TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 461.965 | Formula: C21H24ClN5O3S
H donors: 3 H acceptors: 5 LogP: 1.8 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)[C@H]1NC[C@H]2[C@@H](C1)C[C@H](CC2)Oc1cc(ccc1c1nnn[nH]1)c1cccs1.Cl
InChi: 1S/C21H23N5O3S.ClH/c27-21(28)17-9-14-8-15(5-3-13(14)11-22-17)29-18-10-12(19-2-1-7-30-19)4-6-16(18)20-23-25-26-24-20;/h1-2,4,6-7,10,13-15,17,22H,3,5,8-9,11H2,(H,27,28)(H,23,24,25,26);1H/t13-,14+,15-,17-;/m0./s1
InChiKey: GYQADMUBSVCLFN-SDHFGCOHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glutamate receptor, ionotropic, kainate 1	Starlite/ChEMBL	References
Homo sapiens	glutamate receptor, ionotropic, AMPA 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	Get druggable targets OG5_127034	All targets in OG5_127034
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	Get druggable targets OG5_127034	All targets in OG5_127034
Echinococcus granulosus	glutamate receptor subunit protein glur	Get druggable targets OG5_128645	All targets in OG5_128645
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127034	All targets in OG5_127034
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor 4	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor ionotropic kainate	Get druggable targets OG5_127034	All targets in OG5_127034
Echinococcus granulosus	glutamate receptor ionotropic kainate	Get druggable targets OG5_127034	All targets in OG5_127034
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	Get druggable targets OG5_127034	All targets in OG5_127034
Loa Loa (eye worm)	glutamate receptor 1	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	Get druggable targets OG5_127034	All targets in OG5_127034
Schistosoma japonicum	Glutamate receptor delta-2 subunit precursor, putative	Get druggable targets OG5_127034	All targets in OG5_127034
Echinococcus multilocularis	NMDA receptor	Get druggable targets OG5_127034	All targets in OG5_127034
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128645	All targets in OG5_128645
Brugia malayi	Glutamate receptor 2 precursor	Get druggable targets OG5_128645	All targets in OG5_128645
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128645	All targets in OG5_128645
Schistosoma japonicum	Glutamate receptor, ionotropic kainate 1 precursor, putative	Get druggable targets OG5_127034	All targets in OG5_127034
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	Get druggable targets OG5_128645	All targets in OG5_128645
Schistosoma mansoni	glutamate receptor kainate	Get druggable targets OG5_127034	All targets in OG5_127034
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	Get druggable targets OG5_127034	All targets in OG5_127034
Echinococcus granulosus	glutamate receptor 1	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645
Schistosoma japonicum	Glutamate receptor, ionotropic kainate 3 precursor, putative	Get druggable targets OG5_127034	All targets in OG5_127034
Echinococcus granulosus	glutamate receptor 4	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	Get druggable targets OG5_128645	All targets in OG5_128645
Brugia malayi	Glutamate receptor 1 precursor	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	Get druggable targets OG5_127034	All targets in OG5_127034
Echinococcus multilocularis	glutamate receptor subunit protein glur	Get druggable targets OG5_128645	All targets in OG5_128645
Schistosoma mansoni	glutamate receptor kainate	Get druggable targets OG5_127034	All targets in OG5_127034
Echinococcus granulosus	glutamate receptor ionotropic kainate 3	Get druggable targets OG5_127034	All targets in OG5_127034
Echinococcus multilocularis	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	Get druggable targets OG5_127034	All targets in OG5_127034
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127034	All targets in OG5_127034

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	glutamate receptor, ionotropic, AMPA 2	883 aa	810 aa	34.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Kinase, AGC PKA	0.0981	0.6111	0.5
Entamoeba histolytica	protein kinase, putative	0.0108	0.0375	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0108	0.0375	0.0074
Loa Loa (eye worm)	glutamate receptor 1	0.0112	0.0398	0.0398
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0097	0.0303	0.0449
Trichomonas vaginalis	AGC family protein kinase	0.0108	0.0375	0.0074
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0097	0.0303	0.0449
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0108	0.0375	0.0111
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0097	0.0303	0.0449
Trichomonas vaginalis	AGC family protein kinase	0.0108	0.0375	0.0074
