Detailed information for compound 1842129

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 262.304 | Formula: C14H18N2O3
  • H donors: 0 H acceptors: 1 LogP: 3.44 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1nn(c(=O)o1)Cc1ccc(cc1)CC(C)C
  • InChi: 1S/C14H18N2O3/c1-10(2)8-11-4-6-12(7-5-11)9-16-14(17)19-13(15-16)18-3/h4-7,10H,8-9H2,1-3H3
  • InChiKey: ZBCQHZORMUAUOD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens monoglyceride lipase Starlite/ChEMBL References
Homo sapiens fatty acid amide hydrolase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans similar to YJU3 Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis valacyclovir hydrolase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Echinococcus granulosus fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Plasmodium falciparum lysophospholipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania infantum monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Mycobacterium ulcerans lysophospholipase Get druggable targets OG5_127037 All targets in OG5_127037
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma congolense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
Plasmodium falciparum lysophospholipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma brucei monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma japonicum Fatty-acid amide hydrolase 1, putative Get druggable targets OG5_127783 All targets in OG5_127783
Leishmania mexicana monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
Brugia malayi amidase Get druggable targets OG5_127783 All targets in OG5_127783
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma cruzi monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma congolense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma brucei gambiense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Schistosoma mansoni amidase Get druggable targets OG5_127783 All targets in OG5_127783
Leishmania major monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma congolense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans similar to YJU3 Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma brucei monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Schistosoma mansoni fatty-acid amide hydrolase Get druggable targets OG5_127783 All targets in OG5_127783
Leishmania braziliensis monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Plasmodium vivax PST-A protein Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma brucei gambiense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania donovani monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Schistosoma japonicum Fatty-acid amide hydrolase 1, putative Get druggable targets OG5_127783 All targets in OG5_127783
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Plasmodium falciparum esterase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium falciparum lysophospholipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Echinococcus granulosus fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE Get druggable targets OG5_127037 All targets in OG5_127037
Echinococcus multilocularis fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma japonicum ko:K01175 fatty acid amide hydrolase [EC:3.1.-.-], putative Get druggable targets OG5_127783 All targets in OG5_127783
Mycobacterium tuberculosis Possible lysophospholipase Get druggable targets OG5_127037 All targets in OG5_127037
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major hypothetical protein, conserved fatty acid amide hydrolase 579 aa 471 aa 26.5 %
Plasmodium falciparum esterase, putative monoglyceride lipase 303 aa 254 aa 19.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.193 0.193
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.193 0.193
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Echinococcus granulosus neuropeptide FF receptor 2 0.0036 0.193 0.193
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.193 0.193
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.193 0.1916
Echinococcus granulosus allatostatin A receptor 0.0036 0.193 0.193
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0015 0.0017 0.0017
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.193 0.193
Schistosoma mansoni opsin-like receptor 0.0036 0.193 0.193
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.193 0.193
Brugia malayi Melatonin receptor type 1A 0.0036 0.193 0.1916
Schistosoma mansoni hypothetical protein 0.0036 0.193 0.193
Brugia malayi putative neuropeptide receptor 0.0036 0.193 0.1916
Brugia malayi Dopamine receptor protein 2 0.0036 0.193 0.1916
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0036 0.193 0.1916
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Schistosoma mansoni biogenic amine receptor 0.0036 0.193 0.193
