Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Electrophorus electricus | Acetylcholinesterase | Starlite/ChEMBL | References |
Equus caballus | Cholinesterase | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | neuroligin | Cholinesterase | 574 aa | 492 aa | 24.4 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 517 aa | 25.1 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Cholinesterase | 574 aa | 554 aa | 36.1 % |
Schistosoma japonicum | ko:K01050 cholinesterase [EC3.1.1.8], putative | Cholinesterase | 574 aa | 577 aa | 36.9 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 633 aa | 690 aa | 32.3 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 551 aa | 29.9 % | |
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 633 aa | 549 aa | 30.4 % |
Schistosoma mansoni | gliotactin | Cholinesterase | 574 aa | 587 aa | 27.9 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 597 aa | 25.1 % |
Onchocerca volvulus | Galectin homolog | Cholinesterase | 574 aa | 531 aa | 39.7 % |
Brugia malayi | Carboxylesterase family protein | Cholinesterase | 574 aa | 538 aa | 31.4 % |
Onchocerca volvulus | Acetylcholinesterase | 633 aa | 648 aa | 25.3 % | |
Onchocerca volvulus | Putative nuclear protein | Cholinesterase | 574 aa | 572 aa | 40.9 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 620 aa | 28.4 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 633 aa | 690 aa | 31.7 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 633 aa | 576 aa | 28.8 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 578 aa | 25.3 % | |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 633 aa | 507 aa | 23.9 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 576 aa | 23.4 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 633 aa | 622 aa | 24.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0352 | 0.2536 | 0.5 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.0352 | 0.2536 | 0.5 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0352 | 0.2536 | 0.1741 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 0.1145 | 0.0144 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0352 | 0.2536 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 0.1145 | 0.0151 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.0352 | 0.2536 | 0.5 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.0925 | 1 | 1 |
Giardia lamblia | Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative | 0.0158 | 0 | 0.5 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0352 | 0.2536 | 0.1571 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.1145 | 0.0151 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0352 | 0.2536 | 0.1571 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 0.1145 | 0.0151 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.0352 | 0.2536 | 0.5 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.0352 | 0.2536 | 0.1692 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.0925 | 1 | 1 |
Chlamydia trachomatis | biotin carboxylase | 0.032 | 0.2114 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 0.1145 | 0.0144 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.0352 | 0.2536 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0246 | 0.1145 | 0.0144 |
Entamoeba histolytica | acetyl-coA carboxylase, putative | 0.0158 | 0 | 0.5 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.0892 | 0.9578 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0246 | 0.1145 | 0.0151 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.0925 | 1 | 1 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0352 | 0.2536 | 0.1741 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0246 | 0.1145 | 0.0144 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.0925 | 1 | 1 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.0925 | 1 | 1 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.0352 | 0.2536 | 0.5 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.0925 | 1 | 1 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.0892 | 0.9578 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.1145 | 0.0151 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0669 | 0.6669 | 0.5 |
Mycobacterium ulcerans | pyruvate carboxylase | 0.0352 | 0.2536 | 0.5 |
Schistosoma mansoni | pyruvate carboxylase | 0.0352 | 0.2536 | 0.1571 |
Loa Loa (eye worm) | carboxylesterase | 0.0246 | 0.1145 | 0.0151 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 0.1145 | 0.0144 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0573 | 0.5408 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 0.1145 | 0.0144 |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.0352 | 0.2536 | 0.1692 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0669 | 0.6669 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.043 uM | Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured every 1 min by Ellman's method | ChEMBL. | 24160297 |
IC50 (binding) | = 0.163 uM | Inhibition of human erythrocyte AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured every 1 min by Ellman's method | ChEMBL. | 24160297 |
IC50 (binding) | = 1.362 uM | Inhibition of equine serum BuChE using butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured every 1 min by Ellman's method | ChEMBL. | 24160297 |
Inhibition (binding) | Inhibition of human recombinant AChE-induced amyloid beta (1 to 40) aggregation at 100 uM after 48 hrs by thioflavin T fluorescence assay relative to control | ChEMBL. | 24160297 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.