TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 323.346 | Formula: C18H17N3O3
H donors: 3 H acceptors: 3 LogP: 0.68 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: O=C1NC2=C(C(N1)c1cc3cc(C)ccc3[nH]c1=O)C(=O)CCC2
InChi: 1S/C18H17N3O3/c1-9-5-6-12-10(7-9)8-11(17(23)19-12)16-15-13(20-18(24)21-16)3-2-4-14(15)22/h5-8,16H,2-4H2,1H3,(H,19,23)(H2,20,21,24)
InChiKey: XQJDEYYXCIJJNC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0296	0.8942	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0296	0.8942	0.8942
Brugia malayi	G protein-coupled receptor F59B2.13	0.0296	0.8942	0.8942
Echinococcus granulosus	serotonin receptor	0.0296	0.8942	0.8942
Plasmodium falciparum	3-oxoacyl-acyl-carrier protein synthase I/II	0.0329	1	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0296	0.8942	0.8942
Schistosoma mansoni	biogenic amine receptor	0.0296	0.8942	0.8942
Echinococcus granulosus	tm gpcr rhodopsin	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Onchocerca volvulus		0.0296	0.8942	1
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Echinococcus granulosus	rhodopsin orphan GPCR	0.0296	0.8942	0.8942
Echinococcus granulosus	sex peptide receptor	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0296	0.8942	0.8942
Echinococcus granulosus	7TM GPCR rhodopsin	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Schistosoma mansoni	3-oxoacyl-[ACP] synthase	0.0329	1	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0296	0.8942	0.8942
Trypanosoma cruzi	beta-ketoacyl synthase family protein, putative	0.0329	1	0.5
Schistosoma mansoni	opsin-like receptor	0.0296	0.8942	0.8942
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0296	0.8942	0.8942
Echinococcus granulosus	neuropeptide Y receptor	0.0296	0.8942	0.8942
Echinococcus granulosus	neuropeptide FF receptor 2	0.0296	0.8942	0.8942
Onchocerca volvulus		0.0296	0.8942	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Echinococcus granulosus	rhodopsin orphan GPCR	0.0296	0.8942	0.8942
Echinococcus multilocularis	neuropeptides capa receptor	0.0296	0.8942	0.8942
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Onchocerca volvulus		0.0296	0.8942	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0296	0.8942	0.8942
Onchocerca volvulus		0.0296	0.8942	1
Brugia malayi	G-protein coupled receptor	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Brugia malayi	hypothetical protein	0.0296	0.8942	0.8942
Echinococcus granulosus	rhodopsin orphan GPCR	0.0296	0.8942	0.8942
Mycobacterium tuberculosis	Probable fatty acid synthase Fas (fatty acid synthetase)	0.0115	0.3243	0.3042
Echinococcus granulosus	g protein coupled receptor	0.0296	0.8942	0.8942
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0296	0.8942	1
Brugia malayi	hypothetical protein	0.0296	0.8942	0.8942
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0296	0.8942	0.8942
Brugia malayi	hypothetical protein	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0296	0.8942	0.8942
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0296	0.8942	0.8942
Onchocerca volvulus		0.0296	0.8942	1
Echinococcus granulosus	g protein coupled receptor	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Schistosoma mansoni	myosin xvIII	0.0296	0.8942	0.8942
Onchocerca volvulus		0.0296	0.8942	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0296	0.8942	0.8942
Brugia malayi	Dopamine receptor protein 1	0.0296	0.8942	0.8942
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0054	0.1317	0.1317
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0115	0.3243	0.3243
Loa Loa (eye worm)	hypothetical protein	0.0115	0.3243	0.3243
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Chlamydia trachomatis	3-oxoacyl-ACP synthase	0.0329	1	0.5
Brugia malayi	Serotonin receptor	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Onchocerca volvulus	Fatty acid synthase homolog	0.0115	0.3243	0.3627
Brugia malayi	hypothetical protein	0.0296	0.8942	0.8942
Brugia malayi	follicle stimulating hormone receptor	0.0296	0.8942	0.8942
Toxoplasma gondii	3-oxoacyl-acyl-carrier protein synthase I/II, putative	0.0329	1	1
Echinococcus granulosus	g protein coupled receptor	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Echinococcus granulosus	neuropeptide receptor	0.0296	0.8942	0.8942
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0115	0.3243	0.3042
Brugia malayi	Dopamine receptor protein 2	0.0296	0.8942	0.8942
Plasmodium vivax	3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative	0.0329	1	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0296	0.8942	0.8942
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0115	0.3243	0.3042
Brugia malayi	hypothetical protein	0.0296	0.8942	0.8942
Brugia malayi	sulfakinin receptor protein	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Schistosoma mansoni	amine GPCR	0.0296	0.8942	0.8942
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.1317	0.1317
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0296	0.8942	0.8942
Echinococcus multilocularis	serotonin receptor	0.0296	0.8942	0.8942
