Detailed information for compound 1842539

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 323.346 | Formula: C18H17N3O3
  • H donors: 3 H acceptors: 3 LogP: 0.68 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC2=C(C(N1)c1cc3cc(C)ccc3[nH]c1=O)C(=O)CCC2
  • InChi: 1S/C18H17N3O3/c1-9-5-6-12-10(7-9)8-11(17(23)19-12)16-15-13(20-18(24)21-16)3-2-4-14(15)22/h5-8,16H,2-4H2,1H3,(H,19,23)(H2,20,21,24)
  • InChiKey: XQJDEYYXCIJJNC-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus rhodopsin orphan GPCR 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0115 0.3243 0.3042
Schistosoma mansoni hypothetical protein 0.0296 0.8942 0.8942
Echinococcus granulosus biogenic amine 5HT receptor 0.0296 0.8942 0.8942
Echinococcus multilocularis rhodopsin orphan GPCR 0.0296 0.8942 0.8942
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0296 0.8942 0.8942
Echinococcus granulosus g protein coupled receptor 0.0296 0.8942 0.8942
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0296 0.8942 0.8942
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0296 0.8942 0.8942
Echinococcus granulosus g-protein coupled receptor 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Brugia malayi G-protein coupled receptor 0.0296 0.8942 0.8942
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0296 0.8942 0.8942
Brugia malayi Dopamine receptor protein 2 0.0296 0.8942 0.8942
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0296 0.8942 0.8942
Brugia malayi G protein-coupled receptor 0.0296 0.8942 0.8942
Echinococcus granulosus neuropeptide s receptor 0.0296 0.8942 0.8942
Echinococcus multilocularis neuropeptide receptor 0.0296 0.8942 0.8942
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0296 0.8942 0.8942
Schistosoma mansoni opsin-like receptor 0.0296 0.8942 0.8942
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.1317 0.1317
Brugia malayi neuropeptide F receptor 0.0296 0.8942 0.8942
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.1871 0.1871
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0296 0.8942 0.8942
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0296 0.8942 0.8942
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0296 0.8942 0.8942
Schistosoma mansoni neuropeptide F-like receptor 0.0296 0.8942 0.8942
Mycobacterium ulcerans Type I modular polyketide synthase 0.0115 0.3243 0.1689
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0329 1 1
Loa Loa (eye worm) TYRA-2 protein 0.0296 0.8942 0.8942
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.1317 0.1317
Echinococcus multilocularis g protein coupled receptor 0.0296 0.8942 0.8942
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier protein] synthase 2 KasB (beta-ketoacyl-ACP synthase) (KAS I) 0.0215 0.6383 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0115 0.3243 0.3042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0296 0.8942 0.8942
Echinococcus multilocularis neuropeptides capa receptor 0.0296 0.8942 0.8942
Mycobacterium leprae 3-oxoacyl-[acyl-carrier-protein] synthase 2 KasB (BETA-KETOACYL-ACP SYNTHASE) (KAS I) 0.0215 0.6383 1
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0329 1 0.5
Mycobacterium ulcerans polyketide synthase 0.0115 0.3243 0.1689
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.1317 0.1317
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0115 0.3243 0.1689
Echinococcus granulosus neuropeptide receptor 0.0296 0.8942 0.8942
Schistosoma mansoni alpha-1 adrenergic receptor 0.0296 0.8942 0.8942
Echinococcus granulosus neuropeptides capa receptor 0.0296 0.8942 0.8942
Brugia malayi hypothetical protein 0.0296 0.8942 0.8942
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0296 0.8942 0.8942
Echinococcus granulosus 7tm_1 domain containing protein 0.0296 0.8942 0.8942
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0296 0.8942 0.8942
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Echinococcus granulosus alpha 1A adrenergic receptor 0.0296 0.8942 0.8942
Echinococcus multilocularis neuropeptide FF receptor 2 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0296 0.8942 0.8942
Schistosoma mansoni neuropeptide receptor 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0296 0.8942 0.8942
Schistosoma mansoni amine GPCR 0.0296 0.8942 0.8942
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0329 1 0.5
Brugia malayi G protein-coupled receptor F59B2.13 0.0296 0.8942 0.8942
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0296 0.8942 0.8942
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0329 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Mycobacterium ulcerans Type I modular polyketide synthase 0.0115 0.3243 0.1689
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0296 0.8942 0.8942
Brugia malayi Tachykinin-like peptides receptor 99D 0.0296 0.8942 0.8942
Loa Loa (eye worm) neuropeptide F receptor 0.0296 0.8942 0.8942
Echinococcus multilocularis rhodopsin orphan GPCR 0.0296 0.8942 0.8942
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0115 0.3243 0.3042
