TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 533.499 | Formula: C30H33BrN2O2
H donors: 1 H acceptors: 1 LogP: 5.71 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: O=C([C@@H]1CC[C@H](C[C@H]1c1ccc(cc1)Br)N1CCOCC1)NC(c1ccccc1)c1ccccc1
InChi: 1S/C30H33BrN2O2/c31-25-13-11-22(12-14-25)28-21-26(33-17-19-35-20-18-33)15-16-27(28)30(34)32-29(23-7-3-1-4-8-23)24-9-5-2-6-10-24/h1-14,26-29H,15-21H2,(H,32,34)/t26-,27-,28+/m1/s1
InChiKey: FHIVYCWZQDBZIS-FCEKVYKBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	potassium voltage-gated channel, subfamily H (eag-related), member 2	Starlite/ChEMBL	References
Homo sapiens	prolylcarboxypeptidase (angiotensinase C)	Starlite/ChEMBL	References
Mus musculus	prolylcarboxypeptidase (angiotensinase C)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	Potassium voltage-gated channel subfamily H member 2, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	voltage and ligand gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130246	All targets in OG5_130246
Schistosoma japonicum	ko:K01285 lysosomal Pro-X carboxypeptidase [EC3.4.16.2], putative	Get druggable targets OG5_130246	All targets in OG5_130246
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus granulosus	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	Get druggable targets OG5_130246	All targets in OG5_130246
Schistosoma japonicum	IPR008758,Peptidase S28,domain-containing	Get druggable targets OG5_130246	All targets in OG5_130246
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130246	All targets in OG5_130246
Brugia malayi	Serine carboxypeptidase S28 family protein	Get druggable targets OG5_130246	All targets in OG5_130246
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus multilocularis	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130246	All targets in OG5_130246
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	Get druggable targets OG5_130246	All targets in OG5_130246
Schistosoma mansoni	lysosomal Pro-Xaa carboxypeptidase (S28 family)	Get druggable targets OG5_130246	All targets in OG5_130246
Schistosoma japonicum	IPR008758,Peptidase S28,domain-containing	Get druggable targets OG5_130246	All targets in OG5_130246
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma cruzi	serine carboxypeptidase S28, putative	prolylcarboxypeptidase (angiotensinase C)	491 aa	402 aa	24.1 %
Trypanosoma cruzi	serine carboxypeptidase S28, putative	prolylcarboxypeptidase (angiotensinase C)	496 aa	414 aa	24.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0215	0.2809	0.6305
Schistosoma mansoni	protein kinase	0.0215	0.2809	0.2809
Echinococcus granulosus	polycomb protein SCMH1	0.0052	0.06	0.06
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0049	0.0566	0.1956
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.005	0.0064
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0215	0.2809	0.2809
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0215	0.2809	1
Echinococcus granulosus	insulin receptor	0.0215	0.2809	0.2809
Schistosoma mansoni	protein kinase	0.0215	0.2809	0.2809
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0215	0.2809	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0215	0.2809	0.2809
Entamoeba histolytica	hypothetical protein	0.0215	0.2809	1
Echinococcus granulosus	SAM and MBT domain containing protein	0.0052	0.06	0.06
Loa Loa (eye worm)	hypothetical protein	0.0215	0.2809	0.6305
Entamoeba histolytica	tyrosine kinase, putative	0.0215	0.2809	1
Trypanosoma cruzi	putative prolyl carboxypeptidase, putative	0.0049	0.0566	0.1464
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0215	0.2809	0.2809
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0215	0.2809	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0215	0.2809	0.2809
Entamoeba histolytica	ankyrin repeat protein	0.0215	0.2809	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0429	0.1462
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Leishmania major	importin beta-1 subunit, putative	0.0023	0.021	0.0108
Entamoeba histolytica	protein kinase domain containing protein	0.0215	0.2809	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0215	0.2809	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0215	0.2809	0.2809
Entamoeba histolytica	tyrosine kinase, putative	0.0215	0.2809	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.005	0.005
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.005	0.0064
Entamoeba histolytica	hypothetical protein	0.0215	0.2809	1
Loa Loa (eye worm)	TK protein kinase	0.0215	0.2809	0.6305
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0045	0.0505	0.0505
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0045	0.0505	0.0505
Loa Loa (eye worm)	TK/FER protein kinase	0.0215	0.2809	0.6305
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0215	0.2809	0.2809
Loa Loa (eye worm)	TK/FER protein kinase	0.0215	0.2809	0.6305
Plasmodium falciparum	protein kinase, putative	0.0215	0.2809	1
Trypanosoma cruzi	serine carboxypeptidase S28, putative	0.0049	0.0566	0.1464
Entamoeba histolytica	protein kinase domain containing protein	0.0215	0.2809	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0215	0.2809	0.2809
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0215	0.2809	1
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0215	0.2809	0.2809
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0426	0.0914
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0077	0.0077
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0009	0.0021	0.0021
Entamoeba histolytica	tyrosine kinase, putative	0.0215	0.2809	1
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0429	0.0429
Trypanosoma cruzi	protein kinase, putative	0.0215	0.2809	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0215	0.2809	0.6305
Brugia malayi	Serine protease Z688.6 precursor	0.0049	0.0566	0.1233
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0215	0.2809	0.6305
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.005	0.0064
Brugia malayi	ecdysteroid receptor	0.0011	0.005	0.0064
Schistosoma mansoni	protein kinase	0.0215	0.2809	0.2809
Echinococcus granulosus	tyrosine protein kinase	0.0215	0.2809	0.2809
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0215	0.2809	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0215	0.2809	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0077	0.0125
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0009	0.0021	0.0021
