Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0054 | 0 | 0.5 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0334 | 0.7838 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0228 | 0.4865 | 0.5334 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0379 | 0.912 | 1 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0163 | 0.3042 | 0.3881 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0086 | 0.088 | 0.088 |
Loa Loa (eye worm) | hypothetical protein | 0.0411 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0131 | 0.2162 | 0.2162 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0228 | 0.4865 | 0.4865 |
Brugia malayi | Carboxylesterase family protein | 0.0228 | 0.4865 | 0.6207 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0411 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0228 | 0.4865 | 0.4865 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0302 | 0.6958 | 0.8878 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0054 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0228 | 0.4865 | 0.4865 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.4865 | 0.4865 |
Echinococcus granulosus | carboxylesterase 5A | 0.0228 | 0.4865 | 0.4865 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.028 | 0.6319 | 0.6929 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0228 | 0.4865 | 0.4865 |
Brugia malayi | Carboxylesterase family protein | 0.0228 | 0.4865 | 0.6207 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.028 | 0.6319 | 0.6319 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0086 | 0.088 | 0.1122 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0163 | 0.3042 | 0.3335 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0086 | 0.088 | 0.088 |
Echinococcus granulosus | acetylcholinesterase | 0.0228 | 0.4865 | 0.4865 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.4865 | 0.4865 |
Echinococcus granulosus | acetylcholinesterase | 0.0228 | 0.4865 | 0.4865 |
Loa Loa (eye worm) | carboxylesterase | 0.0228 | 0.4865 | 0.4865 |
Loa Loa (eye worm) | glutamate receptor | 0.0334 | 0.7838 | 0.7838 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.028 | 0.6319 | 0.6319 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.088 | 0.088 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | uM | Inhibitory activity against 5-lipoxygenase in intact rat basophilic leukemia cells stimulated with the calciumionophore A-23,187; Inactive(N)= <50% inhibition at 10 microM | ChEMBL. | 8295221 |
IC50 (binding) | uM | Inhibitory activity against Prostaglandin G/H synthase in intact rat basophilic leukemia cells stimulated with the calciumionophore A-23,187; N=Inactive | ChEMBL. | 8295221 |
IC50 (binding) | N 0 uM | Inhibitory activity against 5-lipoxygenase in intact rat basophilic leukemia cells stimulated with the calciumionophore A-23,187; Inactive(N)= <50% inhibition at 10 microM | ChEMBL. | 8295221 |
IC50 (binding) | 0 uM | Inhibitory activity against Prostaglandin G/H synthase in intact rat basophilic leukemia cells stimulated with the calciumionophore A-23,187; N=Inactive | ChEMBL. | 8295221 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.