TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 548.157 | Formula: C30H46ClN3O4
H donors: 0 H acceptors: 3 LogP: 7.97 Rotable bonds: 20
Rule of 5 violations (Lipinski): 2
SMILES: CCCCCCCCCCC(=O)N(C(=O)c1n(C)nc(c1Cl)C)CCOc1ccc(cc1C)CCOCC
InChi: 1S/C30H46ClN3O4/c1-6-8-9-10-11-12-13-14-15-27(35)34(30(36)29-28(31)24(4)32-33(29)5)19-21-38-26-17-16-25(22-23(26)3)18-20-37-7-2/h16-17,22H,6-15,18-21H2,1-5H3
InChiKey: OQQBSNCUAJWRHI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Giardia lamblia	Cathepsin B precursor	0.01	0.0973	0.5
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0068	0.051	0.1202
Schistosoma mansoni	amine GPCR	0.0068	0.051	0.1202
Echinococcus granulosus	dro:myosuppressin receptor	0.0068	0.051	0.1202
Echinococcus multilocularis	neuropeptide receptor A26	0.0068	0.051	0.1218
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Brugia malayi	hypothetical protein	0.0068	0.051	0.0421
Onchocerca volvulus		0.0068	0.051	1
Schistosoma mansoni	opsin-like receptor	0.0068	0.051	0.1202
Entamoeba histolytica	cysteine proteinase, putative	0.0052	0.027	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0068	0.051	0.1218
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0052	0.027	0.0529
Brugia malayi	calpain family protein 1	0.0053	0.0289	0.0197
Schistosoma mansoni	neuropeptide F-like receptor	0.0068	0.051	0.1202
Schistosoma mansoni	hypothetical protein	0.0068	0.051	0.1202
Brugia malayi	Serotonin receptor	0.0068	0.051	0.0421
Schistosoma mansoni	cathepsin F (C01 family)	0.0052	0.027	0.0511
Echinococcus granulosus	hypothetical protein	0.0068	0.051	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Echinococcus granulosus	g-protein coupled receptor	0.0068	0.051	0.1202
Brugia malayi	Cathepsin L-like precursor	0.0052	0.027	0.0179
Schistosoma mansoni	neuropeptide F-like receptor	0.0068	0.051	0.1202
Brugia malayi	Dopamine receptor protein 1	0.0068	0.051	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0052	0.027	0.027
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Brugia malayi	hypothetical protein	0.0068	0.051	0.0421
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0068	0.051	0.1218
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0068	0.051	0.1218
Schistosoma mansoni	neuropeptide receptor	0.0068	0.051	0.1202
Brugia malayi	hypothetical protein	0.0068	0.051	0.0421
Loa Loa (eye worm)	G-protein coupled receptor	0.0068	0.051	0.051
Schistosoma mansoni	biogenic amine receptor	0.0068	0.051	0.1202
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0068	0.051	0.1202
Echinococcus granulosus	cathepsin b	0.0279	0.3563	1
Loa Loa (eye worm)	calpain family protein 1	0.0039	0.0087	0.0087
Schistosoma mansoni	growth hormone secretagogue receptor	0.0068	0.051	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0093	0.0093
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0068	0.051	0.051
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0068	0.051	0.1218
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0068	0.051	0.1202
Schistosoma mansoni	cathepsin F (C01 family)	0.0052	0.027	0.0511
Echinococcus granulosus	rhodopsin orphan GPCR	0.0068	0.051	0.1202
Brugia malayi	hypothetical protein	0.0068	0.051	0.0421
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0279	0.3563	1
Echinococcus multilocularis	g protein coupled receptor	0.0068	0.051	0.1218
Echinococcus granulosus	neuropeptide s receptor	0.0068	0.051	0.1202
Echinococcus multilocularis	baculoviral IAP repeat containing protein	0.0039	0.0093	0.0019
Onchocerca volvulus		0.0052	0.027	0.5301
Onchocerca volvulus		0.0068	0.051	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0068	0.051	0.1202
Loa Loa (eye worm)	melatonin receptor type 1A	0.0068	0.051	0.051
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0068	0.051	0.1218
Echinococcus granulosus	neuropeptide receptor	0.0068	0.051	0.1202
Onchocerca volvulus	Cathepsin F homolog	0.0052	0.027	0.5301
Brugia malayi	Cathepsin L-like precursor	0.0052	0.027	0.0179
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0068	0.051	0.1202
Onchocerca volvulus		0.0068	0.051	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0068	0.051	0.1202
Onchocerca volvulus		0.0068	0.051	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0055	0.0323	0.0663
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0052	0.027	0.027