Echinococcus granulosus	ephrin type A receptor 4 A	0.0215	0.2809	0.2809
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0215	0.2809	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0215	0.2809	1
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0009	0.0021	0.0021
Brugia malayi	Tyrosine-protein kinase PR2	0.0215	0.2809	0.6305
Entamoeba histolytica	protein kinase, putative	0.0215	0.2809	1
Trypanosoma brucei	Pseudokinase, putative	0.0215	0.2809	1
Brugia malayi	hypothetical protein	0.024	0.3156	0.709
Entamoeba histolytica	protein kinase domain containing protein	0.0215	0.2809	1
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0561	0.0561
Onchocerca volvulus		0.0039	0.0429	0.1373
Onchocerca volvulus		0.0215	0.2809	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0215	0.2809	0.2809
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0215	0.2809	0.6305
Onchocerca volvulus		0.0215	0.2809	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.005	0.005
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Onchocerca volvulus		0.0215	0.2809	1
Entamoeba histolytica	hypothetical protein	0.0215	0.2809	1
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Brugia malayi	Guanylyl cyclase protein 23	0.0215	0.2809	0.6305
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Brugia malayi	beta-lactamase family protein	0.0039	0.0429	0.0921
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0297	0.0624
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0215	0.2809	0.2809
Loa Loa (eye worm)	hypothetical protein	0.0011	0.005	0.0064
Mycobacterium ulcerans	lipase LipD	0.0039	0.0429	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.005	0.0064
Entamoeba histolytica	hypothetical protein	0.0215	0.2809	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0215	0.2809	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0215	0.2809	0.2809
Schistosoma mansoni	protein kinase	0.0215	0.2809	0.2809
Echinococcus granulosus	tyrosine protein kinase Blk	0.0215	0.2809	0.2809
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0215	0.2809	0.2809
Brugia malayi	Raf kinase	0.0215	0.2809	0.6305
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Echinococcus granulosus	tyrosine protein kinase csk	0.0215	0.2809	0.2809
Echinococcus multilocularis	survival motor neuron protein 1	0.024	0.3156	0.3156
Schistosoma mansoni	serine/threonine protein kinase	0.0215	0.2809	0.2809
Brugia malayi	hypothetical protein	0.0215	0.2809	0.6305
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0052	0.06	0.1994
Leishmania major	hypothetical protein, conserved	0.0039	0.0429	0.094
Loa Loa (eye worm)	TK/FER protein kinase	0.0215	0.2809	0.6305
Entamoeba histolytica	protein kinase, putative	0.0215	0.2809	1
Entamoeba histolytica	tyrosine kinase, putative	0.0215	0.2809	1
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0215	0.2809	0.2809
Echinococcus multilocularis	protein kinase	0.0215	0.2809	0.2809
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.0049	0.0566	0.1464
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0429	0.0429
Schistosoma mansoni	cpg binding protein	0.0031	0.032	0.032
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0009	0.0021	0.0021
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0215	0.2809	0.6305
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0215	0.2809	0.2809
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0215	0.2809	0.2809
Loa Loa (eye worm)	TK/FER protein kinase	0.0215	0.2809	0.6305
Entamoeba histolytica	protein kinase domain containing protein	0.0215	0.2809	1
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.0049	0.0566	0.1464
Schistosoma mansoni	hypothetical protein	0.0049	0.0566	0.0566
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0282	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0429	0.0921
Loa Loa (eye worm)	TK/FER protein kinase	0.0215	0.2809	0.6305
Echinococcus multilocularis	muscleblind protein	0.0335	0.4443	0.4443
Echinococcus granulosus	kinase suppressor of Ras 1	0.0215	0.2809	0.2809
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0215	0.2809	0.6305
Echinococcus granulosus	tyrosine protein kinase csk	0.0215	0.2809	0.2809
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0215	0.2809	0.2809
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0215	0.2809	0.2809
Schistosoma mansoni	protein kinase	0.0215	0.2809	0.2809
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.005	0.0064
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0009	0.0021	0.0021
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0215	0.2809	0.2809
Entamoeba histolytica	protein kinase domain containing protein	0.0215	0.2809	1
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0049	0.0566	0.1956
Schistosoma mansoni	ran	0.0021	0.0182	0.0182
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Entamoeba histolytica	hypothetical protein	0.0215	0.2809	1
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	0.0049	0.0566	0.0566
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0234	0.02
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.005	0.0064
Giardia lamblia	Protein 21.1	0.0215	0.2809	1
Entamoeba histolytica	tyrosin kinase, putative	0.0215	0.2809	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0429	0.0921
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0215	0.2809	0.2809
Brugia malayi	hypothetical protein	0.0025	0.0234	0.0482
Entamoeba histolytica	protein kinase domain containing protein	0.0215	0.2809	1
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0429	0.0921
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0215	0.2809	0.2809
Toxoplasma gondii	ABC1 family protein	0.0039	0.0429	0.094
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0059	0.0696	0.0696
Entamoeba histolytica	tyrosine kinase, putative	0.0215	0.2809	1
Plasmodium falciparum	importin beta, putative	0.0028	0.0282	0.0382
Toxoplasma gondii	protein kinase domain-containing protein	0.0215	0.2809	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0215	0.2809	0.2809
Echinococcus multilocularis	protein tyrosine kinase	0.0215	0.2809	0.2809
Loa Loa (eye worm)	TK protein kinase	0.0215	0.2809	0.6305
Loa Loa (eye worm)	hypothetical protein	0.0011	0.005	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0215	0.2809	0.6305
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0049	0.0566	0.1956
Brugia malayi	C-terminal src kinase protein 1	0.0215	0.2809	0.6305
