TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 508.7 | Formula: C32H40N6
H donors: 2 H acceptors: 2 LogP: 4.34 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: CN(CCCNCc1ccc2c(c1)cc1c(n2)c2nc3ccc(cc3cc2cc1)CNCCCN(C)C)C
InChi: 1S/C32H40N6/c1-37(2)15-5-13-33-21-23-7-11-29-27(17-23)19-25-9-10-26-20-28-18-24(22-34-14-6-16-38(3)4)8-12-30(28)36-32(26)31(25)35-29/h7-12,17-20,33-34H,5-6,13-16,21-22H2,1-4H3
InChiKey: JVZSGDGVERXIET-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	projectin	0.015	0.0545	0.0574
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0186	0.0678	0.4112
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0186	0.0678	0.4097
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.015	0.0545	0.329
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0186	0.0678	0.0714
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0678	0.0714
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.01	0.0102
Onchocerca volvulus		0.015	0.0545	0.0574
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0186	0.0678	0.0714
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0186	0.0678	1
Onchocerca volvulus		0.015	0.0545	0.0574
Brugia malayi	hypothetical protein	0.0186	0.0678	0.0674
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.015	0.0545	0.0574
Onchocerca volvulus		0.015	0.0545	0.0574
Schistosoma mansoni	cell adhesion molecule	0.015	0.0545	0.3308
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0008	0.0012	0.0008
Schistosoma mansoni	hypothetical protein	0.0445	0.1649	1
Loa Loa (eye worm)	hypothetical protein	0.015	0.0545	0.0574
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.008	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0678	0.0714
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.008	0.1023
Brugia malayi	Fibronectin type III domain containing protein	0.015	0.0545	0.0541
Onchocerca volvulus		0.015	0.0545	0.0574
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0186	0.0678	0.4097
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0186	0.0678	0.4112
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0186	0.0678	0.0674
Echinococcus granulosus	titin	0.015	0.0545	0.329
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0012	0.0546
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0186	0.0678	0.0714
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0012	0.0008
Echinococcus granulosus	Fibronectin type III domain containing protein	0.015	0.0545	0.329
Schistosoma mansoni	neuroglian	0.015	0.0545	0.3308
Echinococcus granulosus	G1Y162 protein	0.015	0.0545	0.329
Schistosoma mansoni	cpg binding protein	0.0033	0.0107	0.0648
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.0055	0.3349
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0046	0.0157	0.6993
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0186	0.0678	0.0714
Echinococcus granulosus	Fibronectin type III	0.015	0.0545	0.329
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0678	0.0714
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.015	0.0545	0.0541
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0336	0.124	0.7521
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0186	0.0678	0.4097
Schistosoma mansoni	factor for adipocyte differentiation	0.015	0.0545	0.3308
Brugia malayi	Protein-tyrosine phosphatase 1	0.0186	0.0678	0.0674
Echinococcus multilocularis	usherin	0.015	0.0545	0.329
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0678	0.0714
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0186	0.0678	0.4097
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0336	0.124	0.7515
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0678	0.0714
Echinococcus granulosus	neuroglian	0.015	0.0545	0.329
Loa Loa (eye worm)	CAMK protein kinase	0.015	0.0545	0.0574
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0186	0.0678	0.0674
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0186	0.0678	0.0714
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0012	0.0007
Onchocerca volvulus		0.015	0.0545	0.0574
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.008	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0336	0.124	0.7515
Echinococcus multilocularis	Netrin receptor DCC	0.015	0.0545	0.329
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.015	0.0545	0.329
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0019	0.0015
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0046	0.0157	0.0927
Entamoeba histolytica	acetyltransferase, GNAT family	0.0043	0.0142	0.1962
Loa Loa (eye worm)	hypothetical protein	0.015	0.0545	0.0574
Brugia malayi	Fibronectin type III domain containing protein	0.015	0.0545	0.0541
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0012	0.0048
Echinococcus granulosus	EG95	0.015	0.0545	0.329
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0186	0.0678	0.4112
Echinococcus granulosus	anosmin 1	0.015	0.0545	0.329
