Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0155 | 0.1538 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0427 | 0.3721 |
Trichomonas vaginalis | isocitrate dehydrogenase, putative | 0.0066 | 0.0888 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0543 | 1 | 0.5 |
Echinococcus granulosus | isocitrate dehydrogenase NAD subunit | 0.0066 | 0.0888 | 0.0481 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD) subunit | 0.0066 | 0.0888 | 0.0481 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0028 | 0.0155 | 0.0155 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0155 | 0.0134 |
Leishmania major | isocitrate dehydrogenase, putative | 0.0066 | 0.0888 | 0.0744 |
Mycobacterium ulcerans | 3-isopropylmalate dehydrogenase | 0.0066 | 0.0888 | 1 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | 0.0066 | 0.0888 | 0.0744 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0543 | 1 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0543 | 1 | 1 |
Schistosoma mansoni | isocitrate dehydrogenase | 0.0066 | 0.0888 | 0.0481 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0028 | 0.0155 | 0.1538 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0543 | 1 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase gamma subunit | 0.0066 | 0.0888 | 0.0868 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD+) | 0.0066 | 0.0888 | 0.0481 |
Mycobacterium tuberculosis | Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) | 0.0066 | 0.0888 | 0.0888 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0543 | 1 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0543 | 1 | 0.5 |
Brugia malayi | Isocitrate dehydrogenase | 0.0543 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0543 | 1 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0543 | 1 | 1 |
Schistosoma mansoni | unc-13 (munc13) | 0.0066 | 0.0888 | 0.0481 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0021 | 0.0022 | 0.5 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0028 | 0.0155 | 0.0155 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0543 | 1 | 1 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit beta, mitochondrial | 0.0066 | 0.0888 | 0.0744 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0543 | 1 | 0.5 |
Onchocerca volvulus | 0.0028 | 0.0155 | 0.5 | |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0543 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0427 | 0.0277 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0028 | 0.0155 | 0.1538 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0427 | 0.3721 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0066 | 0.0888 | 0.0744 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0155 | 0.1538 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0543 | 1 | 0.5 |
Echinococcus granulosus | isocitrate dehydrogenase NAD | 0.0066 | 0.0888 | 0.0481 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0021 | 0.0022 | 0.0022 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0427 | 0.3721 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0427 | 0.3721 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0888 | 0.0868 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0543 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0028 | 0.0155 | 0.1538 |
Wolbachia endosymbiont of Brugia malayi | isocitrate dehydrogenase | 0.0066 | 0.0888 | 0.5 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0066 | 0.0888 | 0.0744 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0543 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0155 | 0.0134 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0543 | 1 | 1 |
Brugia malayi | Isocitrate dehydrogenase subunit gamma, mitochondrial precursor | 0.0066 | 0.0888 | 0.0744 |
Schistosoma mansoni | Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial | 0.0066 | 0.0888 | 0.0481 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0155 | 0.0134 |
Entamoeba histolytica | tartrate dehydrogenase, putative | 0.0066 | 0.0888 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0155 | 0.1538 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0543 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0543 | 1 | 0.5 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0028 | 0.0155 | 0.1538 |
Mycobacterium leprae | PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) | 0.0066 | 0.0888 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0028 | 0.0155 | 0.1538 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0543 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.