TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 585.781 | Formula: C29H39N5O4S2
H donors: 4 H acceptors: 5 LogP: 2.66 Rotable bonds: 19
Rule of 5 violations (Lipinski): 2
SMILES: CSCC[C@@H](C(=O)O)NC(=O)CN(C[C@H](C(CC)C)NC(=O)CSc1nc2c([nH]1)cccc2)Cc1ccccc1
InChi: 1S/C29H39N5O4S2/c1-4-20(2)25(31-27(36)19-40-29-32-22-12-8-9-13-23(22)33-29)17-34(16-21-10-6-5-7-11-21)18-26(35)30-24(28(37)38)14-15-39-3/h5-13,20,24-25H,4,14-19H2,1-3H3,(H,30,35)(H,31,36)(H,32,33)(H,37,38)/t20?,24-,25+/m0/s1
InChiKey: MHPGTFOKNTYHDW-DUXSLQFZSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	farnesyltransferase, CAAX box, alpha	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium berghei	protein farnesyltransferase subunit alpha, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Giardia lamblia	Rab geranylgeranyltransferase	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium vivax	prenyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Theileria parva	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium falciparum	protein farnesyltransferase subunit alpha	Get druggable targets OG5_128459	All targets in OG5_128459
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Echinococcus granulosus	protein farnesyltransferase alpha subunit	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Neospora caninum	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Candida albicans	alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p)	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium knowlesi	protein farnesyltransferase subunit alpha, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Cryptosporidium parvum	farnesyltransferase	Get druggable targets OG5_128459	All targets in OG5_128459
Cryptosporidium hominis	farnesyltransferase	Get druggable targets OG5_128459	All targets in OG5_128459
Candida albicans	alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p)	Get druggable targets OG5_128459	All targets in OG5_128459
Schistosoma japonicum	ko:K05954 farnesyltransferase, CAAX box, alpha [EC:2.5.1.58 2.5.1.59], putative	Get druggable targets OG5_128459	All targets in OG5_128459
Schistosoma mansoni	protein farnesyltransferase alpha subunit	Get druggable targets OG5_128459	All targets in OG5_128459
Babesia bovis	protein prenyltransferase alpha subunit repeat domain containing protein	Get druggable targets OG5_128459	All targets in OG5_128459
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	Get druggable targets OG5_128459	All targets in OG5_128459

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0136	0.0369	0.0361
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.015	0.015
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0017	0.0009
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0092	0.0237	0.0615
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0017	0.0035
Echinococcus multilocularis	acetylcholinesterase	0.3352	1	1
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0237	0.0229
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0136	0.0369	0.0369
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.005	0.011	0.0574
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0162	0.0445	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0053	0.0053
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.002	0.0021	0.0021
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.1217	0.3606	1
Loa Loa (eye worm)	carboxylesterase	0.3352	1	1
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0017	0.0005
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0092	0.0237	0.0229
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.002	0.0021	0.0021
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0299	0.0857	0.0855
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0017	0.0009
Schistosoma mansoni	hypothetical protein	0.0407	0.118	0.118
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0021	0.0013
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.002	0.0021	0.0021
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0095	0.0244	0.0236
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0092	0.0237	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0016	0.0014
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.005	0.011	0.0108
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.0109	0.4209
Plasmodium falciparum	ataxin-2 like protein, putative	0.005	0.0109	0.1779
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.005	0.011	0.1805
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.3352	1	1
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0017	0.0015
Brugia malayi	nuclear hormone receptor	0.002	0.0021	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0566	0.1657	0.165
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0136	0.0369	0.0369
Schistosoma mansoni	hypothetical protein	0.0095	0.0244	0.0244
Echinococcus granulosus	acetylcholinesterase	0.3352	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.0021	0.0018
Brugia malayi	RNA binding protein	0.0063	0.015	0.0147
Loa Loa (eye worm)	carboxylesterase	0.0566	0.1657	0.165
Onchocerca volvulus		0.003	0.005	0.0177