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.193 0.193
Brugia malayi Serotonin receptor 0.0036 0.193 0.1916
Echinococcus multilocularis neuroglian 0.0015 0.0046 0.0046
Echinococcus multilocularis g protein coupled receptor 0.0036 0.193 0.193
Schistosoma mansoni growth hormone secretagogue receptor 0.0036 0.193 0.193
Echinococcus multilocularis g-protein coupled receptor 0.0036 0.193 0.193
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0036 0.193 0.193
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.193 0.193
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Brugia malayi neuropeptide F receptor 0.0036 0.193 0.1916
Loa Loa (eye worm) hypothetical protein 0.0123 1 1
Echinococcus granulosus somatostatin receptor 0.0036 0.193 0.193
Onchocerca volvulus 0.0036 0.193 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Brugia malayi hypothetical protein 0.0036 0.193 0.1916
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.193 0.193
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0123 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Schistosoma mansoni amidase 0.0123 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Schistosoma mansoni biogenic amine (5HT) receptor 0.0036 0.193 0.193
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0015 0.0017 0.0017
Schistosoma mansoni neuropeptide receptor 0.0036 0.193 0.193
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.193 0.193
Brugia malayi AKH receptor 0.0036 0.193 0.1916
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Echinococcus granulosus neuropeptide s receptor 0.0036 0.193 0.193
Echinococcus multilocularis sex peptide receptor 0.0036 0.193 0.193
Echinococcus multilocularis neuropeptides capa receptor 0.0036 0.193 0.193
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0036 0.193 0.193
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0015 0.0017 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.193 0.193
Schistosoma mansoni biogenic amine receptor 0.0036 0.193 0.193
Onchocerca volvulus 0.0036 0.193 1
Schistosoma mansoni hypothetical protein 0.0036 0.193 0.193
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.193 0.193
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.6416 0.5
Onchocerca volvulus 0.0036 0.193 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.193 0.193
Echinococcus multilocularis somatostatin receptor 0.0036 0.193 0.193
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.193 0.193
Echinococcus multilocularis allatostatin A receptor 0.0036 0.193 0.193
Brugia malayi Dopamine receptor 0.0036 0.193 0.1916
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0036 0.193 0.193
Echinococcus granulosus biogenic amine 5HT receptor 0.0036 0.193 0.193
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0015 0.0017 0.0017
Echinococcus granulosus fmrfamide receptor 0.0036 0.193 0.193
Loa Loa (eye worm) hypothetical protein 0.0015 0.0046 0.0029
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0036 0.193 0.193
Schistosoma mansoni amine GPCR 0.0036 0.193 0.193
Echinococcus granulosus tachykinin peptides receptor 99D 0.0036 0.193 0.193
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Schistosoma mansoni alpha-1 adrenergic receptor 0.0036 0.193 0.193
Echinococcus multilocularis g protein coupled receptor 0.0036 0.193 0.193
Schistosoma mansoni opsin-like receptor 0.0036 0.193 0.193
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0036 0.193 0.193
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.193 0.193
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0036 0.193 0.193
Echinococcus multilocularis neuropeptide s receptor 0.0036 0.193 0.193
Brugia malayi hypothetical protein 0.0036 0.193 0.1916
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0036 0.193 0.193
Schistosoma mansoni hypothetical protein 0.0036 0.193 0.193
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0036 0.193 0.193
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Onchocerca volvulus 0.0036 0.193 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Brugia malayi GnHR receptor homolog 0.0036 0.193 0.1916
Echinococcus granulosus neuropeptide Y receptor 0.0036 0.193 0.193
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0036 0.193 0.193
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.6416 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0036 0.193 0.193
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Onchocerca volvulus 0.0036 0.193 1
Plasmodium falciparum lysophospholipase, putative 0.0084 0.6416 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0036 0.193 0.193
Brugia malayi putative neuropeptide receptor NPR1 0.0036 0.193 0.1916
Brugia malayi Serotonin receptor 0.0036 0.193 0.1916