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0115	0.3243	0.3042
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0296	0.8942	0.8942
Echinococcus granulosus	tm gpcr rhodopsin	0.0296	0.8942	0.8942
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0296	0.8942	0.8942
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Brugia malayi	neuropeptide F receptor	0.0296	0.8942	0.8942
Echinococcus multilocularis	neuropeptide Y receptor	0.0296	0.8942	0.8942
Mycobacterium tuberculosis	Probable polyketide synthase Pks15	0.0115	0.3243	0.3042
Echinococcus granulosus	g-protein coupled receptor	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Brugia malayi	hypothetical protein	0.0296	0.8942	0.8942
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0115	0.3243	0.3042
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0296	0.8942	0.8942
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0071	0.1871	0.1871
Brugia malayi	GnHR receptor homolog	0.0296	0.8942	0.8942
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0296	0.8942	0.8942
Echinococcus multilocularis	fmrfamide receptor	0.0296	0.8942	0.8942
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0296	0.8942	0.8942
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.1317	0.1317
Echinococcus granulosus	neuropeptide receptor	0.0296	0.8942	0.8942
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0296	0.8942	0.8942
Loa Loa (eye worm)	neuropeptide F receptor	0.0296	0.8942	0.8942
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0115	0.3243	0.3042
Echinococcus granulosus	neuropeptide receptor A26	0.0296	0.8942	0.8942
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0296	0.8942	0.8942
Onchocerca volvulus		0.0296	0.8942	1
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0115	0.3243	0.3042
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Onchocerca volvulus		0.0296	0.8942	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Schistosoma mansoni	opsin-like receptor	0.0296	0.8942	0.8942
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0296	0.8942	0.8942
Echinococcus multilocularis	neuropeptide receptor	0.0296	0.8942	0.8942
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0296	0.8942	0.8942
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0296	0.8942	0.8942
Brugia malayi	larval opioid receptor	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0296	0.8942	0.8942
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0296	0.8942	0.8942
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0296	0.8942	0.8942
Echinococcus multilocularis	somatostatin receptor	0.0296	0.8942	0.8942
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0296	0.8942	0.8942
Echinococcus granulosus	fmrfamide receptor	0.0296	0.8942	0.8942
Echinococcus granulosus	neuropeptide s receptor	0.0296	0.8942	0.8942
Brugia malayi	hypothetical protein	0.0296	0.8942	0.8942
Schistosoma mansoni	biogenic amine receptor	0.0296	0.8942	0.8942
Echinococcus granulosus	neuropeptides capa receptor	0.0296	0.8942	0.8942
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0115	0.3243	0.1689
Echinococcus multilocularis	sex peptide receptor	0.0296	0.8942	0.8942
Echinococcus multilocularis	g protein coupled receptor	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0296	0.8942	0.8942
Echinococcus granulosus	G protein coupled receptor 139	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0296	0.8942	0.8942
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0296	0.8942	0.8942
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0071	0.1871	0.1871
Schistosoma mansoni	aldehyde dehydrogenase	0.0071	0.1871	0.1871
Brugia malayi	G-protein coupled receptor	0.0296	0.8942	0.8942
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.1317	0.1317
Brugia malayi	Dopamine receptor	0.0296	0.8942	0.8942
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0115	0.3243	0.3042
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0296	0.8942	0.8942
Brugia malayi	putative neuropeptide receptor NPR1	0.0296	0.8942	0.8942
Brugia malayi	hypothetical protein	0.0296	0.8942	0.8942
Echinococcus granulosus	rhodopsin orphan GPCR	0.0296	0.8942	0.8942
Mycobacterium ulcerans	3-oxoacyl-(acyl carrier protein) synthase II	0.0329	1	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0296	0.8942	0.8942
Mycobacterium ulcerans	polyketide synthase	0.0115	0.3243	0.1689
Echinococcus granulosus	neuropeptides capa receptor	0.0296	0.8942	0.8942
Echinococcus granulosus	somatostatin receptor	0.0296	0.8942	0.8942
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0296	0.8942	0.8942
Brugia malayi	AKH receptor	0.0296	0.8942	0.8942
Brugia malayi	ORL1-like opioid receptor	0.0296	0.8942	0.8942
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0296	0.8942	0.8942
Echinococcus granulosus	neuropeptide Y receptor	0.0296	0.8942	0.8942
Echinococcus multilocularis	g-protein coupled receptor	0.0296	0.8942	0.8942
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0296	0.8942	0.8942
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0296	0.8942	0.8942