Leishmania major	hypothetical protein, conserved	0.005	0.0109	0.4209
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0237	0.0229
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.005	0.011	0.4269
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.005	0.011	0.4269
Leishmania major	UDP-galactopyranose mutase	0.0092	0.0237	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0136	0.0369	0.0361
Plasmodium falciparum	protoporphyrinogen oxidase	0.0092	0.0237	0.4227
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.002	0.0021	0.0013
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0041	0.0153
Brugia malayi	CXXC zinc finger family protein	0.0085	0.0215	0.0212
Echinococcus granulosus	dnaJ subfamily B	0.0407	0.118	0.1173
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0017	0.0009
Echinococcus multilocularis	polycomb protein SCMH1	0.0047	0.0102	0.0094
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0018	0.0013
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0016	0.5
Brugia malayi	steroid hormone receptor	0.002	0.0021	0.0018
Schistosoma mansoni	hypothetical protein	0.0095	0.0244	0.0244
Schistosoma mansoni	amine oxidase	0.0092	0.0237	0.0237
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0018	0.0013
Loa Loa (eye worm)	hypothetical protein	0.002	0.0021	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0244	0.0236
Onchocerca volvulus		0.0085	0.0215	0.1185
Plasmodium vivax	hypothetical protein, conserved	0.0092	0.0237	0.4227
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0054	0.0121	0.0119
Toxoplasma gondii	LsmAD domain-containing protein	0.005	0.0109	0.2164
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0017	0.0035
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0016	0.0008
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.005	0.011	0.1805
Entamoeba histolytica	hypothetical protein	0.0036	0.0068	0.0995
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0017	0.0081
Loa Loa (eye worm)	hypothetical protein	0.002	0.0021	0.0013
Echinococcus granulosus	carboxylesterase 5A	0.3352	1	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0566	0.1657	0.1657
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.002	0.0021	0.0021
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0017	0.0009
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0054	0.0121	0.0113
Brugia malayi	Pre-SET motif family protein	0.0205	0.0573	0.0571
Toxoplasma gondii	hypothetical protein	0.005	0.011	0.2195
Brugia malayi	TAR-binding protein	0.0063	0.015	0.0147
Loa Loa (eye worm)	hypothetical protein	0.3352	1	1
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.005	0.011	1
Schistosoma mansoni	chromobox protein	0.0068	0.0164	0.0164
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0095	0.0244	0.0236
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0193	0.0538	0.053
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0102	0.0102
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.0021	0.0018
Brugia malayi	Nuclear hormone receptor-like 1	0.002	0.0021	0.0018
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.002	0.0021	0.0018
Echinococcus granulosus	SAM and MBT domain containing protein	0.0047	0.0102	0.0094
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.003	0.0051	0.0215
Onchocerca volvulus		0.0566	0.1657	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0017	0.0035
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0053	0.0864
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.015	0.0142
Schistosoma mansoni	cpg binding protein	0.009	0.0229	0.0229
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0021	0.0013
Loa Loa (eye worm)	hypothetical protein	0.002	0.0021	0.0013
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0017	0.0002
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0042	0.0086	0.0086
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0136	0.0369	0.0369
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0017	0.0005
Schistosoma mansoni	cpg binding protein	0.009	0.0229	0.0229
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0566	0.1657	0.1657
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0074	0.0356
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0017	0.0035
Brugia malayi	F/Y-rich N-terminus family protein	0.0027	0.0041	0.0039
Leishmania major	DNA polymerase eta, putative	0.0019	0.0017	0.0035
Giardia lamblia	Rab geranylgeranyltransferase	0.005	0.011	0.1805
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0018	0.0013
Schistosoma mansoni	RAR-like nuclear receptor	0.002	0.0021	0.0021
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.005	0.011	0.0102
Trypanosoma brucei	hypothetical protein, conserved	0.005	0.011	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0181	0.0503	0.0503
Schistosoma mansoni	hypothetical protein	0.0095	0.0244	0.0244
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0017	0.0002
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0095	0.0244	0.0236
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.002	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0237	0.0229
Echinococcus multilocularis	para nitrobenzyl esterase	0.0566	0.1657	0.165
