Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | 5-hydroxytryptamine receptor, putative | Get druggable targets OG5_133680 | All targets in OG5_133680 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133680 | All targets in OG5_133680 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0353 | 0.7748 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0353 | 0.7748 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0353 | 0.7748 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0353 | 0.7748 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0353 | 0.7748 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0353 | 0.7748 | 0.7748 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0353 | 0.7748 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0353 | 0.7748 | 0.5 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0363 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0353 | 0.7748 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0353 | 0.7748 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0353 | 0.7748 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0353 | 0.7748 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0353 | 0.7748 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0353 | 0.7748 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0353 | 0.7748 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0353 | 0.7748 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0353 | 0.7748 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0353 | 0.7748 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0353 | 0.7748 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 7788 nM | Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.