Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.1301 | 1 | 0.5 |
Echinococcus multilocularis | geminin | 0.0188 | 0.1121 | 0.0188 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.1301 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1301 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.1301 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.1301 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0337 | 0.2308 | 0.2308 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0159 | 0.0893 | 0.0893 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0788 | 0.5904 | 0.5474 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1301 | 1 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.1301 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0058 | 0.0083 | 0.0083 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1301 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1301 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.1301 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1301 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.1301 | 1 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0337 | 0.2308 | 0.2308 |
Mycobacterium ulcerans | hypothetical protein | 0.0177 | 0.1037 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0337 | 0.2308 | 0.2308 |
Onchocerca volvulus | 0.0168 | 0.0959 | 0.5 | |
Echinococcus granulosus | mitogen activated protein kinase | 0.1301 | 1 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0159 | 0.0893 | 0.0893 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0177 | 0.1037 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.1301 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.1301 | 1 | 0.5 |
Echinococcus granulosus | geminin | 0.0188 | 0.1121 | 0.0188 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.1301 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.1301 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1301 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0168 | 0.0959 | 0.0009 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.1301 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.1301 | 1 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0337 | 0.2308 | 0.1553 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0959 | 0.0009 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 200 ug ml-1 | Antimicrobial activity against Candida albicans MTCC 227 after 24 to 48 hr by broth microdilution method | ChEMBL. | No reference |
MIC (functional) | = 500 ug ml-1 | Antimicrobial activity against Escherichia coli MTCC 443 after 24 to 48 hr by broth microdilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.