TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 422.381 | Formula: C18H13F3N4O3S
H donors: 2 H acceptors: 4 LogP: 4.01 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccc(cc1C(F)(F)F)/N=N/c1ccc(cc1)S(=O)(=O)Nc1ccccn1
InChi: 1S/C18H13F3N4O3S/c19-18(20,21)15-11-13(6-9-16(15)26)24-23-12-4-7-14(8-5-12)29(27,28)25-17-3-1-2-10-22-17/h1-11,26H,(H,22,25)/b24-23+
InChiKey: ISBRQZZVZNNMKS-WCWDXBQESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	bromodomain containing 4	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Echinococcus multilocularis	bromodomain containing 2	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Entamoeba histolytica	bromodomain-containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126719	All targets in OG5_126719
Brugia malayi	Bromodomain containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Entamoeba histolytica	bromodomain-containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Echinococcus granulosus	bromodomain containing 2	Get druggable targets OG5_126719	All targets in OG5_126719
Candida albicans	two potential bromodomain protein similar to S. cerevisiae transcription regulator BDF1	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Echinococcus multilocularis	Bromodomain containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Neospora caninum	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Schistosoma japonicum	ko:K08871 bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Schistosoma mansoni	bromodomain-containing protein 3 brd3	Get druggable targets OG5_126719	All targets in OG5_126719
Candida albicans	two potential bromodomain protein similar to S. cerevisiae transcription regulator BDF1	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_126719	All targets in OG5_126719
Giardia lamblia	Kinase, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Loa Loa (eye worm)	bromodomain containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Onchocerca volvulus		Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein 4, brd4, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Brugia malayi	Bromodomain containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Toxoplasma gondii	bromodomain-containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Brugia malayi	hypothetical protein	Get druggable targets OG5_126719	All targets in OG5_126719
Entamoeba histolytica	bromodomain-containing protein	Get druggable targets OG5_126719	All targets in OG5_126719

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	activated cdc42 kinase 1	0.016	0.8602	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.016	0.8602	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.016	0.8602	1
Plasmodium falciparum	tyrosine kinase-like protein	0.016	0.8602	0.5
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Brugia malayi	bone morphogenetic protein type 1 receptor	0.016	0.8602	1
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Echinococcus granulosus	tyrosine kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Echinococcus multilocularis	protein tyrosine kinase	0.016	0.8602	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.016	0.8602	1
Echinococcus multilocularis	integrin linked protein kinase	0.016	0.8602	1
Giardia lamblia	Kinase, NEK	0.016	0.8602	0.5
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0053	0.0438	0.0509
Echinococcus multilocularis	epidermal growth factor receptor	0.016	0.8602	1
Onchocerca volvulus		0.016	0.8602	0.5
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.016	0.8602	1
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Schistosoma mansoni	serine/threonine protein kinase	0.016	0.8602	1
Onchocerca volvulus		0.016	0.8602	0.5
Loa Loa (eye worm)	TK protein kinase	0.016	0.8602	1
Loa Loa (eye worm)	TK/FER protein kinase	0.016	0.8602	1
Plasmodium vivax	protein kinase, putative	0.016	0.8602	0.5
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.016	0.8602	1
Brugia malayi	SH2 domain containing protein	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.016	0.8602	1
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.016	0.8602	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.016	0.8602	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.016	0.8602	1
Schistosoma mansoni	protein kinase	0.016	0.8602	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.016	0.8602	1
Echinococcus granulosus	receptor type guanylyl cyclase	0.016	0.8602	1
Echinococcus multilocularis	FL cytokine receptor	0.016	0.8602	1
Loa Loa (eye worm)	TK/FER protein kinase	0.016	0.8602	1
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Echinococcus granulosus	c src tyrosine kinase	0.016	0.8602	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.016	0.8602	1
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.016	0.8602	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.016	0.8602	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.016	0.8602	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.016	0.8602	1
Brugia malayi	Furin-like cysteine rich region family protein	0.016	0.8602	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.016	0.8602	1
Echinococcus granulosus	activin receptor type	0.016	0.8602	1
Loa Loa (eye worm)	TK/Met protein kinase	0.016	0.8602	1
Loa Loa (eye worm)	TK/FER protein kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.016	0.8602	1
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Loa Loa (eye worm)	hypothetical protein	0.016	0.8602	1
Schistosoma mansoni	serine/threonine protein kinase	0.016	0.8602	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.016	0.8602	1
Onchocerca volvulus		0.016	0.8602	0.5
Echinococcus multilocularis	tyrosine protein kinase pr2	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Schistosoma mansoni	protein kinase	0.016	0.8602	1
