Detailed information for compound 1841226

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 364.399 | Formula: C14H12N4O4S2
  • H donors: 2 H acceptors: 5 LogP: 1.32 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)c1nnc(s1)NC(=O)CC1SC(=O)NC1=O
  • InChi: 1S/C14H12N4O4S2/c1-22-8-4-2-3-7(5-8)12-17-18-13(24-12)15-10(19)6-9-11(20)16-14(21)23-9/h2-5,9H,6H2,1H3,(H,15,18,19)(H,16,20,21)
  • InChiKey: AJILCJHLKNHNAS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0067 0.07 0.07
Echinococcus multilocularis aldo keto reductase 0.0067 0.07 0.0617
Echinococcus granulosus Polycystic kidney disease protein 0.0223 0.3005 0.2943
Schistosoma mansoni heat shock protein 0.0033 0.0188 0.0083
Schistosoma mansoni hypothetical protein 0.0601 0.8616 0.8601
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Schistosoma mansoni survival motor neuron protein 0.0049 0.0422 0.0321
Brugia malayi Doublecortin family protein 0.0223 0.3005 0.3408
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0624 0.895 0.8941
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) 0.0502 0.7146 1
Echinococcus multilocularis heat shock protein 0.0033 0.0188 0.01
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0031 0.0164 0.1234
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0067 0.07 0.0617
Loa Loa (eye worm) hypothetical protein 0.0123 0.1531 0.1682
Schistosoma mansoni hypothetical protein 0.0223 0.3005 0.2931
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.07 1
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0224 0.2215
Loa Loa (eye worm) apoptosis regulator protein 0.0601 0.8616 1
Loa Loa (eye worm) hypothetical protein 0.0223 0.3005 0.3413
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.07 1
Echinococcus granulosus lamin 0.0027 0.0105 0.0016
Echinococcus multilocularis lipoxygenase domain containing protein 0.0223 0.3005 0.2943
Schistosoma mansoni endoplasmin 0.0033 0.0188 0.0083
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0067 0.07 0.0617
Trichomonas vaginalis guanylate cyclase, putative 0.0031 0.0164 0.2344
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0067 0.07 0.0617
Echinococcus granulosus aryl hydrocarbon receptor 0.0259 0.354 0.3482
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.0188 0.1615
Loa Loa (eye worm) hypothetical protein 0.0238 0.3231 0.3679
Loa Loa (eye worm) heat shock protein 90 0.0033 0.0188 0.0106
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0224 0.3201
Echinococcus multilocularis lamin dm0 0.0027 0.0105 0.0016
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0031 0.0164 0.2344
Echinococcus granulosus RUN 0.0223 0.3005 0.2943
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0224 0.3201
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0067 0.07 0.07
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0164 0.2344
Brugia malayi hypothetical protein 0.0223 0.3005 0.3408
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0067 0.07 0.0617
Loa Loa (eye worm) oxidoreductase 0.0067 0.07 0.0708
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0031 0.0164 0.2344
Echinococcus granulosus lipoxygenase domain containing protein 0.0223 0.3005 0.2943
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0067 0.07 0.0617
Trichomonas vaginalis adenylate cyclase, putative 0.0031 0.0164 0.2344
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.07 1
Echinococcus granulosus aldo keto reductase 0.0067 0.07 0.0617
Schistosoma mansoni single-minded 0.012 0.1479 0.1389
Echinococcus granulosus heat shock protein 0.0033 0.0188 0.01
Echinococcus multilocularis geminin 0.0171 0.2231 0.2162
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0067 0.07 0.0617
Mycobacterium leprae Possible regulatory protein 0.0031 0.0164 0.0107
Echinococcus granulosus hypothetical protein 0.0067 0.07 0.0617
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0188 0.1615
Trypanosoma cruzi aldo/keto reductase, putative 0.0067 0.07 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0067 0.07 1
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0031 0.0164 0.1234
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0031 0.0164 0.2344
Echinococcus granulosus aldo keto reductase 0.0067 0.07 0.0617
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0105 0.0009
