Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0312 | 0.0834 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.1955 | 0.5224 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0312 | 0.1115 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0021 | 0.0312 | 0.1115 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0021 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.1955 | 0.6982 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0059 | 0.2801 | 0.2801 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1955 | 0.1955 |
Schistosoma mansoni | thyroid hormone receptor | 0.0021 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0312 | 0.1115 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0312 | 0.0834 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0021 | 0.0312 | 0.0312 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0073 | 0.3744 | 0.3744 |
Onchocerca volvulus | 0.0021 | 0.0312 | 0.5 | |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0021 | 0.0312 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0021 | 0.0312 | 0.0834 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0312 | 0.1115 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0021 | 0.0312 | 0.0312 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0021 | 0.0312 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0021 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.2218 | 0.7918 |
Schistosoma mansoni | jumonji domain containing protein | 0.0059 | 0.2801 | 0.2801 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0021 | 0.0312 | 0.0834 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0021 | 0.0312 | 0.0312 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0021 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0312 | 0.1115 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.0312 | 0.0312 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0021 | 0.0312 | 0.1115 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0021 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1191 | 0.4253 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0073 | 0.3744 | 0.3744 |
Brugia malayi | ecdysteroid receptor | 0.0021 | 0.0312 | 0.0834 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1955 | 0.1955 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0021 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0312 | 0.1115 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0059 | 0.2801 | 0.2801 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0312 | 0.0834 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.0312 | 0.0312 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0021 | 0.0312 | 0.0312 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.3744 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.3744 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0312 | 0.0834 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0312 | 0.0834 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0312 | 0.1115 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0312 | 0.0834 |
Brugia malayi | jmjC domain containing protein | 0.0059 | 0.2801 | 0.7481 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.3744 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0312 | 0.0834 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.2218 | 0.5924 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0021 | 0.0312 | 0.0834 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1955 | 0.1955 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.0312 | 0.0312 |
Brugia malayi | steroid hormone receptor | 0.0021 | 0.0312 | 0.0834 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0021 | 0.0312 | 0.0834 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1191 | 0.3182 |
Brugia malayi | nuclear hormone receptor | 0.0021 | 0.0312 | 0.0834 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0059 | 0.2801 | 0.2801 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0312 | 0.1115 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0312 | 0.1115 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0021 | 0.0312 | 0.0312 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.3744 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.0312 | 0.0312 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0312 | 0.0834 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0021 | 0.0312 | 0.0312 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.0312 | 0.0312 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1955 | 0.1955 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1955 | 0.1955 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0312 | 0.1115 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0021 | 0.0312 | 0.0312 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0021 | 0.0312 | 0.0312 |
Brugia malayi | jmjC domain containing protein | 0.0059 | 0.2801 | 0.7481 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0021 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.2218 | 0.7918 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.0312 | 0.0312 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0312 | 0.0834 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0312 | 0.0834 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0021 | 0.0312 | 0.0312 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0059 | 0.2801 | 0.2801 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0312 | 0.1115 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1955 | 0.1955 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1955 | 0.1955 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.2218 | 0.5924 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0059 | 0.2801 | 0.2801 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0312 | 0.1115 |
Brugia malayi | hypothetical protein | 0.0073 | 0.3744 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0021 | 0.0312 | 0.0312 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0021 | 0.0312 | 0.0312 |
Brugia malayi | nuclear receptor NHR-88 | 0.0021 | 0.0312 | 0.0834 |
Schistosoma mansoni | nuclear hormone receptor | 0.0021 | 0.0312 | 0.0312 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1191 | 0.1191 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0312 | 0.1115 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0059 | 0.2801 | 0.2801 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0073 | 0.3744 | 0.3744 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.0312 | 0.0312 |
Schistosoma mansoni | thyroid hormone receptor | 0.0021 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0059 | 0.2801 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0312 | 0.0834 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0312 | 0.1115 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0021 | 0.0312 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.0312 | 0.0312 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.3744 | 0.3744 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0312 | 0.0834 |
Echinococcus multilocularis | geminin | 0.0169 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0312 | 0.1115 |
Echinococcus granulosus | FTZ F1 alpha | 0.0021 | 0.0312 | 0.0312 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.