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Brugia malayi	hypothetical protein	0.0215	0.2809	0.6305
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0215	0.2809	1
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0009	0.0021	0.0021
Schistosoma mansoni	ephrin receptor	0.0215	0.2809	0.2809
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0215	0.2809	0.6305
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0215	0.2809	0.2809
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0215	0.2809	0.2809
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0049	0.0566	0.1956
Loa Loa (eye worm)	hypothetical protein	0.0215	0.2809	0.6305
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.005	0.005
Schistosoma mansoni	hypothetical protein	0.0416	0.5531	0.5531
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0215	0.2809	0.2809
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Echinococcus multilocularis	activin receptor type	0.0215	0.2809	0.2809
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0215	0.2809	0.6305
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Entamoeba histolytica	protein kinase domain containing protein	0.0215	0.2809	1
Echinococcus multilocularis	protein kinase	0.0215	0.2809	0.2809
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Trichomonas vaginalis	TK family protein kinase	0.0215	0.2809	1
Loa Loa (eye worm)	hypothetical protein	0.0335	0.4443	1
Brugia malayi	nuclear hormone receptor	0.0011	0.005	0.0064
Loa Loa (eye worm)	SRC-1	0.0215	0.2809	0.6305
Schistosoma mansoni	serine/threonine protein kinase	0.0215	0.2809	0.2809
Echinococcus granulosus	tyrosine kinase	0.0215	0.2809	0.2809
Entamoeba histolytica	tyrosin kinase, putative	0.0215	0.2809	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.005	0.005
Onchocerca volvulus		0.0049	0.0566	0.187
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0215	0.2809	1
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.005	0.005
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.005	0.0064
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Schistosoma mansoni	serine/threonine protein kinase	0.0215	0.2809	0.2809
Brugia malayi	Furin-like cysteine rich region family protein	0.0215	0.2809	0.6305
Brugia malayi	hypothetical protein	0.0215	0.2809	0.6305
Loa Loa (eye worm)	hypothetical protein	0.0215	0.2809	0.6305
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Brugia malayi	SH2 domain containing protein	0.0215	0.2809	0.6305
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0215	0.2809	1
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0215	0.2809	0.2809
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0282	0.059
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0215	0.2809	1
Entamoeba histolytica	protein kinase domain containing protein	0.0215	0.2809	1
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0059	0.0696	0.1527
Schistosoma mansoni	hypothetical protein	0.0011	0.0051	0.0051
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0215	0.2809	0.6305
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0282	0.0282
Brugia malayi	integrin-linked kinase	0.0215	0.2809	0.6305
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0215	0.2809	0.2809
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0009	0.0021	0.0021
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0215	0.2809	1
Loa Loa (eye worm)	TK protein kinase	0.0215	0.2809	0.6305
Entamoeba histolytica	hypothetical protein	0.0215	0.2809	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0215	0.2809	0.6305
Entamoeba histolytica	hypothetical protein	0.0023	0.021	0.0108
Brugia malayi	Muscleblind-like protein	0.0335	0.4443	1
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	0.0049	0.0566	0.0566
Schistosoma mansoni	protein kinase	0.0215	0.2809	0.2809
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0215	0.2809	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0045	0.0505	0.1095
Entamoeba histolytica	protein kinase, putative	0.0215	0.2809	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.005	0.0064
Loa Loa (eye worm)	TK/FER protein kinase	0.0215	0.2809	0.6305
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0013	0.0077	0.0077
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Leishmania major	protein kinase, putative	0.0215	0.2809	1
Echinococcus multilocularis	tyrosine kinase	0.0215	0.2809	0.2809
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0215	0.2809	0.6305
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.0566	0.1231
Entamoeba histolytica	tyrosine kinase, putative	0.0215	0.2809	1
Brugia malayi	RNA, U transporter 1	0.008	0.0983	0.2175
Echinococcus granulosus	activated cdc42 kinase 1	0.0215	0.2809	0.2809
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0215	0.2809	0.2809
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0049	0.0566	0.1956
Entamoeba histolytica	protein kinase, putative	0.0215	0.2809	1
Echinococcus granulosus	survival motor neuron protein 1	0.024	0.3156	0.3156
Onchocerca volvulus		0.0052	0.06	0.1994
Onchocerca volvulus		0.0215	0.2809	1
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.0429	0.094
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0215	0.2809	0.2809
Onchocerca volvulus		0.0049	0.0566	0.1873
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0234	0.02
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.005	0.0064
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0215	0.2809	0.6305
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.005	0.005
Brugia malayi	beta-lactamase	0.0039	0.0429	0.0921
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0215	0.2809	0.6305
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Entamoeba histolytica	receptor protein kinase, putative	0.0215	0.2809	1
Entamoeba histolytica	protein kinase, putative	0.0215	0.2809	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.005	0.005
Loa Loa (eye worm)	TK/ACK protein kinase	0.0215	0.2809	0.6305
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0215	0.2809	0.2809
Echinococcus granulosus	tyrosine protein kinase pr2	0.0215	0.2809	0.2809
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.005	0.005
Entamoeba histolytica	protein kinase domain containing protein	0.0215	0.2809	1
Onchocerca volvulus		0.0215	0.2809	1
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0466	0.1594