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0083	0.0409
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.0164	0.09
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0017	0.0009
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.015	0.0142
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.005	0.011	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.0109	0.4209
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0136	0.0369	0.0361
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0095	0.0244	0.0236
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0566	0.1657	0.1657
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0193	0.0538	0.3182
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0092	0.0237	0.5
Loa Loa (eye worm)	MBCTL1	0.0054	0.0121	0.0113
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0017	0.0035
Entamoeba histolytica	hypothetical protein	0.0036	0.0068	0.0995
Brugia malayi	SWIRM domain containing protein	0.0092	0.0237	0.0234
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.002	0.0021	0.0013
Schistosoma mansoni	chromobox protein	0.0068	0.0164	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0237	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0566	0.1657	0.165
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0092	0.0237	0.0571
Echinococcus granulosus	chromobox protein 1	0.0068	0.0164	0.0156
Schistosoma mansoni	hypothetical protein	0.0205	0.0573	0.0573
Loa Loa (eye worm)	hypothetical protein	0.0566	0.1657	0.165
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0092	0.0237	0.0229
Mycobacterium ulcerans	carboxylesterase, LipT	0.0566	0.1657	0.4243
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0068	0.006
Brugia malayi	Carboxylesterase family protein	0.0566	0.1657	0.1655
Entamoeba histolytica	hypothetical protein	0.0036	0.0068	0.0995
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0085	0.0215	0.0207
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0193	0.0538	0.3182
Brugia malayi	Carboxylesterase family protein	0.3352	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0017	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0121	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0102	0.0094
Echinococcus multilocularis	cpg binding protein	0.009	0.0229	0.0221
Echinococcus granulosus	tar DNA binding protein	0.0063	0.015	0.0142
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0017	0.0014
Loa Loa (eye worm)	carboxylesterase	0.0566	0.1657	0.165
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.002	0.0021	0.0013
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0092	0.0237	0.4227
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0021	0.0025	0.0053
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0017	0.0081
Plasmodium falciparum	ataxin-2 like protein, putative	0.005	0.0109	0.1779
Echinococcus granulosus	acetylcholinesterase	0.3352	1	1
Schistosoma mansoni	amine oxidase	0.0092	0.0237	0.0237
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0566	0.1657	0.165
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0092	0.0237	0.0229
Trichomonas vaginalis	set domain proteins, putative	0.0233	0.0657	0.3906
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.002	0.0021	0.0018
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.002	0.0021	0.0013
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0018	0.0013
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.002	0.0021	0.0013
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0092	0.0237	0.0237
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0566	0.1657	0.457
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0017	0.0081
Echinococcus multilocularis	chromobox protein 1	0.0068	0.0164	0.0156
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.003	0.0051	0.0215
Brugia malayi	latrophilin 2 splice variant baaae	0.0205	0.0573	0.0571
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.005	0.011	0.4269
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.002	0.0021	0.0018
Onchocerca volvulus		0.0566	0.1657	1
Giardia lamblia	Rab geranylgeranyltransferase	0.0193	0.0538	1
Echinococcus granulosus	neuroligin	0.0566	0.1657	0.165
Echinococcus multilocularis		0.0092	0.0237	0.0229
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0017	0.0081
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0092	0.0237	0.0237
Echinococcus multilocularis	GPCR, family 2	0.0095	0.0244	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0566	0.1657	0.165
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0566	0.1657	0.457
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.002	0.0021	0.0013
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0016	0.0008
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0022	0.0027	0.0019
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.011	0.4269
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0092	0.0237	0.4227
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0017	0.0002
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.002	0.0021	0.0018
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.003	0.0051	0.0215
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0017	0.0017
