TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 313.821 | Formula: C19H20ClNO
H donors: 0 H acceptors: 1 LogP: 4.8 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCN(C(=O)/C(=C/c1ccccc1Cl)/c1ccccc1)CC
InChi: 1S/C19H20ClNO/c1-3-21(4-2)19(22)17(15-10-6-5-7-11-15)14-16-12-8-9-13-18(16)20/h5-14H,3-4H2,1-2H3/b17-14+
InChiKey: QDASWNLAOGAPCX-SAPNQHFASA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0221	0.0857	0.6269
Schistosoma mansoni	histamine h1 receptor	0.0221	0.0857	0.6269
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0221	0.0857	0.0846
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.005	0.0141	0.0427
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0221	0.0857	0.6269
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0221	0.0857	0.6269
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0079	0.0224
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0221	0.0857	0.6269
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0127	0.086
Loa Loa (eye worm)	hypothetical protein	0.005	0.0141	0.1528
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0221	0.0857	0.6269
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0221	0.0857	0.0846
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0221	0.0857	0.6269
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Brugia malayi	GnHR receptor homolog	0.0221	0.0857	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0221	0.0857	0.3072
Brugia malayi	Pre-SET motif family protein	0.0029	0.0053	0.0613
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0127	0.1372
Schistosoma mansoni	hypothetical protein	0.0221	0.0857	0.6269
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.005	0.0141	0.0427
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0127	0.0116
Echinococcus multilocularis	allatostatin A receptor	0.0221	0.0857	0.0846
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0221	0.0857	0.0846
Mycobacterium tuberculosis	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase)	0.005	0.0141	0.0427
Echinococcus multilocularis	geminin	0.0341	0.136	0.135
Mycobacterium ulcerans	short chain dehydrogenase	0.005	0.0141	0.0427
Loa Loa (eye worm)	neuropeptide F receptor	0.0221	0.0857	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0079	0.0502
Echinococcus granulosus	rhodopsin orphan GPCR	0.0221	0.0857	0.3072
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0221	0.0857	0.6269
Trypanosoma brucei	oxidoreductase-like protein	0.005	0.0141	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0221	0.0857	1
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Leishmania major	hypothetical protein, conserved	0.0035	0.0079	0.5243
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0038	0.2077
Echinococcus multilocularis	neuropeptides capa receptor	0.0221	0.0857	0.0846
Brugia malayi	Dopamine receptor	0.0221	0.0857	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0079	0.0801
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0127	0.086
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.005	0.0141	1
Brugia malayi	hypothetical protein	0.0221	0.0857	1
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0221	0.0857	0.0846
Schistosoma mansoni	hypothetical protein	0.0221	0.0857	0.6269
Echinococcus multilocularis	neuropeptide receptor A26	0.0676	0.2763	0.2755
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0741	0.3033	1
Trichomonas vaginalis	set domain proteins, putative	0.0231	0.0899	0.2938
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Onchocerca volvulus		0.0221	0.0857	0.9497
Echinococcus granulosus	orexin receptor type 2	0.0221	0.0857	0.3072
Schistosoma mansoni	amine GPCR	0.0221	0.0857	0.6269
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0221	0.0857	0.0846
Brugia malayi	hypothetical protein	0.0221	0.0857	1
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0079	0.5243
Schistosoma mansoni	neuropeptide F-like receptor	0.0221	0.0857	0.6269
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0079	0.0224
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.005	0.0141	0.0427
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0221	0.0857	0.3072
Brugia malayi	putative neuropeptide receptor NPR1	0.0221	0.0857	1
Schistosoma mansoni	amine GPCR	0.0221	0.0857	0.6269
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0079	0.0224
Onchocerca volvulus		0.0221	0.0857	0.9497
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.005	0.0141	0.0427
Echinococcus granulosus	neuropeptides capa receptor	0.0221	0.0857	0.3072
Echinococcus multilocularis	sex peptide receptor	0.0221	0.0857	0.0846
Echinococcus granulosus	neuropeptides capa receptor	0.0221	0.0857	0.3072
Echinococcus multilocularis	3 oxoacyl acyl carrier protein reductase	0.005	0.0141	0.0129
Echinococcus granulosus	rhodopsin orphan GPCR	0.0221	0.0857	0.3072
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.005	0.0141	0.0427
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0127	0.1487
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.005	0.0141	0.0427
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.005	0.0141	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0079	0.0801
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0221	0.0857	0.0846
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0053	0.0041