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Trichomonas vaginalis	bromodomain containing protein, putative	0.0053	0.0438	0.0509
Brugia malayi	Guanylyl cyclase protein 23	0.016	0.8602	1
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.016	0.8602	1
Loa Loa (eye worm)	TK/FER protein kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Loa Loa (eye worm)	TK/FER protein kinase	0.016	0.8602	1
Loa Loa (eye worm)	hypothetical protein	0.016	0.8602	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.016	0.8602	1
Onchocerca volvulus		0.016	0.8602	0.5
Echinococcus multilocularis	transfer RNA-Thr	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Echinococcus multilocularis	tyrosine protein kinase	0.016	0.8602	1
Leishmania major	hypothetical protein, conserved	0.016	0.8602	0.5
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Schistosoma mansoni	ephrin receptor	0.016	0.8602	1
Trichomonas vaginalis	conserved hypothetical protein	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Loa Loa (eye worm)	TK/FER protein kinase	0.016	0.8602	1
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.016	0.8602	1
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Loa Loa (eye worm)	TK/FER protein kinase	0.016	0.8602	1
Loa Loa (eye worm)	TK/FER protein kinase	0.016	0.8602	1
Trypanosoma cruzi	protein kinase, putative	0.016	0.8602	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.016	0.8602	1
Schistosoma mansoni	protein kinase	0.016	0.8602	1
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Toxoplasma gondii	protein kinase domain-containing protein	0.016	0.8602	0.5
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Loa Loa (eye worm)	hypothetical protein	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Onchocerca volvulus		0.016	0.8602	0.5
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Loa Loa (eye worm)	hypothetical protein	0.016	0.8602	1
Plasmodium falciparum	protein kinase, putative	0.016	0.8602	0.5
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.016	0.8602	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.016	0.8602	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0053	0.0438	0.0509
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.016	0.8602	1
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.016	0.8602	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.016	0.8602	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.016	0.8602	1
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Echinococcus granulosus	integrin linked protein kinase	0.016	0.8602	1
Loa Loa (eye worm)	TK/FER protein kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Echinococcus granulosus	insulin receptor	0.016	0.8602	1
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.016	0.8602	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.016	0.8602	1
Brugia malayi	hypothetical protein	0.016	0.8602	1
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Onchocerca volvulus		0.016	0.8602	0.5
Echinococcus multilocularis	protein kinase	0.016	0.8602	1
Giardia lamblia	Kinase, NEK	0.016	0.8602	0.5
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Loa Loa (eye worm)	TK/FER protein kinase	0.016	0.8602	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.016	0.8602	1
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Leishmania major	protein kinase, putative	0.016	0.8602	0.5
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Echinococcus multilocularis	raf serine:threonine protein kinase	0.016	0.8602	1
Loa Loa (eye worm)	protein kinase domain-containing protein	0.016	0.8602	1
Trichomonas vaginalis	AGC family protein kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Trichomonas vaginalis	CAMK family protein kinase	0.016	0.8602	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.016	0.8602	0.5
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Echinococcus granulosus	ephrin type A receptor 4 A	0.016	0.8602	1
Giardia lamblia	Kinase	0.016	0.8602	0.5
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Loa Loa (eye worm)	hypothetical protein	0.016	0.8602	1
Onchocerca volvulus		0.016	0.8602	0.5
Echinococcus multilocularis	natriuretic peptide receptor 1	0.016	0.8602	1
Echinococcus granulosus	kinase suppressor of Ras 1	0.016	0.8602	1
Loa Loa (eye worm)	TK/CSK protein kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.016	0.8602	1
Brugia malayi	SH2 domain containing protein	0.016	0.8602	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.016	0.8602	1
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.016	0.8602	1
Brugia malayi	hypothetical protein	0.016	0.8602	1
Schistosoma mansoni	protein kinase	0.016	0.8602	1
Schistosoma mansoni	protein kinase	0.016	0.8602	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.016	0.8602	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.016	0.8602	0.5
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Schistosoma mansoni	protein kinase	0.016	0.8602	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.016	0.8602	1
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Echinococcus granulosus	activated cdc42 kinase 1	0.016	0.8602	1
Schistosoma mansoni	protein kinase	0.016	0.8602	1
Brugia malayi	protein-tyrosine kinase	0.016	0.8602	1
Leishmania major	protein kinase, putative	0.016	0.8602	0.5
Echinococcus granulosus	tyrosine protein kinase shark	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.016	0.8602	1
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.016	0.8602	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.016	0.8602	1
Trichomonas vaginalis	conserved hypothetical protein	0.016	0.8602	1
Echinococcus granulosus	epidermal growth factor receptor	0.016	0.8602	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.016	0.8602	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Echinococcus multilocularis	insulin receptor	0.016	0.8602	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.016	0.8602	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.016	0.8602	1
