Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | DINP protein human, muc B family | 0.0021 | 0.1847 | 0.5 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0034 | 0.5597 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0021 | 0.1847 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.9701 | 0.9633 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1847 | 0.1904 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0021 | 0.1847 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.1847 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0048 | 0.9701 | 0.9633 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0048 | 0.9701 | 1 |
Trypanosoma brucei | unspecified product | 0.0021 | 0.1847 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1847 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1847 | 0.1904 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1847 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1847 | 0.1904 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0021 | 0.1847 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.1847 | 0.1904 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.1847 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0048 | 0.9701 | 0.9633 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0021 | 0.1847 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0034 | 0.5597 | 0.4775 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.1847 | 0.1904 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.1847 | 0.1904 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1847 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1847 | 0.1904 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0048 | 0.9701 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0048 | 0.9701 | 0.9633 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1847 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1847 | 0.1904 |
Leishmania major | DNA polymerase eta, putative | 0.0048 | 0.9701 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0021 | 0.1847 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0034 | 0.5597 | 0.4775 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0048 | 0.9701 | 0.9633 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1847 | 0.1904 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 19 % | Inhibition of cyclooxygenase-1 in Homo sapiens (human) whole blood assessed as thromboxane B2 production at 10 uM after 1 hr by enzyme immunoassay | ChEMBL. | No reference |
Inhibition (binding) | = 76 % | Inhibition of cyclooxygenase-2 in Homo sapiens (human) whole blood assessed as LPS-induced PGE2 production at 10 uM incubated 15 min prior to LPS challenge measured after 24 hr by enzyme immunoassay | ChEMBL. | No reference |
Inhibition (binding) | = 93 % | Inhibition of cyclooxygenase-1 in Homo sapiens (human) whole blood assessed as thromboxane B2 production at 100 uM after 1 hr by enzyme immunoassay | ChEMBL. | No reference |
Inhibition (binding) | = 99 % | Inhibition of cyclooxygenase-2 in Homo sapiens (human) whole blood assessed as LPS-induced PGE2 production at 100 uM incubated 15 min prior to LPS challenge measured after 24 hr by enzyme immunoassay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.