Plasmodium vivax	3-oxoacyl-[acyl-carrier-protein] reductase, putative	0.005	0.0141	0.0427
Onchocerca volvulus		0.0221	0.0857	0.9497
Brugia malayi	hypothetical protein	0.0221	0.0857	1
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0079	0.0224
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0127	0.0421
Brugia malayi	hypothetical protein	0.0221	0.0857	1
Mycobacterium tuberculosis	Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase)	0.005	0.0141	0.0427
Onchocerca volvulus		0.0221	0.0857	0.9497
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0221	0.0857	0.6269
Echinococcus multilocularis	fmrfamide receptor	0.0221	0.0857	0.0846
Leishmania major	oxidoreductase-like protein	0.005	0.0141	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0221	0.0857	1
Echinococcus granulosus	g protein coupled receptor	0.0221	0.0857	0.3072
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.005	0.0141	0.1641
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Brugia malayi	hypothetical protein	0.0221	0.0857	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0221	0.0857	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0079	0.0224
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0221	0.0857	0.3072
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0053	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0221	0.0857	0.3072
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0127	0.0116
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.005	0.0141	1
Echinococcus granulosus	geminin	0.0341	0.136	0.49
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0079	0.5243
Schistosoma mansoni	neuropeptide receptor	0.0221	0.0857	0.6269
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0038	0.0089
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0079	0.0224
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0079	0.0224
Onchocerca volvulus		0.0035	0.0079	0.0314
Echinococcus granulosus	neuropeptide FF receptor 2	0.0221	0.0857	0.3072
Brugia malayi	Dopamine receptor protein 1	0.0221	0.0857	1
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.0741	0.3033	1
Echinococcus granulosus	fmrfamide receptor	0.0221	0.0857	0.3072
Brugia malayi	neuropeptide F receptor	0.0221	0.0857	1
Onchocerca volvulus		0.0221	0.0857	0.9497
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0038	0.0089
Brugia malayi	G-protein coupled receptor	0.0221	0.0857	1
Echinococcus granulosus	neuropeptide s receptor	0.0676	0.2763	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0221	0.0857	0.0846
Onchocerca volvulus		0.0221	0.0857	0.9497
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.005	0.0141	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Trypanosoma brucei	beta-ketoacyl-ACP reductase	0.005	0.0141	1
Plasmodium vivax	SET domain protein, putative	0.0029	0.0053	0.0136
Onchocerca volvulus		0.005	0.0141	0.104
Mycobacterium leprae	3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI	0.005	0.0141	0.0208
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0221	0.0857	0.3072
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0079	0.0801
Loa Loa (eye worm)	melatonin receptor type 1A	0.0221	0.0857	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0221	0.0857	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0127	0.086
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0079	0.5243
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.005	0.0141	0.0427
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.005	0.0141	1
Brugia malayi	hypothetical protein	0.0221	0.0857	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0079	0.0801
Brugia malayi	sulfakinin receptor protein	0.0221	0.0857	1
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.005	0.0141	0.1528
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0221	0.0857	0.6269
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0053	0.0305
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0221	0.0857	0.6269
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.005	0.0141	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0221	0.0857	0.6269
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.005	0.0141	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Loa Loa (eye worm)	TYRA-2 protein	0.0221	0.0857	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.005	0.0141	0.1641
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0741	0.3033	1
Echinococcus granulosus	allatostatin A receptor	0.0221	0.0857	0.3072
Schistosoma mansoni	neuropeptide receptor	0.0221	0.0857	0.6269
Mycobacterium ulcerans	short chain dehydrogenase	0.005	0.0141	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.005	0.0141	0.0427
Brugia malayi	hypothetical protein	0.0026	0.0038	0.0446
Schistosoma mansoni	neuropeptide F-like receptor	0.0221	0.0857	0.6269
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.005	0.0141	0.0427
Toxoplasma gondii	ABC1 family protein	0.0035	0.0079	0.0224
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0221	0.0857	1
Echinococcus granulosus	sex peptide receptor	0.0221	0.0857	0.3072
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0079	0.0224
Trichomonas vaginalis	esterase, putative	0.0035	0.0079	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0221	0.0857	0.3072
Brugia malayi	follicle stimulating hormone receptor	0.0221	0.0857	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0221	0.0857	0.9497
