TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 369.838 | Formula: C17H17ClFNO3S
H donors: 0 H acceptors: 2 LogP: 5.27 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC(=C1OC(=O)N(C1=O)c1cc(SC2CCCC2)c(cc1F)Cl)C
InChi: 1S/C17H17ClFNO3S/c1-9(2)15-16(21)20(17(22)23-15)13-8-14(11(18)7-12(13)19)24-10-5-3-4-6-10/h7-8,10H,3-6H2,1-2H3
InChiKey: TWKTZVFEXGRHSS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	glycine receptor subunit beta	0.0049	0.0392	0.0392
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0045	0.0345	0.0219
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0049	0.0392	0.0392
Echinococcus granulosus	acetylcholinesterase	0.0266	0.3287	0.3287
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0049	0.0392	0.0392
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0049	0.0392	0.1072
Loa Loa (eye worm)	hypothetical protein	0.004	0.0282	0.0831
Onchocerca volvulus		0.0049	0.0392	0.1079
Echinococcus multilocularis	acetylcholinesterase	0.0266	0.3287	0.3287
Echinococcus multilocularis	carboxylesterase 5A	0.0266	0.3287	0.3287
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0022	0.0044	0.0044
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0049	0.0392	0.0392
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0049	0.0392	0.0392
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0049	0.0392	0.0392
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0049	0.0392	0.1072
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0345	0.1024
Brugia malayi	Pre-SET motif family protein	0.0033	0.019	0.045
Loa Loa (eye worm)	hypothetical protein	0.004	0.0282	0.0831
Brugia malayi	beta-lactamase	0.004	0.0282	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0266	0.3287	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0282	0.0831
Onchocerca volvulus		0.0169	0.1992	0.6045
Echinococcus multilocularis	microtubule associated protein 2	0.0771	1	1
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0049	0.0392	0.1072
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0049	0.0392	0.1072
Echinococcus granulosus	geminin	0.0189	0.2264	0.2264
Echinococcus multilocularis	zinc finger protein	0.0022	0.0037	0.0037
Brugia malayi	Carboxylesterase family protein	0.0045	0.0345	0.0927
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0049	0.0392	0.0392
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.019	0.019
Echinococcus multilocularis	neuroligin	0.0045	0.0345	0.0345
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.019	0.019
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0026	0.0094	0.0094
Brugia malayi	Cation transporter family protein	0.0049	0.0392	0.1072
Loa Loa (eye worm)	carboxylesterase	0.0045	0.0345	0.1024
Loa Loa (eye worm)	ACC-1 protein	0.0049	0.0392	0.1167
Echinococcus granulosus	BC026374 protein S09 family	0.0045	0.0345	0.0345
Loa Loa (eye worm)	GABA receptor subunit	0.0026	0.0094	0.0259
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0049	0.0392	0.1072
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0049	0.0392	0.1072
Onchocerca volvulus		0.0049	0.0392	0.1079
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0049	0.0392	0.0392
Trypanosoma brucei	hypothetical protein, conserved	0.004	0.0282	0.5
Brugia malayi	hypothetical protein	0.0045	0.0345	0.0927
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.0174	0.0174
Loa Loa (eye worm)	acetylcholine receptor protein	0.0022	0.0044	0.0107
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0026	0.0094	0.0154
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0266	0.3287	0.3287
Trichomonas vaginalis	set domain proteins, putative	0.0265	0.3266	1
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0049	0.0392	0.0392
Brugia malayi	beta-lactamase family protein	0.004	0.0282	0.0732
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0282	1
Loa Loa (eye worm)	carboxylesterase	0.0266	0.3287	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0345	0.1024
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0282	0.5
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0049	0.0392	0.1072
Schistosoma mansoni	acetylcholinesterase	0.0045	0.0345	0.0345
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0049	0.0392	0.0392
Entamoeba histolytica	hypothetical protein	0.0026	0.0094	0.5
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0094	0.0259
Echinococcus granulosus	zinc finger protein	0.0022	0.0037	0.0037
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0049	0.0392	0.0392
Mycobacterium leprae	Probable lipase LipE	0.004	0.0282	0.5
Schistosoma mansoni	nAChR subunit	0.0022	0.0044	0.0044
Trichomonas vaginalis	spcc417.12 protein, putative	0.0045	0.0345	0.0212
Echinococcus granulosus	fetal alzheimer antigen falz	0.0025	0.0082	0.0082
Brugia malayi	Carboxylesterase family protein	0.0045	0.0345	0.0927
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0049	0.0392	0.0392
Brugia malayi	Bromodomain containing protein	0.0084	0.0861	0.2519
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0107
Loa Loa (eye worm)	beta-lactamase	0.004	0.0282	0.0831
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0026	0.0094	0.0154
Echinococcus multilocularis	nAChR subunit	0.0026	0.0094	0.0094
Onchocerca volvulus	Putative nachr subunit	0.0049	0.0392	0.1079
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0049	0.0392	0.1072
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0049	0.0392	0.1072
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0049	0.0392	0.0392
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0045	0.0345	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0107
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0049	0.0392	0.0392
Brugia malayi	beta-lactamase family protein	0.004	0.0282	0.0732
Brugia malayi	PHD-finger family protein	0.0028	0.0117	0.0224
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0026	0.0094	0.0154
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0049	0.0392	0.1072
Brugia malayi	excitatory GABA receptor EXP-1A	0.0049	0.0392	0.1072
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0233	0.2839	0.8633
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0392	0.1167
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0345	0.1024