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0017	0.0035
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0018	0.0013
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0074	0.0066
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.003	0.0051	0.0215
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.002	0.0021	0.0021
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0068	0.0068
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.002	0.0021	0.0018
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0047	0.0102	0.0496
Mycobacterium ulcerans	dehydrogenase	0.0092	0.0237	0.0571
Loa Loa (eye worm)	acetylcholinesterase 1	0.3352	1	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.003	0.0051	0.0215
Loa Loa (eye worm)	mbt repeat family protein	0.0047	0.0102	0.0094
Echinococcus multilocularis	ecdysone induced protein 78C	0.002	0.0021	0.0013
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0092	0.0237	0.0229
Echinococcus granulosus	FTZ F1 alpha	0.002	0.0021	0.0013
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0016	0.0008	0.0008
Schistosoma mansoni	nuclear hormone receptor	0.002	0.0021	0.0021
Onchocerca volvulus		0.0566	0.1657	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.002	0.0021	0.0013
Brugia malayi	hypothetical protein	0.0566	0.1657	0.1655
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0041	0.0153
Loa Loa (eye worm)	histone methyltransferase	0.0027	0.0042	0.0034
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0054	0.0121	0.0121
Brugia malayi	mbt repeat family protein	0.0047	0.0102	0.0099
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0016	0.5
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.019	0.0529	0.0521
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0069	0.0166	0.0166
Trypanosoma brucei	PAB1-binding protein , putative	0.005	0.0109	0.9859
Loa Loa (eye worm)	hypothetical protein	0.002	0.0021	0.0013
Loa Loa (eye worm)	hypothetical protein	0.005	0.0109	0.0101
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0092	0.0237	0.5
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0022	0.0027	0.0019
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0092	0.0237	0.4227
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0083	0.0409
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0017	0.0014
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.002	0.002	0.0027
Schistosoma mansoni	gliotactin	0.0566	0.1657	0.1657
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.002	0.0021	0.0018
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0018	0.0013
Loa Loa (eye worm)	steroid hormone receptor	0.002	0.0021	0.0013
Brugia malayi	mbt repeat family protein	0.0047	0.0102	0.0099
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0566	0.1657	0.1657
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.011	0.4269
Brugia malayi	Heterochromatin protein 1	0.0068	0.0164	0.0161
Trichomonas vaginalis	helicase, putative	0.0019	0.0018	0.0013
Schistosoma mansoni	steroid hormone receptor ad4bp	0.002	0.0021	0.0021
Echinococcus granulosus	histone acetyltransferase MYST2	0.0054	0.0121	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0566	0.1657	0.165
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0092	0.0237	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0021	0.0013
Schistosoma mansoni	hypothetical protein	0.0095	0.0244	0.0244
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.005	0.011	0.1805
Brugia malayi	Carboxylesterase family protein	0.0566	0.1657	0.1655
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0021	0.0013
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0022	0.0027	0.0019
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0017	0.0081
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.005	0.011	0.4269
Loa Loa (eye worm)	hypothetical protein	0.0299	0.0857	0.085
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.0017	0.0015
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0017	0.0081
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0074	0.0328
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.003	0.0051	0.0215
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0092	0.0237	0.4227
Brugia malayi	CHD4 protein	0.0016	0.0008	0.0006
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.019	0.0529	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0566	0.1657	0.165
Brugia malayi	Latrophilin receptor protein 2	0.0095	0.0244	0.0242
Echinococcus granulosus	ecdysone induced protein 78C	0.002	0.0021	0.0013
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.015	0.015
Echinococcus granulosus	chromobox protein 1	0.0068	0.0164	0.0156
Onchocerca volvulus		0.0047	0.0102	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0237	0.0229
Schistosoma mansoni	thyroid hormone receptor	0.002	0.0021	0.0021
Schistosoma mansoni	ap endonuclease	0.0019	0.0016	0.0016
Brugia malayi	Carboxylesterase family protein	0.0566	0.1657	0.1655
Loa Loa (eye worm)	RNA binding protein	0.0063	0.015	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0193	0.0538	0.053
Brugia malayi	hypothetical protein	0.005	0.0109	0.0106