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0221	0.0857	0.0846
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Echinococcus granulosus	neuropeptide receptor A26	0.0676	0.2763	1
Brugia malayi	Pre-SET motif family protein	0.0203	0.0782	0.9125
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0221	0.0857	0.6269
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0053	0.0305
Mycobacterium ulcerans	short chain dehydrogenase	0.005	0.0141	0.0427
Echinococcus granulosus	G protein coupled receptor 139	0.0221	0.0857	0.3072
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0038	0.0089
Onchocerca volvulus		0.0221	0.0857	0.9497
Echinococcus multilocularis	fmrfamide receptor	0.0221	0.0857	0.0846
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0011	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0221	0.0857	0.3072
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Brugia malayi	neuropeptide F receptor	0.0221	0.0857	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0221	0.0857	0.0846
Loa Loa (eye worm)	oxidoreductase	0.005	0.0141	0.1528
Loa Loa (eye worm)	G-protein coupled receptor	0.0221	0.0857	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0079	0.0246
Echinococcus multilocularis	orexin receptor type 2	0.0221	0.0857	0.0846
Brugia malayi	AKH receptor	0.0221	0.0857	1
Onchocerca volvulus		0.0221	0.0857	0.9497
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0079	0.0224
Echinococcus granulosus	tm gpcr rhodopsin	0.0221	0.0857	0.3072
Mycobacterium ulcerans	short chain dehydrogenase	0.005	0.0141	0.0427
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0011	0.5
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0011	0.0133
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0221	0.0857	0.3072
Echinococcus multilocularis	serotonin receptor	0.0221	0.0857	0.0846
Mycobacterium ulcerans	short chain dehydrogenase	0.005	0.0141	0.0427
Echinococcus granulosus	3 oxoacyl acyl carrier protein reductase	0.005	0.0141	0.0469
Echinococcus multilocularis	g protein coupled receptor	0.0221	0.0857	0.0846
Echinococcus granulosus	rhodopsin orphan GPCR	0.0221	0.0857	0.3072
Echinococcus multilocularis	g-protein coupled receptor	0.0221	0.0857	0.0846
Schistosoma mansoni	amine GPCR	0.0221	0.0857	0.6269
Echinococcus multilocularis	neuropeptides capa receptor	0.0221	0.0857	0.0846
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Echinococcus multilocularis	neuropeptide s receptor	0.0676	0.2763	0.2755
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0221	0.0857	1
Echinococcus granulosus	neuropeptide Y receptor	0.0221	0.0857	0.3072
Schistosoma mansoni	neuropeptide f receptor 76f	0.0221	0.0857	0.6269
Echinococcus multilocularis	neuropeptide receptor	0.0221	0.0857	0.0846
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0079	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0038	0.0317
Brugia malayi	G protein-coupled receptor F59B2.13	0.0221	0.0857	1
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0221	0.0857	0.0846
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0221	0.0857	1
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0221	0.0857	1
Schistosoma mansoni	biogenic amine receptor	0.0221	0.0857	0.6269
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0741	0.3033	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0221	0.0857	0.3072
Brugia malayi	hypothetical protein	0.0221	0.0857	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0079	0.0923
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.005	0.0141	0.0427
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0221	0.0857	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.005	0.0141	0.0427
Schistosoma mansoni	hypothetical protein	0.0341	0.136	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0221	0.0857	0.6269
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0079	0.0801
Plasmodium falciparum	3-oxoacyl-[acyl-carrier-protein] reductase	0.005	0.0141	0.0427
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0221	0.0857	0.6269
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0221	0.0857	0.0846
Brugia malayi	hypothetical protein	0.0221	0.0857	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0221	0.0857	0.0846
Trichomonas vaginalis	hypothetical protein	0.0741	0.3033	1
Onchocerca volvulus		0.0221	0.0857	0.9497
Toxoplasma gondii	3-ketoacyl-(acyl-carrier-protein) reductase	0.005	0.0141	0.0427
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0221	0.0857	0.0846
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0079	0.0224
Echinococcus granulosus	g protein coupled receptor	0.0221	0.0857	0.3072
Echinococcus multilocularis	g protein coupled receptor	0.0221	0.0857	0.0846
Echinococcus granulosus	biogenic amine 5HT receptor	0.0221	0.0857	0.3072
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0079	0.0224
Mycobacterium ulcerans	short chain dehydrogenase	0.005	0.0141	0.0427
Mycobacterium ulcerans	short chain dehydrogenase	0.005	0.0141	0.0427
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.005	0.0141	0.0427
Echinococcus granulosus	rhodopsin orphan GPCR	0.0221	0.0857	0.3072
Schistosoma mansoni	opsin-like receptor	0.0221	0.0857	0.6269
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0038	0.2077
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0221	0.0857	0.0846
