Detailed information for compound 1842116

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 547.119 | Formula: C12H21BN5O11P3S
  • H donors: 6 H acceptors: 11 LogP: -4.57 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 4
  • SMILES: CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO[P@](=O)(OP(=O)(CP(=O)(O)O)O)B
  • InChi: 1S/C12H21BN5O11P3S/c1-33-12-16-9(14)6-10(17-12)18(3-15-6)11-8(20)7(19)5(28-11)2-27-32(13,26)29-31(24,25)4-30(21,22)23/h3,5,7-8,11,19-20H,2,4,13H2,1H3,(H,24,25)(H2,14,16,17)(H2,21,22,23)/t5-,7-,8-,11-,32+/m1/s1
  • InChiKey: ADRGMQYBPXHLCR-BUNLBPDVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis AGC family protein kinase 0.0192 0.1653 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0035 0.0133 0.0109
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.073 0.687 0.868
Brugia malayi Trypsin family protein 0.0079 0.0565 0.069
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0035 0.0133 0.0109
Brugia malayi C2 domain containing protein 0.0024 0.0024 0.0029
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0192 0.1653 0.1633
Schistosoma mansoni hypothetical protein 0.004 0.018 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0024 0.0145
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0266 0.0336
Brugia malayi Synapse defective protein 1 0.0024 0.0024 0.0029
Loa Loa (eye worm) hypothetical protein 0.0136 0.1108 0.1401
Brugia malayi C2 domain containing protein 0.0024 0.0024 0.0029
Toxoplasma gondii Elicitor-responsive protein, putative 0.0024 0.0024 0.0145
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0194 0.0171
Brugia malayi Trypsin family protein 0.0079 0.0565 0.069
Brugia malayi C2 domain containing protein 0.0024 0.0024 0.0029
Brugia malayi RhoGEF domain containing protein 0.0136 0.1108 0.1355
Onchocerca volvulus Protein ultraspiracle homolog 0.0035 0.0133 0.0296
Toxoplasma gondii ferlin family protein 0.0024 0.0024 0.0145
Schistosoma mansoni synaptotagmin 12 0.0024 0.0024 0.0024
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.1123 0.1102
Leishmania major basic transcription factor 3a, putative 0.0035 0.0134 0.0906
Loa Loa (eye worm) hypothetical protein 0.0079 0.0565 0.0714
Entamoeba histolytica diacylglycerol kinase, putative 0.0136 0.1108 0.6659
Trichomonas vaginalis vab10 spectraplakin, putative 0.0024 0.0024 0.0145
Loa Loa (eye worm) C2 domain-containing protein 0.0024 0.0024 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0024 0.0145
Trypanosoma brucei leucyl-tRNA synthetase, putative 0.0053 0.0307 0.174
Brugia malayi Variant SH3 domain containing protein 0.003 0.0088 0.0108
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.003
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0033 0.0269
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0192 0.1653 0.1633
Trypanosoma cruzi synaptotagmin, putative 0.0024 0.0024 0.0193
Brugia malayi hypothetical protein 0.0025 0.0033 0.0041
Brugia malayi protein kinase C II. 0.0417 0.384 0.4693
Schistosoma mansoni synaptotagmin 0.0024 0.0024 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0035 0.0133 0.0167
Loa Loa (eye worm) hypothetical protein 0.0035 0.0133 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0024 0.0145
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.003
Schistosoma mansoni unc-13 (munc13) 0.0159 0.1337 0.1337
Schistosoma mansoni valine-tRNA ligase 0.0053 0.0307 0.0307
Schistosoma mansoni cercarial elastase (S01 family) 0.0079 0.0565 0.0565
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0135 0.0111
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0033 0.0269
Schistosoma mansoni hypothetical protein 0.0281 0.2514 0.2514
Brugia malayi protein kinase C3,putative 0.014 0.1149 0.1404
Schistosoma mansoni cercarial elastase (S01 family) 0.0079 0.0565 0.0565
Brugia malayi photoreceptor-specific nuclear receptor 0.0035 0.0133 0.0162
Plasmodium falciparum isoleucine--tRNA ligase, putative 0.033 0.2996 1
Onchocerca volvulus 0.0136 0.1108 0.2959
Loa Loa (eye worm) variant SH3 domain-containing protein 0.003 0.0088 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0024 0.0145
Loa Loa (eye worm) hypothetical protein 0.0035 0.0133 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0024 0.0145
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0079 0.0565 0.069
Loa Loa (eye worm) raf kinase 0.0136 0.1108 0.1401
Loa Loa (eye worm) hypothetical protein 0.0032 0.0103 0.013
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0035 0.0133 0.0109
Echinococcus multilocularis Rac GTPase activating protein 1 0.0136 0.1108 0.1087
Brugia malayi C1-like domain containing protein 0.014 0.1149 0.1404
Schistosoma mansoni E3 ubiquitin-protein ligase nedd-4 0.0024 0.0024 0.0024
Loa Loa (eye worm) C2 domain-containing protein 0.0024 0.0024 0.003
Trichomonas vaginalis synaptotagmin, putative 0.0024 0.0024 0.0145
Trichomonas vaginalis annexin VII, putative 0.0024 0.0024 0.0145
Brugia malayi Synaptotagmin I 0.0024 0.0024 0.0029
Brugia malayi STAT protein, DNA binding domain containing protein 0.0347 0.3161 0.3863
Loa Loa (eye worm) hypothetical protein 0.0035 0.0133 0.0167
Onchocerca volvulus 0.0066 0.0432 0.1113
Trichomonas vaginalis AGC family protein kinase 0.0192 0.1653 1
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0117 0.0143
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.003
Echinococcus multilocularis serine threonine protein kinase 0.0918 0.8687 0.8684
Loa Loa (eye worm) hypothetical protein 0.0035 0.0133 0.0167
Plasmodium vivax ferlin, putative 0.0024 0.0024 0.0193
Schistosoma mansoni rab3 interacting molecule (rim)-related 0.0024 0.0024 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0024 0.0145
Brugia malayi steroid hormone receptor 0.0035 0.0133 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0035 0.0133 0.0162