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0234	0.02
Entamoeba histolytica	protein kinase, putative	0.0215	0.2809	1
Schistosoma mansoni	hypothetical protein	0.0165	0.2136	0.2136
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0215	0.2809	0.6305
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0215	0.2809	0.2809
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	0.0225	0.2946	0.2946
Loa Loa (eye worm)	hypothetical protein	0.0011	0.005	0.0064
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.005	0.0064
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0234	0.02
Onchocerca volvulus		0.0215	0.2809	1
Echinococcus multilocularis	tyrosine kinase	0.0215	0.2809	0.2809
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0215	0.2809	0.2809
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0429	0.094
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0215	0.2809	0.6305
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0215	0.2809	0.2809
Entamoeba histolytica	protein kinase domain containing protein	0.0215	0.2809	1
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.005	0.0064
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Trichomonas vaginalis	protein kinase atn1, putative	0.0215	0.2809	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0215	0.2809	1
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0215	0.2809	0.2809
Entamoeba histolytica	tyrosine kinase, putative	0.0215	0.2809	1
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0009	0.0021	0.0021
Schistosoma mansoni	serine/threonine RGC	0.0215	0.2809	0.2809
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0215	0.2809	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.06	0.1309
Echinococcus granulosus	hyperpolarization activated cyclic	0.0009	0.0021	0.0021
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0215	0.2809	0.2809
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0234	0.02
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0215	0.2809	0.2809
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Mycobacterium ulcerans	beta-lactamase	0.0039	0.0429	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0215	0.2809	0.6305
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0215	0.2809	0.2809
Giardia lamblia	Serine peptidase, putative	0.0049	0.0566	0.1464
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Loa Loa (eye worm)	MBCTL1	0.0059	0.0696	0.1527
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0215	0.2809	0.2809
Entamoeba histolytica	protein kinase domain containing protein	0.0215	0.2809	1
Entamoeba histolytica	protein kinase, putative	0.0215	0.2809	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.005	0.0064
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0215	0.2809	0.2809
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0215	0.2809	0.2809
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.005	0.005
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0429	0.1462
Entamoeba histolytica	serine/threonine kinase, putative	0.0215	0.2809	1
Schistosoma mansoni	hypothetical protein	0.0215	0.2809	0.2809
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0429	0.0921
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Onchocerca volvulus		0.0029	0.0297	0.0897
Loa Loa (eye worm)	TK protein kinase	0.0215	0.2809	0.6305
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Trichomonas vaginalis	conserved hypothetical protein	0.0215	0.2809	1
Onchocerca volvulus		0.0215	0.2809	1
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Echinococcus granulosus	epidermal growth factor receptor	0.0215	0.2809	0.2809
Trichomonas vaginalis	CAMK family protein kinase	0.0215	0.2809	1
Onchocerca volvulus		0.0215	0.2809	1
Loa Loa (eye worm)	TK protein kinase	0.0215	0.2809	0.6305
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0234	0.02
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Schistosoma mansoni	protein kinase	0.0215	0.2809	0.2809
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Schistosoma mansoni	cpg binding protein	0.0031	0.032	0.032
Echinococcus granulosus	histone acetyltransferase MYST2	0.0059	0.0696	0.0696
Plasmodium falciparum	protein kinase, putative	0.0215	0.2809	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.005	0.005
Schistosoma mansoni	sex comb on midleg homolog	0.0052	0.06	0.06
Schistosoma mansoni	protein tyrosine kinase	0.0215	0.2809	0.2809
Onchocerca volvulus		0.0215	0.2809	1
Brugia malayi	ephrin receptor 1 precursor	0.0215	0.2809	0.6305
Loa Loa (eye worm)	hypothetical protein	0.0215	0.2809	0.6305
Echinococcus granulosus	raf serine:threonine protein kinase	0.0215	0.2809	0.2809
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Plasmodium vivax	protein kinase, putative	0.0215	0.2809	1
Entamoeba histolytica	protein kinase, putative	0.0215	0.2809	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0215	0.2809	0.6305
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.005	0.0064
Onchocerca volvulus		0.0215	0.2809	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0215	0.2809	0.2809
Schistosoma mansoni	protein kinase	0.0215	0.2809	0.2809
Entamoeba histolytica	hypothetical protein	0.0215	0.2809	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0215	0.2809	0.2809
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0215	0.2809	0.2809
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0696	0.1527
Schistosoma mansoni	sex comb on midleg homolog	0.0052	0.06	0.06
Loa Loa (eye worm)	TK/ALK protein kinase	0.0215	0.2809	0.6305
Entamoeba histolytica	protein kinase, putative	0.0215	0.2809	1
Echinococcus granulosus	activin receptor type	0.0215	0.2809	0.2809
Loa Loa (eye worm)	TK/Met protein kinase	0.0215	0.2809	0.6305
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0215	0.2809	0.2809
Entamoeba histolytica	hypothetical protein	0.0215	0.2809	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0215	0.2809	0.2809
Echinococcus multilocularis	activated cdc42 kinase 1	0.0215	0.2809	0.2809
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0215	0.2809	0.2809
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0234	0.02
Entamoeba histolytica	receptor protein kinase, putative	0.0215	0.2809	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.005	0.005
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0182	0.0182
Entamoeba histolytica	protein kinase, putative	0.0215	0.2809	1
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0429	0.094
