TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 467.513 | Formula: C19H19F2N5O3S2
H donors: 2 H acceptors: 5 LogP: 2.62 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C1OC(CN1Cc1c(F)cccc1F)CNc1nnc(s1)C(c1scc(n1)C)(O)C
InChi: 1S/C19H19F2N5O3S2/c1-10-9-30-15(23-10)19(2,28)16-24-25-17(31-16)22-6-11-7-26(18(27)29-11)8-12-13(20)4-3-5-14(12)21/h3-5,9,11,28H,6-8H2,1-2H3,(H,22,25)
InChiKey: CYBRTJWKDSMQDV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium knowlesi	enoyl-acyl carrier reductase, putative	Get druggable targets OG5_130466	All targets in OG5_130466
Chlamydia trachomatis	enoyl-acyl-carrier protein reductase	Get druggable targets OG5_130466	All targets in OG5_130466
Plasmodium falciparum	enoyl-acyl carrier reductase	Get druggable targets OG5_130466	All targets in OG5_130466
Plasmodium vivax	enoyl-acyl carrier protein reductase	Get druggable targets OG5_130466	All targets in OG5_130466
Trichomonas vaginalis	hypothetical protein	Get druggable targets OG5_130466	All targets in OG5_130466
Plasmodium yoelii	enoyl-acyl carrier reductase	Get druggable targets OG5_130466	All targets in OG5_130466
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	Get druggable targets OG5_130466	All targets in OG5_130466
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	Get druggable targets OG5_130466	All targets in OG5_130466
Plasmodium berghei	enoyl-acyl carrier reductase	Get druggable targets OG5_130466	All targets in OG5_130466
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	Get druggable targets OG5_130466	All targets in OG5_130466
Neospora caninum	enoyl-acyl carrier reductase, putative	Get druggable targets OG5_130466	All targets in OG5_130466
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	Get druggable targets OG5_130466	All targets in OG5_130466
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	Get druggable targets OG5_130466	All targets in OG5_130466

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Giardia lamblia	Kinase, NEK	0.0475	0.8227	0.5
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0475	0.8227	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0475	0.8227	0.5
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0475	0.8227	0.5
Echinococcus multilocularis	integrin linked protein kinase	0.0475	0.8227	0.5
Onchocerca volvulus		0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0475	0.8227	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0475	0.8227	0.5
Loa Loa (eye worm)	TK/INSR protein kinase	0.0475	0.8227	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0475	0.8227	0.5
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0475	0.8227	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0475	0.8227	0.5
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0475	0.8227	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0475	0.8227	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0475	0.8227	0.5
Toxoplasma gondii	STE kinase	0.0475	0.8227	1
Brugia malayi	Receptor family ligand binding region containing protein	0.0475	0.8227	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0475	0.8227	0.5
Schistosoma mansoni	protein kinase	0.0475	0.8227	0.5
Brugia malayi	hypothetical protein	0.0475	0.8227	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0475	0.8227	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0475	0.8227	0.5
Loa Loa (eye worm)	hypothetical protein	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Plasmodium falciparum	protein kinase, putative	0.0475	0.8227	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0475	0.8227	0.5
Trypanosoma cruzi	protein kinase, putative	0.0475	0.8227	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0475	0.8227	0.5
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0475	0.8227	0.5
Entamoeba histolytica	hypothetical protein	0.0529	1	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0475	0.8227	0.5
Loa Loa (eye worm)	TK/ACK protein kinase	0.0475	0.8227	0.5
Schistosoma mansoni	ephrin receptor	0.0475	0.8227	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0475	0.8227	1
Brugia malayi	SH2 domain containing protein	0.0475	0.8227	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0475	0.8227	0.5
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Echinococcus multilocularis	activated cdc42 kinase 1	0.0475	0.8227	0.5
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0475	0.8227	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0475	0.8227	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0475	0.8227	0.5
Echinococcus multilocularis	tyrosine kinase	0.0475	0.8227	0.5
Echinococcus granulosus	tyrosine kinase	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0475	0.8227	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0475	0.8227	0.5
Onchocerca volvulus		0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Loa Loa (eye worm)	TK protein kinase	0.0475	0.8227	0.5
Loa Loa (eye worm)	hypothetical protein	0.0475	0.8227	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Trichomonas vaginalis	TK family protein kinase	0.0475	0.8227	1
Brugia malayi	SH2 domain containing protein	0.0475	0.8227	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0475	0.8227	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0475	0.8227	0.5