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0022	0.0027	0.0019
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.002	0.0021	0.0013
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0193	0.0538	0.0538
Brugia malayi	Pre-SET motif family protein	0.0031	0.0053	0.0051
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0193	0.0538	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0017	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0573	0.0566
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0136	0.0369	0.0367
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.002	0.0021	0.0013
Schistosoma mansoni	retinoic acid receptor RXR	0.002	0.0021	0.0021
Schistosoma mansoni	acetylcholinesterase	0.0566	0.1657	0.1657
Onchocerca volvulus		0.0566	0.1657	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0205	0.0573	0.0565
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0068	0.006
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0053	0.0045
Brugia malayi	Steroid receptor seven-up type 2	0.002	0.0021	0.0018
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0025	0.0053
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.002	0.0021	0.0013
Onchocerca volvulus		0.0042	0.0086	0.0401
Schistosoma mansoni	thyroid hormone receptor	0.002	0.0021	0.0021
Schistosoma mansoni	hypothetical protein	0.0036	0.0068	0.0068
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0017	0.0017
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0047	0.0102	0.0102
Echinococcus multilocularis	neuroligin	0.0566	0.1657	0.165
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.131	0.3883	1
Schistosoma mansoni	coup transcription factor	0.002	0.0021	0.0021
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.0021	0.0018
Mycobacterium ulcerans	monoamine oxidase	0.0092	0.0237	0.0571
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0017	0.0081
Mycobacterium ulcerans	oxidoreductase	0.0092	0.0237	0.0571
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.005	0.011	1
Brugia malayi	ecdysteroid receptor	0.002	0.0021	0.0018
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.0164	0.09
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0193	0.0538	0.053
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0237	0.0229
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0017	0.0081
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0299	0.0857	0.085
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0022	0.0027	0.0019
Trichomonas vaginalis	spcc417.12 protein, putative	0.0566	0.1657	1
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0022	0.0027	0.0019
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0017	0.0002
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.015	0.015
Loa Loa (eye worm)	hypothetical protein	0.002	0.0021	0.0013
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0102	0.0102
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0016	0.0008
Echinococcus multilocularis	FTZ F1 alpha	0.002	0.0021	0.0013
Echinococcus multilocularis	carboxylesterase 5A	0.3352	1	1
Brugia malayi	hypothetical protein	0.0032	0.0056	0.0054
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.005	0.011	0.0102
Brugia malayi	hypothetical protein	0.0092	0.0237	0.0234
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.002	0.0021	0.0013
Brugia malayi	hypothetical protein	0.0036	0.0068	0.0065
Brugia malayi	chromobox protein homolog 3	0.0038	0.0074	0.0072
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0053	0.0045
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0022	0.0027	0.0027
Trypanosoma brucei	unspecified product	0.0019	0.0017	0.0081
Entamoeba histolytica	hypothetical protein	0.0036	0.0068	0.0995
Brugia malayi	nuclear receptor NHR-88	0.002	0.0021	0.0018
Schistosoma mansoni	cpg binding protein	0.0085	0.0215	0.0215
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0018	0.0013
Onchocerca volvulus		0.0566	0.1657	1
Schistosoma mansoni	hypothetical protein	0.0022	0.0027	0.0027
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0136	0.0369	0.0361
Brugia malayi	amine oxidase, flavin-containing family protein	0.0092	0.0237	0.0234
Toxoplasma gondii	histone lysine-specific demethylase	0.0092	0.0237	0.5141
Loa Loa (eye worm)	hypothetical protein	0.002	0.0021	0.0013
Echinococcus granulosus	BC026374 protein S09 family	0.0566	0.1657	0.165
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.005	0.011	0.0102
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0047	0.0102	0.0094
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0074	0.0356
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.0021	0.0018
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.015	0.015
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0566	0.1657	0.165
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.0021	0.0018
Loa Loa (eye worm)	hypothetical protein	0.003	0.005	0.0042
Loa Loa (eye worm)	heterochromatin protein 1	0.0068	0.0164	0.0156
Echinococcus granulosus	dna polymerase eta	0.0019	0.0017	0.0009
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0193	0.0538	0.0536
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.0021	0.0018
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0044	0.0036