Echinococcus multilocularis	allatostatin A receptor	0.0296	0.8942	0.8942
Echinococcus multilocularis	neuropeptide receptor	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Echinococcus granulosus	allatostatin A receptor	0.0296	0.8942	0.8942
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0296	0.8942	0.8942
Brugia malayi	G protein-coupled receptor	0.0296	0.8942	0.8942
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0296	0.8942	0.8942
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0115	0.3243	0.1689
Echinococcus granulosus	7tm_1 domain containing protein	0.0296	0.8942	0.8942
Wolbachia endosymbiont of Brugia malayi	3-oxoacyl-ACP synthase	0.0329	1	0.5
Schistosoma mansoni	amine GPCR	0.0296	0.8942	0.8942
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0296	0.8942	0.8942
Loa Loa (eye worm)	melatonin receptor type 1A	0.0296	0.8942	0.8942
Echinococcus granulosus	hypothetical protein	0.0296	0.8942	0.8942
Schistosoma mansoni	hypothetical protein	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Schistosoma mansoni	aldehyde dehydrogenase	0.0071	0.1871	0.1871
Schistosoma mansoni	histamine h1 receptor	0.0296	0.8942	0.8942
Mycobacterium ulcerans	polyketide synthase MbtC	0.0115	0.3243	0.1689
Onchocerca volvulus		0.0296	0.8942	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0296	0.8942	0.8942
Loa Loa (eye worm)	TYRA-2 protein	0.0296	0.8942	0.8942
Echinococcus granulosus	orexin receptor type 2	0.0296	0.8942	0.8942
Schistosoma mansoni	hypothetical protein	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Onchocerca volvulus		0.0115	0.3243	0.3627
Mycobacterium tuberculosis	3-oxoacyl-[acyl-carrier protein] synthase 2 KasB (beta-ketoacyl-ACP synthase) (KAS I)	0.0215	0.6383	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0296	0.8942	0.8942
Brugia malayi	putative neuropeptide receptor	0.0296	0.8942	0.8942
Echinococcus granulosus	tm gpcr rhodopsin	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0296	0.8942	0.8942
Mycobacterium ulcerans	polyketide synthase	0.0115	0.3243	0.1689
Onchocerca volvulus		0.0296	0.8942	1
Mycobacterium ulcerans	3-oxoacyl-(acyl carrier protein) synthase II	0.0329	1	1
Trypanosoma cruzi	beta-ketoacyl synthase family protein, putative	0.0329	1	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0296	0.8942	0.8942
Schistosoma mansoni	hypothetical protein	0.0296	0.8942	0.8942
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0296	0.8942	0.8942
Echinococcus granulosus	3 oxoacyl acyl carrier protein synthase	0.0329	1	1
Onchocerca volvulus		0.0296	0.8942	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0296	0.8942	0.8942
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0296	0.8942	1
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0115	0.3243	0.3042
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0115	0.3243	0.3243
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0296	0.8942	0.8942
Schistosoma mansoni	amine GPCR	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Brugia malayi	Serotonin receptor	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0115	0.3243	0.1689
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0296	0.8942	0.8942
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0115	0.3243	0.1689
Onchocerca volvulus		0.0296	0.8942	1
Mycobacterium ulcerans	polyketide synthase Pks13	0.0115	0.3243	0.1689
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0296	0.8942	0.8942
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0296	0.8942	0.8942
Toxoplasma gondii	type I fatty acid synthase, putative	0.0115	0.3243	0.1689
Schistosoma mansoni	biogenic amine receptor	0.0296	0.8942	0.8942
Mycobacterium tuberculosis	3-oxoacyl-[acyl-carrier protein] synthase 1 KasA (beta-ketoacyl-ACP synthase) (KAS I)	0.0215	0.6383	1
Echinococcus multilocularis	fmrfamide receptor	0.0296	0.8942	0.8942
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	0.0115	0.3243	0.3042
Echinococcus granulosus	rhodopsin orphan GPCR	0.0296	0.8942	0.8942
Schistosoma mansoni	neuropeptide receptor	0.0296	0.8942	0.8942
Schistosoma mansoni	opsin-like receptor	0.0296	0.8942	0.8942
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.0115	0.3243	0.1689
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0296	0.8942	0.8942
Schistosoma mansoni	hypothetical protein	0.0296	0.8942	0.8942
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.0115	0.3243	0.3042
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0296	0.8942	0.8942
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0296	0.8942	0.8942
Echinococcus multilocularis	serotonin receptor	0.0296	0.8942	0.8942
Echinococcus multilocularis	g protein coupled receptor	0.0296	0.8942	0.8942
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0115	0.3243	0.1689
Schistosoma mansoni	neuropeptide f receptor 76f	0.0296	0.8942	0.8942
Echinococcus multilocularis	orexin receptor type 2	0.0296	0.8942	0.8942
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0296	0.8942	0.8942
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0296	0.8942	0.8942
