Detailed information for compound 1842504

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 309.19 | Formula: C15H14Cl2N2O
  • H donors: 2 H acceptors: 1 LogP: 4.08 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1Cl)Cl)N[C@@H](c1ccccc1)C
  • InChi: 1S/C15H14Cl2N2O/c1-10(11-6-3-2-4-7-11)18-15(20)19-13-9-5-8-12(16)14(13)17/h2-10H,1H3,(H2,18,19,20)/t10-/m1/s1
  • InChiKey: ZAWJNEPMNSNCTE-SNVBAGLBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0015 0.0196 0.0183
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0196 0.0131
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0043 0.1237 0.1061
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.1551 1
Leishmania major hypothetical protein, conserved 0.0035 0.0931 0.5725
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.002 0.0379 0.2903
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0124 0.4155 0.4147
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.1062 0.6819
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0242 0.1559
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0931 0.0919
Schistosoma mansoni tar DNA-binding protein 0.0124 0.4155 0.4147
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.01 0.0561
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.0347 0.128
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0347 0.2235
Schistosoma mansoni Smad4 0.0016 0.025 0.0237
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0242 0.098
Mycobacterium tuberculosis Conserved protein 0.0035 0.0931 0.0918
Schistosoma mansoni tar DNA-binding protein 0.0124 0.4155 0.4147
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0347 0.1703
Loa Loa (eye worm) hypothetical protein 0.0039 0.1062 0.105
Trypanosoma cruzi DNA polymerase eta, putative 0.0012 0.01 0.0561
Echinococcus granulosus tar DNA binding protein 0.0124 0.4155 0.4038
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0242 0.1478
Leishmania major GTP-binding protein, putative 0.002 0.0379 0.1924
Mycobacterium ulcerans hypothetical protein 0.0035 0.0931 0.8636
Schistosoma mansoni hypothetical protein 0.0023 0.0512 0.0499
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.1237 0.1225
Plasmodium falciparum thioredoxin reductase 0.0046 0.1327 0.8454
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.1062 0.0883
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.002 0.0379 0.2442
Toxoplasma gondii thioredoxin reductase 0.0046 0.1327 0.8553
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0286 1 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0347 0.1703
Trypanosoma brucei unspecified product 0.0027 0.0629 0.3646
Brugia malayi glutathione reductase 0.0046 0.1327 0.1521
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0046 0.134 0.1329
Treponema pallidum NADH oxidase 0.0016 0.0242 1
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.1062 0.1196
Loa Loa (eye worm) hypothetical protein 0.0035 0.0931 0.0919
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.1062 0.1093
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0242 0.0229
Brugia malayi MH1 domain containing protein 0.0016 0.025 0.0197
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1062 0.6629
Echinococcus granulosus bloom syndrome protein 0.0019 0.0347 0.0154
Leishmania major DNA polymerase eta, putative 0.0039 0.1062 0.6629
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0931 0.0749
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.1062 0.6819
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0347 0.0154
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0931 0.84
Echinococcus granulosus Smad4 0.0016 0.025 0.0055
Trypanosoma cruzi importin beta-1 subunit, putative 0.0022 0.0451 0.2849
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0931 0.0918
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.025 0.0237
Plasmodium vivax importin-beta 2, putative 0.0027 0.0634 0.409
Brugia malayi polk-prov protein 0.0012 0.01 0.0013
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.01 0.0086
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.002 0.0379 0.1924
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0931 0.0918
Brugia malayi beta-lactamase 0.0035 0.0931 0.1034
Schistosoma mansoni hypothetical protein 0.0168 0.5756 0.575
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1062 0.6629
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.1551 1
Schistosoma mansoni hypothetical protein 0.0168 0.5756 0.575
Schistosoma mansoni smad1 5 8 and 0.0016 0.025 0.0237
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0242 0.1486
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0347 0.0154
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0242 0.0188
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.0347 0.0317
Leishmania major hypothetical protein, conserved 0.0052 0.1551 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0043 0.1237 0.141
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.1062 0.105
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1062 0.6629
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.1237 0.1225
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0242 0.098
Loa Loa (eye worm) hypothetical protein 0.0015 0.0196 0.0183
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0931 0.84