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Echinococcus granulosus	7TM GPCR rhodopsin	0.0068	0.051	0.1202
Schistosoma mansoni	amine GPCR	0.0068	0.051	0.1202
Brugia malayi	Cathepsin L-like precursor	0.0052	0.027	0.0179
Schistosoma mansoni	hypothetical protein	0.0068	0.051	0.1202
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.01	0.0973	0.2536
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Loa Loa (eye worm)	cysteine protease	0.0052	0.027	0.027
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0052	0.027	0.5
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Onchocerca volvulus		0.0068	0.051	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0052	0.027	0.0529
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Echinococcus granulosus	rhodopsin orphan GPCR	0.0068	0.051	0.1202
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0068	0.051	0.1202
Echinococcus multilocularis	fmrfamide receptor	0.0068	0.051	0.1218
Echinococcus granulosus	rhodopsin orphan GPCR	0.0068	0.051	0.1202
Echinococcus granulosus	g protein coupled receptor	0.0068	0.051	0.1202
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0052	0.027	0.5
Plasmodium vivax	vivapain-2	0.0052	0.027	0.5
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0068	0.051	0.1218
Brugia malayi	AKH receptor	0.0068	0.051	0.0421
Schistosoma mansoni	histamine h1 receptor	0.0068	0.051	0.1202
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0068	0.051	0.0421
Loa Loa (eye worm)	cathepsin B	0.01	0.0973	0.0973
Onchocerca volvulus		0.0052	0.027	0.5301
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0723	1	1
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0279	0.3563	0.3384
Brugia malayi	G-protein coupled receptor	0.0068	0.051	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0289	0.0289
Echinococcus multilocularis	orexin receptor type 2	0.0068	0.051	0.1218
Echinococcus multilocularis	dro:myosuppressin receptor	0.0068	0.051	0.1218
Echinococcus multilocularis	sex peptide receptor	0.0068	0.051	0.1218
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Plasmodium vivax	vivapain-2	0.0052	0.027	0.5
Echinococcus granulosus	cathepsin b	0.0279	0.3563	1
Onchocerca volvulus		0.0052	0.027	0.5301
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0068	0.051	0.1202
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0068	0.051	0.1218
Echinococcus granulosus	orexin receptor type 2	0.0068	0.051	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.01	0.0973	0.0722
Echinococcus multilocularis	g protein coupled receptor	0.0068	0.051	0.1218
Brugia malayi	RE15519p	0.0068	0.051	0.0421
Echinococcus granulosus	biogenic amine 5HT receptor	0.0068	0.051	0.1202
Echinococcus granulosus	cathepsin l1	0.0052	0.027	0.0511
Brugia malayi	G protein-coupled receptor F59B2.13	0.0068	0.051	0.0421
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0068	0.051	0.1218
Brugia malayi	Cathepsin L-like precursor	0.0052	0.027	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0052	0.027	0.027
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0068	0.051	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0068	0.051	0.1218
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0068	0.051	0.1218
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0068	0.051	0.1202
Brugia malayi	putative neuropeptide receptor	0.0068	0.051	0.0421
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0068	0.051	1
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0068	0.051	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Brugia malayi	Dopamine receptor	0.0068	0.051	0.0421
Echinococcus granulosus	neuropeptides capa receptor	0.0068	0.051	0.1202
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0068	0.051	0.1218
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0068	0.051	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Echinococcus granulosus	cathepsin l1	0.0052	0.027	0.0511
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0068	0.051	0.0421
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0068	0.051	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Entamoeba histolytica	cysteine protease, putative	0.0052	0.027	0.5
Echinococcus multilocularis	cathepsin b	0.0279	0.3563	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0068	0.051	0.1202