Loa Loa (eye worm)	hypothetical protein	0.004	0.0282	0.0831
Schistosoma mansoni	BC026374 protein (S09 family)	0.0045	0.0345	0.0345
Mycobacterium ulcerans	carboxylesterase, LipT	0.0045	0.0345	1
Schistosoma mansoni	zinc finger protein	0.0022	0.0037	0.0037
Schistosoma mansoni	nAChR subunit	0.0049	0.0392	0.0392
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0049	0.0392	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0392	0.1167
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0045	0.0345	0.0345
Brugia malayi	hypothetical protein	0.0169	0.1992	0.6006
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0392	0.1167
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0049	0.0392	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0444	0.1325
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0169	0.1992	0.6049
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0392	0.1167
Echinococcus granulosus	para nitrobenzyl esterase	0.0045	0.0345	0.0345
Echinococcus granulosus	carboxylesterase 5A	0.0266	0.3287	0.3287
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0045	0.0345	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0094	0.0259
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.004	0.0282	0.0831
Mycobacterium leprae	conserved hypothetical protein	0.004	0.0282	0.5
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0052	0.0444	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0392	0.1167
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0052	0.0444	0.0444
Echinococcus multilocularis	para nitrobenzyl esterase	0.0045	0.0345	0.0345
Onchocerca volvulus		0.004	0.0282	0.0737
Echinococcus granulosus	acetylcholinesterase	0.0266	0.3287	0.3287
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0049	0.0392	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0392	0.1167
Onchocerca volvulus		0.0045	0.0345	0.0933
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0392	0.1167
Loa Loa (eye worm)	hypothetical protein	0.004	0.0282	0.0831
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0045	0.0345	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0392	0.1167
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0049	0.0392	0.1167
Schistosoma mansoni	nAChR subunit	0.0049	0.0392	0.0392
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0049	0.0392	0.0392
Echinococcus granulosus	nAChR subunit	0.0049	0.0392	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0392	0.1167
Onchocerca volvulus		0.0049	0.0392	0.1079
Schistosoma mansoni	hypothetical protein	0.0189	0.2264	0.2264
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0049	0.0392	0.1167
Onchocerca volvulus		0.004	0.0282	0.0737
Onchocerca volvulus		0.0045	0.0345	0.0933
Schistosoma mansoni	nAChR subunit	0.0022	0.0044	0.0044
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0022	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0107
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0022	0.0044	0.0107
Schistosoma mansoni	nAChR subunit	0.0049	0.0392	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0094	0.0259
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0022	0.0044	0.0044
Schistosoma mansoni	microtubule-associated protein tau	0.0771	1	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0094	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0352	0.1046
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0049	0.0392	0.1167
Echinococcus granulosus	histone lysine methyltransferase setb	0.0052	0.0444	0.0444
Toxoplasma gondii	ABC1 family protein	0.004	0.0282	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0094	0.0259
Brugia malayi	Carboxylesterase family protein	0.0045	0.0345	0.0927
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0049	0.0392	0.1072
Echinococcus granulosus	beta LACTamase domain containing family member	0.004	0.0282	0.0282
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0049	0.0392	0.0392
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0282	0.5
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0045	0.0345	0.0219
Schistosoma mansoni	hypothetical protein	0.0023	0.0053	0.0053
Brugia malayi	Pre-SET motif family protein	0.0233	0.2839	0.8618
Schistosoma mansoni	neurotransmitter gated ion channel	0.0026	0.0094	0.0094
Onchocerca volvulus		0.0026	0.0094	0.0155
Schistosoma mansoni	gliotactin	0.0045	0.0345	0.0345
Schistosoma mansoni	nAChR subunit	0.0049	0.0392	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0345	0.1024
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0049	0.0392	0.1167
Leishmania major	hypothetical protein, conserved	0.004	0.0282	0.5
Echinococcus multilocularis	beta LACTamase domain containing family member	0.004	0.0282	0.0282
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0049	0.0392	0.1072
Loa Loa (eye worm)	transcription factor SMAD2	0.0133	0.152	0.4611
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0392	0.1167
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0282	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0107
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0045	0.0345	0.0345
Onchocerca volvulus		0.0049	0.0392	0.1079
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0022	0.0044	0.0044
Schistosoma mansoni	hypothetical protein	0.0189	0.2264	0.2264
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0049	0.0392	0.1072
Brugia malayi	Bromodomain containing protein	0.0043	0.0316	0.0837
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0094	0.0259
Echinococcus granulosus	neuroligin	0.0045	0.0345	0.0345
Echinococcus multilocularis	glycine receptor subunit beta	0.0049	0.0392	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0392	0.1167
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0257	0.3164	1
Onchocerca volvulus		0.004	0.0282	0.0737
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0282	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0392	0.1167
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0392	0.1167
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0049	0.0392	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0392	0.1167
Schistosoma mansoni	bromodomain containing protein	0.0071	0.0687	0.0687
Echinococcus granulosus	glycine receptor subunit beta	0.0049	0.0392	0.0392
