 0.0118
Trypanosoma cruzi mevalonate kinase, putative 0.0121 0.279 0.2779
Loa Loa (eye worm) hypothetical protein 0.0016 0.0036 0.0081
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0033 0.0467 0.2481
Schistosoma mansoni lamin 0.0028 0.0338 0.0685
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0052 0.0036
Onchocerca volvulus 0.0051 0.0958 0.1849
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0036 0.0081
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0887 0.0854
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.1722 0.3799
Brugia malayi glutathione reductase 0.0049 0.0887 0.1994
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0887 0.0854
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0118 0.0066
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0111 0.2523 0.8705
Schistosoma mansoni diphosphomevalonate decarboxylase 0.0051 0.0958 0.2091
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.0994 0.0947
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.1722 0.6098
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.1722 1
Loa Loa (eye worm) galactokinase 0.0184 0.4447 1
Trypanosoma cruzi fucose kinase, putative 0.007 0.1442 0.1428
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0118 0.0102
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0291 0.1427
Trypanosoma cruzi mevalonate-diphosphate decarboxylase, putative 0.0051 0.0958 0.0944
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0111 0.2523 0.2484
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0956 0.215
Trichomonas vaginalis galactokinase, putative 0.007 0.1442 0.3218
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0036 0.0081
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.2848 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0338 0.1708
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0118 0.023
Brugia malayi ThiF family protein 0.0033 0.0467 0.1049
Mycobacterium ulcerans phosphomevalonate kinase 0.0121 0.279 0.2752
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0049 0.0912 0.1986
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.1722 0.1942
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0582 0.1237
Toxoplasma gondii thioredoxin reductase 0.0049 0.0887 0.1899
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0052 0.0131
Loa Loa (eye worm) hypothetical protein 0.0121 0.279 0.6275
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0887 0.1994
Brugia malayi hypothetical protein 0.0026 0.0291 0.0653
Loa Loa (eye worm) hypothetical protein 0.0035 0.053 0.1192
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0052 0.0082
Trichomonas vaginalis galactokinase, putative 0.0184 0.4447 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0052 0.0017
Entamoeba histolytica hypothetical protein 0.0037 0.0582 0.0566
Loa Loa (eye worm) glutathione reductase 0.0049 0.0887 0.1994
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0291 0.1427
Entamoeba histolytica hypothetical protein 0.0037 0.0582 0.0566
Leishmania major mevalonate kinase, putative 0.0121 0.279 0.2752
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.1722 0.1692
Loa Loa (eye worm) hypothetical protein 0.0027 0.0325 0.073
Schistosoma mansoni intermediate filament proteins 0.0028 0.0338 0.0685
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0118 0.0239
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0845 0.1901
Mycobacterium tuberculosis Probable reductase 0.0111 0.2523 0.2484
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0845 0.0812
Trypanosoma cruzi phosphomevalonate kinase protein, putative 0.0051 0.0958 0.0944
Wolbachia endosymbiont of Brugia malayi 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 0.0121 0.279 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0845 0.1901
Trypanosoma cruzi phosphomevalonate kinase protein, putative 0.0051 0.0958 0.0944
Loa Loa (eye worm) hypothetical protein 0.0126 0.2919 0.6563
Trichomonas vaginalis diphosphomevalonate decarboxylase, putative 0.0051 0.0958 0.2126
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0118 0.0066
Mycobacterium ulcerans 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 0.0121 0.279 0.2752
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0049 0.0912 0.0879
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0118 0.0367
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0111 0.2523 0.2484
Trichomonas vaginalis mevalonate kinase, putative 0.0051 0.0958 0.2126
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0118 0.0101
Mycobacterium leprae PROBABLE HOMOSERINE KINASE THRB 0.0051 0.0958 0.2472
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0036 0.0081
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.0994 0.0962
Trypanosoma brucei trypanothione reductase 0.0049 0.0887 0.1292
Echinococcus multilocularis musashi 0.0028 0.0338 0.0303
Echinococcus multilocularis Mevalonate galactokinase 0.0121 0.279 0.2765
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.053 0.1192
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0338 0.0332
Onchocerca volvulus Huntingtin homolog 0.0126 0.2919 0.7696
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0028 0.0347 0.0331
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0338 0.1708
Schistosoma mansoni galactokinase 0.0184 0.4447 1
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0033 0.0467 0.2481
Echinococcus multilocularis diphosphomevalonate decarboxylase 0.0051 0.0958 0.0926
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0111 0.2523 0.2484
Toxoplasma gondii GHMP kinase, putative 0.0121 0.279 0.623
Brugia malayi Probable ClpP-like protease 0.008 0.1722 0.3872
Toxoplasma gondii hypothetical protein 0.0028 0.0338 0.0649
Toxoplasma gondii ThiF family protein 0.0033 0.0467 0.0942
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0845 0.1835
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0118 0.0102
Schistosoma mansoni ap endonuclease 0.0019 0.0118 0.0186
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.1722 0.1678
Schistosoma mansoni ap endonuclease 0.0019 0.0118 0.0186
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0118 0.0082
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.1722 0.5514
Chlamydia trachomatis 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 0.0051 0.0958 0.5425
Entamoeba histolytica hypothetical protein 0.0037 0.0582 0.0566
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0118 0.0082
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0052 0.0036
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0582 0.0548
Mycobacterium leprae Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) 0.0121 0.279 0.977