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0068	0.051	0.1202
Loa Loa (eye worm)	neuropeptide F receptor	0.0068	0.051	0.051
Loa Loa (eye worm)	hypothetical protein	0.0052	0.027	0.027
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0068	0.051	0.1202
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0055	0.0323	0.0663
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0068	0.051	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0052	0.027	0.0529
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0068	0.051	0.1202
Brugia malayi	hypothetical protein	0.0068	0.051	0.0421
Echinococcus granulosus	rhodopsin orphan GPCR	0.0068	0.051	0.1202
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0279	0.3563	1
Echinococcus multilocularis	allatostatin A receptor	0.0068	0.051	0.1218
Brugia malayi	hypothetical protein	0.0068	0.051	0.0421
Echinococcus multilocularis	cathepsin L cysteine protease	0.0052	0.027	0.0529
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Brugia malayi	Papain family cysteine protease containing protein	0.0052	0.027	0.0179
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0068	0.051	0.0421
Brugia malayi	neuropeptide F receptor	0.0068	0.051	0.0421
Giardia lamblia	Cathepsin B precursor	0.01	0.0973	0.5
Schistosoma mansoni	cathepsin F (C01 family)	0.0052	0.027	0.0511
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0068	0.051	0.1202
Schistosoma mansoni	opsin-like receptor	0.0068	0.051	0.1202
Schistosoma mansoni	amine GPCR	0.0068	0.051	0.1202
Echinococcus granulosus	tm gpcr rhodopsin	0.0068	0.051	0.1202
Loa Loa (eye worm)	calpain family protein 1	0.0053	0.0289	0.0289
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0055	0.0323	0.068
Brugia malayi	Dopamine receptor protein 2	0.0068	0.051	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Leishmania major	C-8 sterol isomerase-like protein	0.0723	1	1
Onchocerca volvulus		0.0068	0.051	1
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Brugia malayi	larval opioid receptor	0.0068	0.051	0.0421
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0068	0.051	0.1202
Brugia malayi	G protein-coupled receptor	0.0068	0.051	0.0421
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0068	0.051	0.1218
Schistosoma mansoni	amine GPCR	0.0068	0.051	0.1202
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0068	0.051	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Onchocerca volvulus		0.0068	0.051	1
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Brugia malayi	Cathepsin L-like precursor	0.0052	0.027	0.0179
Echinococcus granulosus	g protein coupled receptor	0.0068	0.051	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0068	0.051	0.0421
Echinococcus granulosus	g protein coupled receptor	0.0068	0.051	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0068	0.051	0.1218
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0068	0.051	0.1202
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0052	0.027	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0068	0.051	0.1218
Brugia malayi	cathepsin L-like precursor	0.0052	0.027	0.0179
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0052	0.027	0.0511
Echinococcus granulosus	neuropeptide receptor	0.0068	0.051	0.1202
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0068	0.051	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0052	0.027	0.027
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0053	0.0289	0.0563
Onchocerca volvulus		0.0068	0.051	1
Brugia malayi	hypothetical protein	0.0068	0.051	0.0421
Echinococcus multilocularis	serotonin receptor	0.0068	0.051	0.1218
Onchocerca volvulus	Cathepsin L homolog	0.0052	0.027	0.5301
Trypanosoma brucei	cysteine peptidase C (CPC)	0.01	0.0973	0.0722
Onchocerca volvulus		0.0052	0.027	0.5301
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0202	0.0202
Schistosoma mansoni	neuropeptide receptor	0.0068	0.051	0.1202
Brugia malayi	hypothetical protein	0.0068	0.051	0.0421
Schistosoma mansoni	neuropeptide receptor	0.0068	0.051	0.1202
Schistosoma mansoni	neuropeptide f receptor 76f	0.0068	0.051	0.1202
Brugia malayi	hypothetical protein	0.0068	0.051	0.0421
Echinococcus granulosus	biogenic amine 5HT receptor	0.0068	0.051	0.1202
Brugia malayi	follicle stimulating hormone receptor	0.0068	0.051	0.0421