Brugia malayi	hypothetical protein	0.0186	0.0678	0.0674
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.015	0.0545	0.0574
Schistosoma mansoni	protein tyrosine phosphatase	0.0186	0.0678	0.4112
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0063	0.0219	1
Loa Loa (eye worm)	hypothetical protein	0.2343	0.8743	0.9263
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.008	1
Loa Loa (eye worm)	lethal protein 805	0.015	0.0545	0.0574
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.015	0.0545	0.0574
Schistosoma mansoni	serine/threonine protein kinase	0.015	0.0545	0.3308
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0336	0.124	0.7515
Loa Loa (eye worm)	hypothetical protein	0.015	0.0545	0.0574
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0678	0.0714
Leishmania major	hypothetical protein, conserved	0.015	0.0545	0.8009
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0678	0.0714
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0336	0.124	0.131
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0678	0.0714
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0186	0.0678	0.4097
Onchocerca volvulus	4.1 G protein, putative homolog	0.0186	0.0678	0.0717
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0008	0.0012	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0678	0.0714
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0678	0.0714
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.008	1
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0186	0.0678	0.4097
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0046	0.0157	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0186	0.0678	0.4097
Entamoeba histolytica	hypothetical protein	0.0039	0.013	0.1773
Onchocerca volvulus		0.2493	0.9305	1
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0012	0.0546
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0186	0.0678	0.0674
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0186	0.0678	0.4097
Schistosoma mansoni	factor for adipocyte differentiation	0.015	0.0545	0.3308
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0678	0.0714
Brugia malayi	hypothetical protein	0.015	0.0545	0.0541
Onchocerca volvulus		0.0026	0.008	0.0073
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.015	0.0545	0.0574
Echinococcus granulosus	anosmin 1	0.015	0.0545	0.329
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0186	0.0678	0.0674
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0186	0.0678	0.4097
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0186	0.0678	0.0674
Loa Loa (eye worm)	hypothetical protein	0.015	0.0545	0.0574
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0336	0.124	0.7515
Trypanosoma cruzi	hypothetical protein, conserved	0.015	0.0545	0.8009
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0051	0.6071
Onchocerca volvulus		0.0186	0.0678	0.0717
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0186	0.0678	0.0714
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.015	0.0545	0.8009
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0012	0.0074
Onchocerca volvulus		0.0186	0.0678	0.0717
Schistosoma mansoni	cpg binding protein	0.0031	0.01	0.0608
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0012	0.0546
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0186	0.0678	1
Schistosoma mansoni	ephrin receptor	0.015	0.0545	0.3308
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0012	0.0007
Echinococcus granulosus	dnaJ subfamily B	0.0445	0.1649	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0186	0.0678	0.4097
Schistosoma mansoni	nephrin	0.015	0.0545	0.3308
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0336	0.124	0.7515
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.015	0.0545	0.0574
Loa Loa (eye worm)	hypothetical protein	0.015	0.0545	0.0574
Echinococcus granulosus	anosmin 1	0.015	0.0545	0.329
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0186	0.0678	0.0674
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.015	0.0545	0.0574
Giardia lamblia	Protein tyrosine phosphatase	0.0186	0.0678	1
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0008	0.0012	0.0008
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0008	0.0012	0.0044
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.008	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.015	0.0545	0.0541
Echinococcus multilocularis	Phosphotidylinositol phosphatase PTPRQ	0.015	0.0545	0.329
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.008	0.0075
Schistosoma mansoni	protein tyrosine phosphatase	0.0336	0.124	0.7521
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.015	0.0545	0.329
Loa Loa (eye worm)	hypothetical protein	0.015	0.0545	0.0574
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0012	0.0048
Onchocerca volvulus		0.015	0.0545	0.0574
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0186	0.0678	0.0714