Loa Loa (eye worm)	TK protein kinase	0.016	0.8602	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.016	0.8602	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.016	0.8602	1
Loa Loa (eye worm)	TK protein kinase	0.016	0.8602	1
Loa Loa (eye worm)	hypothetical protein	0.016	0.8602	1
Schistosoma mansoni	serine/threonine protein kinase	0.016	0.8602	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.016	0.8602	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.016	0.8602	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.016	0.8602	1
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Trichomonas vaginalis	conserved hypothetical protein	0.016	0.8602	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.016	0.8602	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.016	0.8602	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.016	0.8602	1
Echinococcus multilocularis	activin receptor type	0.016	0.8602	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.016	0.8602	1
Brugia malayi	Tyrosine-protein kinase PR2	0.016	0.8602	1
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.016	0.8602	1
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Echinococcus granulosus	epidermal growth factor receptor	0.016	0.8602	1
Brugia malayi	SRC-1	0.016	0.8602	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.016	0.8602	1
Trichomonas vaginalis	conserved hypothetical protein	0.016	0.8602	1
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.016	0.8602	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.016	0.8602	1
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.016	0.8602	1
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.016	0.8602	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.016	0.8602	1
Echinococcus multilocularis	protein kinase	0.016	0.8602	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0053	0.0438	0.0509
Echinococcus multilocularis	tyrosine kinase	0.016	0.8602	1
Loa Loa (eye worm)	TK/FER protein kinase	0.016	0.8602	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.016	0.8602	1
Brugia malayi	Raf kinase	0.016	0.8602	1
Trichomonas vaginalis	protein kinase atn1, putative	0.016	0.8602	1
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.016	0.8602	1
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Brugia malayi	ephrin receptor 1 precursor	0.016	0.8602	1
Echinococcus multilocularis	activated cdc42 kinase 1	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Schistosoma mansoni	protein kinase	0.016	0.8602	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.016	0.8602	1
Trypanosoma brucei	Pseudokinase, putative	0.016	0.8602	0.5
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Onchocerca volvulus		0.016	0.8602	0.5
Echinococcus multilocularis	kinase suppressor of Ras 1	0.016	0.8602	1
Plasmodium falciparum	protein kinase, putative	0.016	0.8602	0.5
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.016	0.8602	1
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.016	0.8602	1
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.016	0.8602	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.016	0.8602	0.5
Echinococcus multilocularis	heat shock protein 70	0.016	0.8602	1
Onchocerca volvulus		0.016	0.8602	0.5
Loa Loa (eye worm)	hypothetical protein	0.016	0.8602	1
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.016	0.8602	1
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.016	0.8602	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.016	0.8602	1
Onchocerca volvulus		0.016	0.8602	0.5
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.016	0.8602	1
Schistosoma mansoni	ephrin receptor	0.016	0.8602	1
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.016	0.8602	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.016	0.8602	0.5
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Schistosoma mansoni	protein kinase	0.016	0.8602	1
Onchocerca volvulus		0.016	0.8602	0.5
Onchocerca volvulus		0.016	0.8602	0.5
Schistosoma mansoni	protein tyrosine kinase	0.016	0.8602	1
Trypanosoma cruzi	protein kinase, putative	0.016	0.8602	0.5
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0086	0.2935	0.3412
Echinococcus granulosus	tyrosine protein kinase Src64B	0.016	0.8602	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.016	0.8602	1
Trichomonas vaginalis	conserved hypothetical protein	0.016	0.8602	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.016	0.8602	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.016	0.8602	1
Echinococcus multilocularis	epidermal growth factor receptor	0.016	0.8602	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.016	0.8602	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.016	0.8602	1
Loa Loa (eye worm)	TK/FER protein kinase	0.016	0.8602	1
Brugia malayi	Receptor family ligand binding region containing protein	0.016	0.8602	1
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Echinococcus multilocularis	ephrin type A receptor 4 A	0.016	0.8602	1
Brugia malayi	hypothetical protein	0.016	0.8602	1
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Echinococcus granulosus	tyrosine protein kinase csk	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.016	0.8602	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.016	0.8602	1
Toxoplasma gondii	STE kinase	0.016	0.8602	0.5
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.016	0.8602	1
Loa Loa (eye worm)	hypothetical protein	0.016	0.8602	1
Loa Loa (eye worm)	TK/FER protein kinase	0.016	0.8602	1
Echinococcus multilocularis	tyrosine kinase	0.016	0.8602	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.016	0.8602	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.016	0.8602	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.016	0.8602	1