Brugia malayi	mbt repeat family protein	0.0052	0.06	0.1309
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Onchocerca volvulus		0.0215	0.2809	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0215	0.2809	0.6305
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0215	0.2809	0.2809
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.021	0.0678
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0561	0.0561
Brugia malayi	SH2 domain containing protein	0.0215	0.2809	0.6305
Loa Loa (eye worm)	serine/threonine protein kinase	0.0215	0.2809	0.6305
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Schistosoma mansoni	tyrosine protein kinase	0.0215	0.2809	0.2809
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.005	0.005
Loa Loa (eye worm)	hypothetical protein	0.0215	0.2809	0.6305
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0045	0.0505	0.1095
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0429	0.094
Schistosoma mansoni	voltage-gated potassium channel	0.0009	0.0021	0.0021
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0215	0.2809	0.6305
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.005	0.005
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0049	0.0566	0.1956
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0009	0.0021	0.0021
Brugia malayi	nuclear receptor NHR-88	0.0011	0.005	0.0064
Schistosoma mansoni	importin beta-1	0.0028	0.0282	0.0282
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Schistosoma mansoni	family S28 unassigned peptidase (S28 family)	0.0049	0.0566	0.0566
Brugia malayi	mbt repeat family protein	0.0052	0.06	0.1309
Entamoeba histolytica	protein kinase, putative	0.0215	0.2809	1
Loa Loa (eye worm)	TK protein kinase	0.0215	0.2809	0.6305
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Echinococcus granulosus	protein kinase	0.0215	0.2809	0.2809
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0215	0.2809	1
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0429	0.0921
Entamoeba histolytica	protein kinase, putative	0.0215	0.2809	1
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0297	0.0624
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0024	0.0024
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Loa Loa (eye worm)	TK/ROR protein kinase	0.0215	0.2809	0.6305
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.005	0.005
Echinococcus multilocularis	transfer RNA-Thr	0.0215	0.2809	0.2809
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0049	0.0566	0.1956
Entamoeba histolytica	protein kinase domain containing protein	0.0215	0.2809	1
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Plasmodium falciparum	protein kinase, putative	0.0215	0.2809	1
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.005	0.0064
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.0429	0.0429
Entamoeba histolytica	protein kinase domain containing protein	0.0215	0.2809	1
Brugia malayi	protein-tyrosine kinase	0.0215	0.2809	0.6305
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.005	0.005
Schistosoma mansoni	microtubule-associated protein tau	0.0745	1	1
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0051	0.0051
Trichomonas vaginalis	conserved hypothetical protein	0.0215	0.2809	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0215	0.2809	1
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Echinococcus multilocularis	tyrosine protein kinase csk	0.0215	0.2809	0.2809
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0013	0.0077	0.0125
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Loa Loa (eye worm)	mbt repeat family protein	0.0052	0.06	0.1309
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	0.0225	0.2946	0.2946
Echinococcus granulosus	natriuretic peptide receptor 1	0.0215	0.2809	0.2809
Echinococcus multilocularis	tyrosine protein kinase shark	0.0215	0.2809	0.2809
Entamoeba histolytica	tyrosine kinase, putative	0.0215	0.2809	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.005	0.005
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0215	0.2809	0.6305
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0215	0.2809	0.2809
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0215	0.2809	0.2809
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0077	0.0077
Loa Loa (eye worm)	TK/FER protein kinase	0.0215	0.2809	0.6305
Onchocerca volvulus		0.0215	0.2809	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0215	0.2809	0.6305
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0203	0.2652	0.2652
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0009	0.0021	0.0021
Entamoeba histolytica	protein kinase, putative	0.0215	0.2809	1
Brugia malayi	beta-lactamase family protein	0.0039	0.0429	0.0921
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0215	0.2809	1
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0049	0.0566	0.1956
Schistosoma mansoni	lysosomal Pro-Xaa carboxypeptidase (S28 family)	0.0225	0.2946	0.2946
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0466	0.1594
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.005	0.0064
Trichomonas vaginalis	AGC family protein kinase	0.0215	0.2809	1
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0215	0.2809	0.2809
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0182	0.0363
Trypanosoma cruzi	protein kinase, putative	0.0215	0.2809	1
Loa Loa (eye worm)	hypothetical protein	0.0335	0.4443	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.005	0.0064
Loa Loa (eye worm)	TK protein kinase	0.0215	0.2809	0.6305
Brugia malayi	steroid hormone receptor	0.0011	0.005	0.0064
Entamoeba histolytica	serine/threonine kinase, putative	0.0215	0.2809	1
Entamoeba histolytica	protein kinase, putative	0.0215	0.2809	1
Echinococcus granulosus	c src tyrosine kinase	0.0215	0.2809	0.2809
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Entamoeba histolytica	protein kinase domain containing protein	0.0215	0.2809	1
Echinococcus multilocularis	tyrosine protein kinase	0.0215	0.2809	0.2809
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.005	0.0064
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Echinococcus multilocularis	heat shock protein 70	0.0215	0.2809	0.2809
Schistosoma mansoni	cpg binding protein	0.0029	0.0297	0.0297
Onchocerca volvulus		0.0215	0.2809	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.005	0.0064
Entamoeba histolytica	protein kinase, putative	0.0215	0.2809	1
