Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ubiquitin modifier activating enzyme 1 | 0.0185 | 0.0828 | 0.0828 |
Entamoeba histolytica | ubiquitin-activating enzyme, putative | 0.0185 | 0.0828 | 0.0828 |
Trypanosoma cruzi | ubiquitin-activating enzyme E1, putative | 0.012 | 0.0409 | 0.1423 |
Echinococcus multilocularis | ubiquitin modifier activating enzyme 6 | 0.0185 | 0.0828 | 0.0828 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0233 | 0.0233 |
Loa Loa (eye worm) | ThiF family protein | 0.0067 | 0.0067 | 0.0067 |
Echinococcus multilocularis | NEDD8 activating enzyme E1 regulatory subunit | 0.0093 | 0.0233 | 0.0233 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.029 | 0.029 |
Trypanosoma brucei | NEDD8 activating enzyme subunit, putative | 0.0502 | 0.2876 | 1 |
Leishmania major | ubiquitin-activating enzyme e1, putative | 0.012 | 0.0409 | 0.1423 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0553 | 0.3205 | 1 |
Entamoeba histolytica | ThiF family protein | 0.0093 | 0.0233 | 0.0233 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1 X, putative | 0.0095 | 0.0242 | 0.034 |
Trypanosoma cruzi | ubiquitin activating enzyme, putative | 0.0502 | 0.2876 | 1 |
Mycobacterium ulcerans | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase | 0.0553 | 0.3205 | 1 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0093 | 0.0233 | 0.0327 |
Leishmania major | hypothetical protein, conserved | 0.0093 | 0.0233 | 0.0809 |
Entamoeba histolytica | ubiquitin-activating enzyme, putative | 0.0067 | 0.0067 | 0.0067 |
Brugia malayi | ThiF family protein | 0.0102 | 0.029 | 0.029 |
Trypanosoma cruzi | ubiquitin-activating enzyme E1, putative | 0.0089 | 0.0203 | 0.0706 |
Schistosoma mansoni | sumo-1-activating enzyme E1a | 0.0102 | 0.029 | 0.029 |
Plasmodium falciparum | ubiquitin-activating enzyme E1 | 0.0185 | 0.0828 | 0.2879 |
Plasmodium vivax | ubiquitin activating enzyme, putative | 0.0102 | 0.029 | 0.101 |
Echinococcus granulosus | NEDD8 activating enzyme E1 regulatory subunit | 0.0093 | 0.0233 | 0.0233 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0093 | 0.0233 | 0.0327 |
Schistosoma mansoni | app binding protein | 0.0093 | 0.0233 | 0.0233 |
Entamoeba histolytica | ubiquitin-activating enzyme E1 1, putative | 0.0154 | 0.0625 | 0.0625 |
Brugia malayi | ThiF family protein | 0.0093 | 0.0233 | 0.0233 |
Schistosoma mansoni | clathrin coat associated protein ap-50 | 0.0132 | 0.0486 | 0.0486 |
Plasmodium falciparum | ubiquitin-activating enzyme | 0.0067 | 0.0067 | 0.0232 |
Trypanosoma brucei | ubiquitin-activating enzyme E1, putative | 0.012 | 0.0409 | 0.1423 |
Echinococcus granulosus | SUMO activating enzyme subunit 1 | 0.0102 | 0.029 | 0.029 |
Toxoplasma gondii | ThiF family protein | 0.0067 | 0.0067 | 0.0067 |
Schistosoma mansoni | ubiquitin-activating enzyme E1 | 0.0158 | 0.0653 | 0.0653 |
Trypanosoma brucei | NEDD8-activating enzyme E1 regulatory subunit, putative | 0.0093 | 0.0233 | 0.0809 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0067 | 0.0067 | 0.0094 |
Trypanosoma cruzi | ubiquitin-activating enzyme E1, putative | 0.012 | 0.0409 | 0.1423 |
Trypanosoma brucei | ubiquitin-activating enzyme E1, putative | 0.0099 | 0.027 | 0.0938 |
Brugia malayi | ube1-prov protein | 0.0185 | 0.0828 | 0.0828 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0067 | 0.0067 | 0.0094 |
Echinococcus multilocularis | SUMO activating enzyme subunit 1 | 0.0102 | 0.029 | 0.029 |
Trypanosoma cruzi | NEDD8-activating enzyme E1 regulatory subunit, putative | 0.0093 | 0.0233 | 0.0809 |
Echinococcus multilocularis | ubiquitin modifier activating enzyme 1 | 0.0185 | 0.0828 | 0.0828 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0091 | 0.0216 | 0.0303 |
Plasmodium vivax | SUMO-activating enzyme subunit 2, putative | 0.0067 | 0.0067 | 0.0232 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0154 | 0.0625 | 0.0878 |
Plasmodium falciparum | SUMO-activating enzyme subunit 1 | 0.0102 | 0.029 | 0.101 |
Plasmodium vivax | ubiquitin-activating enzyme, putative | 0.0067 | 0.0067 | 0.0232 |
Plasmodium vivax | ubiquitin-activating enzyme E1C, putative | 0.0502 | 0.2876 | 1 |
Plasmodium falciparum | NEDD8-activating enzyme E1 catalytic subunit, putative | 0.0502 | 0.2876 | 1 |
Leishmania major | ubiquitin activating enzyme, putative | 0.0502 | 0.2876 | 1 |
Trypanosoma cruzi | ubiquitin activating enzyme, putative | 0.0502 | 0.2876 | 1 |
Trichomonas vaginalis | molybdopterin biosynthesis moeb protein, putative | 0.0502 | 0.2876 | 0.4038 |
Giardia lamblia | Ubiquitin-conjugating enzyme E1 | 0.012 | 0.0409 | 1 |
Schistosoma mansoni | clathrin coat associated protein ap-50 | 0.0132 | 0.0486 | 0.0486 |
Loa Loa (eye worm) | ube1-prov protein | 0.0185 | 0.0828 | 0.0828 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0067 | 0.0067 | 0.0094 |
Echinococcus granulosus | ubiquitin modifier activating enzyme 6 | 0.0185 | 0.0828 | 0.0828 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1c, putative | 0.0154 | 0.0625 | 0.0878 |
Toxoplasma gondii | ThiF family protein | 0.0093 | 0.0233 | 0.0233 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0154 | 0.0625 | 0.0878 |
Leishmania major | ubiquitin-activating enzyme e1, putative | 0.0099 | 0.027 | 0.0938 |
Toxoplasma gondii | hypothetical protein | 0.0102 | 0.029 | 0.029 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.116 | 0.7124 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 200 uM | Cytostatic activity against human HeLa cells after 3 days by coulter ZI particle counting analysis | ChEMBL. | 24219992 |
IC50 (functional) | > 200 uM | Cytostatic activity against mouse L1210 cells after 2 days by coulter ZI particle counting analysis | ChEMBL. | 24219992 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.