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0035 0.0133 0.0109
Echinococcus multilocularis serine:threonine protein kinase N2 0.0192 0.1653 0.1633
Brugia malayi diacylglycerol kinase 0.0136 0.1108 0.1355
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0142 0.1173 0.1482
Entamoeba histolytica hypothetical protein 0.0136 0.1108 0.6659
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0136 0.1108 0.1401
Loa Loa (eye worm) hypothetical protein 0.0136 0.1108 0.1401
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0079 0.0565 0.0542
Brugia malayi Valyl-tRNA synthetase 0.0053 0.0307 0.0376
Loa Loa (eye worm) STAT protein 0.0347 0.3161 0.3994
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0266 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0024 0.0145
Brugia malayi C2 domain containing protein 0.0024 0.0024 0.0029
Echinococcus multilocularis isoleucyl tRNA synthetase, cytoplasmic 0.0149 0.1239 0.1218
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0142 0.1173 0.1173
Schistosoma mansoni hypothetical protein 0.0334 0.3035 0.3035
Schistosoma mansoni vav2 0.0142 0.1173 0.1173
Echinococcus granulosus protein kinase c iota type 0.0327 0.2966 0.2949
Echinococcus granulosus Mastin 0.0079 0.0565 0.0542
Toxoplasma gondii isoleucyl-tRNA synthetase family protein 0.0149 0.1239 0.7501
Entamoeba histolytica protein kinase, putative 0.0192 0.1653 1
Leishmania major valyl-tRNA synthetase, putative 0.0053 0.0307 0.2332
Echinococcus multilocularis protein dispatched 1 0.0047 0.025 0.0227
Onchocerca volvulus 0.0079 0.0565 0.1476
Onchocerca volvulus 0.0079 0.0565 0.1476
Brugia malayi Ras association domain family 1 isoform A 0.0136 0.1108 0.1355
Plasmodium vivax isoleucine--tRNA ligase, putative 0.0149 0.1239 1
Trichomonas vaginalis AGC family protein kinase 0.0192 0.1653 1
Schistosoma mansoni valine-tRNA ligase 0.0053 0.0307 0.0307
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0024 0.0024 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0035 0.0133 0.0162
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0035 0.0133 0.0133
Brugia malayi hypothetical protein 0.0066 0.0432 0.0528
Plasmodium falciparum ferlin, putative 0.0024 0.0024 0.008
Echinococcus multilocularis leucyl tRNA synthetase 0.0053 0.0307 0.0284
Loa Loa (eye worm) hypothetical protein 0.0035 0.0133 0.0167
Treponema pallidum valyl-tRNA synthetase 0.0053 0.0307 0.18
Schistosoma mansoni serine/threonine protein kinase 0.014 0.1149 0.1149
Echinococcus granulosus enteropeptidase 0.0079 0.0565 0.0542
Echinococcus granulosus isoleucyl trna synthetase mitochondrial 0.0117 0.0932 0.091
Echinococcus multilocularis transcription factor btf3 0.0035 0.0134 0.011
Loa Loa (eye worm) hypothetical protein 0.0079 0.0565 0.0714
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0035 0.0133 0.0109
Toxoplasma gondii MA3 domain-containing protein 0.0117 0.0929 0.5621
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0024 0.0145
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.003
Loa Loa (eye worm) hypothetical protein 0.0402 0.3689 0.4662
Trypanosoma cruzi cAMP binding protein, putative 0.0024 0.0024 0.0193
Onchocerca volvulus 0.0079 0.0565 0.1476
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0035 0.0133 0.0167
Echinococcus granulosus neuropeptide receptor A26 0.0453 0.4187 0.4173
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.003
Brugia malayi isoleucyl-tRNA synthetase 0.0149 0.1239 0.1515
Brugia malayi RhoGAP domain containing protein 0.0142 0.1173 0.1433
Entamoeba histolytica hypothetical protein 0.0035 0.0135 0.0682
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.003
Entamoeba histolytica hypothetical protein 0.0035 0.0135 0.0682
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0725 0.0885
Schistosoma mansoni hypothetical protein 0.0068 0.0454 0.0454
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.003
Schistosoma mansoni Mername-AA248 (C02 family) 0.0024 0.0024 0.0024
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0142 0.1173 0.1152
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0024 0.0193
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0035 0.0133 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0035 0.0133 0.0162
Trichomonas vaginalis synaptotagmin, putative 0.0024 0.0024 0.0145
Entamoeba histolytica hypothetical protein 0.0035 0.0135 0.0682
Trypanosoma cruzi valyl-tRNA synthetase, putative 0.0032 0.0103 0.083
Onchocerca volvulus Huntingtin homolog 0.0119 0.0952 0.2531
Echinococcus multilocularis protein kinase c epsilon type 0.0417 0.384 0.3825
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0024 0.0145
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.003
Schistosoma mansoni rabphilin-3a 0.0024 0.0024 0.0024
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0024 0.0024 0.003
Brugia malayi p70 ribosomal S6 kinase beta 0.0192 0.1653 0.2019
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0409 0.05
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0079 0.0565 0.0565
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0035 0.0133 0.0162
Echinococcus multilocularis thyroid hormone receptor alpha 0.0035 0.0133 0.0109
Brugia malayi leucyl-tRNA synthetase 0.0053 0.0307 0.0376
Echinococcus multilocularis raf serine:threonine protein kinase 0.0136 0.1108 0.1087
Toxoplasma gondii hypothetical protein 0.0024 0.0024 0.0145
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0053 0.0307 0.186
Loa Loa (eye worm) C2 domain-containing protein 0.0024 0.0024 0.003
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0134 0.0676
Brugia malayi RhoGAP domain containing protein 0.0136 0.1108 0.1355
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0032 0.0103 0.0622
Echinococcus multilocularis protein kinase c iota type 0.0327 0.2966 0.2949