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0097	0.0303	0.0303
Schistosoma mansoni	serine/threonine protein kinase	0.0506	0.2988	0.4375
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.097	0.6039	0.8948
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0506	0.2988	0.4427
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0108	0.0375	0.0079
Echinococcus multilocularis	protein kinase c iota type	0.0506	0.2988	0.4427
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0303	0.0303
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.097	0.6039	0.8948
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0303	0.0303
Schistosoma mansoni	hypothetical protein	0.0097	0.0303	0.0359
Schistosoma mansoni	myotubularin-related protein	0.0097	0.0303	0.0359
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0109	0.0384	0.0568
Leishmania major	protein kinase, putative	0.0108	0.0375	1
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0108	0.0375	0.0111
Entamoeba histolytica	hypothetical protein	0.0108	0.0375	0.0074
Onchocerca volvulus		0.0097	0.0303	0.5
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0097	0.0303	0.0449
Loa Loa (eye worm)	cytohesin 3	0.0097	0.0303	0.0303
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0506	0.2988	0.4427
Leishmania major	folate/biopterin transporter, putative	0.0108	0.0375	1
Echinococcus granulosus	beta 1 syntrophin	0.0097	0.0303	0.0449
Echinococcus granulosus	Oxysterol binding protein 11	0.0097	0.0303	0.0449
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0506	0.2988	0.4427
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0108	0.0375	0.0111
Echinococcus granulosus	protein kinase c iota type	0.0506	0.2988	0.4427
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0109	0.0384	0.0568
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0108	0.0375	0.0074
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0108	0.0375	0.0074
Echinococcus granulosus	nervana 2	0.097	0.6039	0.8948
Trichomonas vaginalis	AGC family protein kinase	0.0506	0.2988	0.2769
Echinococcus granulosus	glutamate receptor ionotropic kainate	0.006	0.0057	0.0085
Trichomonas vaginalis	AGC family protein kinase	0.0108	0.0375	0.0074
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0097	0.0303	0.0449
Echinococcus granulosus	GRB2 associated binding protein 3	0.0097	0.0303	0.0449
Loa Loa (eye worm)	Plekhf2 protein	0.0097	0.0303	0.0303
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0061	0.0063	0.0093
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.1476	0.9362	0.9362
Echinococcus multilocularis	glutamate receptor 2	0.0123	0.0474	0.0702
Onchocerca volvulus		0.0097	0.0303	0.5
Echinococcus multilocularis	oxysterol binding protein 1	0.0097	0.0303	0.0449
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0097	0.0303	0.0449
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0097	0.0303	0.0449
Schistosoma mansoni	oxysterol-binding protein 1	0.0097	0.0303	0.0359
Entamoeba histolytica	protein kinase, putative	0.0506	0.2988	0.2769
Trypanosoma cruzi	NIMA-related kinase, putative	0.0108	0.0375	0.0111
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0108	0.0375	0.0074
Schistosoma mansoni	serine/threonine protein kinase	0.0506	0.2988	0.4375
Echinococcus granulosus	serine/threonine protein kinase	0.1078	0.6749	1
Schistosoma mansoni	glutamate receptor kainate	0.0098	0.0308	0.0367
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0097	0.0303	0.0449
Echinococcus multilocularis	glutamate receptor 2	0.0101	0.0326	0.0483
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0506	0.2988	0.2988
Echinococcus multilocularis	serine threonine protein kinase	0.0506	0.2988	0.4427
Onchocerca volvulus	Putative zinc finger protein	0.0097	0.0303	0.5
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0097	0.0303	0.0303
Trichomonas vaginalis	AGC family protein kinase	0.0506	0.2988	0.2769
Echinococcus multilocularis	NMDA receptor	0.006	0.0057	0.0085
Echinococcus granulosus	glutamate receptor 2	0.0101	0.0326	0.0483
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0097	0.0303	0.0449
Echinococcus granulosus	pleckstrin y domain containing family A	0.0097	0.0303	0.0449
Schistosoma mansoni	zinc finger protein	0.0097	0.0303	0.0359
Trypanosoma cruzi	Protein kinase B	0.1078	0.6749	1
Schistosoma mansoni	hypothetical protein	0.0097	0.0303	0.0359
Echinococcus granulosus	nervana 2	0.097	0.6039	0.8948
Brugia malayi	p70 ribosomal S6 kinase beta	0.1476	0.9362	0.9342
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0108	0.0375	0.0074
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0108	0.0375	0.0074
Echinococcus granulosus	glutamate receptor subunit protein glur	0.0073	0.0147	0.0218
