TDR Targets

Basic information

Technical information

TDR Targets ID: 1839984
Name: (3,8-dihydroxy-6-methoxy-4,5-dimethyl-1-oxois ochroman-3-yl)methyl 4-hydroxy-3-(3-methylbut -2-enyl)benzoate
MW: 456.485 | Formula: C25H28O8
H donors: 3 H acceptors: 5 LogP: 5.09 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(O)c2c(c1C)C(C)C(OC2=O)(O)COC(=O)c1ccc(c(c1)CC=C(C)C)O
InChi: 1S/C25H28O8/c1-13(2)6-7-16-10-17(8-9-18(16)26)23(28)32-12-25(30)15(4)21-14(3)20(31-5)11-19(27)22(21)24(29)33-25/h6,8-11,15,26-27,30H,7,12H2,1-5H3
InChiKey: LHROABAUHBYOHP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(3,8-dihydroxy-6-methoxy-4,5-dimethyl-1-oxo-isochroman-3-yl)methyl 4-hydroxy-3-(3-methylbut-2-enyl)benzoate
4-hydroxy-3-(3-methylbut-2-enyl)benzoic acid (3,8-dihydroxy-6-methoxy-4,5-dimethyl-1-oxo-3-isochromanyl)methyl ester
4-hydroxy-3-(3-methylbut-2-enyl)benzoic acid (3,8-dihydroxy-1-keto-6-methoxy-4,5-dimethyl-isochroman-3-yl)methyl ester

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Musca domestica	GABA receptor subunit	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	glycine receptor subunit alpha 1	Get druggable targets OG5_128286	All targets in OG5_128286
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	Get druggable targets OG5_128286	All targets in OG5_128286
Loa Loa (eye worm)	GABA receptor subunit	Get druggable targets OG5_128286	All targets in OG5_128286
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	Get druggable targets OG5_128286	All targets in OG5_128286
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	Get druggable targets OG5_128286	All targets in OG5_128286
Echinococcus multilocularis	glycine receptor subunit alpha 1	Get druggable targets OG5_128286	All targets in OG5_128286
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	Get druggable targets OG5_128286	All targets in OG5_128286
Schistosoma japonicum	ko:K05194 glycine receptor, alpha 2, putative	Get druggable targets OG5_128286	All targets in OG5_128286
Echinococcus multilocularis	glycine receptor subunit alpha 1	Get druggable targets OG5_128286	All targets in OG5_128286
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128286	All targets in OG5_128286
Echinococcus granulosus	glycine receptor subunit alpha 1	Get druggable targets OG5_128286	All targets in OG5_128286
Schistosoma japonicum	ko:K05195 glycine receptor, alpha 3, putative	Get druggable targets OG5_128286	All targets in OG5_128286
Schistosoma japonicum	Glycine receptor subunit alpha-3 precursor, putative	Get druggable targets OG5_128286	All targets in OG5_128286
Echinococcus granulosus	glycine receptor subunit beta	Get druggable targets OG5_128286	All targets in OG5_128286
Echinococcus granulosus	glycine receptor subunit beta	Get druggable targets OG5_128286	All targets in OG5_128286
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	Get druggable targets OG5_128286	All targets in OG5_128286
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	Get druggable targets OG5_128286	All targets in OG5_128286
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	Get druggable targets OG5_128286	All targets in OG5_128286
Echinococcus multilocularis	glycine receptor subunit beta	Get druggable targets OG5_128286	All targets in OG5_128286
Echinococcus multilocularis	glycine receptor subunit beta	Get druggable targets OG5_128286	All targets in OG5_128286
Echinococcus multilocularis	glycine receptor subunit alpha 1	Get druggable targets OG5_128286	All targets in OG5_128286
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	Get druggable targets OG5_128286	All targets in OG5_128286
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128286	All targets in OG5_128286
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	Get druggable targets OG5_128286	All targets in OG5_128286
Brugia malayi	Cation transporter family protein	Get druggable targets OG5_128286	All targets in OG5_128286
Echinococcus granulosus	glycine receptor subunit alpha 1	Get druggable targets OG5_128286	All targets in OG5_128286