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0068	0.051	0.1202
Echinococcus granulosus	tm gpcr rhodopsin	0.0068	0.051	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Onchocerca volvulus		0.0052	0.027	0.5301
Echinococcus granulosus	G protein coupled receptor 139	0.0068	0.051	0.1202
Schistosoma mansoni	amine GPCR	0.0068	0.051	0.1202
Echinococcus multilocularis	cysteine protease	0.0052	0.027	0.0529
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0068	0.051	0.1202
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0068	0.051	0.051
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0055	0.0323	0.0663
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0068	0.051	0.1218
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0068	0.051	0.1202
Onchocerca volvulus		0.0068	0.051	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0068	0.051	0.1202
Schistosoma mansoni	myosin xvIII	0.0068	0.051	0.1202
Echinococcus multilocularis	G protein coupled receptor 139	0.0068	0.051	0.1218
Echinococcus granulosus	neuropeptide FF receptor 2	0.0068	0.051	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Schistosoma mansoni	biogenic amine receptor	0.0068	0.051	0.1202
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0068	0.051	0.051
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0068	0.051	0.1202
Brugia malayi	calpain family protein 1	0.0053	0.0289	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0279	0.3563	0.3563
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0068	0.051	0.1218
Brugia malayi	Cathepsin L-like precursor	0.0052	0.027	0.0179
Onchocerca volvulus		0.0068	0.051	1
Toxoplasma gondii	cathepsin B	0.01	0.0973	1
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Onchocerca volvulus		0.0052	0.027	0.5301
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0068	0.051	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0068	0.051	0.0421
Brugia malayi	cathepsin B-like cysteine proteinase	0.0279	0.3563	0.3502
Echinococcus granulosus	fmrfamide receptor	0.0068	0.051	0.1202
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0068	0.051	0.1202
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0723	1	1
Echinococcus multilocularis	calpain A	0.0055	0.0323	0.068
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0068	0.051	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0068	0.051	0.1218
Schistosoma mansoni	biogenic amine receptor	0.0068	0.051	0.1202
Echinococcus granulosus	serotonin receptor	0.0068	0.051	0.1202
Brugia malayi	GnHR receptor homolog	0.0068	0.051	0.0421
Echinococcus multilocularis	neuropeptide Y receptor	0.0068	0.051	0.1218
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0068	0.051	0.1218
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Echinococcus granulosus	neuropeptide Y receptor	0.0068	0.051	0.1202
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0068	0.051	0.1218
Echinococcus multilocularis	somatostatin receptor	0.0068	0.051	0.1218
Loa Loa (eye worm)	TYRA-2 protein	0.0068	0.051	0.051
Brugia malayi	Serotonin receptor	0.0068	0.051	0.0421
Brugia malayi	sulfakinin receptor protein	0.0068	0.051	0.0421
Onchocerca volvulus		0.0052	0.027	0.5301
Echinococcus granulosus	allatostatin A receptor	0.0068	0.051	0.1202
Echinococcus granulosus	somatostatin receptor	0.0068	0.051	0.1202
Echinococcus granulosus	rhodopsin orphan GPCR	0.0068	0.051	0.1202
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0279	0.3563	1
Onchocerca volvulus		0.0068	0.051	1
Echinococcus multilocularis	inhibitor of apoptosis protein	0.0039	0.0093	0.0019
Brugia malayi	neuropeptide F receptor	0.0068	0.051	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Schistosoma mansoni	opsin-like receptor	0.0068	0.051	0.1202
Entamoeba histolytica	cysteine proteinase, putative	0.0052	0.027	0.5
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0068	0.051	0.1202
Echinococcus granulosus	neuropeptide receptor A26	0.0068	0.051	0.1202
Loa Loa (eye worm)	G-protein coupled receptor	0.0068	0.051	0.051
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0068	0.051	0.1218
Echinococcus multilocularis	g protein coupled receptor	0.0068	0.051	0.1218
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0068	0.051	0.1218
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0068	0.051	0.1202
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0068	0.051	0.1202
