Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | beta-site APP-cleaving enzyme 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K07747 beta-site APP-cleaving enzyme 2 (memapsin 1) [EC3.4.23.45], putative | Get druggable targets OG5_135830 | All targets in OG5_135830 |
Schistosoma mansoni | memapsin-2 (A01 family) | Get druggable targets OG5_135830 | All targets in OG5_135830 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | plasmepsin VII | beta-site APP-cleaving enzyme 1 | 401 aa | 352 aa | 21.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.1288 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.1288 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1288 | 1 | 1 |
Plasmodium falciparum | protein kinase, putative | 0.0377 | 0 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1288 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1288 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.1288 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.1288 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1288 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1288 | 1 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.1288 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1288 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.1288 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.1288 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.1288 | 1 | 0.5 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0521 | 0.1577 | 0.1577 |
Echinococcus granulosus | mitogen activated protein kinase | 0.1288 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1288 | 1 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0377 | 0 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.1288 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.1288 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.1288 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.1288 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 18.1 uM | Inhibition of human recombinant BACE1 using [acetyl-C(W8044Eu)-EVNLDAEFK-QSY7] as substrate by TR-FRET assay | ChEMBL. | 24158015 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.