Echinococcus multilocularis N acetylgalactosamine kinase 0.0184 0.4447 0.4427
Mycobacterium tuberculosis Probable dehydrogenase 0.0111 0.2523 0.2484
Toxoplasma gondii hypothetical protein 0.0049 0.0912 0.1956
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0118 0.0076
Echinococcus granulosus diphosphomevalonate decarboxylase 0.0051 0.0958 0.0926
Plasmodium vivax ubiquitin activating enzyme, putative 0.0049 0.0912 0.5148
Trypanosoma brucei phosphomevalonate kinase protein, putative 0.0121 0.279 0.4239
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0118 0.0265
Leishmania major ubiquitin-activating enzyme-like protein 0.0033 0.0467 0.0416
Onchocerca volvulus 0.0155 0.3691 1
Trypanosoma cruzi homoserine kinase 0.0121 0.279 0.2779
Echinococcus granulosus intermediate filament protein 0.0028 0.0338 0.0303
Trypanosoma cruzi mevalonate-diphosphate decarboxylase, putative 0.0051 0.0958 0.0944
Loa Loa (eye worm) hypothetical protein 0.0028 0.0338 0.076
Leishmania major phosphomevalonate kinase protein, putative 0.0121 0.279 0.2752
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0118 0.023
Echinococcus multilocularis lamin 0.0028 0.0338 0.0303
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.1722 0.3799
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.2848 0.281
Trypanosoma brucei galactokinase-like protein, putative 0.0262 0.6511 1
Giardia lamblia Mevalonate kinase 0.0121 0.279 1
Echinococcus granulosus N acetylgalactosamine kinase 0.0184 0.4447 0.4427
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0111 0.2523 0.2484
Leishmania major mevalonate-diphosphate decarboxylase, putative 0.0051 0.0958 0.0911
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0045 0.0792 0.1715
Loa Loa (eye worm) hypothetical protein 0.0049 0.0912 0.205
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0338 0.076
Trypanosoma cruzi galactokinase-like protein, putative 0.0344 0.8652 0.8649
Echinococcus multilocularis lamin dm0 0.0028 0.0338 0.0303
Toxoplasma gondii exonuclease III APE 0.0019 0.0118 0.0149
Loa Loa (eye worm) hypothetical protein 0.0126 0.2919 0.6563
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0845 0.0812
Schistosoma mansoni hypothetical protein 0.0035 0.053 0.1121
Mycobacterium ulcerans mevalonate kinase, Erg12 0.0121 0.279 0.2752
Entamoeba histolytica hypothetical protein 0.0037 0.0582 0.0566
Leishmania major homoserine kinase, putative 0.0121 0.279 0.2752
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0887 0.0872
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0338 0.076
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0033 0.0467 0.0451
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.1722 0.1678
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.0994 0.0947
Mycobacterium tuberculosis Probable homoserine kinase ThrB 0.0051 0.0958 0.0911
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0291 0.0275
Trichomonas vaginalis galactokinase, putative 0.0184 0.4447 1
Brugia malayi intermediate filament protein 0.0028 0.0338 0.076
Loa Loa (eye worm) hypothetical protein 0.0026 0.0291 0.0653
Trypanosoma brucei mevalonate kinase, putative 0.0121 0.279 0.4239
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0052 0.0037
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0052 0.0036
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0887 0.0839
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.1722 1
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0958 0.2126
Treponema pallidum hypothetical protein 0.0121 0.279 0.3184
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0033 0.0467 0.0432
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0118 0.0265
Toxoplasma gondii GHMP kinase, N-terminal domain-containing protein 0.0184 0.4447 1
Brugia malayi hypothetical protein 0.0126 0.2919 0.6563
Plasmodium falciparum glutathione reductase 0.0049 0.0887 0.4999
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0291 0.0542
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.2834 0.6373
Treponema pallidum galactokinase 0.0344 0.8652 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.2848 0.281
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0033 0.0467 0.0641
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0052 0.0082
Plasmodium falciparum thioredoxin reductase 0.0049 0.0887 0.4999
Trypanosoma cruzi homoserine kinase 0.0121 0.279 0.2779
Brugia malayi Thioredoxin reductase 0.0049 0.0887 0.1994
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.1722 1
Trypanosoma brucei homoserine kinase 0.0121 0.279 0.4239
Schistosoma mansoni mevalonate kinase 0.0121 0.279 0.6245
Trypanosoma brucei mevalonate-diphosphate decarboxylase 0.0051 0.0958 0.1402
Mycobacterium tuberculosis Possible D-alpha-D-heptose-7-phosphate kinase HddA 0.0121 0.279 0.2752
Brugia malayi hypothetical protein 0.0155 0.3691 0.83
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0887 0.4999
Plasmodium vivax glutathione reductase, putative 0.0049 0.0887 0.4999
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0033 0.0467 0.0432
Leishmania major fucose kinase, putative 0.0051 0.0958 0.0911
Brugia malayi ThiF family protein 0.0049 0.0912 0.205
Onchocerca volvulus Huntingtin homolog 0.0126 0.2919 0.7696
Giardia lamblia Diphosphomevalonate decarboxylase 0.0051 0.0958 0.3396
Brugia malayi MH2 domain containing protein 0.0123 0.2834 0.6373
Trypanosoma brucei mevalonate diphosphate decarboxylase 0.0051 0.0958 0.1402
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0845 0.1835
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.0994 0.0962
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0291 0.1427
Mycobacterium ulcerans diphosphomevalonate decarboxylase 0.0051 0.0958 0.0911
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.1722 1
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.1722 0.3822
Brugia malayi hypothetical protein 0.0037 0.0582 0.1308
Trichomonas vaginalis galactokinase, putative 0.0184 0.4447 1
Loa Loa (eye worm) hypothetical protein 0.008 0.1722 0.3872
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0052 0.0036
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0033 0.0467 0.0976
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0052 0.0036
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0118 0.0392
Loa Loa (eye worm) ThiF family protein 0.0033 0.0467 0.1049
Loa Loa (eye worm) hypothetical protein 0.0155 0.3691 0.83
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0118 0.0066

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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