Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled | Starlite/ChEMBL | No references |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Schistosoma japonicum | 5-hydroxytryptamine receptor, putative | Get druggable targets OG5_133680 | All targets in OG5_133680 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133680 | All targets in OG5_133680 |
Schistosoma japonicum | ko:K04165 Oamb gene product from transcript, putative | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | AT19640p | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | 390 aa | 335 aa | 21.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0353 | 0.7748 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0353 | 0.7748 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0353 | 0.7748 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0353 | 0.7748 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0353 | 0.7748 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0353 | 0.7748 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0353 | 0.7748 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0353 | 0.7748 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0353 | 0.7748 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0353 | 0.7748 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0353 | 0.7748 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0353 | 0.7748 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0353 | 0.7748 | 0.7748 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0363 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0353 | 0.7748 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0353 | 0.7748 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0353 | 0.7748 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0353 | 0.7748 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0353 | 0.7748 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0353 | 0.7748 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 6288 nM | Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay | ChEMBL. | No reference |
Ki (binding) | > 10000 nM | Binding affinity to Homo sapiens (human) 5HT1B receptor by radioligand binding assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.