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0049	0.0392	0.0392
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0022	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0107
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0025	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0107
Echinococcus granulosus	nAChR subunit	0.0026	0.0094	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0266	0.3287	1
Schistosoma mansoni	nAChR subunit	0.0049	0.0392	0.0392
Schistosoma mansoni	nAChR subunit	0.0049	0.0392	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0094	0.0259
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0049	0.0392	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0048	0.038	0.1132
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0045	0.0345	0.0345
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0049	0.0392	0.0392
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0067	0.0634	0.0634
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0049	0.0392	0.1167
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0317	0.0938
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0094	0.0259
Loa Loa (eye worm)	acetylcholinesterase 1	0.0266	0.3287	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0107
Onchocerca volvulus		0.0033	0.019	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0345	0.1024
Schistosoma mansoni	neurotransmitter gated ion channel	0.0022	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0107
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0022	0.0044	0.0044
Brugia malayi	Carboxylesterase family protein	0.0045	0.0345	0.0927
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0392	0.1167
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0049	0.0392	0.1072
Onchocerca volvulus		0.0045	0.0345	0.0933
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0052	0.0444	0.0444
Schistosoma mansoni	nAChR subunit	0.0049	0.0392	0.0392
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.004	0.0281	0.0281
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0026	0.0094	0.0094
Onchocerca volvulus		0.0045	0.0345	0.0933
Schistosoma mansoni	neurotransmitter gated ion channel	0.0022	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0392	0.1167
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0107
Loa Loa (eye worm)	carboxylesterase	0.0045	0.0345	0.1024
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0049	0.0392	0.0392
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0067	0.0634	0.0634
Onchocerca volvulus		0.0265	0.3266	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.019	0.019
Brugia malayi	MH2 domain containing protein	0.0133	0.152	0.4552
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0025	0.0082	0.0082
Brugia malayi	Carboxylesterase family protein	0.0266	0.3287	1
Brugia malayi	Cation transporter family protein	0.0049	0.0392	0.1072
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0049	0.0392	0.0392
Brugia malayi	Cation transporter family protein	0.0049	0.0392	0.1072
Loa Loa (eye worm)	ACC-1 protein	0.0049	0.0392	0.1167
Onchocerca volvulus		0.0045	0.0345	0.0933
Loa Loa (eye worm)	hypothetical protein	0.004	0.0282	0.0831
Echinococcus multilocularis	acetylcholinesterase	0.0266	0.3287	0.3287
Loa Loa (eye worm)	LGC-31 protein	0.0049	0.0392	0.1167
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.004	0.0282	0.0732
Echinococcus multilocularis	geminin	0.0189	0.2264	0.2264
Echinococcus granulosus	glycine receptor subunit beta	0.0049	0.0392	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0345	0.1024
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0797	0.2405
Onchocerca volvulus		0.0049	0.0392	0.1079
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0045	0.0345	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0094	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0392	0.1167
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0392	0.1167
Loa Loa (eye worm)	PHD-finger family protein	0.0023	0.0053	0.0134
Echinococcus multilocularis	nAChR subunit	0.0049	0.0392	0.0392
Onchocerca volvulus		0.0026	0.0094	0.0155
Loa Loa (eye worm)	MH2 domain-containing protein	0.0133	0.152	0.4611
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0107
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0049	0.0392	0.0392
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0049	0.0392	0.0392
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0045	0.0345	0.0219
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0049	0.0392	0.1072
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.004	0.0281	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0107
Onchocerca volvulus		0.0049	0.0392	0.1079
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0049	0.0392	0.1167
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0345	0.1024
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0049	0.0392	0.1072
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0045	0.0345	0.0345
Schistosoma mansoni	acetylcholine receptor-related	0.0022	0.0044	0.0044
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0049	0.0392	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0392	0.1167
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0022	0.0044	0.0107
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0026	0.0094	0.0154
Brugia malayi	Carboxylesterase family protein	0.0266	0.3287	1

Activities

Activity type	Activity value	Assay description	Source	Reference
ED10 (ADMET)	= 200 gAi/ha	Pre-emergence phytotoxicity against Oryza sativa cv. Koshihikari (rice) assessed as phytotoxic crop injury visual ratings measured after 14 days post treatment	ChEMBL.	No reference
ED10 (ADMET)	= 800 gAi/ha	Post-emergence phytotoxicity against Oryza sativa cv. Koshihikari (rice) assessed as phytotoxic crop injury visual ratings measured after 14 days post treatment	ChEMBL.	No reference
Phytotoxicity (ADMET)	= 0 %	Pre-emergence phytotoxicity against Oryza sativa cv. Koshihikari (rice) assessed as phytotoxic crop injury visual ratings at 25 g ai/ha measured after 14 days post treatment under flooded conditions	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2269479

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1845024