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0678	0.0714
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0051	0.6071
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0055	0.6617
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0186	0.0678	0.0714
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0336	0.124	0.7515
Echinococcus granulosus	titin	0.015	0.0545	0.329
Brugia malayi	Immunoglobulin I-set domain containing protein	0.015	0.0545	0.0541
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0186	0.0678	0.4112
Echinococcus granulosus	cell adhesion molecule	0.015	0.0545	0.329
Echinococcus multilocularis	anosmin 1	0.015	0.0545	0.329
Echinococcus granulosus	cpg binding protein	0.0033	0.0107	0.0623
Onchocerca volvulus		0.0186	0.0678	0.0717
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.008	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0153	0.0557	0.336
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0055	0.0054
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0336	0.124	0.7515
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0186	0.0678	1
Onchocerca volvulus		0.015	0.0545	0.0574
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0186	0.0678	0.0674
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0186	0.0678	0.4097
Schistosoma mansoni	zinc finger protein	0.0006	0.0004	0.0026
Brugia malayi	Fibronectin type III domain containing protein	0.015	0.0545	0.0541
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0186	0.0678	0.4097
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0051	0.6071
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0186	0.0678	0.4097
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0186	0.0678	0.4097
Onchocerca volvulus		0.0186	0.0678	0.0717
Echinococcus multilocularis	cell adhesion molecule	0.015	0.0545	0.329
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.015	0.0545	0.0541
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0186	0.0678	0.0714
Brugia malayi	SPRY domain containing protein	0.015	0.0545	0.0541
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0158	0.0573	0.3478
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.008	1
Echinococcus multilocularis	Fibronectin type III domain containing protein	0.015	0.0545	0.329
Entamoeba histolytica	hypothetical protein	0.0039	0.013	0.1773
Brugia malayi	Fibronectin type III domain containing protein	0.015	0.0545	0.0541
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0008	0.0012	0.0546
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.008	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0055	0.0054
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0186	0.0678	0.4097
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0678	0.0714
Schistosoma mansoni	cell adhesion molecule	0.015	0.0545	0.3308
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0336	0.124	0.7521
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0186	0.0678	0.4097
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0186	0.0678	0.0674
Brugia malayi	Fibronectin type III domain containing protein	0.015	0.0545	0.0541
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0186	0.0678	0.0674
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0186	0.0678	0.0674
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0186	0.0678	0.4097
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0336	0.124	0.7515
Entamoeba histolytica	acyl-coA synthetase, putative	0.0026	0.008	0.1023
Schistosoma mansoni	cell adhesion molecule	0.015	0.0545	0.3308
Echinococcus multilocularis	dnaJ subfamily B	0.0445	0.1649	1
Echinococcus multilocularis	roundabout 2	0.015	0.0545	0.329
Onchocerca volvulus		0.015	0.0545	0.0574
Onchocerca volvulus		0.0186	0.0678	0.0717
Schistosoma mansoni	cell adhesion molecule	0.015	0.0545	0.3308
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0186	0.0678	0.4097
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0186	0.0678	0.0714
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0336	0.124	0.7521
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0186	0.0678	1
Onchocerca volvulus		0.0186	0.0678	0.0717
Entamoeba histolytica	hypothetical protein	0.0039	0.013	0.1773
Echinococcus multilocularis	anosmin 1	0.015	0.0545	0.329
Loa Loa (eye worm)	hypothetical protein	0.015	0.0545	0.0574
Loa Loa (eye worm)	hypothetical protein	0.015	0.0545	0.0574
Brugia malayi	hypothetical protein	0.0039	0.013	0.0125
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0186	0.0678	0.0714
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.015	0.0545	0.0574
Brugia malayi	protein unc-22	0.015	0.0545	0.0541
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0186	0.0678	0.4097
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0186	0.0678	0.4097
Loa Loa (eye worm)	hypothetical protein	0.015	0.0545	0.0574
Brugia malayi	Protein-tyrosine phosphatase	0.0186	0.0678	0.0674
