Detailed information for compound 184079

Basic information

Technical information
  • TDR Targets ID: 184079
  • Name: ST 1481
  • MW: 447.483 | Formula: C25H25N3O5
  • H donors: 1 H acceptors: 4 LogP: 2.02 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[C@@]1(O)C(=O)OCc2c1cc1c3nc4ccccc4c(c3Cn1c2=O)/C=N/OC(C)(C)C
  • InChi: 1S/C25H25N3O5/c1-5-25(31)18-10-20-21-16(12-28(20)22(29)17(18)13-32-23(25)30)15(11-26-33-24(2,3)4)14-8-6-7-9-19(14)27-21/h6-11,31H,5,12-13H2,1-4H3/b26-11+/t25-/m0/s1
  • InChiKey: UIVFUQKYVFCEKJ-OPTOVBNMSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 7-tert-butoxyiminomethylcamptothecin
  • 292618-32-7
  • 292620-90-7
  • 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-11-carboxaldehyde, 4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-, 11-(O-(1,1-dimethylethyl)oxime), (4S)-
  • CPT 184
  • ST1481
  • (4S)-11-((E)-((1,1-Dimethylethoxy)imino)methyl)-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano(3?,4?:6,7)indolizino(1,2-b)quinoline-3,14(4H)-dione
  • 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-11-carboxaldehyde, 4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-, 11-(O-(1,1-dimethylethyl)oxime), (C(E),4S)-
  • Gimatecan
  • Gimatecan [INN]

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens peroxisome proliferator-activated receptor delta Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi ecdysteroid receptor peroxisome proliferator-activated receptor delta 441 aa 369 aa 24.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0007 0 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.135 0.135
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.135 0.135
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.135 0.135
Entamoeba histolytica hypothetical protein 0.0043 0.9033 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.135 0.135
Brugia malayi nuclear receptor NHR-88 0.0012 0.135 0.135
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.135 0.135
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.135 0.135
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.135 0.135
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.135 0.135
Schistosoma mansoni thyroid hormone receptor 0.0012 0.135 0.135
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 1 1
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.135 0.135
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 1 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.135 0.135
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.135 0.135
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0007 0 0.5
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0007 0 0.5
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.135 0.135
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.135 0.135
Toxoplasma gondii isocitrate dehydrogenase 0.0047 1 1
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0007 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.135 0.135
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.135 0.135
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.135 0.135
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.135 0.135
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.135 0.135
Entamoeba histolytica hypothetical protein 0.0043 0.9033 0.5
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0007 0 0.5
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0007 0 0.5
Mycobacterium leprae Conserved hypothetical protein 0.0007 0 0.5
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0007 0 0.5
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.135 0.135
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0007 0 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.135 0.135
Brugia malayi steroid hormone receptor 0.0012 0.135 0.135
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.135 0.135
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0007 0 0.5
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.135 0.135
Loa Loa (eye worm) hypothetical protein 0.0012 0.135 0.135
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0007 0 0.5
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0007 0 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.135 0.135
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.135 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.135 0.135
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0007 0 0.5
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0047 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.135 0.135
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.135 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.135 0.135
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0047 1 0.5
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0007 0 0.5
Schistosoma mansoni thyroid hormone receptor 0.0012 0.135 0.135
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0007 0 0.5
Entamoeba histolytica hypothetical protein 0.0043 0.9033 0.5
Mycobacterium leprae putative cytochrome p450 0.0007 0 0.5
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.135 0.135
Toxoplasma gondii isocitrate dehydrogenase 0.0047 1 1
Entamoeba histolytica hypothetical protein 0.0043 0.9033 0.5
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.9033 0.9033
Brugia malayi hypothetical protein 0.0043 0.9033 0.9033
Loa Loa (eye worm) hypothetical protein 0.0012 0.135 0.135
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0047 1 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.135 0.135
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.135 0.135
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.135 0.135
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.135 0.135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.135 0.135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.135 0.135
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 1 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0047 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.135 0.135
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.135 0.135
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0047 1 1
Echinococcus granulosus FTZ F1 alpha 0.0012 0.135 0.135
Onchocerca volvulus 0.0012 0.135 0.5
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.135 0.135
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.135 0.135
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0007 0 0.5
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.135 0.135
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.135 0.135
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.135 0.135
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 1 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.9033 0.9033
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.135 0.135
Schistosoma mansoni hypothetical protein 0.0043 0.9033 0.9033
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.135 0.135
Loa Loa (eye worm) isocitrate dehydrogenase 0.0047 1 1
Brugia malayi Isocitrate dehydrogenase 0.0047 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.135 0.135
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.135 0.135
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0007 0 0.5
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.135 0.135
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0007 0 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.135 0.135
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0007 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.135 0.135
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.135 0.5
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.135 0.135
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.135 0.135
Schistosoma mansoni coup transcription factor 0.0012 0.135 0.135
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0047 1 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0047 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.9033 0.9033
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0007 0 0.5
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.135 0.135
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.135 0.135
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0007 0 0.5
Brugia malayi nuclear hormone receptor 0.0012 0.135 0.135
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.135 0.135
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.135 0.135
Echinococcus multilocularis isocitrate dehydrogenase 0.0047 1 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0047 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.135 0.135
Brugia malayi ecdysteroid receptor 0.0012 0.135 0.135
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.135 0.135
Schistosoma mansoni nuclear hormone receptor 0.0012 0.135 0.135
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0007 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.135 0.135