Echinococcus granulosus rhodopsin orphan GPCR 0.0296 0.8942 0.8942
Brugia malayi larval opioid receptor 0.0296 0.8942 0.8942
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0115 0.3243 0.1689
Echinococcus multilocularis g protein coupled receptor 0.0296 0.8942 0.8942
Onchocerca volvulus 0.0296 0.8942 1
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0329 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Onchocerca volvulus 0.0296 0.8942 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0296 0.8942 0.8942
Echinococcus multilocularis rhodopsin orphan GPCR 0.0296 0.8942 0.8942
Onchocerca volvulus 0.0296 0.8942 1
Schistosoma mansoni adenoreceptor 0.0296 0.8942 0.8942
Schistosoma mansoni biogenic amine receptor 0.0296 0.8942 0.8942
Schistosoma mansoni amine GPCR 0.0296 0.8942 0.8942
Echinococcus multilocularis rhodopsin orphan GPCR 0.0296 0.8942 0.8942
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0296 0.8942 0.8942
Schistosoma mansoni biogenic amine receptor 0.0296 0.8942 0.8942
Schistosoma mansoni neuropeptide receptor 0.0296 0.8942 0.8942
Loa Loa (eye worm) neuropeptide F receptor 0.0296 0.8942 0.8942
Echinococcus granulosus orexin receptor type 2 0.0296 0.8942 0.8942
Brugia malayi Serotonin receptor 0.0296 0.8942 0.8942
Schistosoma mansoni hypothetical protein 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Echinococcus multilocularis neuropeptide receptor 0.0296 0.8942 0.8942
Onchocerca volvulus 0.0296 0.8942 1
Brugia malayi Dopamine receptor protein 1 0.0296 0.8942 0.8942
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0329 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0296 0.8942 0.8942
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.1317 0.1317
Echinococcus multilocularis dro:myosuppressin receptor 0.0296 0.8942 0.8942
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0115 0.3243 0.1689
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Echinococcus granulosus neuropeptide FF receptor 2 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Echinococcus granulosus neuropeptide receptor 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Schistosoma mansoni opsin-like receptor 0.0296 0.8942 0.8942
Echinococcus multilocularis sex peptide receptor 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Echinococcus multilocularis rhodopsin orphan GPCR 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0296 0.8942 0.8942
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0296 0.8942 0.8942
Echinococcus multilocularis g-protein coupled receptor 0.0296 0.8942 0.8942
Schistosoma mansoni myosin xvIII 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0115 0.3243 0.3042
Brugia malayi hypothetical protein 0.0296 0.8942 0.8942
Echinococcus multilocularis serotonin receptor 0.0296 0.8942 0.8942
Brugia malayi follicle stimulating hormone receptor 0.0296 0.8942 0.8942
Echinococcus multilocularis serotonin receptor 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Brugia malayi Serotonin receptor 0.0296 0.8942 0.8942
Schistosoma mansoni biogenic amine (5HT) receptor 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0115 0.3243 0.3243
Echinococcus granulosus somatostatin receptor 0.0296 0.8942 0.8942
Onchocerca volvulus 0.0296 0.8942 1
Onchocerca volvulus 0.0115 0.3243 0.3627
Brugia malayi hypothetical protein 0.0296 0.8942 0.8942
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0296 0.8942 0.8942
Echinococcus multilocularis neuropeptide Y receptor 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0115 0.3243 0.3243
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Mycobacterium ulcerans polyketide synthase Pks9 0.0115 0.3243 0.1689
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0296 0.8942 0.8942
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0329 1 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.0296 0.8942 0.8942
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0296 0.8942 0.8942
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0296 0.8942 0.8942
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0329 1 0.5
Brugia malayi hypothetical protein 0.0296 0.8942 0.8942
Echinococcus granulosus peptide allatostatin:somatostatin 0.0296 0.8942 0.8942
Brugia malayi Dopamine receptor 0.0296 0.8942 0.8942
Echinococcus granulosus serotonin receptor 0.0296 0.8942 0.8942
Echinococcus multilocularis rhodopsin orphan GPCR 0.0296 0.8942 0.8942
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0115 0.3243 0.3042
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0115 0.3243 0.1689
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0296 0.8942 0.8942
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0329 1 1
Schistosoma mansoni amine GPCR 0.0296 0.8942 0.8942
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0296 0.8942 0.8942
Schistosoma mansoni opsin-like receptor 0.0296 0.8942 0.8942
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0329 1 1
Mycobacterium ulcerans polyketide synthase 0.0115 0.3243 0.1689
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0115 0.3243 0.1689
