Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Allosteric enhancer activity at Homo sapiens (human) Adenosine A1 receptor expressed in CHO cells assessed as increase in cAMP level at 10 uM after 6 min by radioimmunoassay | ChEMBL. | No reference | |
Activity (binding) | = -29 % | Allosteric modulation of Homo sapiens (human) Adenosine A1 receptor expressed in CHO cells assessed as reduction of cAMP level at 10 uM after 6 min by radioimmunoassay | ChEMBL. | No reference |
Activity (binding) | = -8 % | Allosteric modulation of Homo sapiens (human) Adenosine A1 receptor expressed in CHO cells assessed as reduction of cAMP level at 0.01 uM after 6 min by radioimmunoassay | ChEMBL. | No reference |
Activity (binding) | = -6 % | Allosteric modulation of Homo sapiens (human) Adenosine A1 receptor expressed in CHO cells assessed as reduction of cAMP level at 1 uM after 6 min by radioimmunoassay | ChEMBL. | No reference |
Activity (binding) | = -5 % | Allosteric modulation of Homo sapiens (human) Adenosine A1 receptor expressed in CHO cells assessed as reduction of cAMP level at 0.1 uM after 6 min by radioimmunoassay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.