Echinococcus multilocularis	neuropeptide Y receptor	0.0296	0.8942	0.8942
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0296	0.8942	0.8942
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0054	0.1317	0.1317
Echinococcus granulosus	rhodopsin orphan GPCR	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Onchocerca volvulus		0.0296	0.8942	1
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0115	0.3243	0.1689
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0115	0.3243	0.3042
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0115	0.3243	0.1689
Loa Loa (eye worm)	G-protein coupled receptor	0.0296	0.8942	0.8942
Onchocerca volvulus		0.0296	0.8942	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0296	0.8942	0.8942
Brugia malayi	RE15519p	0.0296	0.8942	0.8942
Schistosoma mansoni	adenoreceptor	0.0296	0.8942	0.8942
Schistosoma mansoni	neuropeptide receptor	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Mycobacterium leprae	3-oxoacyl-[acyl-carrier-protein] synthase 1 KasA (BETA-KETOACYL-ACP SYNTHASE) (KAS I)	0.0215	0.6383	1
Mycobacterium ulcerans	polyketide synthase Pks9	0.0115	0.3243	0.1689
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.1317	0.1317
Mycobacterium leprae	3-oxoacyl-[acyl-carrier-protein] synthase 2 KasB (BETA-KETOACYL-ACP SYNTHASE) (KAS I)	0.0215	0.6383	1
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0296	0.8942	0.8942
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0296	0.8942	0.8942
Onchocerca volvulus		0.0296	0.8942	1
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0296	0.8942	0.8942
Trypanosoma brucei	beta-ketoacyl-ACP synthase	0.0329	1	0.5
Echinococcus multilocularis	3 oxoacyl (acyl carrier protein) synthase	0.0329	1	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0296	0.8942	0.8942
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0115	0.3243	0.3042
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0115	0.3243	0.1689
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0296	0.8942	0.8942
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.1317	0.1317
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0115	0.3243	0.3243
Toxoplasma gondii	type I fatty acid synthase, putative	0.0115	0.3243	0.1689
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0296	0.8942	0.8942
Brugia malayi	Melatonin receptor type 1A	0.0296	0.8942	0.8942
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.1317	0.1317
Leishmania major	beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative	0.0329	1	1
Brugia malayi	hypothetical protein	0.0296	0.8942	0.8942
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0296	0.8942	0.8942
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0296	0.8942	0.8942
Echinococcus granulosus	biogenic amine 5HT receptor	0.0296	0.8942	0.8942
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	0.0115	0.3243	0.1689
Mycobacterium ulcerans	fatty acid synthase Fas	0.0115	0.3243	0.1689
Echinococcus granulosus	rhodopsin orphan GPCR	0.0296	0.8942	0.8942
Brugia malayi	hypothetical protein	0.0296	0.8942	0.8942
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.1317	0.1317
Schistosoma mansoni	neuropeptide receptor	0.0296	0.8942	0.8942
Echinococcus multilocularis	neuropeptide s receptor	0.0296	0.8942	0.8942
Mycobacterium tuberculosis	Polyketide synthetase MbtC (polyketide synthase)	0.0115	0.3243	0.3042
Onchocerca volvulus		0.0296	0.8942	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0296	0.8942	0.8942
Echinococcus multilocularis	dro:myosuppressin receptor	0.0296	0.8942	0.8942
Schistosoma mansoni	neuropeptide F-like receptor	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Echinococcus granulosus	biogenic amine 5HT receptor	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Schistosoma mansoni	amine GPCR	0.0296	0.8942	0.8942
Schistosoma mansoni	neuropeptide F-like receptor	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0115	0.3243	0.1689
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0296	0.8942	0.8942
Schistosoma mansoni	neuropeptide receptor	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Loa Loa (eye worm)	beta-ketoacyl synthase domain-containing protein	0.0329	1	1
Schistosoma mansoni	amine GPCR	0.0296	0.8942	0.8942
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0296	0.8942	0.8942
Loa Loa (eye worm)	G-protein coupled receptor	0.0296	0.8942	0.8942
Loa Loa (eye worm)	hypothetical protein	0.0296	0.8942	0.8942
Brugia malayi	neuropeptide F receptor	0.0296	0.8942	0.8942
Echinococcus multilocularis	g protein coupled receptor	0.0296	0.8942	0.8942

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 500 ug ml-1	Antimicrobial activity against Escherichia coli MTCC 443 after 24 to 48 hr by broth microdilution method	ChEMBL.	No reference
MIC (functional)	= 1000 ug ml-1	Antimicrobial activity against Candida albicans MTCC 227 after 24 to 48 hr by broth microdilution method	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2260799

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1842539