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Schistosoma mansoni amine GPCR 0.0036 0.193 0.193
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0036 0.193 0.193
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0036 0.193 0.193
Loa Loa (eye worm) hypothetical protein 0.0024 0.0832 0.0816
Brugia malayi G-protein coupled receptor 0.0036 0.193 0.1916
Schistosoma mansoni opsin-like receptor 0.0036 0.193 0.193
Echinococcus multilocularis serotonin receptor 0.0036 0.193 0.193
Schistosoma mansoni hypothetical protein 0.0036 0.193 0.193
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Echinococcus multilocularis roundabout 2 0.0015 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.193 0.193
Brugia malayi Tachykinin-like peptides receptor 99D 0.0036 0.193 0.1916
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0038 0.217 0.217
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0036 0.193 0.193
Schistosoma mansoni amine GPCR 0.0036 0.193 0.193
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.6416 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Echinococcus granulosus twitchin 0.0015 0.0046 0.0046
Brugia malayi neuropeptide F receptor 0.0036 0.193 0.1916
Schistosoma mansoni amine GPCR 0.0036 0.193 0.193
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.193 0.193
Onchocerca volvulus 0.0036 0.193 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0036 0.193 0.193
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0036 0.193 0.193
Echinococcus multilocularis neuropeptide receptor A26 0.0036 0.193 0.193
Echinococcus multilocularis orexin receptor type 2 0.0036 0.193 0.193
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.193 0.193
Schistosoma mansoni nephrin 0.0015 0.0046 0.0046
Echinococcus granulosus neuropeptide Y receptor 0.0036 0.193 0.193
Echinococcus multilocularis G-protein coupled receptor, putative 0.0036 0.193 0.193
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.193 0.1916
Schistosoma mansoni amine GPCR 0.0036 0.193 0.193
Echinococcus granulosus roundabout 2 0.0015 0.0046 0.0046
Echinococcus granulosus neuropeptide receptor A26 0.0036 0.193 0.193
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Schistosoma mansoni biogenic amine receptor 0.0036 0.193 0.193
Echinococcus multilocularis neuropeptide Y receptor 0.0036 0.193 0.193
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.193 0.193
Brugia malayi RE15519p 0.0036 0.193 0.1916
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.193 0.193
Echinococcus multilocularis neuropeptide receptor 0.0036 0.193 0.193
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Echinococcus multilocularis sodium channel protein 0.0038 0.217 0.217
Echinococcus granulosus fatty acid amide hydrolase 1 0.0015 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.193 0.193
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0015 0.0017 0.0017
Echinococcus granulosus g protein coupled receptor 0.0036 0.193 0.193
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0015 0.0017 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Brugia malayi G protein-coupled receptor 0.0036 0.193 0.1916
Echinococcus granulosus hypothetical protein 0.0036 0.193 0.193
Echinococcus granulosus 7tm_1 domain containing protein 0.0036 0.193 0.193
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.193 0.193
Brugia malayi ORL1-like opioid receptor 0.0036 0.193 0.1916
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0038 0.217 0.3364
Schistosoma mansoni fatty-acid amide hydrolase 0.0123 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0036 0.193 0.193
Trypanosoma brucei monoglyceride lipase, putative 0.0084 0.6416 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0036 0.193 0.193
Echinococcus granulosus sodium channel protein 0.0038 0.217 0.217
Mycobacterium ulcerans lysophospholipase 0.0084 0.6416 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Echinococcus multilocularis neuropeptide receptor 0.0036 0.193 0.193
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.193 0.193
Echinococcus granulosus fatty acid amide hydrolase 1 0.0123 1 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0036 0.193 0.1916
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.193 0.193
Schistosoma mansoni neuropeptide F-like receptor 0.0036 0.193 0.193
Echinococcus multilocularis G protein coupled receptor 139 0.0036 0.193 0.193
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0036 0.193 0.193
Onchocerca volvulus 0.0036 0.193 1
Plasmodium vivax PST-A protein 0.0084 0.6416 1
Echinococcus multilocularis fmrfamide receptor 0.0036 0.193 0.193
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.193 0.193
Onchocerca volvulus 0.0036 0.193 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0036 0.193 1
Echinococcus granulosus g protein coupled receptor 0.0036 0.193 0.193