Echinococcus multilocularis valyl tRNA synthetase 0.0053 0.0307 0.0284
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0024 0.0024 0.0145
Toxoplasma gondii valyl-tRNA synthetase 0.0053 0.0307 0.186
Brugia malayi Copine VIII 0.0024 0.0024 0.0029
Trichomonas vaginalis synaptotagmin, putative 0.0024 0.0024 0.0145
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0409 0.0409
Plasmodium falciparum double C2-like domain-containing protein 0.0024 0.0024 0.008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0035 0.0133 0.0162
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0033 0.0111
Giardia lamblia Isoleucyl-tRNA synthetase 0.0149 0.1239 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0035 0.0133 0.0109
Schistosoma mansoni protein kinase C mu 0.014 0.1149 0.1149
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0702 0.6601 0.6593
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0024 0.0145
Plasmodium falciparum valine--tRNA ligase, putative 0.0053 0.0307 0.1026
Echinococcus granulosus myotubularin protein 13 0.0136 0.1108 0.1087
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0079 0.0565 0.0565
Schistosoma mansoni cercarial elastase (S01 family) 0.0079 0.0565 0.0565
Mycobacterium tuberculosis Isoleucyl-tRNA synthetase IleS 0.0096 0.0728 0.1931
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0035 0.0133 0.0167
Trypanosoma cruzi valyl-tRNA synthetase, putative 0.0053 0.0307 0.248
Schistosoma mansoni cercarial elastase (S01 family) 0.0079 0.0565 0.0565
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.003
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0417 0.384 0.4852
Loa Loa (eye worm) trypsin family protein 0.0079 0.0565 0.0714
Toxoplasma gondii leucyl-tRNA synthetase 0.0053 0.0307 0.186
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0035 0.0133 0.0109
Schistosoma mansoni programmed cell death protein 0.0117 0.0929 0.0929
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.003
Loa Loa (eye worm) CAMK/PKD protein kinase 0.014 0.1149 0.1451
Toxoplasma gondii diacylglycerol kinase, putative 0.0136 0.1108 0.6708
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0024 0.0193
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0084 0.0606 0.0583
Echinococcus multilocularis serine:threonine protein kinase 38 0.0192 0.1653 0.1633
Brugia malayi WW domain containing protein 0.0024 0.0024 0.0029
Trichomonas vaginalis valyl-tRNA synthetase, putative 0.0032 0.0103 0.0622
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0035 0.0133 0.0167
Schistosoma mansoni synaptotagmin 0.0024 0.0024 0.0024
Plasmodium vivax ferlin, putative 0.0024 0.0024 0.0193
Entamoeba histolytica protein kinase, putative 0.0028 0.0064 0.0246
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0035 0.0133 0.0133
Entamoeba histolytica protein kinase, putative 0.0192 0.1653 1
Schistosoma mansoni hypothetical protein 0.0035 0.0135 0.0135
Schistosoma mansoni thyroid hormone receptor 0.0035 0.0133 0.0133
Schistosoma mansoni cercarial elastase (S01 family) 0.0079 0.0565 0.0565
Trichomonas vaginalis copine, putative 0.0024 0.0024 0.0145
Schistosoma mansoni hypothetical protein 0.004 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0133 0.0167
Leishmania major hypothetical protein, conserved 0.0024 0.0024 0.00000013978
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.014 0.1149 0.1404
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0024 0.0145
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0159 0.1337 0.1316
Plasmodium falciparum valine--tRNA ligase, putative 0.0053 0.0307 0.1026
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0035 0.0133 0.0133
Giardia lamblia Valine-tRNA ligase 0.0053 0.0307 0.248
Echinococcus multilocularis protein kinase c eta type 0.0136 0.1108 0.1087
Brugia malayi Protein kinase domain containing protein 0.014 0.1149 0.1404
Schistosoma mansoni nedd-4-like E3 ubiquitin-protein ligase 0.0024 0.0024 0.0024
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.079 0.7448 0.7442
Loa Loa (eye worm) hypothetical protein 0.0049 0.0266 0.0336
Schistosoma mansoni synaptotagmin 0.0024 0.0024 0.0024
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0188 0.1612 0.9758
Trypanosoma brucei valyl-tRNA synthetase, putative 0.0053 0.0307 0.174
Loa Loa (eye worm) hypothetical protein 0.0136 0.1108 0.1401
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0136 0.1108 0.1401
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0024 0.0193
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0032 0.0103 0.0079
Entamoeba histolytica valyl-tRNA synthetase, putative 0.0053 0.0307 0.174
Onchocerca volvulus 0.0079 0.0565 0.1476
Echinococcus multilocularis Mastin 0.0079 0.0565 0.0542
Mycobacterium tuberculosis Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA glycosylase) 0.0277 0.2484 1
Trichomonas vaginalis ion channel nompc, putative 0.0024 0.0024 0.0145
Trichomonas vaginalis AGC family protein kinase 0.0192 0.1653 1
Loa Loa (eye worm) hypothetical protein 0.0159 0.1337 0.1689
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0134 0.0811
Schistosoma mansoni cercarial elastase (S01 family) 0.0079 0.0565 0.0565
Mycobacterium tuberculosis Possible DNA glycosylase 0.0277 0.2484 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0565 0.0714
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0079 0.0565 0.0565
Brugia malayi nuclear hormone receptor 0.0035 0.0133 0.0162
Brugia malayi Hr1 repeat family protein 0.0192 0.1653 0.2019
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0409 0.0409
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0024 0.0024 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0024 0.0193
Schistosoma mansoni synaptotagmin 12 0.0024 0.0024 0.0024