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0068	0.051	0.051
Schistosoma mansoni	adenoreceptor	0.0068	0.051	0.1202
Loa Loa (eye worm)	neuropeptide F receptor	0.0068	0.051	0.051
Echinococcus granulosus	neuropeptide Y receptor	0.0068	0.051	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Brugia malayi	hypothetical protein	0.0068	0.051	0.0421
Onchocerca volvulus		0.0068	0.051	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0068	0.051	0.1202
Brugia malayi	Melatonin receptor type 1A	0.0068	0.051	0.0421
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0052	0.027	0.0511
Loa Loa (eye worm)	hypothetical protein	0.0723	1	1
Onchocerca volvulus		0.0068	0.051	1
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Echinococcus granulosus	tm gpcr rhodopsin	0.0068	0.051	0.1202
Loa Loa (eye worm)	hypothetical protein	0.037	0.4878	0.4878
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0068	0.051	0.1218
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0068	0.051	0.1218
Echinococcus multilocularis	serotonin receptor	0.0068	0.051	0.1218
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0052	0.027	0.027
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0068	0.051	0.1218
Echinococcus multilocularis	neuropeptide Y receptor	0.0068	0.051	0.1218
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0068	0.051	0.1202
Echinococcus multilocularis	neuropeptide s receptor	0.0068	0.051	0.1218
Entamoeba histolytica	cysteine proteinase, putative	0.0052	0.027	0.5
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0068	0.051	0.051
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0068	0.051	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Echinococcus granulosus	calpain A	0.0055	0.0323	0.0663
Echinococcus multilocularis	neuropeptides capa receptor	0.0068	0.051	0.1218
Onchocerca volvulus		0.0052	0.027	0.5301
Echinococcus granulosus	neuropeptides capa receptor	0.0068	0.051	0.1202
Echinococcus multilocularis	cathepsin b	0.0279	0.3563	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0068	0.051	0.1202
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.01	0.0973	0.0722
Onchocerca volvulus		0.0039	0.0093	0.1829
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0068	0.051	0.1218
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.01	0.0973	1
Echinococcus multilocularis	fmrfamide receptor	0.0068	0.051	0.1218
Schistosoma mansoni	hypothetical protein	0.0068	0.051	0.1202
Onchocerca volvulus	Deterin homolog	0.0039	0.0093	0.1829
Onchocerca volvulus		0.0068	0.051	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0279	0.3563	1
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Brugia malayi	G-protein coupled receptor	0.0068	0.051	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0093	0.0093
Brugia malayi	Cathepsin L-like precursor	0.0052	0.027	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0052	0.027	0.0179
Onchocerca volvulus	Cathepsin L homolog	0.0052	0.027	0.5301
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Brugia malayi	ORL1-like opioid receptor	0.0068	0.051	0.0421
Echinococcus multilocularis	g-protein coupled receptor	0.0068	0.051	0.1218
Loa Loa (eye worm)	ctsf protein	0.0052	0.027	0.027
Giardia lamblia	Cathepsin B precursor	0.01	0.0973	0.5
Schistosoma mansoni	neuropeptide receptor	0.0068	0.051	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0087	0.0087
Echinococcus multilocularis	neuropeptide receptor	0.0068	0.051	0.1218
Onchocerca volvulus		0.0068	0.051	1
Schistosoma mansoni	hypothetical protein	0.0068	0.051	0.1202
Brugia malayi	Cathepsin L-like precursor	0.0052	0.027	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Echinococcus multilocularis	neuropeptide receptor	0.0068	0.051	0.1218
Loa Loa (eye worm)	hypothetical protein	0.0068	0.051	0.051
Onchocerca volvulus		0.0068	0.051	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0068	0.051	0.1202
Onchocerca volvulus		0.0068	0.051	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0068	0.051	0.1202
Loa Loa (eye worm)	fibroinase	0.0052	0.027	0.027
Echinococcus multilocularis	cysteine protease	0.0052	0.027	0.0529
Echinococcus granulosus	sex peptide receptor	0.0068	0.051	0.1202

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2269973

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1842046