Echinococcus granulosus g protein coupled receptor 0.0296 0.8942 0.8942
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0296 0.8942 0.8942
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0296 0.8942 0.8942
Echinococcus multilocularis G-protein coupled receptor, putative 0.0296 0.8942 0.8942
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.1317 0.1317
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Echinococcus multilocularis neuropeptide s receptor 0.0296 0.8942 0.8942
Onchocerca volvulus 0.0296 0.8942 1
Mycobacterium ulcerans fatty acid synthase Fas 0.0115 0.3243 0.1689
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0115 0.3243 0.1689
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0115 0.3243 0.3042
Brugia malayi GnHR receptor homolog 0.0296 0.8942 0.8942
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0115 0.3243 0.3042
Onchocerca volvulus 0.0296 0.8942 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Echinococcus multilocularis allatostatin A receptor 0.0296 0.8942 0.8942
Brugia malayi G-protein coupled receptor 0.0296 0.8942 0.8942
Echinococcus multilocularis fmrfamide receptor 0.0296 0.8942 0.8942
Echinococcus granulosus allatostatin A receptor 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0115 0.3243 0.3042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Echinococcus granulosus sex peptide receptor 0.0296 0.8942 0.8942
Brugia malayi ORL1-like opioid receptor 0.0296 0.8942 0.8942
Echinococcus multilocularis rhodopsin orphan GPCR 0.0296 0.8942 0.8942
Onchocerca volvulus Fatty acid synthase homolog 0.0115 0.3243 0.3627
Echinococcus granulosus neuropeptide receptor A26 0.0296 0.8942 0.8942
Brugia malayi hypothetical protein 0.0296 0.8942 0.8942
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0296 0.8942 0.8942
Loa Loa (eye worm) G-protein coupled receptor 0.0296 0.8942 0.8942
Echinococcus multilocularis neuropeptides capa receptor 0.0296 0.8942 0.8942
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.1871 0.1871
Echinococcus granulosus neuropeptides capa receptor 0.0296 0.8942 0.8942
Mycobacterium ulcerans Type I modular polyketide synthase 0.0115 0.3243 0.1689
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0296 0.8942 0.8942
Brugia malayi RE15519p 0.0296 0.8942 0.8942
Echinococcus multilocularis g protein coupled receptor 0.0296 0.8942 0.8942
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0115 0.3243 0.3042
Echinococcus granulosus neuropeptide Y receptor 0.0296 0.8942 0.8942
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0296 0.8942 0.8942
Schistosoma mansoni amine GPCR 0.0296 0.8942 0.8942
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0296 0.8942 0.8942
Mycobacterium ulcerans polyketide synthase MbtC 0.0115 0.3243 0.1689
Echinococcus granulosus rhodopsin orphan GPCR 0.0296 0.8942 0.8942
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0296 0.8942 0.8942
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0296 0.8942 0.8942
Echinococcus granulosus rhodopsin orphan GPCR 0.0296 0.8942 0.8942
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0115 0.3243 0.1689
Mycobacterium leprae 3-oxoacyl-[acyl-carrier-protein] synthase 1 KasA (BETA-KETOACYL-ACP SYNTHASE) (KAS I) 0.0215 0.6383 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0296 0.8942 0.8942
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0296 0.8942 0.8942
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0296 0.8942 0.8942
Onchocerca volvulus 0.0296 0.8942 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Brugia malayi Melatonin receptor type 1A 0.0296 0.8942 0.8942
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0115 0.3243 0.3243
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0054 0.1317 0.1317
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0115 0.3243 0.1689
Onchocerca volvulus Neuropeptide F receptor homolog 0.0296 0.8942 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Onchocerca volvulus 0.0296 0.8942 1
Brugia malayi AKH receptor 0.0296 0.8942 0.8942
Schistosoma mansoni neuropeptide receptor 0.0296 0.8942 0.8942
Echinococcus granulosus tm gpcr rhodopsin 0.0296 0.8942 0.8942
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0115 0.3243 0.3042
Echinococcus granulosus hypothetical protein 0.0296 0.8942 0.8942
Brugia malayi sulfakinin receptor protein 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Brugia malayi putative neuropeptide receptor 0.0296 0.8942 0.8942
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0296 0.8942 0.8942
Onchocerca volvulus 0.0296 0.8942 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.1317 0.1317
Echinococcus granulosus neuropeptide Y receptor 0.0296 0.8942 0.8942
Toxoplasma gondii type I fatty acid synthase, putative 0.0115 0.3243 0.1689
Brugia malayi hypothetical protein 0.0296 0.8942 0.8942
Echinococcus granulosus biogenic amine 5HT receptor 0.0296 0.8942 0.8942
Echinococcus multilocularis neuropeptide receptor A26 0.0296 0.8942 0.8942