Toxoplasma gondii	protein kinase	0.0475	0.8227	1
Trichomonas vaginalis	STE family protein kinase	0.0475	0.8227	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0475	0.8227	0.5
Echinococcus granulosus	activin receptor type	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0475	0.8227	0.5
Brugia malayi	hypothetical protein	0.0475	0.8227	0.5
Echinococcus granulosus	natriuretic peptide receptor 1	0.0475	0.8227	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0475	0.8227	0.5
Brugia malayi	integrin-linked kinase	0.0475	0.8227	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0475	0.8227	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0475	0.8227	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0475	0.8227	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.0475	0.8227	0.5
Echinococcus granulosus	kinase suppressor of Ras 1	0.0475	0.8227	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0475	0.8227	0.5
Trypanosoma cruzi	protein kinase, putative	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Schistosoma mansoni	protein kinase	0.0475	0.8227	0.5
Plasmodium falciparum	protein kinase, putative	0.0475	0.8227	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Entamoeba histolytica	protein kinase, putative	0.0529	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Loa Loa (eye worm)	TK protein kinase	0.0475	0.8227	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0475	0.8227	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0475	0.8227	0.5
Echinococcus multilocularis	insulin receptor	0.0475	0.8227	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0475	0.8227	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0475	0.8227	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0475	0.8227	0.5
Brugia malayi	Guanylyl cyclase protein 23	0.0475	0.8227	0.5
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0475	0.8227	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0475	0.8227	0.5
Brugia malayi	C-terminal src kinase protein 1	0.0475	0.8227	0.5
Leishmania major	protein kinase, putative	0.0475	0.8227	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0475	0.8227	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0475	0.8227	0.5
Giardia lamblia	Protein 21.1	0.0475	0.8227	0.5
Echinococcus granulosus	c src tyrosine kinase	0.0475	0.8227	0.5
Echinococcus multilocularis	protein kinase	0.0475	0.8227	0.5
Schistosoma mansoni	protein kinase	0.0475	0.8227	0.5
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.0475	0.8227	0.5
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0475	0.8227	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0475	0.8227	1
Trichomonas vaginalis	conserved hypothetical protein	0.0475	0.8227	1
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine protein kinase	0.0475	0.8227	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0475	0.8227	0.5
Loa Loa (eye worm)	hypothetical protein	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Onchocerca volvulus		0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0475	0.8227	0.5
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Echinococcus granulosus	integrin linked protein kinase	0.0475	0.8227	0.5
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0475	0.8227	0.5
Onchocerca volvulus		0.0475	0.8227	0.5
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Loa Loa (eye worm)	hypothetical protein	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0475	0.8227	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0475	0.8227	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0475	0.8227	0.5
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0223	0	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0475	0.8227	0.5
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0475	0.8227	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0475	0.8227	0.5
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Brugia malayi	ephrin receptor 1 precursor	0.0475	0.8227	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0475	0.8227	0.5
Loa Loa (eye worm)	TK/RYK protein kinase	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Echinococcus multilocularis	protein kinase	0.0475	0.8227	0.5
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Leishmania major	hypothetical protein, conserved	0.0475	0.8227	0.5
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0475	0.8227	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0475	0.8227	0.5
Echinococcus multilocularis	c src tyrosine kinase	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0475	0.8227	0.5
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Loa Loa (eye worm)	hypothetical protein	0.0475	0.8227	0.5
Schistosoma mansoni	protein kinase	0.0475	0.8227	0.5
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Onchocerca volvulus		0.0475	0.8227	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0475	0.8227	0.5
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0475	0.8227	1
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0475	0.8227	0.5
Echinococcus multilocularis	activin receptor type	0.0475	0.8227	0.5
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Echinococcus multilocularis	transfer RNA-Thr	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Loa Loa (eye worm)	TK protein kinase	0.0475	0.8227	0.5
