Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.1886 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.1886 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1886 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.1886 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1886 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.1886 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1886 | 1 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.1886 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1886 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1886 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.1886 | 1 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.1886 | 1 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1886 | 1 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.1886 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.1886 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.1886 | 1 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.1886 | 1 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1886 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.1886 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.1886 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 5 mm | Antifungal activity against Candida albicans at 100 ug/ml by cup-plate method | ChEMBL. | No reference |
IZ (functional) | = 10 mm | Antibacterial activity against Escherichia coli at 100 ug/ml by cup-plate method | ChEMBL. | No reference |
Ratio (functional) | = 0.55 | Ratio of compound IZ to amphotericin B IZ for Candida albicans | ChEMBL. | No reference |
Ratio (functional) | = 0.66 | Ratio of compound IZ to ciprofloxacin IZ for Escherichia coli | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.