Echinococcus granulosus rhodopsin orphan GPCR 0.0296 0.8942 0.8942
Onchocerca volvulus 0.0296 0.8942 1
Echinococcus multilocularis fmrfamide receptor 0.0296 0.8942 0.8942
Schistosoma mansoni neuropeptide F-like receptor 0.0296 0.8942 0.8942
Echinococcus granulosus rhodopsin orphan GPCR 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Echinococcus multilocularis rhodopsin orphan GPCR 0.0296 0.8942 0.8942
Echinococcus multilocularis somatostatin receptor 0.0296 0.8942 0.8942
Onchocerca volvulus 0.0296 0.8942 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0296 0.8942 0.8942
Schistosoma mansoni hypothetical protein 0.0296 0.8942 0.8942
Schistosoma mansoni biogenic amine receptor 0.0296 0.8942 0.8942
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0115 0.3243 0.3042
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0329 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Loa Loa (eye worm) G-protein coupled receptor 0.0296 0.8942 0.8942
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0296 0.8942 0.8942
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier protein] synthase 1 KasA (beta-ketoacyl-ACP synthase) (KAS I) 0.0215 0.6383 1
Echinococcus granulosus fmrfamide receptor 0.0296 0.8942 0.8942
Onchocerca volvulus 0.0296 0.8942 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0296 0.8942 0.8942
Echinococcus multilocularis G protein coupled receptor 139 0.0296 0.8942 0.8942
Brugia malayi hypothetical protein 0.0296 0.8942 0.8942
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0329 1 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.0296 0.8942 0.8942
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0115 0.3243 0.3042
Brugia malayi hypothetical protein 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0329 1 1
Echinococcus granulosus g protein coupled receptor 0.0296 0.8942 0.8942
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.1871 0.1871
Echinococcus granulosus tachykinin peptides receptor 99D 0.0296 0.8942 0.8942
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Echinococcus granulosus tm gpcr rhodopsin 0.0296 0.8942 0.8942
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0296 0.8942 0.8942
Schistosoma mansoni neuropeptide f receptor 76f 0.0296 0.8942 0.8942
Loa Loa (eye worm) melatonin receptor type 1A 0.0296 0.8942 0.8942
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0115 0.3243 0.3042
Toxoplasma gondii type I fatty acid synthase, putative 0.0115 0.3243 0.1689
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0329 1 1
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0329 1 1
Brugia malayi neuropeptide F receptor 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Schistosoma mansoni hypothetical protein 0.0296 0.8942 0.8942
Schistosoma mansoni amine GPCR 0.0296 0.8942 0.8942
Schistosoma mansoni biogenic amine (5HT) receptor 0.0296 0.8942 0.8942
Mycobacterium ulcerans polyketide synthase Pks13 0.0115 0.3243 0.1689
Echinococcus granulosus G protein coupled receptor 139 0.0296 0.8942 0.8942
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0296 0.8942 1
Onchocerca volvulus 0.0296 0.8942 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Schistosoma mansoni neuropeptide receptor 0.0296 0.8942 0.8942
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0115 0.3243 0.3042
Echinococcus granulosus rhodopsin orphan GPCR 0.0296 0.8942 0.8942
Echinococcus multilocularis neuropeptide Y receptor 0.0296 0.8942 0.8942
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0296 0.8942 0.8942
Onchocerca volvulus 0.0296 0.8942 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.1317 0.1317
Brugia malayi hypothetical protein 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Brugia malayi hypothetical protein 0.0296 0.8942 0.8942
Echinococcus granulosus 7TM GPCR rhodopsin 0.0296 0.8942 0.8942
Schistosoma mansoni histamine h1 receptor 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Onchocerca volvulus 0.0296 0.8942 1
Echinococcus multilocularis orexin receptor type 2 0.0296 0.8942 0.8942
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0296 0.8942 0.8942
Onchocerca volvulus 0.0296 0.8942 1
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0115 0.3243 0.3243
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0296 0.8942 0.8942
Loa Loa (eye worm) hypothetical protein 0.0296 0.8942 0.8942
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0054 0.1317 0.1317
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.1871 0.1871
Echinococcus granulosus tm gpcr rhodopsin 0.0296 0.8942 0.8942
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0115 0.3243 0.3042

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 500 ug ml-1 Antimicrobial activity against Escherichia coli MTCC 443 after 24 to 48 hr by broth microdilution method ChEMBL. No reference
MIC (functional) = 1000 ug ml-1 Antimicrobial activity against Candida albicans MTCC 227 after 24 to 48 hr by broth microdilution method ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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