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	Get druggable targets OG5_128286	All targets in OG5_128286
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	Get druggable targets OG5_128286	All targets in OG5_128286

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0098	0.0213	0.0251
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.1088	0.6718	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.099	0.6075	0.9035
Entamoeba histolytica	protein kinase, putative	0.0109	0.0285	0.0074
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0109	0.0285	0.0111
Trichomonas vaginalis	AGC family protein kinase	0.0109	0.0285	0.0074
Echinococcus granulosus	oxysterol binding protein 3	0.0098	0.0213	0.0251
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0098	0.0213	0.0213
Brugia malayi	PH domain containing protein	0.0098	0.0213	0.0213
Brugia malayi	Cation transporter family protein	0.0073	0.0046	0.0046
Brugia malayi	Plekhf2 protein	0.0098	0.0213	0.0213
Trichomonas vaginalis	AGC family protein kinase	0.0109	0.0285	0.0074
Trypanosoma brucei	protein kinase, putative	0.0109	0.0285	0.0074
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0098	0.0213	0.0251
Trichomonas vaginalis	AGC family protein kinase	0.0109	0.0285	0.0074
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0098	0.0213	0.0251
Brugia malayi	PH domain containing protein	0.0098	0.0213	0.0213
Trypanosoma cruzi	Protein kinase B	0.1088	0.6718	1
Brugia malayi	Syntrophin-1	0.0098	0.0213	0.0213
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0109	0.0285	0.0123
Echinococcus multilocularis	Oxysterol binding protein 11	0.0098	0.0213	0.0251
Echinococcus granulosus	oxysterol binding protein 9	0.0098	0.0213	0.0251
Trichomonas vaginalis	AGC family protein kinase	0.1588	1	1
Echinococcus granulosus	serine threonine protein kinase nrc	0.099	0.6075	0.9035
Echinococcus granulosus	pdz domain containing protein	0.0098	0.0213	0.0251
Echinococcus multilocularis	oxysterol binding protein 9	0.0098	0.0213	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0213	0.0213
Schistosoma mansoni	goodpasture antigen-binding protein	0.0098	0.0213	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0213	0.0213
Echinococcus granulosus	nervana 2	0.0979	0.6002	0.8927
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0213	0.0213
Trichomonas vaginalis	AGC family protein kinase	0.0109	0.0285	0.0074
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0098	0.0213	0.0251
Echinococcus granulosus	Pleckstrin y	0.0098	0.0213	0.0251
Entamoeba histolytica	p21-activated kinase	0.0109	0.0285	0.0074
Echinococcus multilocularis	serine:threonine protein kinase N2	0.051	0.2923	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0046	0.0046
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.051	0.2923	0.2923
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0109	0.0285	0.0074
Echinococcus granulosus	calcium dependent secretion activator 1	0.0098	0.0213	0.0251
Trichomonas vaginalis	AGC family protein kinase	0.051	0.2923	0.2769
Entamoeba histolytica	hypothetical protein	0.0109	0.0285	0.0074
Schistosoma mansoni	dynamin	0.0098	0.0213	0.0251
Brugia malayi	PH domain containing protein	0.0098	0.0213	0.0213
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0979	0.6002	0.8927
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0979	0.6002	0.8927
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0109	0.0285	0.0111
Toxoplasma gondii	protein kinase domain-containing protein	0.0109	0.0285	0.0079
Trypanosoma cruzi	NIMA-related kinase, putative	0.0109	0.0285	0.0111
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.099	0.6075	0.901
Schistosoma mansoni	serine/threonine protein kinase	0.051	0.2923	0.4312
Echinococcus granulosus	DCC interacting protein 13 beta	0.0098	0.0213	0.0251
Echinococcus granulosus	serine:threonine protein kinase N2	0.051	0.2923	0.4312
Brugia malayi	Protein kinase domain containing protein	0.051	0.2923	0.2923
Schistosoma mansoni	zinc finger protein	0.0098	0.0213	0.0251