Schistosoma mansoni neuropeptide receptor 0.0036 0.193 0.193
Onchocerca volvulus 0.0036 0.193 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0036 0.193 0.1916
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0084 0.6416 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0036 0.193 0.193
Echinococcus multilocularis g protein coupled receptor 0.0036 0.193 0.193
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Brugia malayi hypothetical protein 0.0036 0.193 0.1916
Onchocerca volvulus 0.0036 0.193 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.193 0.1916
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0036 0.193 0.1916
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0036 0.193 0.1916
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0123 1 1
Brugia malayi follicle stimulating hormone receptor 0.0036 0.193 0.1916
Echinococcus multilocularis fmrfamide receptor 0.0036 0.193 0.193
Brugia malayi hypothetical protein 0.0036 0.193 0.1916
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.193 0.193
Echinococcus granulosus orexin receptor type 2 0.0036 0.193 0.193
Echinococcus granulosus 7TM GPCR rhodopsin 0.0036 0.193 0.193
Brugia malayi G protein-coupled receptor F59B2.13 0.0036 0.193 0.1916
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.6416 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.193 0.193
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Trypanosoma cruzi monoglyceride lipase, putative 0.0084 0.6416 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0036 0.193 0.193
Echinococcus granulosus neuropeptides capa receptor 0.0036 0.193 0.193
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0036 0.193 1
Loa Loa (eye worm) TYRA-2 protein 0.0036 0.193 0.1916
Loa Loa (eye worm) melatonin receptor type 1A 0.0036 0.193 0.1916
Echinococcus granulosus g-protein coupled receptor 0.0036 0.193 0.193
Brugia malayi hypothetical protein 0.0036 0.193 0.1916
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Schistosoma mansoni neuropeptide receptor 0.0036 0.193 0.193
Echinococcus granulosus G protein coupled receptor 139 0.0036 0.193 0.193
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.193 0.193
Leishmania major monoglyceride lipase, putative 0.0084 0.6416 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0036 0.193 0.193
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0084 0.6416 0.5
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.6416 0.5
Echinococcus granulosus peptide allatostatin:somatostatin 0.0036 0.193 0.193
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0015 0.0017 0.5
Mycobacterium tuberculosis Possible lysophospholipase 0.0084 0.6416 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.193 0.193
Echinococcus multilocularis neuropeptides capa receptor 0.0036 0.193 0.193
Brugia malayi hypothetical protein 0.0036 0.193 0.1916
Trypanosoma brucei monoglyceride lipase, putative 0.0084 0.6416 1
Schistosoma mansoni neuropeptide receptor 0.0036 0.193 0.193
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0036 0.193 0.193
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0036 0.193 0.193
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Onchocerca volvulus 0.0036 0.193 1
Echinococcus multilocularis serotonin receptor 0.0036 0.193 0.193
Schistosoma mansoni histamine h1 receptor 0.0036 0.193 0.193
Echinococcus granulosus fatty acid amide hydrolase 1 0.0123 1 1
Brugia malayi Dopamine receptor protein 1 0.0036 0.193 0.1916
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0084 0.6416 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Echinococcus granulosus sex peptide receptor 0.0036 0.193 0.193
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.6416 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.193 0.193
Schistosoma mansoni neuropeptide f receptor 76f 0.0036 0.193 0.193
Brugia malayi hypothetical protein 0.0036 0.193 0.1916
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Echinococcus granulosus alpha 1A adrenergic receptor 0.0036 0.193 0.193
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.193 0.193
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.193 0.1916
Schistosoma mansoni biogenic amine (5HT) receptor 0.0036 0.193 0.193
Schistosoma mansoni myosin xvIII 0.0036 0.193 0.193
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0036 0.193 0.193
Echinococcus granulosus dro:myosuppressin receptor 0.0036 0.193 0.193
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0036 0.193 0.1916
Echinococcus granulosus biogenic amine 5HT receptor 0.0036 0.193 0.193
Brugia malayi larval opioid receptor 0.0036 0.193 0.1916
Echinococcus granulosus serotonin receptor 0.0036 0.193 0.193
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0036 0.193 0.1916
Echinococcus granulosus g protein coupled receptor 0.0036 0.193 0.193
