Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Muscarinic acetylcholine receptor M3 | Starlite/ChEMBL | No references |
Oryctolagus cuniculus | Uncharacterized protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133264 | All targets in OG5_133264 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133264 | All targets in OG5_133264 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | biogenic amine 5HT receptor | Uncharacterized protein | 460 aa | 434 aa | 27.0 % |
Echinococcus multilocularis | alpha 1A adrenergic receptor | Uncharacterized protein | 460 aa | 469 aa | 20.0 % |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | Muscarinic acetylcholine receptor M3 | 587 aa | 504 aa | 26.8 % |
Onchocerca volvulus | Glycoprotein hormone beta 5 homolog | Muscarinic acetylcholine receptor M3 | 587 aa | 506 aa | 34.6 % |
Schistosoma mansoni | amine GPCR | Uncharacterized protein | 460 aa | 469 aa | 26.2 % |
Loa Loa (eye worm) | hypothetical protein | Uncharacterized protein | 460 aa | 432 aa | 21.3 % |
Echinococcus multilocularis | serotonin receptor | Uncharacterized protein | 460 aa | 434 aa | 27.0 % |
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Uncharacterized protein | 460 aa | 462 aa | 23.4 % |
Echinococcus multilocularis | g protein coupled receptor | Uncharacterized protein | 460 aa | 460 aa | 19.8 % |
Schistosoma mansoni | biogenic amine (5HT) receptor | Uncharacterized protein | 460 aa | 467 aa | 25.5 % |
Onchocerca volvulus | Uncharacterized protein | 460 aa | 467 aa | 24.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0826 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0826 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0826 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0826 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0826 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0826 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0826 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0826 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0826 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0826 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0826 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0826 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0826 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0826 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0826 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.1786 | 0.1786 |
Echinococcus granulosus | FTZ F1 alpha | 0.0826 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0826 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0826 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0826 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0826 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0826 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0826 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0826 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0826 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0826 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0826 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0826 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0826 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0826 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0826 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0826 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0826 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0826 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0826 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0826 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0826 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0826 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0826 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0826 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0826 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0826 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0826 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0826 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0826 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0826 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0826 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0826 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0826 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0826 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0826 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0826 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0826 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0826 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0826 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0826 | 1 | 1 |
Onchocerca volvulus | 0.0826 | 1 | 0.5 | |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0826 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0826 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0826 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0826 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0826 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.1786 | 0.1786 |
Loa Loa (eye worm) | hypothetical protein | 0.0826 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0826 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0826 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0826 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0826 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0826 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0826 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0826 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0826 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (binding) | = 7.13 | Antagonist activity at Cavia porcellus (guinea pig) ileum M3 receptor after 30 min | ChEMBL. | No reference |
Kd (binding) | = 7.13 | Antagonist activity at Cavia porcellus (guinea pig) ileum M3 receptor after 30 min | LITERATURE. | No reference |
Kd (binding) | = 7.57 | Antagonist activity at Oryctolagus cuniculus (rabbit) vas deferens M1 receptor after 1 hr | ChEMBL. | No reference |
Kd (binding) | = 7.57 | Antagonist activity at Oryctolagus cuniculus (rabbit) vas deferens M1 receptor after 1 hr | LITERATURE. | No reference |
pKb (binding) | = 6.02 | Binding affinity to Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr | ChEMBL. | No reference |
pKb (binding) | = 6.02 | Binding affinity to Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr | LITERATURE. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.