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0109	0.0285	0.0111
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0098	0.0213	0.0213
Echinococcus granulosus	pleckstrin y domain containing family A	0.0098	0.0213	0.0251
Echinococcus multilocularis	pdz domain containing protein	0.0098	0.0213	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0213	0.0213
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0098	0.0213	0.0251
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0109	0.0285	0.0079
Trichomonas vaginalis	AGC family protein kinase	0.1588	1	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0213	0.0213
Echinococcus granulosus	protein kinase c epsilon type	0.051	0.2923	0.4312
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0098	0.0213	0.0213
Echinococcus multilocularis	cytohesin 1	0.0098	0.0213	0.0251
Trichomonas vaginalis	AGC family protein kinase	0.0109	0.0285	0.0074
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.099	0.6075	0.9035
Entamoeba histolytica	protein kinase, putative	0.1588	1	1
Loa Loa (eye worm)	PH domain-containing protein	0.0098	0.0213	0.0213
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0098	0.0213	0.0251
Brugia malayi	Protein kinase domain containing protein	0.051	0.2923	0.2923
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0213	0.0213
Brugia malayi	Variant SH3 domain containing protein	0.0098	0.0213	0.0213
Schistosoma mansoni	serine/threonine-protein kinase	0.1088	0.6718	1
Trichomonas vaginalis	AGC family protein kinase	0.051	0.2923	0.2769
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0098	0.0213	0.0251
Schistosoma mansoni	zinc finger protein	0.0098	0.0213	0.0251
Trichomonas vaginalis	AGC family protein kinase	0.1588	1	1
Brugia malayi	protein kinase C II.	0.051	0.2923	0.2923
Echinococcus multilocularis	Pleckstrin y	0.0098	0.0213	0.0251
Leishmania major	folate/biopterin transporter, putative	0.0109	0.0285	1
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0098	0.0213	0.0251
Entamoeba histolytica	protein kinase, putative	0.149	0.9356	0.9342
Echinococcus granulosus	oxysterol binding protein 1	0.0098	0.0213	0.0251
Entamoeba histolytica	protein kinase, putative	0.0109	0.0285	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0109	0.0285	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0109	0.0285	0.0074
Loa Loa (eye worm)	rho-GTPase-activating	0.0098	0.0213	0.0213
Onchocerca volvulus		0.0098	0.0213	0.5
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0098	0.0213	0.0251
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.051	0.2923	0.4312
Onchocerca volvulus	Putative zinc finger protein	0.0098	0.0213	0.5
Loa Loa (eye worm)	uncoordinated protein 104	0.0098	0.0213	0.0213
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0098	0.0213	0.0251
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.051	0.2923	0.2923
Echinococcus granulosus	GRB2 associated binding protein 3	0.0098	0.0213	0.0251
Onchocerca volvulus	Protein melted homolog	0.0098	0.0213	0.5
Schistosoma mansoni	hypothetical protein	0.0098	0.0213	0.0251
Echinococcus granulosus	Glutaredoxin protein 5	0.0979	0.6002	0.8927
Schistosoma mansoni	oxysterol-binding protein 1	0.0098	0.0213	0.0251
Trichomonas vaginalis	AGC family protein kinase	0.0109	0.0285	0.0074
Leishmania major	serine/threonine-protein kinase a, putative	0.0109	0.0285	1
Trichomonas vaginalis	AGC family protein kinase	0.0609	0.3567	0.3427
Brugia malayi	PH domain containing protein	0.0098	0.0213	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0213	0.0213
Echinococcus granulosus	Pleckstrin y	0.0098	0.0213	0.0251
Trichomonas vaginalis	AGC family protein kinase	0.0109	0.0285	0.0074
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0109	0.0285	0.0074
Onchocerca volvulus		0.0098	0.0213	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.051	0.2923	0.4312
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.051	0.2923	0.2923
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0109	0.0285	0.0074
Loa Loa (eye worm)	oxysterol binding protein	0.0098	0.0213	0.0213