Brugia malayi	larval opioid receptor	0.0221	0.0857	1
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0221	0.0857	0.9497
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Onchocerca volvulus		0.0221	0.0857	0.9497
Onchocerca volvulus		0.0221	0.0857	0.9497
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.005	0.0141	1
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Mycobacterium ulcerans	short chain dehydrogenase	0.005	0.0141	0.0427
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0221	0.0857	0.3072
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0221	0.0857	0.3072
Echinococcus granulosus	neuropeptide Y receptor	0.0221	0.0857	0.3072
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0221	0.0857	0.6269
Mycobacterium ulcerans	short chain dehydrogenase	0.005	0.0141	0.0427
Echinococcus multilocularis	neuropeptide receptor	0.0221	0.0857	0.0846
Leishmania major	3-oxoacyl-ACP reductase, putative	0.005	0.0141	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0221	0.0857	0.0846
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0221	0.0857	0.6269
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0221	0.0857	0.0846
Echinococcus granulosus	neuropeptide receptor	0.0221	0.0857	0.3072
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0079	0.0224
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0079	0.0224
Echinococcus granulosus	serotonin receptor	0.0221	0.0857	0.3072
Mycobacterium tuberculosis	Possible oxidoreductase	0.005	0.0141	0.0427
Onchocerca volvulus		0.0221	0.0857	0.9497
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0221	0.0857	0.6269
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0221	0.0857	0.6269
Brugia malayi	beta-lactamase family protein	0.0035	0.0079	0.0923
Brugia malayi	ORL1-like opioid receptor	0.0221	0.0857	1
Schistosoma mansoni	neuropeptide receptor	0.0221	0.0857	0.6269
Brugia malayi	RE15519p	0.0221	0.0857	1
Leishmania major	pteridine reductase 1	0.005	0.0141	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0221	0.0857	0.0846
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0221	0.0857	0.0846
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0221	0.0857	0.6269
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.005	0.0141	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Onchocerca volvulus		0.0221	0.0857	0.9497
Mycobacterium ulcerans	20-beta-hydroxysteroid dehydrogenase FabG3	0.005	0.0141	0.0427
Brugia malayi	G-protein coupled receptor	0.0221	0.0857	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0221	0.0857	0.0846
Mycobacterium tuberculosis	Possible oxidoreductase	0.005	0.0141	0.0427
Mycobacterium ulcerans	short chain dehydrogenase	0.005	0.0141	0.0427
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0221	0.0857	0.6269
Onchocerca volvulus		0.0231	0.0899	1
Onchocerca volvulus		0.0035	0.0079	0.0314
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0053	0.0041
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0221	0.0857	0.0846
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0741	0.3033	1
Schistosoma mansoni	amine GPCR	0.0221	0.0857	0.6269
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0221	0.0857	0.6269
Toxoplasma gondii	short chain dehydrogenase family protein, putative	0.005	0.0141	0.0427
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0221	0.0857	0.6269
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0227	0.088	0.2876
Schistosoma mansoni	myosin xvIII	0.0221	0.0857	0.6269
Mycobacterium tuberculosis	Probable oxidoreductase	0.005	0.0141	0.0427
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0079	0.0224
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0053	0.0305
Onchocerca volvulus		0.0221	0.0857	0.9497
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0221	0.0857	0.0846
Onchocerca volvulus		0.0221	0.0857	0.9497
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.005	0.0141	0.0427
Mycobacterium ulcerans	short chain dehydrogenase	0.005	0.0141	0.0427
Brugia malayi	hypothetical protein	0.0221	0.0857	1
Schistosoma mansoni	hypothetical protein	0.0221	0.0857	0.6269
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0221	0.0857	0.0846
Schistosoma mansoni	hypothetical protein	0.0341	0.136	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0221	0.0857	0.6269
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0221	0.0857	0.6269
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0079	0.0224
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0079	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.005	0.0141	0.0427
Echinococcus granulosus	somatostatin receptor	0.0221	0.0857	0.3072
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0053	0.0136
Echinococcus multilocularis	somatostatin receptor	0.0221	0.0857	0.0846
Brugia malayi	hypothetical protein	0.0221	0.0857	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0079	0.0801
Brugia malayi	beta-lactamase	0.0035	0.0079	0.0923
Chlamydia trachomatis	enoyl-acyl-carrier protein reductase	0.0741	0.3033	1
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0221	0.0857	1
Schistosoma mansoni	neuropeptide receptor	0.0221	0.0857	0.6269
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.005	0.0141	0.0427
Echinococcus multilocularis	g protein coupled receptor	0.0221	0.0857	0.0846
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Brugia malayi	Serotonin receptor	0.0221	0.0857	1
