Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0043 | 0.0031 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0321 | 0.1525 | 0.1499 |
Schistosoma mansoni | acetylcholinesterase | 0.0321 | 0.1525 | 0.1525 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0043 | 0.0031 | 0.5 |
Brugia malayi | hypothetical protein | 0.0321 | 0.1525 | 0.1525 |
Echinococcus granulosus | carboxylesterase 5A | 0.1901 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0031 | 0.0031 |
Schistosoma mansoni | amine oxidase | 0.0043 | 0.0031 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 0.1525 | 0.1525 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 0.1525 | 0.1525 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0031 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0091 | 0.0091 |
Echinococcus multilocularis | acetylcholinesterase | 0.1901 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1901 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1901 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1901 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1901 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0321 | 0.1525 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0321 | 0.1525 | 0.1499 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0031 | 0.0031 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0043 | 0.0031 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0043 | 0.0031 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0321 | 0.1525 | 0.1499 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0031 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 0.1525 | 0.1525 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0321 | 0.1525 | 0.5 |
Leishmania major | UDP-galactopyranose mutase | 0.0043 | 0.0031 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 0.1525 | 0.1525 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0321 | 0.1525 | 0.1499 |
Brugia malayi | Carboxylesterase family protein | 0.0321 | 0.1525 | 0.1525 |
Onchocerca volvulus | 0.0321 | 0.1525 | 1 | |
Echinococcus granulosus | acetylcholinesterase | 0.1901 | 1 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0043 | 0.0031 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0043 | 0.0031 | 0.0031 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0604 | 0.3042 | 1 |
Onchocerca volvulus | 0.0321 | 0.1525 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0031 | 0.0031 |
Echinococcus granulosus | acetylcholinesterase | 0.1901 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.0321 | 0.1525 | 0.1499 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0031 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0043 | 0.0031 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0321 | 0.1525 | 0.1499 |
Brugia malayi | SWIRM domain containing protein | 0.0043 | 0.0031 | 0.0031 |
Brugia malayi | Carboxylesterase family protein | 0.0321 | 0.1525 | 0.1525 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0321 | 0.1525 | 0.537 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0043 | 0.0031 | 0.0031 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1901 | 1 | 1 |
Onchocerca volvulus | 0.0321 | 0.1525 | 1 | |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0043 | 0.0031 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1901 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0321 | 0.1525 | 0.1525 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0321 | 0.1525 | 0.1525 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0043 | 0.0031 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0043 | 0.0031 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1901 | 1 | 1 |
Onchocerca volvulus | 0.0321 | 0.1525 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0031 | 0.0031 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0321 | 0.1525 | 0.1525 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1901 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0321 | 0.1525 | 0.1525 |
Loa Loa (eye worm) | carboxylesterase | 0.0321 | 0.1525 | 0.1525 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0321 | 0.1525 | 0.4963 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0604 | 0.3042 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0321 | 0.1525 | 0.1499 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0321 | 0.1525 | 0.1525 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0321 | 0.1525 | 0.537 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0031 | 0.0031 |
Loa Loa (eye worm) | carboxylesterase | 0.0321 | 0.1525 | 0.1525 |
Schistosoma mansoni | gliotactin | 0.0321 | 0.1525 | 0.1525 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0031 | 0.0031 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0043 | 0.0031 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 0.1525 | 0.1525 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0043 | 0.0031 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0321 | 0.1525 | 0.1525 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0043 | 0.0031 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 0.1525 | 0.1525 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 0.1525 | 0.1525 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0321 | 0.1525 | 0.1525 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0091 | 0.0091 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0321 | 0.1525 | 0.537 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0091 | 0.0091 |
Onchocerca volvulus | 0.0321 | 0.1525 | 1 | |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0321 | 0.1525 | 0.1499 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0091 | 0.0091 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0043 | 0.0031 | 0.5 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0561 | 0.2814 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Activity of the compound to produce DNA topoisomerase I-mediated DNA cleavage at concentration up to 10 microM; +, indicates weak activity | ChEMBL. | 12852757 | |
Activity (binding) | 0 | Activity of the compound to produce DNA topoisomerase I-mediated DNA cleavage at concentration up to 10 microM; +, indicates weak activity | ChEMBL. | 12852757 |
GI50 (functional) | -4.702 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.591 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.527 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.445 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.269 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.259 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.085 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | = 0 uM | Cytotoxic concentration against human CNS SF-539 cell line growth inhibition | ChEMBL. | 12852757 |
GI50 (functional) | = 17.5 uM | Cytotoxic concentration against human lung HOP-62 cell line growth inhibition | ChEMBL. | 12852757 |
GI50 (functional) | = 17.5 uM | Cytotoxic concentration against human lung HOP-62 cell line growth inhibition | ChEMBL. | 12852757 |
GI50 (functional) | = 33.3 uM | Cytotoxic concentration against human melanoma UACC-62 cell line growth inhibition | ChEMBL. | 12852757 |
GI50 (functional) | = 33.3 uM | Cytotoxic concentration against human melanoma UACC-62 cell line growth inhibition | ChEMBL. | 12852757 |
GI50 (functional) | = 35.9 uM | Cytotoxic concentration against human prostate DU-145 cell line growth inhibition | ChEMBL. | 12852757 |
GI50 (functional) | = 35.9 uM | Cytotoxic concentration against human prostate DU-145 cell line growth inhibition | ChEMBL. | 12852757 |
GI50 (functional) | = 40.4 uM | Cytotoxic concentration against human colon HCT-116 cell line growth inhibition | ChEMBL. | 12852757 |
GI50 (functional) | = 40.4 uM | Cytotoxic concentration against human colon HCT-116 cell line growth inhibition | ChEMBL. | 12852757 |
GI50 (functional) | = 42.3 uM | Cytotoxic concentration against human ovarian OVCAR-3 cell line growth inhibition | ChEMBL. | 12852757 |
GI50 (functional) | = 42.3 uM | Cytotoxic concentration against human ovarian OVCAR-3 cell line growth inhibition | ChEMBL. | 12852757 |
GI50 (functional) | > 100 uM | Cytotoxic concentration against human renal SN12C cell line growth inhibition | ChEMBL. | 12852757 |
GI50 (functional) | > 100 uM | Cytotoxic concentration against human breast MDA-MB-435 cell line growth inhibition | ChEMBL. | 12852757 |
GI50 (functional) | > 100 uM | Cytotoxic concentration against human renal SN12C cell line growth inhibition | ChEMBL. | 12852757 |
GI50 (functional) | > 100 uM | Cytotoxic concentration against human breast MDA-MB-435 cell line growth inhibition | ChEMBL. | 12852757 |
MGM (functional) | = 33.1 | Mean graph midpoint for growth inhibition of all human cancer cell lines | ChEMBL. | 12852757 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.