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0098	0.0213	0.0251
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0499	0.2851	0.2695
Brugia malayi	Cadps2 protein	0.0098	0.0213	0.0213
Trichomonas vaginalis	AGC family protein kinase	0.0109	0.0285	0.0074
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0098	0.0213	0.0251
Trichomonas vaginalis	AGC family protein kinase	0.1588	1	1
Echinococcus multilocularis	serine threonine protein kinase	0.051	0.2923	0.4312
Echinococcus granulosus	beta 1 syntrophin	0.0098	0.0213	0.0251
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0109	0.0285	0.0111
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.099	0.6075	1
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0098	0.0213	0.0251
Entamoeba histolytica	protein kinase 2, putative	0.099	0.6075	0.5989
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0098	0.0213	0.0251
Echinococcus multilocularis	oxysterol binding protein 1	0.0098	0.0213	0.0251
Schistosoma mansoni	myotubularin-related protein	0.0098	0.0213	0.0251
Brugia malayi	Dynamin	0.0098	0.0213	0.0213
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0109	0.0285	1
Echinococcus multilocularis	protein kinase c epsilon type	0.051	0.2923	0.4312
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0098	0.0213	0.0251
Entamoeba histolytica	protein kinase, putative	0.051	0.2923	0.2769
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0213	0.0213
Brugia malayi	Oxysterol binding protein	0.0098	0.0213	0.0213
Brugia malayi	Hr1 repeat family protein	0.051	0.2923	0.2923
Echinococcus multilocularis	protein kinase c iota type	0.051	0.2923	0.4312
Entamoeba histolytica	protein kinase, putative	0.1588	1	1
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0098	0.0213	0.0213
Brugia malayi	PH domain containing protein	0.0098	0.0213	0.0213
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.051	0.2923	0.2923
Echinococcus granulosus	serine/threonine protein kinase	0.1088	0.6718	1
Trichomonas vaginalis	AGC family protein kinase	0.1588	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.051	0.2923	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0213	0.0213
Onchocerca volvulus		0.0098	0.0213	0.5
Echinococcus granulosus	Oxysterol binding protein 11	0.0098	0.0213	0.0251
Schistosoma mansoni	serine/threonine protein kinase	0.051	0.2923	0.4312
Onchocerca volvulus		0.0098	0.0213	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0098	0.0213	0.0251
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0109	0.0285	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0213	0.0213
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0109	0.0285	0.0074
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.149	0.9356	0.9356
Brugia malayi	MAX-1A	0.0098	0.0213	0.0213
Onchocerca volvulus		0.0098	0.0213	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0109	0.0285	0.0074
Echinococcus granulosus	cytohesin 1	0.0098	0.0213	0.0251
Echinococcus multilocularis	oxysterol binding protein 3	0.0098	0.0213	0.0251
Schistosoma mansoni	goodpasture antigen-binding protein	0.0098	0.0213	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0213	0.0213
Echinococcus multilocularis	nervana 2	0.0979	0.6002	0.8927
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0098	0.0213	0.0251
Brugia malayi	Variant SH3 domain containing protein	0.0098	0.0213	0.0213
Loa Loa (eye worm)	syntrophin-1	0.0098	0.0213	0.0213
Trichomonas vaginalis	AGC family protein kinase	0.0109	0.0285	0.0074
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0109	0.0285	0.0111
Echinococcus granulosus	NDR protein kinase	0.051	0.2923	0.4312
Brugia malayi	probable spectrin beta chain	0.0098	0.0213	0.0213
Echinococcus multilocularis	Glutaredoxin protein 5	0.0979	0.6002	0.8927
Brugia malayi	PH domain containing protein	0.0098	0.0213	0.0213
Trypanosoma cruzi	NIMA-related kinase, putative	0.0109	0.0285	0.0111
Echinococcus granulosus	dynamin 1	0.0098	0.0213	0.0251
Entamoeba histolytica	protein kinase, putative	0.0109	0.0285	0.0074
Brugia malayi	PH domain containing protein	0.0098	0.0213	0.0213