Leishmania major protein kinase, putative 0.0031 0.0164 0.1234
Schistosoma mansoni aryl hydrocarbon receptor 0.0347 0.4855 0.48
Onchocerca volvulus 0.0223 0.3005 0.8481
Brugia malayi PAS domain containing protein 0.012 0.1479 0.1615
Schistosoma mansoni pol-related 0.0067 0.07 0.0602
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0601 0.8616 0.8604
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0067 0.07 0.0617
Mycobacterium ulcerans isocitrate lyase Icl 0.0502 0.7146 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0067 0.07 0.0617
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Entamoeba histolytica aldose reductase, putative 0.0067 0.07 1
Echinococcus multilocularis microtubule associated protein 2 0.0694 1 1
Schistosoma mansoni rab6-interacting 0.0223 0.3005 0.2931
Schistosoma mansoni endoplasmin 0.0033 0.0188 0.0083
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.07 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0031 0.0164 0.1234
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0601 0.8616 1
Loa Loa (eye worm) hypothetical protein 0.0123 0.1531 0.1682
Brugia malayi hypothetical protein 0.0223 0.3005 0.3408
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Toxoplasma gondii aldose reductase, putative 0.0067 0.07 1
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0188 0.1615
Trichomonas vaginalis aldo/keto reductase, putative 0.0067 0.07 1
Loa Loa (eye worm) oxidoreductase 0.0067 0.07 0.0708
Loa Loa (eye worm) hypothetical protein 0.0027 0.0105 0.0009
Schistosoma mansoni aldo-keto reductase 0.0067 0.07 0.0602
Giardia lamblia Heat shock protein HSP 90-alpha 0.0033 0.0188 0.1615
Mycobacterium tuberculosis Probable oxidoreductase 0.0067 0.07 0.0867
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0067 0.07 0.0617
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0067 0.07 0.0617
Echinococcus granulosus heat shock protein 90 0.0033 0.0188 0.01
Echinococcus multilocularis Polycystic kidney disease protein 0.0223 0.3005 0.2943
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0224 0.013
Echinococcus multilocularis RUN 0.0223 0.3005 0.2943
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.07 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0067 0.07 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0223 0.3005 0.2943
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0601 0.8616 0.8601
Loa Loa (eye worm) hypothetical protein 0.0031 0.0164 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0164 0.2344
Echinococcus multilocularis transfer RNA-Lys 0.0089 0.1017 0.0937
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.07 1
Onchocerca volvulus 0.0223 0.3005 0.8481
Brugia malayi hypothetical protein 0.0123 0.1531 0.1675
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0031 0.0164 0.2344
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Trypanosoma cruzi aldo-keto reductase 0.0067 0.07 1
Leishmania major basic transcription factor 3a, putative 0.0035 0.0224 0.2215
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Schistosoma mansoni hypothetical protein 0.0601 0.8616 0.8601
Onchocerca volvulus 0.0067 0.07 0.1742
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0067 0.07 0.0617
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0067 0.07 0.0617
Brugia malayi hypothetical protein 0.0238 0.3231 0.3673
Trichomonas vaginalis aldo/keto reductase, putative 0.0067 0.07 1
Echinococcus multilocularis aldo keto reductase 0.0067 0.07 0.0617
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.07 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.07 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.07 1
Schistosoma mansoni hypothetical protein 0.0171 0.2231 0.2149
Onchocerca volvulus 0.0067 0.07 0.1742
Onchocerca volvulus 0.0067 0.07 0.1742
Mycobacterium leprae Isocitrate lyase 0.0235 0.3192 0.4397
Loa Loa (eye worm) hypothetical protein 0.0227 0.3063 0.3481
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0164 0.2344
Brugia malayi Endoplasmin precursor 0.0033 0.0188 0.0097
Loa Loa (eye worm) oxidoreductase 0.0067 0.07 0.0708
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0224 0.0746
Brugia malayi beta-NAC-like protein 0.0035 0.0224 0.014
Onchocerca volvulus Huntingtin homolog 0.0123 0.1531 0.4169
