Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | prostaglandin f synthase, putative | 0.0128 | 0.5 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0128 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0128 | 0.5 | 0.5 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0128 | 0.5 | 0.5 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0128 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0128 | 0.5 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0128 | 0.5 | 0.5 |
Plasmodium vivax | oxidoreductase, aldo/keto reductase domain containing protein | 0.0128 | 0.5 | 0.5 |
Trypanosoma cruzi | aldo-keto reductase | 0.0128 | 0.5 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0128 | 0.5 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0128 | 0.5 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0128 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0128 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0128 | 0.5 | 0.5 |
Echinococcus multilocularis | voltage gated potassium channel subunit | 0.0128 | 0.5 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0128 | 0.5 | 0.5 |
Toxoplasma gondii | aldo/keto reductase family oxidoreductase | 0.0128 | 0.5 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0128 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0128 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0128 | 0.5 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0128 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0128 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0128 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0128 | 0.5 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1, member B4 | 0.0128 | 0.5 | 0.5 |
Toxoplasma gondii | aldose reductase, putative | 0.0128 | 0.5 | 0.5 |
Brugia malayi | glutamate-cysteine ligase modifier subunit | 0.0128 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0128 | 0.5 | 0.5 |
Plasmodium vivax | aldehyde reductase, putative | 0.0128 | 0.5 | 0.5 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0128 | 0.5 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0128 | 0.5 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0128 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0128 | 0.5 | 0.5 | |
Toxoplasma gondii | oxidoreductase, aldo/keto reductase family protein | 0.0128 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0128 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0128 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0128 | 0.5 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0128 | 0.5 | 0.5 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0128 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0128 | 0.5 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0128 | 0.5 | 0.5 |
Loa Loa (eye worm) | glutamate-cysteine ligase modifier subunit | 0.0128 | 0.5 | 0.5 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0128 | 0.5 | 0.5 |
Trypanosoma brucei | aldo/keto reductase, putative | 0.0128 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0128 | 0.5 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0128 | 0.5 | 0.5 |
Leishmania major | aldo-keto reductase-like protein | 0.0128 | 0.5 | 0.5 |
Brugia malayi | NADH-dependent xylose reductase | 0.0128 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0128 | 0.5 | 0.5 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0128 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0128 | 0.5 | 0.5 |
Trypanosoma brucei | prostaglandin f synthase | 0.0128 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0128 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0128 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0128 | 0.5 | 0.5 | |
Leishmania major | aldo/keto reductase, putative,aldo/keto reductase family-like protein | 0.0128 | 0.5 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0128 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0128 | 0.5 | 0.5 |
Entamoeba histolytica | alcohol dehydrogenase, putative | 0.0128 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0128 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0128 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0128 | 0.5 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0128 | 0.5 | 0.5 |
Echinococcus granulosus | voltage gated potassium channel subunit | 0.0128 | 0.5 | 0.5 |
Entamoeba histolytica | alcohol dehydrogenase, putative | 0.0128 | 0.5 | 0.5 |
Plasmodium falciparum | aldo-keto reductase, putative | 0.0128 | 0.5 | 0.5 |
Mycobacterium leprae | Possible oxidoreductase | 0.0128 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0128 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0128 | 0.5 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0128 | 0.5 | 0.5 |
Schistosoma mansoni | pol-related | 0.0128 | 0.5 | 0.5 |
Toxoplasma gondii | aldo-keto reductase | 0.0128 | 0.5 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0128 | 0.5 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0128 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0128 | 0.5 | 0.5 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0128 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0128 | 0.5 | 0.5 | |
Schistosoma mansoni | potassium channel beta | 0.0128 | 0.5 | 0.5 |
Plasmodium falciparum | aldehyde reductase, putative | 0.0128 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0128 | 0.5 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0128 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0128 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0128 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0128 | 0.5 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0128 | 0.5 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0128 | 0.5 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0128 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.5 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0128 | 0.5 | 0.5 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0128 | 0.5 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0128 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0128 | 0.5 | 0.5 | |
Entamoeba histolytica | aldose reductase, putative | 0.0128 | 0.5 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0128 | 0.5 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0128 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0128 | 0.5 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0128 | 0.5 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0128 | 0.5 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0128 | 0.5 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.0128 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0128 | 0.5 | 0.5 | |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0128 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0128 | 0.5 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0128 | 0.5 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0128 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0128 | 0.5 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0128 | 0.5 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0128 | 0.5 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0128 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | > 100 uM | Cytotoxicity against Homo sapiens (human) MT4 cells containing integrated HTLV-1 genome after 96 hr by MTT assay | ChEMBL. | No reference |
MIC (functional) | > 100 uM | Antifungal activity against Candida albicans DSM 1386 after 24 to 48 hr by broth microdilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.