Schistosoma mansoni	serine/threonine protein kinase	0.051	0.2923	0.4312
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0109	0.0285	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0109	0.0285	0.0074
Onchocerca volvulus	outspread protein homolog	0.0098	0.0213	0.5
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0098	0.0213	0.0251
Brugia malayi	hypothetical protein	0.0098	0.0213	0.0213
Loa Loa (eye worm)	hypothetical protein	0.051	0.2923	0.2923
Schistosoma mansoni	rho gtpase activating protein	0.0098	0.0213	0.0251
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0109	0.0285	0.0074
Brugia malayi	Dynamin	0.0098	0.0213	0.0213
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0109	0.0285	1
Schistosoma mansoni	hypothetical protein	0.0098	0.0213	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0213	0.0213
Trichomonas vaginalis	AGC family protein kinase	0.1588	1	1
Echinococcus multilocularis	rac serine:threonine kinase	0.1088	0.6718	1
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.051	0.2923	0.4312
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0098	0.0213	0.0251
Brugia malayi	p70 ribosomal S6 kinase beta	0.149	0.9356	0.9356
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0098	0.0213	0.0251
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0109	0.0285	0.0123
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0098	0.0213	0.5
Loa Loa (eye worm)	cytohesin 3	0.0098	0.0213	0.0213
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.051	0.2923	0.4312
Entamoeba histolytica	PH domain containing protein kinase, putative	0.1088	0.6718	0.6647
Schistosoma mansoni	centaurin alpha	0.0098	0.0213	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0213	0.0213
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0098	0.0213	0.0251
Echinococcus granulosus	protein kinase C gamma type	0.051	0.2923	0.4312
Loa Loa (eye worm)	AGC/NDR protein kinase	0.051	0.2923	0.2923
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0213	0.0213
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0098	0.0213	0.0213
Entamoeba histolytica	hypothetical protein	0.0109	0.0285	0.0074
Echinococcus granulosus	protein kinase c iota type	0.051	0.2923	0.4312
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0098	0.0213	0.0213
Trichomonas vaginalis	AGC family protein kinase	0.0109	0.0285	0.0074
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0098	0.0213	0.0251
Giardia lamblia	Kinase, AGC PKA	0.099	0.6075	0.5
Schistosoma mansoni	dynamin	0.0098	0.0213	0.0251
Echinococcus multilocularis	serine:threonine protein kinase 38	0.051	0.2923	0.4312
Trichomonas vaginalis	AGC family protein kinase	0.0109	0.0285	0.0074
Schistosoma mansoni	syntrophin	0.0098	0.0213	0.0251
Onchocerca volvulus		0.0098	0.0213	0.5
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0213	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0213	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0213	0.0213
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0098	0.0213	0.0251
Echinococcus granulosus	nervana 2	0.0979	0.6002	0.8927
Echinococcus multilocularis	beta 1 syntrophin	0.0098	0.0213	0.0251
Echinococcus multilocularis	dynamin 1	0.0098	0.0213	0.0251
Schistosoma mansoni	hypothetical protein	0.0098	0.0213	0.0251
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0109	0.0285	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0109	0.0285	0.0074
Brugia malayi	Pleckstrin Homology Domain	0.0098	0.0213	0.0213
Trichomonas vaginalis	AGC family protein kinase	0.0109	0.0285	0.0074
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0109	0.0285	0.0111
Trichomonas vaginalis	AGC family protein kinase	0.0109	0.0285	0.0074
Schistosoma mansoni	hypothetical protein	0.0098	0.0213	0.0251
Loa Loa (eye worm)	Plekhf2 protein	0.0098	0.0213	0.0213
Entamoeba histolytica	protein kinase, putative	0.0109	0.0285	0.0074
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0098	0.0213	0.0251
Schistosoma mansoni	serine/threonine protein kinase	0.051	0.2923	0.4312
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0109	0.0285	0.0111