Echinococcus granulosus	Glutaredoxin protein 5	0.097	0.6039	0.8948
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0097	0.0303	0.0449
Echinococcus granulosus	dynamin 1	0.0097	0.0303	0.0449
Schistosoma mansoni	dynamin	0.0097	0.0303	0.0359
Entamoeba histolytica	protein kinase, putative	0.0108	0.0375	0.0074
Echinococcus granulosus	Pleckstrin y	0.0097	0.0303	0.0449
Trichomonas vaginalis	AGC family protein kinase	0.0108	0.0375	0.0074
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0108	0.0375	1
Trichomonas vaginalis	AGC family protein kinase	0.0108	0.0375	0.0074
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0097	0.0303	0.0449
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0108	0.0375	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0303	0.0303
Trichomonas vaginalis	AGC family protein kinase	0.0108	0.0375	0.0074
Entamoeba histolytica	protein kinase, putative	0.1476	0.9362	0.9342
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0108	0.0375	0.0111
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0981	0.6111	0.9055
Entamoeba histolytica	PH domain containing protein kinase, putative	0.1078	0.6749	0.6647
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0097	0.0303	0.0449
Trichomonas vaginalis	AGC family protein kinase	0.0108	0.0375	0.0074
Brugia malayi	protein kinase C II.	0.0506	0.2988	0.2769
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0108	0.0375	0.0074
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0506	0.2988	0.2988
Trichomonas vaginalis	AGC family protein kinase	0.0108	0.0375	0.0074
Echinococcus multilocularis	rac serine:threonine kinase	0.1078	0.6749	1
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0097	0.0303	0.0449
Leishmania major	serine/threonine-protein kinase a, putative	0.0108	0.0375	1
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0097	0.0303	0.0303
Echinococcus granulosus	cytohesin 1	0.0097	0.0303	0.0449
Schistosoma mansoni	hypothetical protein	0.0097	0.0303	0.0359
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0109	0.0384	0.0568
Schistosoma mansoni	dynamin	0.0097	0.0303	0.0359
Echinococcus granulosus	protein kinase c epsilon type	0.0506	0.2988	0.4427
Schistosoma mansoni	glutamate receptor NMDA	0.0072	0.0138	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0303	0.0303
Echinococcus granulosus	Pleckstrin y	0.0097	0.0303	0.0449
Echinococcus multilocularis	oxysterol binding protein 9	0.0097	0.0303	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0303	0.0303
Trichomonas vaginalis	AGC family protein kinase	0.0108	0.0375	0.0074
Schistosoma mansoni	serine/threonine protein kinase	0.0506	0.2988	0.4375
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0097	0.0303	0.5
Schistosoma mansoni	goodpasture antigen-binding protein	0.0097	0.0303	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0303	0.0303
Schistosoma mansoni	serine/threonine protein kinase	0.0506	0.2988	0.4375
Echinococcus multilocularis	cytohesin 1	0.0097	0.0303	0.0449
Echinococcus multilocularis	Oxysterol binding protein 11	0.0097	0.0303	0.0449
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0097	0.0303	0.0449
Entamoeba histolytica	p21-activated kinase	0.0108	0.0375	0.0074
Entamoeba histolytica	protein kinase, putative	0.0108	0.0375	0.0074
Entamoeba histolytica	hypothetical protein	0.0108	0.0375	0.0074
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0097	0.0303	0.0449
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0108	0.0375	0.0123
Echinococcus multilocularis	oxysterol binding protein 3	0.0097	0.0303	0.0449
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.1078	0.6749	1
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0097	0.0303	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0303	0.0303
Schistosoma mansoni	rho gtpase activating protein	0.0097	0.0303	0.0359
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0506	0.2988	0.4427
Echinococcus multilocularis	actin binding protein anillin	0.0097	0.0303	0.0449
Echinococcus granulosus	myotubularin protein 13	0.0097	0.0303	0.0449
Echinococcus granulosus	serine threonine protein kinase nrc	0.0981	0.6111	0.9055
Schistosoma mansoni	syntrophin	0.0097	0.0303	0.0359
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.006	0.0057	0.0085
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0109	0.0384	0.0568
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0303	0.0303
Schistosoma mansoni	serine/threonine kinase	0.0506	0.2988	0.4375
Onchocerca volvulus		0.0097	0.0303	0.5
Loa Loa (eye worm)	glutamate receptor 2	0.0061	0.0063	0.0063
Loa Loa (eye worm)	PH domain-containing protein	0.0097	0.0303	0.0303
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0981	0.6111	1