Entamoeba histolytica PH domain containing protein kinase, putative 0.0071 0.0482 0.281
Brugia malayi C2 domain containing protein 0.0024 0.0024 0.0029
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0079 0.0565 0.0565
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0024 0.0145
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0024 0.0193
Brugia malayi hypothetical protein 0.0079 0.0565 0.069
Loa Loa (eye worm) AGC/NDR protein kinase 0.0192 0.1653 0.2088
Brugia malayi calpain 5 0.0024 0.0024 0.0029
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.003
Echinococcus granulosus N chimaerin 0.0142 0.1173 0.1152
Echinococcus multilocularis myotubularin protein 13 0.0136 0.1108 0.1087
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.003
Schistosoma mansoni programmed cell death protein 0.0117 0.0929 0.0929
Wolbachia endosymbiont of Brugia malayi formamidopyrimidine-DNA glycosylase 0.0277 0.2484 1
Echinococcus granulosus protein kinase C gamma type 0.0918 0.8687 0.8684
Loa Loa (eye worm) C2 domain-containing protein 0.0024 0.0024 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0024 0.0193
Toxoplasma gondii leucyl-tRNA synthetase (LeuRS2) 0.0053 0.0307 0.186
Echinococcus multilocularis expressed conserved protein 0.009 0.0668 0.0646
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0035 0.0133 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0024 0.0145
Loa Loa (eye worm) hypothetical protein 0.0119 0.0952 0.1202
Loa Loa (eye worm) hypothetical protein 0.0119 0.0952 0.1202
Trichomonas vaginalis synaptotagmin, putative 0.0024 0.0024 0.0145
Echinococcus granulosus geminin 0.0334 0.3035 0.3019
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0266 0.0325
Echinococcus multilocularis Diacylglycerol kinase theta 0.0136 0.1108 0.1087
Loa Loa (eye worm) hypothetical protein 0.0032 0.0103 0.013
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0079 0.0565 0.0565
Schistosoma mansoni diacylglycerol kinase theta 0.0136 0.1108 0.1108
Schistosoma mansoni hypothetical protein 0.0024 0.0024 0.0024
Brugia malayi CHE-14 protein 0.0041 0.0194 0.0237
Brugia malayi Protein kinase domain containing protein 0.0192 0.1653 0.2019
Schistosoma mansoni glut4 vesicle protein-related 0.0024 0.0024 0.0024
Echinococcus granulosus expressed conserved protein 0.009 0.0668 0.0646
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0024 0.0193
Schistosoma mansoni nuclear hormone receptor 0.0035 0.0133 0.0133
Onchocerca volvulus 0.0402 0.3689 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0117 0.0929 0.3101
Brugia malayi isoleucyl-tRNA synthetase family protein 0.0149 0.1239 0.1515
Brugia malayi C2 domain containing protein 0.0024 0.0024 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0194 0.1175
Plasmodium falciparum isoleucine--tRNA ligase, putative 0.0149 0.1239 0.4137
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0079 0.0565 0.0565
Schistosoma mansoni cercarial elastase (S01 family) 0.0079 0.0565 0.0565
Echinococcus multilocularis serine:threonine protein kinase N2 0.0258 0.2299 0.228
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0024 0.0145
Brugia malayi Steroid receptor seven-up type 2 0.0035 0.0133 0.0162
Leishmania major isoleucyl-tRNA synthetase, putative 0.0149 0.1239 1
Schistosoma mansoni rho gtpase activating protein 0.0024 0.0024 0.0024
Echinococcus multilocularis glycoprotein Antigen 5 0.0079 0.0565 0.0542
Echinococcus multilocularis valyl tRNA synthetase 0.0053 0.0307 0.0284
Loa Loa (eye worm) hypothetical protein 0.0136 0.1108 0.1401
Trichomonas vaginalis copine, putative 0.0024 0.0024 0.0145
Brugia malayi C2 domain containing protein 0.0024 0.0024 0.0029
Brugia malayi C2 domain containing protein 0.0024 0.0024 0.0029
Schistosoma mansoni steroid hormone receptor ad4bp 0.0035 0.0133 0.0133
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0142 0.1173 0.1152
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.014 0.1149 0.1127
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.003
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0024 0.0024 0.0029
Brugia malayi valyl-tRNA synthetase family protein 0.0053 0.0307 0.0376
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0079 0.0565 0.0542
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0035 0.0133 0.0296
Schistosoma mansoni hypothetical protein 0.004 0.018 0.018
Trichomonas vaginalis synaptotagmin, putative 0.0024 0.0024 0.0145
Leishmania major leucyl-tRNA synthetase, putative 0.0053 0.0307 0.2332
Echinococcus granulosus leucyl tRNA synthetase 0.0053 0.0307 0.0284
Mycobacterium ulcerans hypothetical protein 0.0079 0.0565 0.194
Echinococcus granulosus unc 13 munc13 0.0159 0.1337 0.1316
Schistosoma mansoni synaptotagmin 0.0024 0.0024 0.0024
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0409 0.0409
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0024 0.0145
Loa Loa (eye worm) steroid hormone receptor 0.0035 0.0133 0.0167
Loa Loa (eye worm) hypothetical protein 0.0096 0.0725 0.0915
Schistosoma mansoni diacylglycerol kinase theta 0.0136 0.1108 0.1108
Schistosoma mansoni hypothetical protein 0.0024 0.0024 0.0024
Schistosoma mansoni synaptic ras gtpase activating protein syngap 0.0024 0.0024 0.0024
Trichomonas vaginalis AGC family protein kinase 0.0192 0.1653 1
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0024 0.0145
Trichomonas vaginalis AGC family protein kinase 0.0192 0.1653 1
Echinococcus multilocularis leucyl tRNA synthetase 0.0053 0.0307 0.0284
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.1108 0.1108
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0024 0.0024 0.0193
Brugia malayi NEDD4.2 0.0024 0.0024 0.0029
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0084 0.0606 0.0583
Mycobacterium ulcerans formamidopyrimidine-DNA glycosylase 0.0277 0.2484 1