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.6416 0.5
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0036 0.193 0.1916
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0036 0.193 0.193
Echinococcus multilocularis dro:myosuppressin receptor 0.0036 0.193 0.193
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.193 0.193
Echinococcus granulosus neuropeptide receptor 0.0036 0.193 0.193
Plasmodium falciparum lysophospholipase, putative 0.0084 0.6416 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0036 0.193 0.1916
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Onchocerca volvulus 0.0036 0.193 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0036 0.193 0.1916
Plasmodium falciparum esterase, putative 0.0084 0.6416 1
Brugia malayi G-protein coupled receptor 0.0036 0.193 0.1916
Schistosoma mansoni fatty-acid amide hydrolase 0.0015 0.0017 0.0017
Schistosoma mansoni adenoreceptor 0.0036 0.193 0.193
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0084 0.6416 0.5
Echinococcus granulosus neuroglian 0.0015 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0036 0.193 0.1916
Echinococcus multilocularis neuropeptide Y receptor 0.0036 0.193 0.193
Plasmodium falciparum lysophospholipase, putative 0.0084 0.6416 1
Mycobacterium ulcerans hypothetical protein 0.0084 0.6416 1
Onchocerca volvulus 0.0036 0.193 1
Brugia malayi hypothetical protein 0.0036 0.193 0.1916
Brugia malayi hypothetical protein 0.0036 0.193 0.1916
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.193 0.193
Schistosoma mansoni neuropeptide F-like receptor 0.0036 0.193 0.193
Echinococcus granulosus neuropeptide receptor 0.0036 0.193 0.193
Onchocerca volvulus 0.0036 0.193 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0036 0.193 0.193
Onchocerca volvulus 0.0036 0.193 1
Onchocerca volvulus 0.0036 0.193 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0036 0.193 0.193
Onchocerca volvulus 0.0036 0.193 1
Brugia malayi hypothetical protein 0.0036 0.193 0.1916
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.193 0.193
Onchocerca volvulus Tyrosine kinase homolog 0.0017 0.0202 0.1044
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0036 0.193 0.193
Brugia malayi sulfakinin receptor protein 0.0036 0.193 0.1916

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.87 Inhibition of human recombinant MAGL overexpressed in HEK cells using 2-AG as substrate preincubated for 10 mins before substrate addition measured after 10 mins by HPLC analysis ChEMBL. 24083878
IC50 (binding) = 5.87 Inhibition of human MAGL expressed in HEK293 cells pre-incubated for 10 mins before 2-AG substrate addition by HPLC method ChEMBL. 26344596
IC50 (binding) = 7.05 Inhibition of human recombinant FAAH overexpressed in African green monkey COS7 cells using [3H]-anandamide as substrate preincubated for 10 mins before substrate addition measured after 10 mins by liquid scintillation counting analysis ChEMBL. 24083878
IC50 (binding) = 7.05 Inhibition of human FAAH expressed in COS7 cell membranes pre-incubated for 10 mins before [3H]-AEA substrate addition by liquid scintillation counting ChEMBL. 26344596
IC50 (binding) = 0.091 uM Inhibition of human recombinant FAAH overexpressed in African green monkey COS7 cells using [3H]-anandamide as substrate preincubated for 10 mins before substrate addition measured after 10 mins by liquid scintillation counting analysis ChEMBL. 24083878
IC50 (binding) = 0.091 uM Inhibition of human FAAH expressed in COS7 cell membranes pre-incubated for 10 mins before [3H]-AEA substrate addition by liquid scintillation counting ChEMBL. 26344596
IC50 (binding) = 1.3 uM Inhibition of human recombinant MAGL overexpressed in HEK cells using 2-AG as substrate preincubated for 10 mins before substrate addition measured after 10 mins by HPLC analysis ChEMBL. 24083878
IC50 (binding) = 1.3 uM Inhibition of human MAGL expressed in HEK293 cells pre-incubated for 10 mins before 2-AG substrate addition by HPLC method ChEMBL. 26344596
Inhibition (binding) Inhibition of human ABHD6 expressed in HEK293 cells assessed as remaining enzyme activity by measuring reduction in glycerol production from 1-AG hydrolysis at 1 uM pre-incubated for 30 mins before 1-AG substrate addition and measured 90 mins post substrate addition by fluorescence method ChEMBL. 26344596
Inhibition (binding) Inhibition of human ABHD12 overexpressed in HEK293 cells assessed as 2-AG hydrolysis at 1 uM by fluorescent glycerol assay ChEMBL. 24083878
Inhibition (binding) Inhibition of human ABHD6 overexpressed in HEK293 cells assessed as 2-AG hydrolysis at 1 uM by fluorescent glycerol assay ChEMBL. 24083878

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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