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) 0 Toxicity in human CoBa cells xenografted athymic mouse assessed as survival at 2 mg/kg, po administered in q4dx4 schedule ChEMBL. 18424133
Activity (ADMET) = 18 % Toxicity in human CoBa cells xenografted athymic mouse assessed as loss of body weight at 2 mg/kg, po administered in q4dx4 schedule ChEMBL. 18424133
Activity (ADMET) = 18 % Toxicity in human CoBa cells xenografted athymic mouse assessed as loss of body weight at 2 mg/kg, po administered in q4dx4 schedule ChEMBL. 18424133
Activity (binding) = 90 % Stimulation of human topoisomerase 1-mediated DNA damage at 10 uM after 10 mins in presence of sodium chloride ChEMBL. 18424133
Activity (binding) = 90 % Inhibition of human topoisomerase 1-mediated DNA damage persistence in presence of NaCl at 10 uM after 10 mins ChEMBL. 18434153
Activity (binding) = 90 % Stimulation of human topoisomerase 1-mediated DNA damage at 10 uM after 10 mins in presence of sodium chloride ChEMBL. 18424133
BWL (functional) = 0 % Percentage of body weight loss in CD1 mice with human Non-Small-Cell tumor at a oral dose of 1 mg/kg ChEMBL. 11563925
BWL (functional) = 0 % Percentage of body weight loss in CD1 mice with human Non-Small-Cell tumor at a oral dose of 1 mg/kg ChEMBL. 11563925
BWL (functional) = 1 % Percentage of body weight loss in CD1 mice with human Non-Small-Cell tumor at a oral dose of 2 mg/kg ChEMBL. 11563925
BWL (functional) = 1 % Percentage of body weight loss in CD1 mice with human Non-Small-Cell tumor at a oral dose of 2 mg/kg ChEMBL. 11563925
BWL (functional) = 5 % Percentage of body weight loss in CD1 mice with human Non-Small-Cell tumor at a oral dose of 4 mg/kg ChEMBL. 11563925
BWL (functional) = 11 % Percentage of body weight loss in mice with lung carcinoma LX-1 at a oral dose of 3 mg/kg ChEMBL. 11563925
BWL (functional) = 23 % Percentage of body weight loss in CD1 mice with human Non-Small-Cell tumor at a oral dose of 3 mg/kg ChEMBL. 11563925
BWL (functional) = 23 % Percentage of body weight loss in CD1 mice with human Non-Small-Cell tumor at a oral dose of 3 mg/kg ChEMBL. 11563925
CR (functional) = 0 Complete response in CD1 mice with human Non-Small-Cell tumor at a oral dose of 1 mg/kg ChEMBL. 11563925
CR (functional) = 4 Complete response in CD1 mice with human Non-Small-Cell tumor at a oral dose of 4 mg/kg ChEMBL. 11563925
CR (functional) = 5 Complete response in CD1 mice with human Non-Small-Cell tumor at a oral dose of 2 mg/kg ChEMBL. 11563925
CR (functional) = 8 Complete responsein CD1 mice with human Non-Small-Cell tumor at a oral dose of 3 mg/kg ChEMBL. 11563925
CR (functional) = 8 Complete responsein mice with lung carcinoma LX-1 at a oral dose of 3 mg/kg ChEMBL. 11563925
IC50 (functional) = 0.015 uM Cytotoxicity against human non-small-cell lung carcinoma cell line H460 (NSCLC-H460) ChEMBL. 11563925
IC50 (functional) = 0.015 uM Antiproliferative activity against human H460 cells after 2 hrs of drug exposure measured after 72 hrs ChEMBL. 18424133
IC50 (functional) = 0.015 uM Cytotoxicity against human H460 cells ChEMBL. 18434153
IC50 (functional) = 0.015 uM Antiproliferative activity against human H460 cells after 2 hrs of drug exposure measured after 72 hrs ChEMBL. 18424133
IC50 (functional) = 0.015 uM Cytotoxicity against human H460 cells ChEMBL. 18434153
IC50 (functional) = 0.02 uM Antiproliferative activity against human H460 cells after 1 hr of drug exposure measured after 72 hrs ChEMBL. 18424133
IC50 (functional) = 0.02 uM Antiproliferative activity against human H460 cells after 1 hr of drug exposure measured after 72 hrs ChEMBL. 18424133
IC50 (functional) = 0.056 uM Antiproliferative activity against human HT29 cells after 1 hr of drug exposure measured after 72 hrs ChEMBL. 18424133
IC50 (functional) = 0.056 uM Antiproliferative activity against human HT29 cells after 1 hr of drug exposure measured after 72 hrs ChEMBL. 18424133
IC50 (functional) = 0.07 uM Antiproliferative activity against BCRP overexpressing mitoxantrone-resistant human HT29 cells after 1 hr of drug exposure measured after 72 hrs ChEMBL. 18424133