Chlamydia trachomatis isoleucine--tRNA ligase 0.0149 0.1239 1
Onchocerca volvulus 0.0079 0.0565 0.1476
Onchocerca volvulus 0.0032 0.0103 0.0215
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0922 0.1165
Loa Loa (eye worm) hypothetical protein 0.005 0.0284 0.0359
Loa Loa (eye worm) hypothetical protein 0.0402 0.3689 0.4662
Trichomonas vaginalis synaptotagmin, putative 0.0024 0.0024 0.0145
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0725 0.0702
Brugia malayi Trypsin family protein 0.0079 0.0565 0.069
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0035 0.0133 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0035 0.0133 0.0162
Schistosoma mansoni serine/threonine protein kinase 0.0192 0.1653 0.1653
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0033 0.0202
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0035 0.0133 0.0167
Loa Loa (eye worm) hypothetical protein 0.0033 0.0117 0.0148
Loa Loa (eye worm) hypothetical protein 0.0537 0.5002 0.6321
Onchocerca volvulus 0.0159 0.1337 0.3582
Schistosoma mansoni serine/threonine protein kinase 0.014 0.1149 0.1149
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0024 0.0024 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0024 0.0145
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0024 0.0024 0.0024
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0922 0.1165
Loa Loa (eye worm) hypothetical protein 0.0136 0.1108 0.1401
Brugia malayi Protein kinase domain containing protein 0.0192 0.1653 0.2019
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0409 0.0386
Loa Loa (eye worm) hypothetical protein 0.0136 0.1108 0.1401
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0079 0.0565 0.0542
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0024 0.0024 0.0145
Trichomonas vaginalis synaptotagmin, putative 0.0024 0.0024 0.0145
Schistosoma mansoni thyroid hormone receptor 0.0035 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0838 0.7914 1
Schistosoma mansoni hypothetical protein 0.0136 0.1108 0.1108
Brugia malayi Protein kinase domain containing protein 0.0192 0.1653 0.2019
Onchocerca volvulus 0.0117 0.0932 0.2478
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.003
Schistosoma mansoni protein kinase C 0.0159 0.1337 0.1337
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.003
Brugia malayi RNA binding protein 0.0063 0.0409 0.05
Brugia malayi bZIP transcription factor family protein 0.0084 0.0606 0.074
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0035 0.0133 0.0162
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.003
Echinococcus granulosus serine:threonine protein kinase N2 0.0071 0.0482 0.0459
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0192 0.1653 0.2088
Plasmodium falciparum leucine--tRNA ligase, putative 0.0053 0.0307 0.1026
Loa Loa (eye worm) C2 domain-containing protein 0.0024 0.0024 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0024 0.0145
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0134 0.1081
Schistosoma mansoni otoferlin 0.0024 0.0024 0.0024
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0192 0.1653 0.2088
Toxoplasma gondii Sma protein 0.0024 0.0024 0.0145
Schistosoma mansoni cercarial elastase (S01 family) 0.0079 0.0565 0.0565
Brugia malayi C2 domain containing protein 0.0024 0.0024 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0035 0.0133 0.0162
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0134 0.0676
Trypanosoma cruzi leucyl-tRNA synthetase, putative 0.0053 0.0307 0.248
Trypanosoma brucei isoleucyl-tRNA synthetase, putative 0.0149 0.1239 0.7464
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0024 0.0145
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.003
Echinococcus granulosus transcription factor btf3 0.0035 0.0134 0.011
Plasmodium vivax valine--tRNA ligase, putative 0.0053 0.0307 0.248
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0035 0.0133 0.0133
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0035 0.0133 0.0109
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0725 0.0702
Trypanosoma brucei rac serine-threonine kinase, putative 0.0192 0.1653 1
Echinococcus granulosus leucyl tRNA synthetase 0.0053 0.0307 0.0284
Loa Loa (eye worm) hypothetical protein 0.0079 0.0565 0.0714
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.003
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0192 0.1653 0.1633
Schistosoma mansoni cercarial elastase (S01 family) 0.0079 0.0565 0.0565
Schistosoma mansoni cercarial elastase (S01 family) 0.0079 0.0565 0.0565
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0159 0.1337 0.1316
Echinococcus granulosus serine:threonine protein kinase N2 0.0192 0.1653 0.1633
Mycobacterium ulcerans formamidopyrimidine-DNA glycosylase 0.0277 0.2484 1
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0134 0.0811
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0134 0.1081
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0024 0.0145
Schistosoma mansoni unc-13 (munc13) 0.0161 0.1356 0.1356
Onchocerca volvulus 0.0136 0.1108 0.2959
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.003
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0033 0.0111
Echinococcus granulosus raf serine:threonine protein kinase 0.0136 0.1108 0.1087
Schistosoma mansoni serine/threonine protein kinase 0.1053 1 1
Echinococcus granulosus valyl tRNA synthetase 0.0053 0.0307 0.0284
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.003
Schistosoma mansoni copine 0.0024 0.0024 0.0024
Brugia malayi TAR-binding protein 0.0063 0.0409 0.05
Echinococcus granulosus Rac GTPase activating protein 1 0.0136 0.1108 0.1087
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0035 0.0133 0.0167
Brugia malayi Variant SH3 domain containing protein 0.0142 0.1173 0.1433