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.005	0.005
Trichomonas vaginalis	STE family protein kinase	0.0215	0.2809	1
Entamoeba histolytica	hypothetical protein	0.0215	0.2809	1
Entamoeba histolytica	protein kinase, putative	0.0215	0.2809	1
Trichomonas vaginalis	conserved hypothetical protein	0.0215	0.2809	1
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0059	0.0696	0.0696
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0429	0.1462
Trichomonas vaginalis	conserved hypothetical protein	0.0215	0.2809	1
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0248	0.3268	1
Echinococcus multilocularis	muscleblind protein 1	0.0335	0.4443	0.4443
Schistosoma mansoni	ephrin receptor	0.0215	0.2809	0.2809
Loa Loa (eye worm)	TK protein kinase	0.0215	0.2809	0.6305
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Entamoeba histolytica	tyrosin kinase, putative	0.0215	0.2809	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0215	0.2809	0.6305
Entamoeba histolytica	ankyrin repeat protein	0.0215	0.2809	1
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Onchocerca volvulus		0.0215	0.2809	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0215	0.2809	0.2809
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.005	0.005
Entamoeba histolytica	tyrosine kinase, putative	0.0215	0.2809	1
Loa Loa (eye worm)	hypothetical protein	0.0215	0.2809	0.6305
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0215	0.2809	1
Entamoeba histolytica	cysteine surface protein, putative	0.0215	0.2809	1
Echinococcus multilocularis	cpg binding protein	0.0031	0.032	0.032
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0203	0.2652	0.2652
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.0049	0.0566	0.1464
Plasmodium falciparum	tyrosine kinase-like protein	0.0215	0.2809	1
Schistosoma mansoni	protein kinase	0.0215	0.2809	0.2809
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0429	0.1462
Giardia lamblia	Kinase, NEK	0.0215	0.2809	1
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Echinococcus multilocularis	microtubule associated protein 2	0.0745	1	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0215	0.2809	0.2809
Loa Loa (eye worm)	TK/FER protein kinase	0.0215	0.2809	0.6305
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.0429	0.0921
Leishmania major	hypothetical protein, conserved	0.0215	0.2809	1
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0215	0.2809	1
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0215	0.2809	0.6305
Echinococcus multilocularis	c src tyrosine kinase	0.0215	0.2809	0.2809
Loa Loa (eye worm)	TK/FER protein kinase	0.0215	0.2809	0.6305
Echinococcus multilocularis	snurportin 1	0.03	0.3961	0.3961
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0023	0.0003
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.005	0.0064
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0215	0.2809	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0429	0.0921
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0429	0.1462
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0051	0.0051
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.03	0.3961	0.8909
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0215	0.2809	0.2809
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0182	0.0182
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0215	0.2809	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0215	0.2809	0.2809
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.024	0.3156	0.709
Entamoeba histolytica	protein kinase, putative	0.0215	0.2809	1
Echinococcus multilocularis	FL cytokine receptor	0.0215	0.2809	0.2809
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0215	0.2809	0.2809
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0566	0.1956
Loa Loa (eye worm)	TK/FAK protein kinase	0.0215	0.2809	0.6305
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0215	0.2809	0.6305
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0182	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0215	0.2809	0.6305
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Entamoeba histolytica	tyrosin kinase, putative	0.0215	0.2809	1
Echinococcus granulosus	tyrosine protein kinase shark	0.0215	0.2809	0.2809
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0052	0.06	0.06
Echinococcus multilocularis	epidermal growth factor receptor	0.0215	0.2809	0.2809
Echinococcus multilocularis	tyrosine protein kinase csk	0.0215	0.2809	0.2809
Echinococcus granulosus	activated cdc42 kinase 1	0.0215	0.2809	0.2809
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0215	0.2809	0.2809
Loa Loa (eye worm)	hypothetical protein	0.0215	0.2809	0.6305
Echinococcus granulosus	hyperpolarization activated cyclic	0.0009	0.0021	0.0021
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0215	0.2809	0.2809
Echinococcus granulosus	voltage gated potassium channel	0.0013	0.0077	0.0077
Echinococcus multilocularis	voltage gated potassium channel	0.0013	0.0077	0.0077
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0215	0.2809	0.2809
Onchocerca volvulus		0.0039	0.0429	0.1373
Echinococcus granulosus	protein tyrosine kinase	0.0215	0.2809	0.2809
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Trichomonas vaginalis	esterase, putative	0.0039	0.0429	0.1462
Loa Loa (eye worm)	TK/RYK protein kinase	0.0215	0.2809	0.6305
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.005	0.005
Loa Loa (eye worm)	TK/FER protein kinase	0.0215	0.2809	0.6305
Loa Loa (eye worm)	TK/FER protein kinase	0.0215	0.2809	0.6305
Loa Loa (eye worm)	TK/DDR protein kinase	0.0215	0.2809	0.6305
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.021	0.0108
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0059	0.0696	0.0696
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0009	0.0021	0.0021
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0215	0.2809	0.6305
Echinococcus granulosus	tyrosine protein kinase HCK	0.0215	0.2809	0.2809
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0049	0.0566	0.1956
Loa Loa (eye worm)	hypothetical protein	0.0215	0.2809	0.6305
Echinococcus granulosus	epidermal growth factor receptor	0.0215	0.2809	0.2809
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Leishmania major	protein kinase, putative	0.0215	0.2809	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0215	0.2809	1
Loa Loa (eye worm)	TK protein kinase	0.0215	0.2809	0.6305
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.005	0.0064