Plasmodium vivax glutathione reductase, putative 0.0046 0.1327 0.8553
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.1062 0.6819
Brugia malayi latrophilin 2 splice variant baaae 0.0032 0.081 0.0887
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0242 0.5
Loa Loa (eye worm) RNA binding protein 0.0124 0.4155 0.4147
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.025 0.0237
Loa Loa (eye worm) hypothetical protein 0.0052 0.1551 0.154
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0931 0.0919
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0931 0.5725
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0242 0.098
Trypanosoma brucei trypanothione reductase 0.0046 0.1327 0.8454
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0347 0.128
Schistosoma mansoni hypothetical protein 0.0015 0.0196 0.0183
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.002 0.0379 0.2378
Brugia malayi RNA binding protein 0.0124 0.4155 0.4996
Loa Loa (eye worm) hypothetical protein 0.0035 0.0931 0.0919
Brugia malayi hypothetical protein 0.0052 0.1551 0.1797
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.002 0.0379 0.2442
Loa Loa (eye worm) MH2 domain-containing protein 0.0237 0.8226 0.8224
Schistosoma mansoni tar DNA-binding protein 0.0124 0.4155 0.4147
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.3454 0.4282
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0022 0.0451 0.2556
Trichomonas vaginalis importin beta-1, putative 0.0022 0.0451 0.2556
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.025 0.0055
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0242 0.1486
Loa Loa (eye worm) hypothetical protein 0.0032 0.081 0.0798
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0242 0.098
Loa Loa (eye worm) glutathione reductase 0.0046 0.1327 0.1315
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0347 0.0154
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1062 0.6629
Brugia malayi MH2 domain containing protein 0.0016 0.025 0.0197
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.01 0.0642
Mycobacterium tuberculosis Conserved protein 0.0035 0.0931 0.0918
Echinococcus multilocularis dna polymerase eta 0.0039 0.1062 0.0883
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0242 0.098
Entamoeba histolytica Ran family GTPase 0.002 0.0379 0.3568
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.3876 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.1551 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0347 0.0154
Plasmodium vivax DNA repair protein REV1, putative 0.0012 0.01 0.0642
Loa Loa (eye worm) hypothetical protein 0.0035 0.0931 0.0919
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.1062 0.0883
Echinococcus granulosus dna polymerase kappa 0.0039 0.1062 0.0883
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0347 0.128
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.1327 0.1315
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0242 0.098
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.00000000028088
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.1551 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0629 0.3646
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0931 0.0919
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0013 0.0085
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0347 0.0317
Leishmania major trypanothione reductase 0.0046 0.1327 0.8454
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.002 0.0379 0.0366
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0931 0.84
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0242 0.1478
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0931 0.0918
Onchocerca volvulus 0.0035 0.0931 0.5
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.1062 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.002 0.0379 0.0187
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0347 0.2569
Entamoeba histolytica recQ family DNA helicase 0.001 0.0013 0.0124
Schistosoma mansoni hypothetical protein 0.0015 0.0196 0.0183
Loa Loa (eye worm) Smad1 0.0016 0.025 0.0237
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0347 0.1703
Leishmania major DNA polymerase kappa, putative 0.0039 0.1062 0.6629
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.1062 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0043 0.1237 0.1061
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.01 0.0561
Echinococcus granulosus geminin 0.0168 0.5756 0.5671
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.1237 0.1225
Echinococcus multilocularis importin subunit beta 1 0.0027 0.0634 0.0447
Echinococcus multilocularis bloom syndrome protein 0.0019 0.0347 0.0154
Brugia malayi Calcitonin receptor-like protein seb-1 0.0046 0.134 0.1537
Mycobacterium ulcerans lipase LipD 0.0035 0.0931 0.8636
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0242 0.1478
Echinococcus granulosus dna polymerase eta 0.0039 0.1062 0.0883
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.002 0.0379 0.2378
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.1062 0.105
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.1551 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0242 0.1486
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0347 0.0317
