Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0104 | 0.5461 | 0.4879 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2446 | 0.3302 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.4902 | 0.4247 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.4902 | 0.4247 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0104 | 0.5461 | 1 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0095 | 0.4806 | 0.9611 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0096 | 0.4902 | 1 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.0104 | 0.5461 | 0.4879 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2446 | 0.3302 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0095 | 0.4806 | 0.974 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2446 | 0.3302 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0095 | 0.4806 | 0.3295 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.9372 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0096 | 0.4902 | 0.0184 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.6869 | 0.6385 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.4902 | 0.4247 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.6869 | 0.6385 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0104 | 0.5461 | 0.1261 |
Onchocerca volvulus | 0.0154 | 0.9372 | 1 | |
Trypanosoma brucei | polo-like protein kinase | 0.0096 | 0.4902 | 0.0184 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.4902 | 0.4247 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0095 | 0.4806 | 0.5 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0096 | 0.4902 | 0.3545 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0095 | 0.4806 | 0.9611 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0096 | 0.4902 | 1 |
Brugia malayi | hypothetical protein | 0.0154 | 0.9372 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2446 | 0.3302 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0104 | 0.5461 | 1 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0095 | 0.4806 | 0.3407 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.4902 | 0.4247 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0104 | 0.5461 | 0.4879 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0096 | 0.4902 | 0.0184 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.4902 | 0.4247 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0096 | 0.4902 | 0.3545 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0096 | 0.4902 | 0.0184 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0095 | 0.4806 | 0.5 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0095 | 0.4806 | 0.3407 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2446 | 0.3302 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.4902 | 0.4247 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.6869 | 0.6385 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0096 | 0.4902 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.