IC50 (functional) = 0.07 uM Antiproliferative activity against BCRP overexpressing mitoxantrone-resistant human HT29 cells after 1 hr of drug exposure measured after 72 hrs ChEMBL. 18424133
Inhibition (functional) = 90 % Percentage inhibition of tumor volume in treated versus control mice against human Non-Small-Cell tumor xenograft at a oral dose of 1 mg/kg ChEMBL. 11563925
Inhibition (functional) = 90 % Antitumor activity against human CoBa cells xenografted in athymic mouse assessed as inhibition of tumor volume at 2 mg/kg, po administered in q4dx4 schedule ChEMBL. 18424133
Inhibition (functional) = 90 % Percentage inhibition of tumor volume in treated versus control mice against human Non-Small-Cell tumor xenograft at a oral dose of 1 mg/kg ChEMBL. 11563925
Inhibition (functional) = 99 % Percentage inhibition of tumor volume in treated versus control mice against human Non-Small-Cell tumor xenograft at a oral dose of 2 mg/kg ChEMBL. 11563925
Inhibition (functional) = 99 % Percentage inhibition of tumor volume in treated versus control mice against human Non-Small-Cell tumor xenograft at a oral dose of 4 mg/kg ChEMBL. 11563925
Inhibition (functional) = 99 % Percentage inhibition of tumor volume in treated versus control mice against human Non-Small-Cell tumor xenograft at a oral dose of 2 mg/kg ChEMBL. 11563925
Inhibition (functional) = 100 % Percentage inhibition of tumor volume in treated versus control mice against human Non-Small-Cell tumor xenograft at a oral dose of 3 mg/kg ChEMBL. 11563925
Inhibition (functional) = 100 % Percentage inhibition of tumor volume mice with lung carcinoma LX-1 at a oral dose of 3 mg/kg ChEMBL. 11563925
Inhibition (functional) = 100 % Percentage inhibition of tumor volume in treated versus control mice against human Non-Small-Cell tumor xenograft at a oral dose of 3 mg/kg ChEMBL. 11563925
LCK (functional) = 1.1 Antitumor activity against human CoBa cells xenografted in athymic mouse assessed as inhibition of tumor volume at 2 mg/kg, po administered in q4dx4 schedule ChEMBL. 18424133
LCK (functional) = 1.4 Log 10 cell kill induced by treatment iin CD1 mice with human Non-Small-Cell tumor at a oral dose of 1 mg/kg ChEMBL. 11563925
LCK (functional) = 2.4 Log 10 cell kill induced by treatment in CD1 mice with human Non-Small-Cell tumor at a oral dose of 2 mg/kg ChEMBL. 11563925
LCK (functional) = 2.4 Log 10 cell kill induced by treatment in CD1 mice with human Non-Small-Cell tumor at a oral dose of 4 mg/kg ChEMBL. 11563925
LCK (functional) = 2.5 Log 10 cell kill induced by treatment in CD1 mice with human Non-Small-Cell tumor at a oral dose of 3 mg/kg ChEMBL. 11563925
LCK (functional) = 5.3 Log 10 cell kill induced by treatment in mice with lung carcinoma LX-1 at a oral dose of 3 mg/kg ChEMBL. 11563925
Potency (functional) 11.8823 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.3322 uM PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.6011 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.8325 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the NFkB signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 33.4889 uM PubChem BioAssay: Tox21. qHTS assay for small molecule activators of the heat shock response signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Ratio IC50 (functional) = 1.2 Resistant index, ratio of IC50 for BCRP overexpressing mitoxantrone-resistant human HT29 cells to IC50 for human HT29 cells ChEMBL. 18424133
Toxicity (ADMET) = 0 No. of dead mice/ total No. of mice in CD1 mice with human Non-Small-Cell tumor at a oral dose of 1 mg/kg ChEMBL. 11563925
Toxicity (ADMET) = 0 No. of dead mice/ total No. of mice with human Non-Small-Cell tumor at a oral dose of 2 mg/kg ChEMBL. 11563925
Toxicity (ADMET) = 0 No. of dead mice/ total No. of mice with human Non-Small-Cell tumor at a oral dose of 4 mg/kg ChEMBL. 11563925
Toxicity (ADMET) = 0 No. of dead mice/ total No. of mice in mice with lung carcinoma LX-1 at a oral dose of 3 mg/kg ChEMBL. 11563925
Toxicity (ADMET) = 2 No. of dead mice/ total No. of mice with human Non-Small-Cell tumor at a oral dose of 3 mg/kg ChEMBL. 11563925

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 18424133

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.