Schistosoma mansoni serine/threonine protein kinase 0.0192 0.1653 0.1653
Echinococcus granulosus NDR protein kinase 0.0192 0.1653 0.1633
Echinococcus multilocularis transmembrane protease serine 3 0.0079 0.0565 0.0542
Toxoplasma gondii AGC kinase 0.0192 0.1653 1
Schistosoma mansoni fer-1-related 0.0024 0.0024 0.0024
Echinococcus granulosus ecdysone induced protein 78C 0.0035 0.0133 0.0109
Echinococcus multilocularis jun protein 0.0084 0.0606 0.0583
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0024 0.0145
Loa Loa (eye worm) hypothetical protein 0.0136 0.1108 0.1401
Entamoeba histolytica hypothetical protein 0.0035 0.0135 0.0682
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0024 0.0024 0.0024
Echinococcus multilocularis unc 13 (munc13) 0.0159 0.1337 0.1316
Trichomonas vaginalis copine, putative 0.0024 0.0024 0.0145
Schistosoma mansoni coup transcription factor 0.0035 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0593 0.5546 0.7008
Entamoeba histolytica diacylglycerol kinase, putative 0.0136 0.1108 0.6659
Onchocerca volvulus Huntingtin homolog 0.0119 0.0952 0.2531
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0192 0.1653 0.1633
Brugia malayi Protein kinase c protein 2 0.0866 0.8183 1
Entamoeba histolytica protein kinase, putative 0.0192 0.1653 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.1108 0.1401
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.003
Echinococcus granulosus protein kinase c epsilon type 0.0417 0.384 0.3825
Leishmania major hypothetical protein, conserved 0.0025 0.0033 0.0077
Trichomonas vaginalis AGC family protein kinase 0.0192 0.1653 1
Loa Loa (eye worm) RasGEF domain-containing protein 0.0136 0.1108 0.1401
Echinococcus multilocularis RNA directed DNA polymerase 0.0702 0.6601 0.6593
Brugia malayi beta-NAC-like protein 0.0035 0.0134 0.0164
Schistosoma mansoni serine/threonine protein kinase 0.1053 1 1
Trypanosoma cruzi isoleucyl-tRNA synthetase, putative 0.0149 0.1239 1
Plasmodium vivax hypothetical protein, conserved 0.0117 0.0929 0.7495
Trypanosoma cruzi synaptotagmin, putative 0.0024 0.0024 0.0193
Schistosoma mansoni hypothetical protein 0.0079 0.0565 0.0565
Onchocerca volvulus 0.0053 0.0307 0.0773
Echinococcus granulosus FTZ F1 alpha 0.0035 0.0133 0.0109
Brugia malayi LD23056p 0.0024 0.0024 0.0029
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0079 0.0565 0.0565
Entamoeba histolytica valyl tRNA synthetase, putative 0.0053 0.0307 0.174
Brugia malayi Pleckstrin Homology Domain 0.0136 0.1108 0.1355
Echinococcus granulosus valyl tRNA synthetase 0.0053 0.0307 0.0284
Echinococcus granulosus tar DNA binding protein 0.0063 0.0409 0.0386
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.014 0.1149 0.1127
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0079 0.0565 0.0542
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0409 0.0517
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0024 0.0145
Loa Loa (eye worm) hypothetical protein 0.0079 0.0565 0.0714
Mycobacterium ulcerans valyl-tRNA synthetase 0.0053 0.0307 0.0859
Trichomonas vaginalis copine, putative 0.0024 0.0024 0.0145
Treponema pallidum isoleucyl-tRNA synthetase 0.0149 0.1239 1
Mycobacterium ulcerans isoleucyl-tRNA synthetase 0.0149 0.1239 0.4773
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0035 0.0133 0.0133
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0032 0.0103 0.0079
Schistosoma mansoni hypothetical protein 0.0334 0.3035 0.3035
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0409 0.0409
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0024 0.0145
Trichomonas vaginalis synaptotagmin 1, 3, C.elegans, putative 0.0024 0.0024 0.0145
Echinococcus multilocularis N chimaerin 0.0142 0.1173 0.1152
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0035 0.0133 0.0162
Entamoeba histolytica protein kinase, putative 0.0192 0.1653 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0135 0.0111
Entamoeba histolytica isoleucyl-tRNA synthetase, putative 0.0149 0.1239 0.7464
Brugia malayi C2 domain containing protein 0.0024 0.0024 0.0029
Entamoeba histolytica hypothetical protein 0.0035 0.0134 0.0676
Schistosoma mansoni isoleucine--tRNA ligase 0.0149 0.1239 0.1239
Schistosoma mansoni hypothetical protein 0.0024 0.0024 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0024 0.0145
Schistosoma mansoni rac gtpase activating protein 0.0136 0.1108 0.1108
Echinococcus multilocularis geminin 0.0334 0.3035 0.3019
Trichomonas vaginalis isoleucyl, leucyl, tyrosyl, valyl and methionyl-tRNA synthetases, putative 0.0032 0.0103 0.0622
Schistosoma mansoni hypothetical protein 0.0079 0.0565 0.0565
Loa Loa (eye worm) hypothetical protein 0.0081 0.0584 0.0737
Echinococcus granulosus Diacylglycerol kinase theta 0.0136 0.1108 0.1087
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0134 0.0811
Loa Loa (eye worm) hypothetical protein 0.0402 0.3689 0.4662
Brugia malayi Trypsin-like protease protein 5 0.0079 0.0565 0.069
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0033 0.0058
Loa Loa (eye worm) hypothetical protein 0.0025 0.0033 0.0042
Loa Loa (eye worm) AGC/AKT protein kinase 0.0192 0.1653 0.2088
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0409 0.0409
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0035 0.0133 0.0109
Schistosoma mansoni isoleucine--tRNA ligase 0.0149 0.1239 0.1239
Schistosoma mansoni serine/threonine protein kinase 0.0417 0.384 0.384
Brugia malayi C2 domain containing protein 0.0024 0.0024 0.0029
Loa Loa (eye worm) hypothetical protein 0.0117 0.0932 0.1178
Schistosoma mansoni cercarial elastase (S01 family) 0.0079 0.0565 0.0565
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0035 0.0133 0.0109
Schistosoma mansoni unc-13 (munc13) 0.0024 0.0024 0.0024
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0035 0.0133 0.0109
