Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0215 | 0.2309 | 0.2981 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0094 | 0 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0215 | 0.2309 | 0.2981 |
Mycobacterium ulcerans | polyketide synthase | 0.0325 | 0.442 | 0.5834 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0345 | 0.4807 | 0.6357 |
Onchocerca volvulus | 0.0303 | 0.401 | 0.2813 | |
Loa Loa (eye worm) | fatty acid synthase | 0.032 | 0.4337 | 0.5009 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0325 | 0.442 | 0.5856 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0345 | 0.4807 | 0.6337 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0294 | 0.3834 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0325 | 0.442 | 0.5834 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0261 | 0.3202 | 0.4155 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0485 | 0.7502 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0294 | 0.3834 | 0.3794 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0315 | 0.4229 | 0.5599 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0193 | 0.1893 | 0.4849 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0112 | 0.033 | 0.0356 |
Onchocerca volvulus | 0.0565 | 0.9035 | 0.9486 | |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0325 | 0.442 | 0.5856 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0193 | 0.1893 | 0.4849 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0325 | 0.442 | 0.4383 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0325 | 0.442 | 0.5834 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0585 | 0.9422 | 1 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0485 | 0.7502 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0546 | 0.8657 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0215 | 0.2309 | 0.2941 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0193 | 0.1893 | 0.4849 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0345 | 0.4807 | 0.6376 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0345 | 0.4807 | 0.6337 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0294 | 0.3834 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0294 | 0.3834 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0325 | 0.442 | 0.5834 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0203 | 0.2092 | 0.5378 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0294 | 0.3834 | 1 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0271 | 0.3381 | 0.4398 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0325 | 0.442 | 0.5856 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0193 | 0.1893 | 0.4849 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0294 | 0.3834 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0266 | 0.3284 | 0.4329 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0485 | 0.7502 | 1 |
Mycobacterium ulcerans | thioesterase | 0.0271 | 0.3381 | 0.443 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0231 | 0.2624 | 0.3708 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0193 | 0.1893 | 0.4849 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0345 | 0.4807 | 0.6357 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0325 | 0.442 | 0.581 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0233 | 0.2664 | 0.3495 |
Brugia malayi | AMP-binding enzyme family protein | 0.0303 | 0.401 | 0.3971 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0193 | 0.1893 | 0.4849 |
Giardia lamblia | Methyltransferase like 2 | 0.0098 | 0.0065 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0261 | 0.3202 | 0.4188 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0315 | 0.4229 | 0.5599 |
Mycobacterium ulcerans | polyketide synthase | 0.0345 | 0.4807 | 0.6357 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0345 | 0.4807 | 0.6376 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0203 | 0.2092 | 0.5378 |
Schistosoma mansoni | methyltransferase-related | 0.0098 | 0.0065 | 0.5 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0485 | 0.7502 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0325 | 0.442 | 0.5834 |
Brugia malayi | AMP-binding enzyme family protein | 0.01 | 0.0104 | 0.0039 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.01 | 0.0104 | 0.0052 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0102 | 0.0145 | 0.0056 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0303 | 0.401 | 0.5305 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0094 | 0 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0325 | 0.442 | 0.581 |
Leishmania major | hypothetical protein, conserved | 0.0098 | 0.0065 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0294 | 0.3834 | 1 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0102 | 0.0145 | 0.0108 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0185 | 0.173 | 0.224 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0271 | 0.3381 | 0.4459 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0193 | 0.1893 | 0.4849 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0211 | 0.223 | 0.2574 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0303 | 0.401 | 0.4632 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0294 | 0.3834 | 0.4429 |
Loa Loa (eye worm) | acyl carrier protein | 0.0149 | 0.1053 | 0.1217 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0345 | 0.4807 | 0.6337 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0131 | 0.0708 | 0.0864 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.1679 | 0.194 |
Mycobacterium ulcerans | thioesterase TesA | 0.0271 | 0.3381 | 0.443 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0345 | 0.4807 | 0.6376 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0345 | 0.4807 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0261 | 0.3202 | 0.4188 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.