Plasmodium falciparum glutathione reductase 0.0046 0.1327 0.8454
Schistosoma mansoni smad1 5 8 and 0.0016 0.025 0.0237
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.3876 0.4845
Brugia malayi hypothetical protein 0.0034 0.0883 0.0976
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.025 0.0237
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.1062 1
Loa Loa (eye worm) RecQ helicase 0.0019 0.0347 0.0334
Schistosoma mansoni hypothetical protein 0.0032 0.081 0.0798
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0931 0.0918
Brugia malayi TAR-binding protein 0.0124 0.4155 0.4996
Toxoplasma gondii HEAT repeat-containing protein 0.0027 0.0634 0.409
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1062 0.6629
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0242 0.0047
Onchocerca volvulus 0.0035 0.0931 0.5
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0242 0.0047
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0931 0.8636
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0931 0.0918
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.1327 0.1153
Schistosoma mansoni ran 0.002 0.0379 0.0366
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.7743 1
Loa Loa (eye worm) TAR-binding protein 0.0124 0.4155 0.4147
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0046 0.134 0.1537
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0242 0.5
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0242 0.1486
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.002 0.0379 0.0356
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.1062 0.6629
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1062 0.6629
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0931 0.0918
Schistosoma mansoni DNA helicase recq1 0.0019 0.0347 0.0334
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.3454 0.8565
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.1062 0.6629
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0196 0.0131
Echinococcus multilocularis Smad4 0.0016 0.025 0.0055
Mycobacterium ulcerans beta-lactamase 0.0035 0.0931 0.8636
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.1551 1
Trypanosoma brucei unspecified product 0.0027 0.0629 0.3646
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.1327 0.1446
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0242 0.098
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0931 0.1034
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.025 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1062 0.6629
Mycobacterium tuberculosis Conserved protein 0.0035 0.0931 0.0918
Trypanosoma brucei importin beta-1 subunit, putative 0.0027 0.0634 0.3685
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0242 0.1486
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.1327 0.8541
Echinococcus granulosus smad 0.0016 0.025 0.0055
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.3454 0.4282
Loa Loa (eye worm) beta-lactamase 0.0035 0.0931 0.0919
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.01 0.0642
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.1062 1
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0347 0.3265
Loa Loa (eye worm) transcription factor SMAD2 0.0237 0.8226 0.8224
Loa Loa (eye worm) hypothetical protein 0.0019 0.0347 0.0334
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.1327 0.1153
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.1551 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0242 0.098
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.1062 0.6629
Schistosoma mansoni DNA polymerase eta 0.0039 0.1062 0.105
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.025 0.0055
Trichomonas vaginalis esterase, putative 0.0035 0.0931 0.84
Echinococcus granulosus importin subunit beta 1 0.0027 0.0634 0.0447
Echinococcus multilocularis snurportin 1 0.0286 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0629 0.3646
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0043 0.1237 0.1225
Brugia malayi Importin beta-1 subunit 0.0027 0.0634 0.067
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1062 0.6629
Plasmodium falciparum importin beta, putative 0.0027 0.0634 0.3685
Trypanosoma brucei importin beta-1 subunit, putative 0.0027 0.0634 0.3685
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0242 0.1478
Brugia malayi beta-lactamase family protein 0.0035 0.0931 0.1034
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0022 0.0451 0.2556
Toxoplasma gondii ABC1 family protein 0.0035 0.0931 0.6
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0931 0.6
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.3454 0.4282
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0196 0.0183
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.1062 0.1196
Loa Loa (eye worm) hypothetical protein 0.0046 0.134 0.1329
Plasmodium falciparum glutathione reductase 0.0016 0.0242 0.098
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.1062 0.6629
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0931 0.0749
Schistosoma mansoni smad 0.0016 0.025 0.0237
Schistosoma mansoni smad1 5 8 and 0.0016 0.025 0.0237
Giardia lamblia DINP protein human, muc B family 0.0039 0.1062 1
Brugia malayi Smad1 0.0016 0.025 0.0197
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.1062 0.105