Entamoeba histolytica	tyrosine kinase, putative	0.0215	0.2809	1
Trichomonas vaginalis	conserved hypothetical protein	0.0215	0.2809	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0215	0.2809	1
Brugia malayi	Serine protease Z688.6 precursor	0.0049	0.0566	0.1233
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.005	0.0064
Echinococcus granulosus	tyrosine kinase	0.0215	0.2809	0.2809
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0009	0.0021	0.0021
Trypanosoma cruzi	serine carboxypeptidase S28, putative	0.0049	0.0566	0.1464
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0049	0.0566	0.1956
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0282	0.0282
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Echinococcus multilocularis	dnaJ subfamily B	0.0416	0.5531	0.5531
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0215	0.2809	0.2809
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0215	0.2809	0.2809
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0009	0.0021	0.0021
Echinococcus granulosus	muscleblind protein	0.0335	0.4443	0.4443
Echinococcus granulosus	geminin	0.0165	0.2136	0.2136
Entamoeba histolytica	hypothetical protein	0.0215	0.2809	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0234	0.0482
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.005	0.005
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Toxoplasma gondii	serine carboxypeptidase s28 protein	0.0049	0.0566	0.1464
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0049	0.0566	0.1956
Giardia lamblia	Kinase, NEK	0.0215	0.2809	1
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0215	0.2809	0.6305
Entamoeba histolytica	protein kinase, putative	0.0215	0.2809	1
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Onchocerca volvulus		0.0039	0.0429	0.1373
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0215	0.2809	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.0429	0.0429
Echinococcus granulosus	tyrosine protein kinase csk	0.0215	0.2809	0.2809
Trichomonas vaginalis	ran, putative	0.0021	0.0182	0.0575
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.0651	0.1785
Loa Loa (eye worm)	beta-lactamase	0.0039	0.0429	0.0921
Loa Loa (eye worm)	hypothetical protein	0.0225	0.2946	0.6614
Entamoeba histolytica	protein kinase domain containing protein	0.0215	0.2809	1
Trichomonas vaginalis	conserved hypothetical protein	0.0215	0.2809	1
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Loa Loa (eye worm)	hypothetical protein	0.0215	0.2809	0.6305
Entamoeba histolytica	tyrosine kinase, putative	0.0215	0.2809	1
Loa Loa (eye worm)	hypothetical protein	0.0225	0.2946	0.6614
Trichomonas vaginalis	conserved hypothetical protein	0.0215	0.2809	1
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Entamoeba histolytica	serine/threonine kinase, putative	0.0215	0.2809	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0215	0.2809	0.6305
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0215	0.2809	0.2809
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0059	0.0696	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0011	0.005	0.0064
Toxoplasma gondii	protein kinase	0.0215	0.2809	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0215	0.2809	0.2809
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.0215	0.2809	0.6305
Trichomonas vaginalis	lysosomal pro-X carboxypeptidase, putative	0.0049	0.0566	0.1956
Loa Loa (eye worm)	hypothetical protein	0.0215	0.2809	0.6305
Echinococcus granulosus	snurportin 1	0.03	0.3961	0.3961
Brugia malayi	Importin beta-1 subunit	0.0028	0.0282	0.059
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0215	0.2809	0.2809
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0215	0.2809	0.2809
Echinococcus granulosus	integrin linked protein kinase	0.0215	0.2809	0.2809
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.005	0.0064
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.005	0.005
Brugia malayi	hypothetical protein	0.0016	0.0116	0.0215
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0.0429	0.5
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Entamoeba histolytica	tyrosine kinase, putative	0.0215	0.2809	1
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0049	0.0566	0.1956
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0566	0.1956
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0215	0.2809	0.2809
Loa Loa (eye worm)	TK/CSK protein kinase	0.0215	0.2809	0.6305
Trichomonas vaginalis	prolylcarboxypeptidase, putative	0.0049	0.0566	0.1956
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.021	0.0678
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0215	0.2809	1
Brugia malayi	Serine carboxypeptidase S28 family protein	0.0225	0.2946	0.6614
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0282	0.0382
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0215	0.2809	0.2809
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0215	0.2809	1
Echinococcus multilocularis	geminin	0.0165	0.2136	0.2136
Trichomonas vaginalis	prolylcarboxypeptidase, putative	0.0049	0.0566	0.1956
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.005	0.0064
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.005	0.0064
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.005	0.0064
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.005	0.005
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Echinococcus multilocularis	tyrosine protein kinase csk	0.0215	0.2809	0.2809
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.074	0.074
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Entamoeba histolytica	protein kinase domain containing protein	0.0215	0.2809	1
Schistosoma mansoni	protein kinase	0.0215	0.2809	0.2809
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0215	0.2809	0.2809
Schistosoma mansoni	protein kinase	0.0215	0.2809	0.2809
Brugia malayi	SRC-1	0.0215	0.2809	0.6305
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0215	0.2809	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0215	0.2809	0.2809
Entamoeba histolytica	protein kinase domain containing protein	0.0215	0.2809	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.021	0.0678
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0566	0.1233
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.005	0.0064
Loa Loa (eye worm)	TK/FER protein kinase	0.0215	0.2809	0.6305