Loa Loa (eye worm) oxidoreductase 0.0067 0.07 0.0708
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0624 0.895 0.8941
Schistosoma mansoni transcription factor btf3 0.0035 0.0224 0.0121
Entamoeba histolytica aldose reductase, putative 0.0067 0.07 1
Echinococcus multilocularis transcription factor btf3 0.0035 0.0224 0.0137
Mycobacterium leprae Conserved hypothetical protein 0.0048 0.0411 0.0457
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0224 0.0716
Echinococcus multilocularis heat shock protein 90 0.0033 0.0188 0.01
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0067 0.07 1
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0188 0.1615
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0601 0.8616 0.8604
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0032 0.018 0.0092
Mycobacterium ulcerans putative regulatory protein 0.0089 0.1017 0.1316
Trypanosoma cruzi Heat shock protein 83, putative 0.0033 0.0188 0.1615
Echinococcus multilocularis lipoxygenase domain containing protein 0.0223 0.3005 0.2943
Schistosoma mansoni apoptosis regulator bax 0.0601 0.8616 0.8601
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Brugia malayi bHLH-PAS transcription factor 0.0089 0.1017 0.1072
Schistosoma mansoni hypothetical protein 0.0049 0.0422 0.0321
Loa Loa (eye worm) hypothetical protein 0.0601 0.8616 1
Onchocerca volvulus 0.0258 0.3524 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0067 0.07 0.0617
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0031 0.0164 0.2344
Mycobacterium ulcerans isocitrate lyase AceAb 0.0502 0.7146 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0026 0.0089 0.5
Onchocerca volvulus 0.0049 0.0422 0.0928
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0067 0.07 1
Entamoeba histolytica aldose reductase, putative 0.0067 0.07 1
Mycobacterium ulcerans oxidoreductase 0.0067 0.07 0.0867
Onchocerca volvulus 0.0067 0.07 0.1742
Brugia malayi heat shock protein 90 0.0033 0.0188 0.0097
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0031 0.0164 0.1234
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 0.0502 0.7146 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0067 0.07 0.0617
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0067 0.07 0.0617
Trypanosoma brucei aldo-keto reductase, putative 0.0067 0.07 1
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.3231 0.3171
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) 0.0502 0.7146 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0031 0.0164 0.1234
Echinococcus granulosus intermediate filament protein 0.0027 0.0105 0.0016
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.07 1
Schistosoma mansoni microtubule-associated protein tau 0.0694 1 1
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0031 0.0164 0.1234
Leishmania major prostaglandin f synthase, putative 0.0067 0.07 1
Leishmania major protein kinase, putative 0.0031 0.0164 0.1234
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0067 0.07 0.0617
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0067 0.07 0.0617
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0224 0.0716
Loa Loa (eye worm) hypothetical protein 0.0228 0.3078 0.3499
Loa Loa (eye worm) oxidoreductase 0.0067 0.07 0.0708
Entamoeba histolytica hypothetical protein 0.0035 0.0224 0.0716
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0089 0.1267
Loa Loa (eye worm) hypothetical protein 0.0258 0.3524 0.4023
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0032 0.018 0.0092
Echinococcus granulosus geminin 0.0171 0.2231 0.2162
Onchocerca volvulus 0.009 0.1033 0.2713
Leishmania major aldo-keto reductase-like protein 0.0067 0.07 1
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0224 0.0149
Echinococcus multilocularis aldo keto reductase 0.0067 0.07 0.0617
Echinococcus multilocularis musashi 0.0027 0.0105 0.0016
Trichomonas vaginalis aldo/keto reductase, putative 0.0067 0.07 1
Plasmodium falciparum LCCL domain-containing protein 0.0223 0.3005 1
Treponema pallidum heat shock protein 90 0.0026 0.0089 0.5
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Schistosoma mansoni loxhd1 0.0223 0.3005 0.2931
Schistosoma mansoni heat shock protein 0.0033 0.0188 0.0083
Echinococcus multilocularis aryl hydrocarbon receptor 0.0259 0.354 0.3482