Echinococcus granulosus	NDR protein kinase	0.0506	0.2988	0.4427
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0506	0.2988	0.4427
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0097	0.0303	0.0449
Schistosoma mansoni	serine/threonine-protein kinase	0.1078	0.6749	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0108	0.0375	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0303	0.0303
Brugia malayi	Hr1 repeat family protein	0.0506	0.2988	0.2769
Trichomonas vaginalis	AGC family protein kinase	0.0108	0.0375	0.0074
Schistosoma mansoni	serine/threonine-protein kinase	0.1078	0.6749	1
Trichomonas vaginalis	AGC family protein kinase	0.0108	0.0375	0.0074
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0097	0.0303	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0303	0.0303
Echinococcus granulosus	pdz domain containing protein	0.0097	0.0303	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0303	0.0303
Echinococcus granulosus	DCC interacting protein 13 beta	0.0097	0.0303	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0303	0.0303
Echinococcus multilocularis	myotubularin protein 13	0.0097	0.0303	0.0449
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0108	0.0375	0.0074
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0108	0.0375	0.0111
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0506	0.2988	0.4427
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0506	0.2988	0.4427
Trichomonas vaginalis	AGC family protein kinase	0.0108	0.0375	0.0074
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0097	0.0303	0.0449
Schistosoma mansoni	growth factor receptor-bound protein	0.0097	0.0303	0.0359
Trichomonas vaginalis	AGC family protein kinase	0.0108	0.0375	0.0074
Entamoeba histolytica	protein kinase, putative	0.0108	0.0375	0.0074
Echinococcus multilocularis	Glutaredoxin protein 5	0.097	0.6039	0.8948
Brugia malayi	Glutamate receptor 2 precursor	0.0112	0.0398	0.0098
Echinococcus granulosus	oxysterol binding protein 3	0.0097	0.0303	0.0449
Schistosoma mansoni	serine/threonine protein kinase	0.0506	0.2988	0.4375
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0303	0.0303
Trichomonas vaginalis	AGC family protein kinase	0.0108	0.0375	0.0074
Echinococcus granulosus	Rho GTPase activating protein 24	0.0097	0.0303	0.0449
Echinococcus multilocularis	pdz domain containing protein	0.0097	0.0303	0.0449
Echinococcus granulosus	glutamate receptor ionotropic kainate 3	0.006	0.0057	0.0085
Echinococcus multilocularis	beta 1 syntrophin	0.0097	0.0303	0.0449
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0108	0.0375	0.0111
Brugia malayi	Protein kinase domain containing protein	0.0506	0.2988	0.2769
Leishmania major	protein kinase, putative	0.0108	0.0375	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0303	0.0303
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0506	0.2988	0.4427
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0108	0.0375	0.0111
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0097	0.0303	0.0359
Loa Loa (eye worm)	oxysterol binding protein	0.0097	0.0303	0.0303
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0981	0.6111	0.901
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0123	0.0474	0.0702
Onchocerca volvulus	outspread protein homolog	0.0097	0.0303	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.1078	0.6749	0.6647
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0097	0.0303	0.5
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0506	0.2988	0.2988
Onchocerca volvulus	Protein melted homolog	0.0097	0.0303	0.5
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0495	0.2916	0.2695
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0506	0.2988	0.4427
Loa Loa (eye worm)	uncoordinated protein 104	0.0097	0.0303	0.0303
Echinococcus multilocularis	nervana 2	0.097	0.6039	0.8948
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0108	0.0375	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0303	0.0303
Schistosoma mansoni	hypothetical protein	0.0097	0.0303	0.0359
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0506	0.2988	0.2988
Echinococcus multilocularis	glutamate receptor ionotropic kainate	0.006	0.0057	0.0085
Echinococcus granulosus	Protein kinase C brain isozyme	0.0506	0.2988	0.4427
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0303	0.0303
Echinococcus multilocularis	Pleckstrin y	0.0097	0.0303	0.0449
Echinococcus granulosus	oxysterol binding protein 1	0.0097	0.0303	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0506	0.2988	0.2988
Schistosoma mansoni	goodpasture antigen-binding protein	0.0097	0.0303	0.0359
Schistosoma mansoni	centaurin alpha	0.0097	0.0303	0.0359