Loa Loa (eye worm)	retinol dehydrogenase 12	0.005	0.0141	0.1528
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Mycobacterium ulcerans	lipase LipD	0.0035	0.0079	0.0224
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0221	0.0857	0.6269
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.005	0.0141	0.0427
Echinococcus granulosus	hypothetical protein	0.0221	0.0857	0.3072
Plasmodium falciparum	enoyl-acyl carrier reductase	0.0741	0.3033	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0221	0.0857	0.3072
Schistosoma mansoni	opsin-like receptor	0.0221	0.0857	0.6269
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0038	0.2077
Brugia malayi	Melatonin receptor type 1A	0.0221	0.0857	1
Brugia malayi	beta-lactamase family protein	0.0035	0.0079	0.0923
Echinococcus granulosus	tm gpcr rhodopsin	0.0221	0.0857	0.3072
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0127	0.0421
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0203	0.0782	0.9113
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0221	0.0857	0.0846
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.005	0.0141	0.0427
Brugia malayi	Serotonin receptor	0.0221	0.0857	1
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Onchocerca volvulus		0.0221	0.0857	0.9497
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.005	0.0141	0.0427
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0221	0.0857	0.6269
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0079	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Brugia malayi	Dopamine receptor protein 2	0.0221	0.0857	1
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Schistosoma mansoni	3-oxoacyl-[ACP] reductase	0.005	0.0141	0.0958
Mycobacterium ulcerans	short chain dehydrogenase	0.005	0.0141	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0053	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0079	0.0801
Onchocerca volvulus		0.0221	0.0857	0.9497
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0079	0.0224
Schistosoma mansoni	dihydropteridine reductase	0.005	0.0141	0.0958
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0221	0.0857	0.6269
Echinococcus granulosus	tm gpcr rhodopsin	0.0221	0.0857	0.3072
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0079	0.0502
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0221	0.0857	1
Schistosoma mansoni	biogenic amine receptor	0.0221	0.0857	0.6269
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0221	0.0857	0.0846
Echinococcus granulosus	rhodopsin orphan GPCR	0.0221	0.0857	0.3072
Schistosoma mansoni	biogenic amine receptor	0.0221	0.0857	0.6269
Onchocerca volvulus		0.005	0.0141	0.104
Onchocerca volvulus		0.0035	0.0079	0.0314
Echinococcus granulosus	neuropeptide receptor	0.0221	0.0857	0.3072
Echinococcus granulosus	7tm_1 domain containing protein	0.0221	0.0857	0.3072
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0741	0.3033	1
Brugia malayi	G protein-coupled receptor	0.0221	0.0857	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0048	0.0133
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0038	0.0089
Brugia malayi	putative neuropeptide receptor	0.0221	0.0857	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0053	0.0149
Loa Loa (eye worm)	G-protein coupled receptor	0.0221	0.0857	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0221	0.0857	0.0846
Trypanosoma brucei	pteridine reductase 1	0.005	0.0141	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0079	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Echinococcus granulosus	g-protein coupled receptor	0.0221	0.0857	0.3072
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Schistosoma mansoni	opsin-like receptor	0.0221	0.0857	0.6269
Schistosoma mansoni	amine GPCR	0.0221	0.0857	0.6269
Echinococcus granulosus	g protein coupled receptor	0.0221	0.0857	0.3072
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0221	0.0857	0.0846
Entamoeba histolytica	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.005	0.0141	1
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0857	1
Leishmania major	hypothetical protein, conserved	0.0026	0.0038	0.2077
Echinococcus granulosus	rhodopsin orphan GPCR	0.0221	0.0857	0.3072
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0079	0.0224
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0221	0.0857	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0221	0.0857	0.0846
Echinococcus multilocularis	serotonin receptor	0.0221	0.0857	0.0846
Echinococcus granulosus	rhodopsin orphan GPCR	0.0221	0.0857	0.3072
Mycobacterium leprae	POSSIBLE OXIDOREDUCTASE	0.005	0.0141	0.0208
Schistosoma mansoni	adenoreceptor	0.0221	0.0857	0.6269
Mycobacterium ulcerans	oxidoreductase	0.005	0.0141	0.0427
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0221	0.0857	0.0846
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0079	0.0801

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 18 ug ml-1	Cytostatic activity against Homo sapiens (human) CEM cells after 72 hr by coulter counter analysis	ChEMBL.	No reference
IC50 (functional)	= 24 ug ml-1	Cytostatic activity against Mus musculus (mouse) L1210 cells after 48 hr by coulter counter analysis	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2261276

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1844692