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.051	0.2923	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0213	0.0213
Schistosoma mansoni	atypical protein kinase C	0.051	0.2923	0.4312
Brugia malayi	PH domain containing protein	0.0098	0.0213	0.0213
Brugia malayi	Cytohesin 3	0.0098	0.0213	0.0213
Schistosoma mansoni	oxysterol-binding protein 1	0.0098	0.0213	0.0251
Loa Loa (eye worm)	AGC/PKN protein kinase	0.051	0.2923	0.2923
Echinococcus multilocularis	serine:threonine protein kinase N2	0.051	0.2923	0.4312
Entamoeba histolytica	protein kinase, putative	0.0109	0.0285	0.0074
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.051	0.2923	0.4312
Trypanosoma brucei	rac serine-threonine kinase, putative	0.1588	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.051	0.2923	0.4312
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0098	0.0213	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0213	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0213	0.0213
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0098	0.0213	0.0213
Onchocerca volvulus		0.0098	0.0213	0.5
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0109	0.0285	0.0074
Loa Loa (eye worm)	AGC/AKT protein kinase	0.1588	1	1
Leishmania major	protein kinase, putative	0.0109	0.0285	1
Echinococcus multilocularis	actin binding protein anillin	0.0098	0.0213	0.0251
Echinococcus granulosus	myotubularin protein 13	0.0098	0.0213	0.0251
Echinococcus granulosus	Pleckstrin y	0.0098	0.0213	0.0251
Echinococcus multilocularis	myotubularin protein 13	0.0098	0.0213	0.0251
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.099	0.6075	1
Brugia malayi	Uncoordinated protein 104	0.0098	0.0213	0.0213
Brugia malayi	Oxysterol-binding protein	0.0098	0.0213	0.0213
Echinococcus granulosus	Rho GTPase activating protein 24	0.0098	0.0213	0.0251
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0098	0.0213	0.0251
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0098	0.0213	0.5
Brugia malayi	PH domain containing protein	0.0098	0.0213	0.0213
Toxoplasma gondii	AGC kinase	0.149	0.9356	1
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0098	0.0213	0.0251
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0109	0.0285	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0109	0.0285	0.0074
Schistosoma mansoni	serine/threonine-protein kinase	0.1088	0.6718	1
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0073	0.0046	0.0046
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0109	0.0285	0.0111
Trichomonas vaginalis	AGC family protein kinase	0.051	0.2923	0.2769
Echinococcus multilocularis	nervana 2	0.0979	0.6002	0.8927
Trichomonas vaginalis	AGC family protein kinase	0.0109	0.0285	0.0074
Schistosoma mansoni	vav2	0.0098	0.0213	0.0251
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.051	0.2923	0.4312
Trichomonas vaginalis	AGC family protein kinase	0.1588	1	1
Schistosoma mansoni	hypothetical protein	0.0098	0.0213	0.0251
Echinococcus multilocularis	Pleckstrin y	0.0098	0.0213	0.0251
Leishmania major	protein kinase, putative	0.0109	0.0285	1
Echinococcus multilocularis	Pleckstrin y	0.0098	0.0213	0.0251
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.051	0.2923	0.4312
Echinococcus granulosus	Protein kinase C brain isozyme	0.051	0.2923	0.4312
Schistosoma mansoni	serine/threonine kinase	0.051	0.2923	0.4312
Entamoeba histolytica	PH domain containing protein kinase, putative	0.1088	0.6718	0.6647
Brugia malayi	TBC domain containing protein	0.0098	0.0213	0.0213

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 88 nM	Displacement of [3H]EBOB from GABA receptor in Musca domestica (house fly) head P2 membrane after 70 min by liquid scintillation counting	ChEMBL.	No reference
Inhibition (binding)	= 65 %	Displacement of [3H]EBOB from GABA receptor in Musca domestica (house fly) head P2 membrane at 2.2 uM after 70 min by liquid scintillation counting	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2269235

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1839984