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0566	0.1657	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0808	0.2379	0.2373
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0017	0.0009
Onchocerca volvulus		0.005	0.011	0.0547
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.002	0.0021	0.0013
Schistosoma mansoni	BC026374 protein (S09 family)	0.0566	0.1657	0.1657
Echinococcus granulosus	polycomb protein SCMH1	0.0047	0.0102	0.0094
Toxoplasma gondii	hypothetical protein	0.0143	0.0388	0.8673
Echinococcus multilocularis	acetylcholinesterase	0.3352	1	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0095	0.0244	0.0236
Schistosoma mansoni	hypothetical protein	0.0291	0.0832	0.0832
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0193	0.0538	0.3182
Mycobacterium tuberculosis	Possible oxidoreductase	0.0092	0.0237	0.0615
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0021	0.0013
Loa Loa (eye worm)	hypothetical protein	0.3352	1	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0017	0.0081
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0054	0.0121	0.0113
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0054	0.0121	0.0113
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0193	0.0538	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0021	0.0013
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.002	0.0021	0.0018
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0017	0.0081
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.002	0.0021	0.0013
Echinococcus granulosus	para nitrobenzyl esterase	0.0566	0.1657	0.165
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.015	0.015
Brugia malayi	Carboxylesterase family protein	0.0566	0.1657	0.1655
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0193	0.0538	0.053
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0027	0.0042	0.0034
Echinococcus multilocularis	chromobox protein 1	0.0068	0.0164	0.0156
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0018	0.0013
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0097	0.0252	0.5502
Echinococcus multilocularis	dnaJ subfamily B	0.0407	0.118	0.1173
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.005	0.011	0.0102
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0017	0.0081
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0083	0.0381
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.003	0.0051	0.0215
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0017	0.0035
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0566	0.1657	0.457
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.002	0.0021	0.0013
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0017	0.0081
Onchocerca volvulus		0.0092	0.0237	0.132
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.002	0.0021	0.0013
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.005	0.011	0.0102
Brugia malayi	photoreceptor-specific nuclear receptor	0.002	0.0021	0.0018
Echinococcus granulosus	cpg binding protein	0.009	0.0229	0.0221
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0193	0.0538	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0053	0.0053
Onchocerca volvulus		0.0233	0.0658	0.3893
Loa Loa (eye worm)	hypothetical protein	0.0566	0.1657	0.165
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0143	0.0388	0.2269
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0027	0.0042	0.0034
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.003	0.0051	0.0215
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.015	0.0147
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0017	0.0009
Echinococcus granulosus	GPCR family 2	0.0095	0.0244	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0053	0.0045
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0018	0.0013
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0299	0.0857	0.0855
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0136	0.0369	0.0361
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.015	0.0142
Plasmodium vivax	hypothetical protein, conserved	0.0092	0.0237	0.4227
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0566	0.1657	0.165
Plasmodium vivax	SET domain protein, putative	0.0031	0.0053	0.0711
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0095	0.0244	0.0242
Schistosoma mansoni	ap endonuclease	0.0019	0.0016	0.0016
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0053	0.0045
Plasmodium vivax	ataxin-2 like protein, putative	0.005	0.0109	0.1779
Echinococcus multilocularis	thyroid hormone receptor alpha	0.002	0.0021	0.0013
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.131	0.3883	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.002	0.0021	0.0013

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 10000 nM	Inhibition of FTase-catalyzed incorporation of [3H]- FPP radioligand into recombinant Ha-Ras by 50% at an enzyme concentration of 1 nM.	ChEMBL.	9873725
IC50 (binding)	> 10000 nM	Inhibition of FTase-catalyzed incorporation of [3H]- FPP radioligand into recombinant Ha-Ras by 50% at an enzyme concentration of 1 nM.	ChEMBL.	9873725

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 184488