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0186	0.0678	0.0674
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.015	0.0545	0.0574
Loa Loa (eye worm)	hypothetical protein	0.0026	0.008	0.008
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.015	0.0545	0.8009
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0019	0.0092
Echinococcus multilocularis	roundabout 2	0.015	0.0545	0.329
Echinococcus multilocularis	neuroglian	0.015	0.0545	0.329
Entamoeba histolytica	hypothetical protein	0.0039	0.013	0.1773
Schistosoma mansoni	tripartite motif protein trim9	0.015	0.0545	0.3308
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0186	0.0678	0.0714
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0336	0.124	0.7515
Loa Loa (eye worm)	hypothetical protein	0.015	0.0545	0.0574
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.013	0.0762
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0186	0.0678	0.0674
Brugia malayi	Immunoglobulin I-set domain containing protein	0.015	0.0545	0.0541
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0012	0.0546
Schistosoma mansoni	bromodomain containing protein	0.0006	0.0004	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0678	0.0714
Onchocerca volvulus		0.015	0.0545	0.0574
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0186	0.0678	0.0714
Loa Loa (eye worm)	hypothetical protein	0.2529	0.9438	1
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.015	0.0545	0.329
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0678	0.0714
Brugia malayi	Immunoglobulin I-set domain containing protein	0.015	0.0545	0.0541
Loa Loa (eye worm)	oxidoreductase	0.0008	0.0012	0.0008
Echinococcus granulosus	contactin	0.015	0.0545	0.329
Onchocerca volvulus		0.0186	0.0678	0.0717
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0186	0.0678	0.4097
Loa Loa (eye worm)	hypothetical protein	0.015	0.0545	0.0574
Echinococcus multilocularis	Netrin receptor DCC	0.015	0.0545	0.329
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0186	0.0678	0.4112
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0051	0.6071
Schistosoma mansoni	titin	0.015	0.0545	0.3308
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.008	1
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0019	0.0016
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0186	0.0678	0.0714
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0008	0.0012	0.0007
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.008	0.1023
Brugia malayi	hypothetical protein	0.015	0.0545	0.0541
Schistosoma mansoni	bromodomain containing protein	0.0006	0.0004	0.0026
Echinococcus granulosus	Netrin receptor DCC	0.015	0.0545	0.329
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0186	0.0678	0.0674
Brugia malayi	Immunoglobulin I-set domain containing protein	0.015	0.0545	0.0541
Schistosoma mansoni	hypothetical protein	0.015	0.0545	0.3308
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0336	0.124	0.7515
Loa Loa (eye worm)	acetyltransferase	0.0158	0.0573	0.0603
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0186	0.0678	0.4097
Onchocerca volvulus		0.0186	0.0678	0.0717
Onchocerca volvulus		0.0186	0.0678	0.0717
Onchocerca volvulus		0.0186	0.0678	0.0717
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0046	0.0157	0.2201
Onchocerca volvulus		0.0186	0.0678	0.0717
Echinococcus granulosus	roundabout 2	0.015	0.0545	0.329
Echinococcus multilocularis	anosmin 1	0.015	0.0545	0.329
Brugia malayi	Lethal protein 805	0.015	0.0545	0.0541
Echinococcus multilocularis	fibronectin type III domain-containing protein	0.015	0.0545	0.329
Onchocerca volvulus		0.0186	0.0678	0.0717
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.0055	0.3521
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0008	0.0012	0.0546
Loa Loa (eye worm)	hypothetical protein	0.015	0.0545	0.0574
Brugia malayi	Immunoglobulin I-set domain containing protein	0.015	0.0545	0.0541
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0066	0.0231	0.1403
Trichomonas vaginalis	antibiotic synthetase, putative	0.0008	0.0012	0.0028
Onchocerca volvulus		0.0186	0.0678	0.0717
Brugia malayi	Immunoglobulin I-set domain containing protein	0.015	0.0545	0.0541
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0186	0.0678	0.4097
Schistosoma mansoni	cell adhesion molecule	0.015	0.0545	0.3308
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0678	0.0714
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0186	0.0678	0.0674
Schistosoma mansoni	hypothetical protein	0.015	0.0545	0.3308
Onchocerca volvulus		0.0186	0.0678	0.0717
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0186	0.0678	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.015	0.0545	0.0541
Brugia malayi	Immunoglobulin I-set domain containing protein	0.015	0.0545	0.0541
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.013	0.0787
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.015	0.0545	0.0574