Trypanosoma brucei	protein kinase, putative	0.0215	0.2809	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0215	0.2809	0.2809
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Loa Loa (eye worm)	hypothetical protein	0.0225	0.2946	0.6614
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Echinococcus multilocularis	insulin receptor	0.0215	0.2809	0.2809
Loa Loa (eye worm)	TK/FER protein kinase	0.0215	0.2809	0.6305
Schistosoma mansoni	hypothetical protein	0.0313	0.4145	0.4145
Loa Loa (eye worm)	TK/FER protein kinase	0.0215	0.2809	0.6305
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.005	0.0064
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0215	0.2809	0.2809
Loa Loa (eye worm)	hypothetical protein	0.0011	0.005	0.0064
Entamoeba histolytica	hypothetical protein	0.0215	0.2809	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0215	0.2809	1
Entamoeba histolytica	tyrosine kinase, putative	0.0215	0.2809	1
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.0429	0.5
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Entamoeba histolytica	protein kinase, putative	0.0215	0.2809	1
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Entamoeba histolytica	tyrosine kinase, putative	0.0215	0.2809	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.005	0.005
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.005	0.005
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0215	0.2809	1
Loa Loa (eye worm)	hypothetical protein	0.0215	0.2809	0.6305
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0215	0.2809	0.2809
Onchocerca volvulus		0.0215	0.2809	1
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0429	0.5
Onchocerca volvulus	Tyrosine kinase homolog	0.0215	0.2809	1
Entamoeba histolytica	hypothetical protein, conserved	0.0215	0.2809	1
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Entamoeba histolytica	protein kinase domain containing protein	0.0215	0.2809	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.005	0.005
Entamoeba histolytica	tyrosine kinase, putative	0.0215	0.2809	1
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.005	0.005
Entamoeba histolytica	protein kinase domain containing protein	0.0215	0.2809	1
Schistosoma mansoni	ran	0.0021	0.0182	0.0182
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0215	0.2809	0.2809
Schistosoma mansoni	survival motor neuron protein	0.0049	0.0566	0.0566
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0052	0.06	0.06
Entamoeba histolytica	protein kinase domain containing protein	0.0215	0.2809	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0215	0.2809	1
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0282	0.0382
Loa Loa (eye worm)	TK/EPH protein kinase	0.0215	0.2809	0.6305
Entamoeba histolytica	tyrosine kinase, putative	0.0215	0.2809	1
Giardia lamblia	Thymus-specific serine protease precursor	0.0049	0.0566	0.1464
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.005	0.005
Leishmania major	hypothetical protein, conserved	0.0025	0.0234	0.02
Entamoeba histolytica	tyrosine kinase, putative	0.0215	0.2809	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.005	0.005
Echinococcus granulosus	dnaJ subfamily B	0.0416	0.5531	0.5531
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0215	0.2809	0.2809
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0215	0.2809	0.2809
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0215	0.2809	0.2809
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0282	0.0382
Echinococcus multilocularis	integrin linked protein kinase	0.0215	0.2809	0.2809
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.005	0.005
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.0429	0.5
Echinococcus multilocularis	polycomb protein SCMH1	0.0052	0.06	0.06
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Toxoplasma gondii	STE kinase	0.0215	0.2809	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0215	0.2809	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.005	0.005
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.0429	0.0921
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0215	0.2809	1
Schistosoma mansoni	hypothetical protein	0.03	0.3961	0.3961
Schistosoma mansoni	coup transcription factor	0.0011	0.005	0.005
Echinococcus granulosus	cpg binding protein	0.0031	0.032	0.032
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0215	0.2809	0.2809
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0024	0.0007
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0013	0.0077	0.0077
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0215	0.2809	0.2809
Trichomonas vaginalis	TKL family protein kinase	0.0215	0.2809	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0215	0.2809	1
Giardia lamblia	Kinase	0.0215	0.2809	1
Entamoeba histolytica	protein kinase domain containing protein	0.0215	0.2809	1
Schistosoma mansoni	tyrosine kinase	0.0215	0.2809	0.2809
Schistosoma mansoni	serine/threonine protein kinase	0.0215	0.2809	0.2809
Schistosoma mansoni	hypothetical protein	0.0165	0.2136	0.2136
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0009	0.0021	0.0021
Brugia malayi	Receptor family ligand binding region containing protein	0.0215	0.2809	0.6305
Mycobacterium leprae	Probable lipase LipE	0.0039	0.0429	0.5
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2809	0.6305
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0215	0.2809	0.2809
Entamoeba histolytica	protein kinase domain containing protein	0.0215	0.2809	1
Echinococcus granulosus	receptor type guanylyl cyclase	0.0215	0.2809	0.2809
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0215	0.2809	0.6305
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0215	0.2809	1
Loa Loa (eye worm)	TK protein kinase	0.0215	0.2809	0.6305
Echinococcus granulosus	tyrosine kinase	0.0215	0.2809	0.2809

Activities

Activity type	Activity value	Assay description	Source	Reference
Fu (ADMET)	= 3.2 %	Fraction unbound in C57BL/6 mouse plasma	ChEMBL.	24157366
IC50 (binding)	= 2.5 nM	Inhibition of recombinant human PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by fluorescence assay	ChEMBL.	24157366
IC50 (binding)	= 12 nM	Inhibition of recombinant mouse PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by fluorescence assay	ChEMBL.	24157366
IC50 (binding)	= 530 nM	Inhibition of human ERG	ChEMBL.	24157366

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3086048

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1840723