Schistosoma mansoni DNA helicase recq5 0.0019 0.0347 0.0334
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.3454 0.4282
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0931 0.84
Brugia malayi RNA, U transporter 1 0.0076 0.2419 0.2864
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0242 0.1486
Brugia malayi beta-lactamase family protein 0.0035 0.0931 0.1034
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0931 0.0918
Plasmodium falciparum thioredoxin reductase 0.0016 0.0242 0.098
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.1062 0.1093
Echinococcus multilocularis dna polymerase kappa 0.0039 0.1062 0.0883
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1062 0.6629
Trichomonas vaginalis ran, putative 0.002 0.0379 0.1672
Brugia malayi Thioredoxin reductase 0.0046 0.1327 0.1521
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0931 0.5965
Leishmania major importin beta-1 subunit, putative 0.0022 0.0451 0.2424
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0043 0.1237 0.1061
Brugia malayi MH2 domain containing protein 0.0237 0.8226 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0347 0.2235
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.01 0.0561
Entamoeba histolytica hypothetical protein 0.0022 0.0451 0.4251
Loa Loa (eye worm) hypothetical protein 0.0012 0.01 0.0086
Brugia malayi RNA recognition motif domain containing protein 0.0124 0.4155 0.4996
Echinococcus multilocularis geminin 0.0168 0.5756 0.5671
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.3876 0.4845
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1062 0.6629
Echinococcus granulosus GTP binding nuclear protein Ran 0.002 0.0379 0.0187
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0931 0.8636
Loa Loa (eye worm) hypothetical protein 0.0035 0.0931 0.0919
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0347 0.1703
Schistosoma mansoni tar DNA-binding protein 0.0124 0.4155 0.4147
Brugia malayi MH1 domain containing protein 0.0016 0.025 0.0197
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0013 0.0085
Echinococcus multilocularis tar DNA binding protein 0.0124 0.4155 0.4038
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.1062 0.6629
Schistosoma mansoni hypothetical protein 0.0286 1 1
Schistosoma mansoni ran 0.002 0.0379 0.0366
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0242 0.1486
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0242 0.1486
Echinococcus multilocularis smad 0.0016 0.025 0.0055
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0242 0.1559
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0931 0.5965
Loa Loa (eye worm) hypothetical protein 0.0035 0.0931 0.0919
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0242 0.1559
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0512 0.0322
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.01 0.0561
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.1062 0.6819
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.025 0.0055
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0347 0.0334
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0242 0.5
Schistosoma mansoni tar DNA-binding protein 0.0124 0.4155 0.4147
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.002 0.0379 0.1924
Brugia malayi MH2 domain containing protein 0.0016 0.025 0.0197
Loa Loa (eye worm) hypothetical protein 0.0035 0.0931 0.0919
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.3454 0.4282
Trypanosoma brucei unspecified product 0.0039 0.1062 0.6629
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0931 0.84
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0043 0.1237 0.1061
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.1327 0.8553
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0242 0.1559
Onchocerca volvulus 0.0035 0.0931 0.5
Schistosoma mansoni hypothetical protein 0.0015 0.0196 0.0183
Loa Loa (eye worm) hypothetical protein 0.0027 0.0634 0.0622
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0242 0.098
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.1062 0.6819
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0629 0.3646
Mycobacterium tuberculosis Probable reductase 0.0105 0.3454 0.4282
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.1062 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.3876 0.4845
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0242 0.098
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0512 0.0322
Schistosoma mansoni importin beta-1 0.0027 0.0634 0.0622
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0242 0.1486
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0347 0.2169
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.01 0.0642

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) = 0 % Phytotoxicity against directly seeded Oryza sativa (rice) seedlings assessed as phytotoxic activity ratings (0- no effect to 5-complete killing rating scale) at 100 g/a measured after 3 weeks post compound treatment under green house conditions ChEMBL. 27393589
Activity (ADMET) = 100 % Effect on Oryza sativa (rice) assessed as growth rate at 1 uM relative to control ChEMBL. 27393060

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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