Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0271 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0194 | 0.3545 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0194 | 0.3545 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0462 | 0.0462 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0271 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0462 | 0.0462 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0462 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0462 | 1 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0462 | 0.0462 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0194 | 0.3545 | 1 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0271 | 0.5 |
Brugia malayi | Inositol-1 | 0.0038 | 0.0271 | 0.5859 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.05 | 1 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0038 | 0.0271 | 0.0271 |
Echinococcus multilocularis | neuropeptide s receptor | 0.05 | 1 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0194 | 0.3545 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0462 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0194 | 0.3545 | 1 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0194 | 0.3545 | 1 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.0271 | 0.5859 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0462 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0038 | 0.0271 | 0.5859 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0025 | 0 | 0.5 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0038 | 0.0271 | 0.0271 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0194 | 0.3545 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0025 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0462 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0462 | 0.0462 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.0271 | 0.5859 |
Trichomonas vaginalis | hypothetical protein | 0.0194 | 0.3545 | 1 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.05 | 1 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0194 | 0.3545 | 1 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0038 | 0.0271 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0271 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 15 mm | Antifungal activity against Candida albicans at 25 ug/ml after 48 hr by two-fold serial dilution method | ChEMBL. | No reference |
IZ (functional) | = 18 mm | Antifungal activity against Candida albicans at 50 ug/ml after 48 hr by two-fold serial dilution method | ChEMBL. | No reference |
IZ (functional) | = 21 mm | Antifungal activity against Candida albicans at 100 ug/ml after 48 hr by two-fold serial dilution method | ChEMBL. | No reference |
MIC (functional) | = 1 ug ml-1 | Antibacterial activity against Escherichia coli after 24 hr by two-fold serial dilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.