Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | endoplasmin, putative | 0.0033 | 0.1073 | 0.045 |
Trypanosoma brucei | heat shock protein, putative | 0.0045 | 0.1871 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.1871 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.2986 | 1 |
Mycobacterium leprae | PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) | 0.0042 | 0.1693 | 0.5 |
Brugia malayi | heat shock protein 90 | 0.0045 | 0.1871 | 0.2734 |
Plasmodium vivax | endoplasmin, putative | 0.0045 | 0.1871 | 0.1074 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.1871 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.1871 | 1 |
Trichomonas vaginalis | endoplasmin, putative | 0.0033 | 0.1073 | 0.345 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1335 | 0.4511 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.6845 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.1871 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0045 | 0.1871 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.2986 | 0.4362 |
Echinococcus multilocularis | heat shock protein 90 | 0.0045 | 0.1871 | 0.6268 |
Mycobacterium ulcerans | heat shock protein 90 | 0.0042 | 0.1693 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2986 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.2986 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0042 | 0.1693 | 0.8533 |
Brugia malayi | Endoplasmin precursor | 0.0045 | 0.1871 | 0.2734 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0045 | 0.1871 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1209 | 0.1767 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.1871 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0045 | 0.1871 | 1 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0045 | 0.1871 | 1 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.0042 | 0.1693 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.6845 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0045 | 0.1871 | 1 |
Echinococcus multilocularis | heat shock protein 90 | 0.0038 | 0.1451 | 0.4858 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.1335 | 0.447 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2986 | 1 |
Echinococcus granulosus | endoplasmin | 0.0042 | 0.1693 | 0.5669 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0045 | 0.1871 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1335 | 0.4511 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.1871 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.1871 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0045 | 0.1871 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.1871 | 1 |
Echinococcus multilocularis | endoplasmin | 0.0042 | 0.1693 | 0.5669 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.1871 | 1 |
Echinococcus granulosus | heat shock protein 90 | 0.0045 | 0.1871 | 0.6268 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.2251 | 0.3289 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.1871 | 1 |
Plasmodium vivax | heat shock protein 86, putative | 0.0045 | 0.1871 | 0.1074 |
Echinococcus multilocularis | heat shock protein | 0.0045 | 0.1871 | 0.6268 |
Trypanosoma brucei | heat shock protein, putative | 0.0045 | 0.1871 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.1871 | 1 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0038 | 0.1451 | 0.4858 |
Plasmodium falciparum | heat shock protein 90 | 0.0045 | 0.1871 | 0.1305 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.2986 | 0.4362 |
Echinococcus granulosus | heat shock protein | 0.0045 | 0.1871 | 0.6268 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.2986 | 0.4362 |
Schistosoma mansoni | endoplasmin | 0.0045 | 0.1871 | 0.6268 |
Trypanosoma brucei | heat shock protein, putative | 0.0045 | 0.1871 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0045 | 0.1871 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1335 | 0.447 |
Giardia lamblia | Grp94/Hsp90 | 0.0042 | 0.1693 | 0.5748 |
Schistosoma mansoni | heat shock protein | 0.0045 | 0.1871 | 0.6268 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0045 | 0.1871 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0045 | 0.1871 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.2251 | 0.3289 |
Echinococcus multilocularis | heat shock protein 75 kDa, mitochondrial | 0.003 | 0.0894 | 0.2993 |
Brugia malayi | Hsp90 protein | 0.003 | 0.0894 | 0.1305 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.1871 | 1 |
Brugia malayi | hypothetical protein | 0.0037 | 0.1335 | 0.195 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.1871 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2986 | 1 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.2986 | 0.4362 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2986 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.2986 | 0.4362 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2986 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0042 | 0.1693 | 0.8533 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0045 | 0.1871 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0038 | 0.1451 | 0.7515 |
Onchocerca volvulus | Heat shock protein 75 kDa, mitochondrial homolog | 0.003 | 0.0894 | 0.5 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0038 | 0.1451 | 0.7515 |
Loa Loa (eye worm) | heat shock protein 75 | 0.003 | 0.0894 | 0.1305 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.1871 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.1871 | 1 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0045 | 0.1871 | 0.1074 |
Brugia malayi | RNA binding protein | 0.0062 | 0.2986 | 0.4362 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.1335 | 0.447 |
Trichomonas vaginalis | heat shock protein, putative | 0.0038 | 0.1451 | 0.655 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.1871 | 1 |
Mycobacterium tuberculosis | Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) | 0.0042 | 0.1693 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.1209 | 0.1767 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0045 | 0.1871 | 1 |
Trypanosoma cruzi | heat shock protein, putative | 0.003 | 0.0894 | 0.4226 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.2251 | 0.3289 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.1871 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.2251 | 0.3289 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0045 | 0.1871 | 0.2734 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0045 | 0.1871 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0045 | 0.1871 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0045 | 0.1871 | 1 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0045 | 0.1871 | 0.1074 |
Schistosoma mansoni | heat shock protein | 0.0045 | 0.1871 | 0.6268 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.6845 | 1 |
Leishmania major | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative | 0.0042 | 0.1693 | 0.817 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.0045 | 0.1871 | 1 |
Loa Loa (eye worm) | endoplasmin | 0.0045 | 0.1871 | 0.2734 |
Schistosoma mansoni | endoplasmin | 0.0045 | 0.1871 | 0.6268 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0045 | 0.1871 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0033 | 0.1073 | 0.345 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.1335 | 0.447 |
Echinococcus granulosus | heat shock protein 90 | 0.0038 | 0.1451 | 0.4858 |
Schistosoma mansoni | heat shock protein | 0.003 | 0.0894 | 0.2993 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1335 | 0.4511 |
Echinococcus granulosus | heat shock protein 75 kDa mitochondrial | 0.003 | 0.0894 | 0.2993 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1209 | 0.405 |
Treponema pallidum | heat shock protein 90 | 0.0042 | 0.1693 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1335 | 0.4511 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.