Loa Loa (eye worm)	hypothetical protein	0.015	0.0545	0.0574
Onchocerca volvulus		0.0186	0.0678	0.0717
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0008	0.0012	0.0546
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0186	0.0678	0.4112
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0012	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0678	0.0714
Onchocerca volvulus		0.0186	0.0678	0.0717
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0186	0.0678	0.0674
Echinococcus multilocularis	transfer RNA-Phe	0.015	0.0545	0.329
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0678	0.0714
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.008	0.0075
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0186	0.0678	0.4097
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0186	0.0678	0.0674
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.013	0.0762
Loa Loa (eye worm)	hypothetical protein	0.0026	0.008	0.008
Loa Loa (eye worm)	hypothetical protein	0.015	0.0545	0.0574
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0055	0.0054
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0186	0.0678	0.4097
Onchocerca volvulus		0.0186	0.0678	0.0717
Brugia malayi	myotactin form B	0.015	0.0545	0.0541
Echinococcus multilocularis	titin	0.015	0.0545	0.329
Schistosoma mansoni	acetyl-CoA synthetase	0.0008	0.0012	0.007
Onchocerca volvulus		0.0186	0.0678	0.0717
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0186	0.0678	1
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0678	0.0714
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.015	0.0545	0.329
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0186	0.0678	0.0714
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.008	0.1023
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0186	0.0678	0.0674
Loa Loa (eye worm)	hypothetical protein	0.2343	0.8743	0.9263
Loa Loa (eye worm)	hypothetical protein	0.2343	0.8743	0.9263
Echinococcus multilocularis	cpg binding protein	0.0033	0.0107	0.0623
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.008	1
Schistosoma mansoni	hypothetical protein	0.015	0.0545	0.3308
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0046	0.0157	0.6993
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0055	0.5
Echinococcus multilocularis	hypothetical protein	0.0186	0.0678	0.4097
Schistosoma mansoni	hemicentin	0.015	0.0545	0.3308
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0186	0.0678	0.4112
Plasmodium falciparum	histone acetyltransferase GCN5	0.0043	0.0142	1
Echinococcus granulosus	nephrin	0.015	0.0545	0.329
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.015	0.0545	0.0541
Schistosoma mansoni	factor for adipocyte differentiation	0.015	0.0545	0.3308
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0186	0.0678	0.0674
Brugia malayi	Lethal protein 805	0.015	0.0545	0.0541
Loa Loa (eye worm)	hypothetical protein	0.015	0.0545	0.0574
Schistosoma mansoni	myosin-binding protein-related	0.015	0.0545	0.3308
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0186	0.0678	0.4112
Trypanosoma brucei	Fibronectin type III domain containing protein, putative	0.015	0.0545	0.8009
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0336	0.124	0.7521
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0186	0.0678	0.0714
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0186	0.0678	0.0714
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0008	0.0012	0.0546
Loa Loa (eye worm)	hypothetical protein	0.015	0.0545	0.0574
Echinococcus multilocularis	Fibronectin, type III	0.015	0.0545	0.329
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.015	0.0545	0.0574
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0186	0.0678	0.0674
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0678	0.0714
Brugia malayi	Immunoglobulin I-set domain containing protein	0.015	0.0545	0.0541
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0012	0.0048
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0186	0.0678	0.4097
Echinococcus granulosus	roundabout 2	0.015	0.0545	0.329
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0186	0.0678	0.0674
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0055	0.0054
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0186	0.0678	0.4097
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0678	0.0714
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0186	0.0678	1
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0012	0.0048
Onchocerca volvulus		0.0186	0.0678	0.0717
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0186	0.0678	0.0674
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.008	1
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0678	0.0714
Loa Loa (eye worm)	hypothetical protein	0.015	0.0545	0.0574
Echinococcus granulosus	roundabout 2	0.015	0.0545	0.329
Loa Loa (eye worm)	hypothetical protein	0.015	0.0545	0.0574