Entamoeba histolytica	protein kinase, putative	0.0108	0.0375	0.0074
Echinococcus granulosus	protein kinase C gamma type	0.0506	0.2988	0.4427
Schistosoma mansoni	glutamate receptor kainate	0.0098	0.0308	0.0367
Echinococcus multilocularis	Pleckstrin y	0.0097	0.0303	0.0449
Trichomonas vaginalis	AGC family protein kinase	0.0603	0.3626	0.3427
Loa Loa (eye worm)	rho-GTPase-activating	0.0097	0.0303	0.0303
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0506	0.2988	0.2988
Onchocerca volvulus		0.0097	0.0303	0.5
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0109	0.0384	0.0568
Trichomonas vaginalis	AGC family protein kinase	0.0108	0.0375	0.0074
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0061	0.0063	0.0093
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0108	0.0375	0.0074
Echinococcus multilocularis	nervana 2	0.097	0.6039	0.8948
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0097	0.0303	0.0359
Onchocerca volvulus		0.0097	0.0303	0.5
Echinococcus multilocularis	dynamin 1	0.0097	0.0303	0.0449
Trypanosoma cruzi	NIMA-related kinase, putative	0.0108	0.0375	0.0111
Schistosoma mansoni	vav2	0.0097	0.0303	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0303	0.0303
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.0073	0.0147	0.0218
Toxoplasma gondii	AGC kinase	0.1476	0.9362	1
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0108	0.0375	0.0123
Schistosoma mansoni	zinc finger protein	0.0097	0.0303	0.0359
Schistosoma mansoni	serine/threonine protein kinase	0.0506	0.2988	0.4375
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0506	0.2988	0.4427
Onchocerca volvulus		0.0097	0.0303	0.5
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0109	0.0384	0.0568
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0097	0.0303	0.0449
Schistosoma mansoni	oxysterol-binding protein 1	0.0097	0.0303	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0303	0.0303
Trypanosoma brucei	protein kinase, putative	0.0108	0.0375	0.0074
Toxoplasma gondii	protein kinase domain-containing protein	0.0108	0.0375	0.0079
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0097	0.0303	0.0449
Echinococcus granulosus	calcium dependent secretion activator 1	0.0097	0.0303	0.0449
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0981	0.6111	0.9055
Loa Loa (eye worm)	syntrophin-1	0.0097	0.0303	0.0303
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0097	0.0303	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0303	0.0303
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0981	0.6111	1
Trichomonas vaginalis	AGC family protein kinase	0.0506	0.2988	0.2769
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0097	0.0303	0.0359
Trichomonas vaginalis	AGC family protein kinase	0.0108	0.0375	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0108	0.0375	0.0074
Echinococcus multilocularis	protein kinase c epsilon type	0.0506	0.2988	0.4427
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0506	0.2988	0.2988
Trichomonas vaginalis	AGC family protein kinase	0.0108	0.0375	0.0074
Echinococcus multilocularis	glutamate receptor 2	0.0112	0.0398	0.059
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0097	0.0303	0.0303
Echinococcus multilocularis	Pleckstrin y	0.0097	0.0303	0.0449
Schistosoma mansoni	hypothetical protein	0.0097	0.0303	0.0359
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0123	0.0474	0.0702
Entamoeba histolytica	protein kinase 2, putative	0.0981	0.6111	0.5989
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0097	0.0303	0.0449
Trichomonas vaginalis	AGC family protein kinase	0.0108	0.0375	0.0074
Onchocerca volvulus		0.0097	0.0303	0.5
Echinococcus granulosus	oxysterol binding protein 9	0.0097	0.0303	0.0449
Echinococcus granulosus	glutamate receptor 2	0.0123	0.0474	0.0702
Brugia malayi	Glutamate receptor 1 precursor	0.0112	0.0398	0.0098
Brugia malayi	Protein kinase domain containing protein	0.0506	0.2988	0.2769
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0108	0.0375	1
Schistosoma mansoni	atypical protein kinase C	0.0506	0.2988	0.4375
Schistosoma mansoni	serine/threonine protein kinase	0.0506	0.2988	0.4375
Echinococcus granulosus	serine:threonine protein kinase N2	0.0506	0.2988	0.4427
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0303	0.0303
Echinococcus granulosus	Pleckstrin y	0.0097	0.0303	0.0449

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.09 uM	Displacement of [3H]ATPA from human Gluk1 receptor	ChEMBL.	24140446
Ki (binding)	= 4.4 uM	Displacement of [3H]AMPA from homomeric recombinant GluA2 receptor (unknown origin)	ChEMBL.	24140446

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3088072

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1839609