Giardia lamblia	Protein 21.1	0.016	0.8602	0.5
Loa Loa (eye worm)	SRC-1	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Schistosoma mansoni	serine/threonine protein kinase	0.016	0.8602	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.016	0.8602	1
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Plasmodium falciparum	tyrosine kinase-like protein	0.016	0.8602	0.5
Loa Loa (eye worm)	TK protein kinase	0.016	0.8602	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.016	0.8602	1
Loa Loa (eye worm)	TK/FER protein kinase	0.016	0.8602	1
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Echinococcus granulosus	tyrosine protein kinase csk	0.016	0.8602	1
Trichomonas vaginalis	STE family protein kinase	0.016	0.8602	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Echinococcus granulosus	protein kinase	0.016	0.8602	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.016	0.8602	1
Loa Loa (eye worm)	TK protein kinase	0.016	0.8602	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0438	0.0509
Schistosoma mansoni	serine/threonine RGC	0.016	0.8602	1
Loa Loa (eye worm)	hypothetical protein	0.016	0.8602	1
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.016	0.8602	1
Schistosoma mansoni	protein kinase	0.016	0.8602	1
Loa Loa (eye worm)	hypothetical protein	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Brugia malayi	integrin-linked kinase	0.016	0.8602	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.016	0.8602	1
Brugia malayi	C-terminal src kinase protein 1	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.016	0.8602	1
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Onchocerca volvulus		0.016	0.8602	0.5
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Loa Loa (eye worm)	TK protein kinase	0.016	0.8602	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.016	0.8602	1
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.016	0.8602	1
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Echinococcus multilocularis	tyrosine protein kinase HCK	0.016	0.8602	1
Echinococcus granulosus	tyrosine protein kinase csk	0.016	0.8602	1
Loa Loa (eye worm)	TK/FER protein kinase	0.016	0.8602	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.016	0.8602	1
Toxoplasma gondii	protein kinase	0.016	0.8602	0.5
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Trypanosoma brucei	protein kinase, putative	0.016	0.8602	0.5
Echinococcus granulosus	tyrosine kinase	0.016	0.8602	1
Onchocerca volvulus		0.016	0.8602	0.5
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.016	0.8602	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.016	0.8602	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.016	0.8602	0.5
Loa Loa (eye worm)	TK protein kinase	0.016	0.8602	1
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.016	0.8602	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.016	0.8602	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.016	0.8602	1
Schistosoma mansoni	tyrosine protein kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.016	0.8602	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0086	0.2935	0.3412
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Echinococcus granulosus	protein tyrosine kinase	0.016	0.8602	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.016	0.8602	0.5
Schistosoma mansoni	hypothetical protein	0.016	0.8602	1
Echinococcus multilocularis	c src tyrosine kinase	0.016	0.8602	1
Loa Loa (eye worm)	TK protein kinase	0.016	0.8602	1
Onchocerca volvulus	Tyrosine kinase homolog	0.016	0.8602	0.5
Trichomonas vaginalis	TK family protein kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.016	0.8602	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.016	0.8602	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.016	0.8602	1
Onchocerca volvulus		0.016	0.8602	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.016	0.8602	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.016	0.8602	1
Echinococcus granulosus	tyrosine kinase	0.016	0.8602	1
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Loa Loa (eye worm)	hypothetical protein	0.016	0.8602	1
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.016	0.8602	1
Trichomonas vaginalis	conserved hypothetical protein	0.016	0.8602	1
Loa Loa (eye worm)	hypothetical protein	0.016	0.8602	1
Brugia malayi	Protein kinase domain containing protein	0.016	0.8602	1
Loa Loa (eye worm)	TK protein kinase	0.016	0.8602	1
Plasmodium falciparum	protein kinase, putative	0.016	0.8602	0.5
Echinococcus granulosus	raf serine:threonine protein kinase	0.016	0.8602	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.016	0.8602	1
Echinococcus granulosus	tyrosine protein kinase	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Loa Loa (eye worm)	hypothetical protein	0.016	0.8602	1
Loa Loa (eye worm)	TK protein kinase	0.016	0.8602	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.016	0.8602	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.016	0.8602	1
Trichomonas vaginalis	TKL family protein kinase	0.016	0.8602	1
Schistosoma mansoni	tyrosine kinase	0.016	0.8602	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.016	0.8602	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.016	0.8602	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.016	0.8602	1
Schistosoma mansoni	protein kinase	0.016	0.8602	1
Trichomonas vaginalis	conserved hypothetical protein	0.016	0.8602	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 6.83 uM	Displacement of fluorescein-labeled MS574 from recombinant human BRD4 BrD2 after 1 hr by fluorescence anisotropy assay	ChEMBL.	24144283
Ki (binding)	= 9.45 uM	Displacement of fluorescein-labeled MS574 from recombinant human BRD4 BrD1 after 1 hr by fluorescence anisotropy assay	ChEMBL.	24144283

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3086882

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1839490