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.015	0.0545	0.329
Brugia malayi	myotactin form A	0.015	0.0545	0.0541
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0008	0.0012	0.0724
Onchocerca volvulus		0.015	0.0545	0.0574
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0012	0.0008
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0019	0.0092
Echinococcus multilocularis		0.0186	0.0678	0.4097
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0678	0.0714
Onchocerca volvulus		0.0186	0.0678	0.0717
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0186	0.0678	0.4097
Loa Loa (eye worm)	UNCoordinated family member	0.015	0.0545	0.0574
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0008	0.0012	0.0007
Onchocerca volvulus		0.015	0.0545	0.0574
Brugia malayi	Fibronectin type III domain containing protein	0.015	0.0545	0.0541
Schistosoma mansoni	protein tyrosine phosphatase	0.0186	0.0678	0.4112
Loa Loa (eye worm)	myotactin form A	0.015	0.0545	0.0574
Onchocerca volvulus		0.0186	0.0678	0.0717
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0186	0.0678	0.0714
Echinococcus granulosus	Netrin receptor DCC	0.015	0.0545	0.329
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0678	0.0714
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0678	0.0714
Trichomonas vaginalis	antibiotic synthetase, putative	0.0008	0.0012	0.0028
Loa Loa (eye worm)	hypothetical protein	0.015	0.0545	0.0574
Echinococcus granulosus	fibronectin type III domain-containing protein	0.015	0.0545	0.329
Onchocerca volvulus		0.015	0.0545	0.0574
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0186	0.0678	0.4112
Brugia malayi	Immunoglobulin I-set domain containing protein	0.015	0.0545	0.0541
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0186	0.0678	0.4097
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0019	0.0055	0.6421
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0186	0.0678	0.0674
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0186	0.0678	0.0674
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0186	0.0678	0.0674
Loa Loa (eye worm)	hypothetical protein	0.015	0.0545	0.0574
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.008	1
Schistosoma mansoni	titin	0.015	0.0545	0.3308
Echinococcus granulosus	usherin	0.015	0.0545	0.329
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0158	0.0573	0.3461
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0186	0.0678	0.0714
Brugia malayi	acetyltransferase, GNAT family protein	0.0158	0.0573	0.0569
Echinococcus multilocularis	roundabout 2	0.015	0.0545	0.329
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.008	0.1023
Echinococcus multilocularis	titin	0.015	0.0545	0.329
Trichomonas vaginalis	pten, drome, putative	0.0186	0.0678	1
Brugia malayi	hypothetical protein	0.0186	0.0678	0.0674
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0055	0.0054
Onchocerca volvulus		0.015	0.0545	0.0574
Loa Loa (eye worm)	hypothetical protein	0.0026	0.008	0.008
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0008	0.0012	0.0546
Schistosoma mansoni	pcd6 interacting protein-related	0.0186	0.0678	0.4112
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.008	0.1023
Brugia malayi	hypothetical protein	0.0186	0.0678	0.0674
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0186	0.0678	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0336	0.124	0.7521
Leishmania major	tyrosine specific protein phosphatase, putative	0.0186	0.0678	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0186	0.0678	0.4097
Schistosoma mansoni	cpg binding protein	0.0033	0.0107	0.0648
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0008	0.0012	0.0044
Loa Loa (eye worm)	hypothetical protein	0.015	0.0545	0.0574
Schistosoma mansoni	hypothetical protein	0.0039	0.013	0.0787
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0186	0.0678	0.4112
Schistosoma mansoni	nephrin	0.015	0.0545	0.3308
Brugia malayi	hypothetical protein	0.0186	0.0678	0.0674
Mycobacterium ulcerans	hypothetical protein	0.0026	0.008	1
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0046	0.0157	0.2201
Schistosoma mansoni	titin	0.015	0.0545	0.3308
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0186	0.0678	0.0674
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0008	0.0012	0.0546
Onchocerca volvulus		0.0186	0.0678	0.0717
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0186	0.0678	0.4097
Onchocerca volvulus		0.0186	0.0678	0.0717
Brugia malayi	Immunoglobulin I-set domain containing protein	0.015	0.0545	0.0541
Onchocerca volvulus		0.0031	0.01	0.0095
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.015	0.0545	0.329
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0012	0.0007
Brugia malayi	CXXC zinc finger family protein	0.0031	0.01	0.0096

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2260295

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1840508