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0529	1	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0475	0.8227	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Schistosoma mansoni	protein kinase	0.0475	0.8227	0.5
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Loa Loa (eye worm)	TK/ALK protein kinase	0.0475	0.8227	0.5
Loa Loa (eye worm)	TK/EPH protein kinase	0.0475	0.8227	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0475	0.8227	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0475	0.8227	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0475	0.8227	0.5
Schistosoma mansoni	protein kinase	0.0475	0.8227	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0475	0.8227	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0475	0.8227	1
Echinococcus multilocularis	heat shock protein 70	0.0475	0.8227	0.5
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Schistosoma mansoni	hypothetical protein	0.0475	0.8227	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0475	0.8227	0.5
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0475	0.8227	0.5
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0475	0.8227	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0475	0.8227	0.5
Loa Loa (eye worm)	TK protein kinase	0.0475	0.8227	0.5
Loa Loa (eye worm)	TK/ROR protein kinase	0.0475	0.8227	0.5
Giardia lamblia	Kinase, NEK	0.0475	0.8227	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0475	0.8227	1
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0223	0	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Schistosoma mansoni	protein kinase	0.0475	0.8227	0.5
Schistosoma mansoni	protein kinase	0.0475	0.8227	0.5
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0475	0.8227	0.5
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0475	0.8227	0.5
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0475	0.8227	0.5
Onchocerca volvulus		0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0475	0.8227	0.5
Echinococcus granulosus	tyrosine protein kinase shark	0.0475	0.8227	0.5
Brugia malayi	Furin-like cysteine rich region family protein	0.0475	0.8227	0.5
Onchocerca volvulus		0.0475	0.8227	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0475	0.8227	0.5
Brugia malayi	Tyrosine-protein kinase PR2	0.0475	0.8227	0.5
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0475	0.8227	0.5
Chlamydia trachomatis	enoyl-acyl-carrier protein reductase	0.0223	0	0.5
Echinococcus granulosus	protein kinase	0.0475	0.8227	0.5
Loa Loa (eye worm)	TK protein kinase	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0475	0.8227	1
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0475	0.8227	0.5
Onchocerca volvulus		0.0475	0.8227	0.5
Loa Loa (eye worm)	TK protein kinase	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Echinococcus granulosus	receptor type guanylyl cyclase	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0475	0.8227	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0475	0.8227	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Brugia malayi	Tyrosine-protein kinase abl-1	0.0475	0.8227	0.5
Echinococcus granulosus	protein tyrosine kinase	0.0475	0.8227	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0475	0.8227	0.5
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Onchocerca volvulus		0.0475	0.8227	0.5
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0475	0.8227	0.5
Schistosoma mansoni	protein kinase	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Loa Loa (eye worm)	TK protein kinase	0.0475	0.8227	0.5
Plasmodium vivax	protein kinase, putative	0.0475	0.8227	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0475	0.8227	0.5
Loa Loa (eye worm)	TK protein kinase	0.0475	0.8227	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0475	0.8227	0.5
Leishmania major	protein kinase, putative	0.0475	0.8227	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.0475	0.8227	1
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Trypanosoma brucei	protein kinase, putative	0.0475	0.8227	0.5
Echinococcus multilocularis	FL cytokine receptor	0.0475	0.8227	0.5
Schistosoma mansoni	ephrin receptor	0.0475	0.8227	0.5
Brugia malayi	Raf kinase	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Loa Loa (eye worm)	hypothetical protein	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0475	0.8227	0.5
Plasmodium falciparum	protein kinase, putative	0.0475	0.8227	1
Brugia malayi	hypothetical protein	0.0475	0.8227	0.5
Trypanosoma brucei	Pseudokinase, putative	0.0475	0.8227	0.5
Onchocerca volvulus		0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0475	0.8227	1
Echinococcus granulosus	insulin receptor	0.0475	0.8227	0.5
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0475	0.8227	0.5
Loa Loa (eye worm)	TK/CSK protein kinase	0.0475	0.8227	0.5
Brugia malayi	protein-tyrosine kinase	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0475	0.8227	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0475	0.8227	1
Schistosoma mansoni	protein kinase	0.0475	0.8227	0.5
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Echinococcus granulosus	tyrosine protein kinase	0.0475	0.8227	0.5
Loa Loa (eye worm)	hypothetical protein	0.0475	0.8227	0.5