Echinococcus multilocularis aldehyde reductase 0.0048 0.0411 0.0326
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0224 0.3201
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0601 0.8616 0.8604
Echinococcus granulosus single minded 2 0.0089 0.1017 0.0937
Loa Loa (eye worm) doublecortin family protein 0.0223 0.3005 0.3413
Plasmodium falciparum heat shock protein 90 0.0033 0.0188 0.0624
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0067 0.07 0.0617
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.07 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0031 0.0164 0.1234
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0067 0.07 0.07
Loa Loa (eye worm) hypothetical protein 0.0223 0.3005 0.3413
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0422 0.0373
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Schistosoma mansoni hypothetical protein 0.0601 0.8616 0.8601
Mycobacterium leprae PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) 0.0502 0.7146 1
Schistosoma mansoni rab6-interacting 0.0223 0.3005 0.2931
Loa Loa (eye worm) hypothetical protein 0.0067 0.07 0.0708
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0038 0.0263 0.5
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0188 0.2677
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0601 0.8616 0.8604
Echinococcus granulosus transcription factor btf3 0.0035 0.0224 0.0137
Onchocerca volvulus 0.0067 0.07 0.1742
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0067 0.07 0.0617
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0067 0.07 0.07
Brugia malayi hypothetical protein 0.0031 0.0164 0.007
Schistosoma mansoni hypothetical protein 0.0171 0.2231 0.2149
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0224 0.2215
Echinococcus granulosus aldehyde reductase 0.0048 0.0411 0.0326
Echinococcus multilocularis lamin 0.0027 0.0105 0.0016
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0067 0.07 0.0867
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0067 0.07 1
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0224 0.0716
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0105 0.0009
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Trypanosoma brucei prostaglandin f synthase 0.0067 0.07 1
Onchocerca volvulus 0.0067 0.07 0.1742
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0067 0.07 0.0617
Giardia lamblia Aldose reductase 0.0067 0.07 1
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0032 0.018 0.0096
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0227 0.3063 0.3475
Plasmodium vivax multidomain scavenger receptor, putative 0.0223 0.3005 1
Schistosoma mansoni aldo-keto reductase 0.0067 0.07 0.0602
Echinococcus granulosus lamin dm0 0.0027 0.0105 0.0016
Schistosoma mansoni lipoxygenase 0.0624 0.895 0.8939
Loa Loa (eye worm) endoplasmin 0.0033 0.0188 0.0106
Echinococcus granulosus aldo keto reductase 0.0067 0.07 0.0617
Trichomonas vaginalis guanylate cyclase, putative 0.0031 0.0164 0.2344
Giardia lamblia Aldose reductase 0.0067 0.07 1
Onchocerca volvulus Huntingtin homolog 0.0123 0.1531 0.4169
Schistosoma mansoni lipoxygenase 0.0223 0.3005 0.2931
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.07 1
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0089 0.1267
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0089 0.1267
Schistosoma mansoni polycystin 1-related 0.0223 0.3005 0.2931
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.3231 0.3171
Echinococcus multilocularis aldo keto reductase 0.0067 0.07 0.0617

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 58 uM Cytotoxicity against Homo sapiens (human) MCF7 cells after 24 hr by MTT assay ChEMBL. No reference
MIC (functional) = 16 ug ml-1 Antifungal activity against Cryptococcus neoformans clinical isolate after 48 hr by NCCLS two-fold serial dilution method ChEMBL. No reference
MIC (functional) = 16 ug ml-1 Antifungal activity against Candida albicans ATCC 2091 after 48 hr by NCCLS two-fold serial dilution method ChEMBL. No reference
MIC (functional) = 16 ug ml-1 Antibacterial activity against Escherichia coli ATCC 35218 after 24 hr by NCCLS two-fold serial dilution method ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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