Brugia malayi C2 domain containing protein 0.0024 0.0024 0.0029
Loa Loa (eye worm) copine family protein 0.0024 0.0024 0.003
Chlamydia trachomatis valine--tRNA ligase 0.0053 0.0307 0.18
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0024 0.0029
Schistosoma mansoni patched 1 0.0041 0.0194 0.0194
Toxoplasma gondii hypothetical protein 0.0024 0.0024 0.0145
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0024 0.0193
Brugia malayi ecdysteroid receptor 0.0035 0.0133 0.0162
Echinococcus multilocularis FTZ F1 alpha 0.0035 0.0133 0.0109
Echinococcus multilocularis neuropeptide s receptor 0.0453 0.4187 0.4173
Schistosoma mansoni serine/threonine protein kinase 0.0192 0.1653 0.1653
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0194 0.0245
Trichomonas vaginalis calcium-dependent lipid-binding protein, putative 0.0024 0.0024 0.0145
Onchocerca volvulus 0.0035 0.0133 0.0296
Trichomonas vaginalis AGC family protein kinase 0.0192 0.1653 1
Mycobacterium leprae Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA GLYCOSYLASE) 0.0277 0.2484 1
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0024 0.0145
Brugia malayi C2 domain containing protein 0.0024 0.0024 0.0029
Echinococcus multilocularis Protein kinase C, brain isozyme 0.1053 1 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0033 0.0269
Brugia malayi MH2 domain containing protein 0.0116 0.0922 0.1127
Loa Loa (eye worm) AGC/PKN protein kinase 0.0192 0.1653 0.2088
Brugia malayi C2 domain containing protein 0.0024 0.0024 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0035 0.0133 0.0162
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0134 0.0447
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0135 0.0135
Schistosoma mansoni synaptotagmin 0.0024 0.0024 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0024 0.0145
Schistosoma mansoni retinoic acid receptor RXR 0.0035 0.0133 0.0133
Schistosoma mansoni RAR-like nuclear receptor 0.0035 0.0133 0.0133
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0192 0.1653 0.2088
Schistosoma mansoni hypothetical protein 0.0024 0.0024 0.0024
Echinococcus granulosus protein kinase c eta type 0.0136 0.1108 0.1087
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0142 0.1173 0.1173
Toxoplasma gondii hypothetical protein 0.0024 0.0024 0.0145
Brugia malayi nuclear receptor NHR-88 0.0035 0.0133 0.0162
Plasmodium vivax double C2-like domain-containing protein, putative 0.0024 0.0024 0.0193
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0409 0.0517
Trichomonas vaginalis AGC family protein kinase 0.0192 0.1653 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.1239 0.1566
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0035 0.0133 0.0133
Echinococcus multilocularis enteropeptidase 0.0079 0.0565 0.0542
Trichomonas vaginalis AGC family protein kinase 0.0192 0.1653 1
Trichomonas vaginalis synaptotagmin 1, 3, C.elegans, putative 0.0024 0.0024 0.0145
Trichomonas vaginalis isoleucyl tRNA synthetase, putative 0.0149 0.1239 0.7501
Trypanosoma brucei C2 domain/Ankyrin repeats (3 copies), putative 0.0024 0.0024 0.00000010433
Echinococcus granulosus isoleucyl tRNA synthetase, cytoplasmic 0.0149 0.1239 0.1218
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0725 0.4302
Brugia malayi Copine family protein 0.0024 0.0024 0.0029
Echinococcus granulosus jun protein 0.0084 0.0606 0.0583
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.0133 0.0162
Trichomonas vaginalis splicing factor 3A subunit, putative 0.0024 0.0024 0.0145
Loa Loa (eye worm) RNA binding protein 0.0063 0.0409 0.0517
Brugia malayi hypothetical protein 0.0119 0.0952 0.1163
Schistosoma mansoni jun-related protein 0.0068 0.0454 0.0454
Schistosoma mansoni mctp-related 0.0024 0.0024 0.0024
Echinococcus granulosus programmed cell death protein 4 0.0117 0.0929 0.0907
Loa Loa (eye worm) hypothetical protein 0.0035 0.0133 0.0167
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0134 0.0811
Echinococcus granulosus RNA directed DNA polymerase 0.0702 0.6601 0.6593
Schistosoma mansoni hypothetical protein 0.0024 0.0024 0.0024
Trypanosoma cruzi cytoskeleton associated protein, putative 0.0024 0.0024 0.0193
Brugia malayi hypothetical protein 0.0035 0.0135 0.0165
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0192 0.1653 0.2088
Loa Loa (eye worm) hypothetical protein 0.0035 0.0133 0.0167
Trichomonas vaginalis Proline-rich protein, putative 0.0024 0.0024 0.0145
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0024 0.0024 0.003
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0035 0.0133 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0024 0.0145
Mycobacterium leprae isoleucyl-tRNA synthetase IleS 0.0149 0.1239 0.4282
Loa Loa (eye worm) synaptotagmin-1 0.0024 0.0024 0.003
Loa Loa (eye worm) hypothetical protein 0.0079 0.0565 0.0714
Loa Loa (eye worm) hypothetical protein 0.0136 0.1108 0.1401
Schistosoma mansoni serine/threonine protein kinase 0.0192 0.1653 0.1653
Trypanosoma cruzi cytoskeleton associated protein, putative 0.0024 0.0024 0.0193
Schistosoma mansoni transcription factor btf3 0.0035 0.0134 0.0134
Echinococcus granulosus X box binding protein 1 0.0281 0.2514 0.2496
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0024 0.0024 0.008
Brugia malayi diacylglycerol kinase 0.0136 0.1108 0.1355
Echinococcus multilocularis neuropeptide receptor A26 0.0453 0.4187 0.4173
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0134 0.0169
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.014 0.1149 0.1451
Toxoplasma gondii C2 domain-containing protein 0.0024 0.0024 0.0145
Loa Loa (eye worm) hypothetical protein 0.0702 0.6601 0.8341
Schistosoma mansoni synaptotagmin-like protein 0.0024 0.0024 0.0024
Echinococcus granulosus neuropeptide s receptor 0.0453 0.4187 0.4173