Loa Loa (eye worm)	hypothetical protein	0.0475	0.8227	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0475	0.8227	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0475	0.8227	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0475	0.8227	1
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Loa Loa (eye worm)	TK/Met protein kinase	0.0475	0.8227	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0475	0.8227	0.5
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0475	0.8227	0.5
Echinococcus multilocularis	protein tyrosine kinase	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Onchocerca volvulus		0.0475	0.8227	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0475	0.8227	0.5
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0475	0.8227	0.5
Onchocerca volvulus		0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Echinococcus multilocularis	tyrosine protein kinase	0.0475	0.8227	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0475	0.8227	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0475	0.8227	0.5
Schistosoma mansoni	protein kinase	0.0475	0.8227	0.5
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Loa Loa (eye worm)	TK protein kinase	0.0475	0.8227	0.5
Loa Loa (eye worm)	hypothetical protein	0.0475	0.8227	0.5
Onchocerca volvulus		0.0475	0.8227	0.5
Loa Loa (eye worm)	hypothetical protein	0.0475	0.8227	0.5
Schistosoma mansoni	protein tyrosine kinase	0.0475	0.8227	0.5
Onchocerca volvulus		0.0475	0.8227	0.5
Loa Loa (eye worm)	hypothetical protein	0.0475	0.8227	0.5
Giardia lamblia	Kinase	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Brugia malayi	SRC-1	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Onchocerca volvulus	Tyrosine kinase homolog	0.0475	0.8227	0.5
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Loa Loa (eye worm)	hypothetical protein	0.0475	0.8227	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0475	0.8227	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0475	0.8227	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0475	0.8227	0.5
Loa Loa (eye worm)	hypothetical protein	0.0475	0.8227	0.5
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0475	0.8227	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0475	0.8227	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0475	0.8227	0.5
Echinococcus granulosus	raf serine:threonine protein kinase	0.0475	0.8227	0.5
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0223	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0475	0.8227	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0475	0.8227	0.5
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0475	0.8227	0.5
Schistosoma mansoni	serine/threonine RGC	0.0475	0.8227	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0475	0.8227	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0475	0.8227	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0475	0.8227	1
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0475	0.8227	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0475	0.8227	1
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0475	0.8227	0.5
Loa Loa (eye worm)	TK protein kinase	0.0475	0.8227	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0475	0.8227	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0475	0.8227	1
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Onchocerca volvulus		0.0475	0.8227	0.5
Loa Loa (eye worm)	SRC-1	0.0475	0.8227	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0475	0.8227	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0475	0.8227	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Schistosoma mansoni	serine/threonine protein kinase	0.0475	0.8227	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0475	0.8227	0.5
Echinococcus granulosus	ephrin type A receptor 4 A	0.0475	0.8227	0.5
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0475	0.8227	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Echinococcus multilocularis	tyrosine kinase	0.0475	0.8227	0.5
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0223	0	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0475	0.8227	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0475	0.8227	0.5
Echinococcus granulosus	tyrosine kinase	0.0475	0.8227	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0475	0.8227	0.5
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0475	0.8227	1
Echinococcus granulosus	tyrosine kinase	0.0475	0.8227	0.5
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5
Echinococcus granulosus	tyrosine protein kinase pr2	0.0475	0.8227	0.5
Schistosoma mansoni	tyrosine kinase	0.0475	0.8227	0.5
Entamoeba histolytica	hypothetical protein	0.0529	1	1
Brugia malayi	Protein kinase domain containing protein	0.0475	0.8227	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.4 uM	Inhibition of Mycobacterium tuberculosis full length inhA expressed in Escherichia coli BL21 preincubated for 15 mins by fluorescence based assay in presence of NADH	ChEMBL.	24107081
MIC (functional)	> 100 uM	Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as parasite growth inhibition after 7 days by Alamar Blue assay	ChEMBL.	24107081

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3087016

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1840770