Echinococcus multilocularis programmed cell death protein 4 0.0117 0.0929 0.0907
Echinococcus multilocularis protein patched 0.0041 0.0194 0.0171
Echinococcus multilocularis ecdysone induced protein 78C 0.0035 0.0133 0.0109
Schistosoma mansoni hypothetical protein 0.004 0.018 0.018
Trypanosoma cruzi C2 domain/Ankyrin repeats (3 copies), putative 0.0024 0.0024 0.0193
Brugia malayi Synaptotagmin protein 3 0.0024 0.0024 0.0029
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0079 0.0565 0.0565
Trypanosoma cruzi Coiled-coil and C2 domain-containing protein 0.0024 0.0024 0.0193
Brugia malayi Trypsin family protein 0.0079 0.0565 0.069
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0194 0.0171
Toxoplasma gondii isoleucyl-tRNA synthetase, putative 0.0053 0.0307 0.186
Trichomonas vaginalis Circumsporozoite protein precursor, putative 0.0024 0.0024 0.0145
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0192 0.1653 0.1633
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0035 0.0133 0.0109
Schistosoma mansoni synaptotagmin 0.0024 0.0024 0.0024
Onchocerca volvulus 0.0079 0.0565 0.1476
Schistosoma mansoni leucyl-tRNA synthetase 0.0053 0.0307 0.0307
Echinococcus granulosus transmembrane protease serine 3 0.0079 0.0565 0.0542
Toxoplasma gondii tRNA synthetase, putative 0.0053 0.0307 0.186
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0035 0.0133 0.0162
Loa Loa (eye worm) hypothetical protein 0.0041 0.0194 0.0245
Loa Loa (eye worm) C2 domain-containing protein 0.0024 0.0024 0.003
Schistosoma mansoni atypical protein kinase C 0.0327 0.2966 0.2966
Trypanosoma cruzi C2 domain containing protein, putative 0.0024 0.0024 0.0193
Wolbachia endosymbiont of Brugia malayi isoleucyl-tRNA synthetase 0.0149 0.1239 0.4282
Loa Loa (eye worm) hypothetical protein 0.0053 0.0307 0.0388
Onchocerca volvulus Bile acid receptor homolog 0.0035 0.0133 0.0296
Entamoeba histolytica leucyl-tRNA synthetase, putative 0.0053 0.0307 0.174
Entamoeba histolytica protein kinase, putative 0.0028 0.0064 0.0246
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0024 0.0145
Brugia malayi phospholipase C homolog 0.0024 0.0024 0.0029
Loa Loa (eye worm) hypothetical protein 0.0079 0.0565 0.0714
Schistosoma mansoni protein kinase C mu 0.0136 0.1108 0.1108
Echinococcus multilocularis X box binding protein 1 0.0281 0.2514 0.2496
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0134 0.1081
Echinococcus granulosus glycoprotein Antigen 5 0.0079 0.0565 0.0542
Schistosoma mansoni hypothetical protein 0.0033 0.0117 0.0117
Trichomonas vaginalis copine, putative 0.0024 0.0024 0.0145
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0739 0.0739
Brugia malayi Synapse defective protein 1 0.0024 0.0024 0.0029
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0192 0.1653 0.1633
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0024 0.0024 0.0024
Plasmodium falciparum ferlin, putative 0.0024 0.0024 0.008
Echinococcus multilocularis isoleucyl tRNA synthetase, mitochondrial 0.0117 0.0932 0.091
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.1123 0.1102
Loa Loa (eye worm) isoleucyl-tRNA synthetase 0.0149 0.1239 0.1566
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0053 0.0307 0.186
Schistosoma mansoni methionine-tRNA synthetase 0.0032 0.0103 0.0103
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0194 0.0171
Plasmodium vivax hypothetical protein, conserved 0.0053 0.0307 0.248
Trichomonas vaginalis AGC family protein kinase 0.0192 0.1653 1
Schistosoma mansoni serine/threonine kinase 0.0192 0.1653 0.1653
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0024 0.0024 0.0145
Loa Loa (eye worm) Nedd4-PD 0.0024 0.0024 0.003

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) < 18 % Inhibition of human NTPDase8 assessed as amount of inorganic phosphate released using ATP as the substrate preincubated at 100 uM for 3 mins before substrate addition after 15 mins by malachite green reagent method ChEMBL. 24083941
Inhibition (binding) < 18 % Inhibition of human NTPDase3 assessed as amount of inorganic phosphate released using ATP as the substrate preincubated at 100 uM for 3 mins before substrate addition after 15 mins by malachite green reagent method ChEMBL. 24083941
Inhibition (binding) < 18 % Inhibition of human NTPDase2 assessed as amount of inorganic phosphate released using ATP as the substrate preincubated at 100 uM for 3 mins before substrate addition after 15 mins by malachite green reagent method ChEMBL. 24083941
Inhibition (binding) < 18 % Inhibition of human NTPDase1 assessed as amount of inorganic phosphate released using ATP as the substrate preincubated at 100 uM for 3 mins before substrate addition after 15 mins by malachite green reagent method ChEMBL. 24083941
Inhibition (binding) = 80 % Inhibition of human NPP1 expressed in COS7 cells assessed as production of p-nitrophenol using pnp-TMP as the substrate preincubated at 100 uM for 3 mins before substrate addition measured after 15 mins by HPLC analysis ChEMBL. 24083941
Inhibition (binding) = 90 % Inhibition of NPP3 in human HTB-85 cells assessed as production of p-nitrophenol using pnp-TMP at 100 uM measured after 20 mins by spectrophotometry ChEMBL. 24083941
Inhibition (binding) = 90 % Inhibition of NPP1 in human HTB-85 cells assessed as production of p-nitrophenol using pnp-TMP at 100 uM measured after 20 mins by spectrophotometry ChEMBL. 24083941
Ki (binding) = 56 uM Mixed type inhibition of human NPP1 expressed in COS7 cells assessed as production of p-nitrophenol using pnp-TMP as the substrate preincubated for 3 mins before substrate addition measured after 15 mins by Dixon/Cornish Bowden method ChEMBL. 24083941

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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