Detailed information for compound 1845672

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 318.29 | Formula: C13H10F4N2OS
  • H donors: 0 H acceptors: 1 LogP: 3.7 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: FCC(=O)/N=c/1\sc(cn1c1cccc(c1)C(F)(F)F)C
  • InChi: 1S/C13H10F4N2OS/c1-8-7-19(12(21-8)18-11(20)6-14)10-4-2-3-9(5-10)13(15,16)17/h2-5,7H,6H2,1H3/b18-12-
  • InChiKey: NEIDLOONWMZTDB-PDGQHHTCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear receptor NHR-67 0.029 0.3914 0.4489
Brugia malayi Bromodomain containing protein 0.0039 0.0236 0.0232
Brugia malayi serine/threonine-protein kinase plk-2 0.01 0.113 0.1267
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0201 0.0201
Brugia malayi HSF-type DNA-binding domain containing protein 0.0101 0.1148 0.1287
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0224 0.1893
Entamoeba histolytica serine/threonine protein kinase, putative 0.01 0.113 0.9847
Loa Loa (eye worm) hypothetical protein 0.0037 0.0203 0.0127
Echinococcus granulosus snurportin 1 0.0315 0.4274 0.4274
Trichomonas vaginalis glutathione reductase, putative 0.0031 0.0121 0.0967
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0615 0.8675 1
Brugia malayi conserved hypotetical protein 0.029 0.3914 0.4489
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0229 0.3016 1
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0164 0.1357
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0615 0.8675 0.8675
Schistosoma mansoni steroid hormone receptor ad4bp 0.0615 0.8675 0.8675
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0386 1
Mycobacterium ulcerans hypothetical protein 0.0049 0.0386 1
Schistosoma mansoni phosphoglucomutase 0.005 0.0401 0.0401
Trypanosoma brucei hypothetical protein, conserved 0.0055 0.0464 0.1581
Schistosoma mansoni zinc finger protein 0.029 0.3914 0.3914
Echinococcus multilocularis neuropeptide receptor A26 0.0478 0.6662 0.6662
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0615 0.8675 0.8675
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0615 0.8675 0.8675
Trypanosoma brucei unspecified product 0.0055 0.0464 0.1581
Plasmodium falciparum thioredoxin reductase 0.0031 0.0121 0.0296
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0121 0.0967
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0615 0.8675 1
Loa Loa (eye worm) hypothetical protein 0.0615 0.8675 1
Schistosoma mansoni hypothetical protein 0.0173 0.2201 0.2201
Echinococcus multilocularis nuclear receptor nhr 48 0.029 0.3914 0.3914
Brugia malayi Nuclear hormone receptor-like 1 0.0325 0.4424 0.5079
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0224 0.1893
Loa Loa (eye worm) hypothetical protein 0.0044 0.0301 0.0241
Loa Loa (eye worm) hypothetical protein 0.0325 0.4424 0.5045
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0031 0.0121 0.0113
Loa Loa (eye worm) hypothetical protein 0.029 0.3914 0.4451
Brugia malayi RNase H family protein 0.005 0.0401 0.0424
Brugia malayi hypothetical protein 0.029 0.3914 0.4489
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0173 0.0182
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.029 0.3914 0.3914
Brugia malayi RNA, U transporter 1 0.0084 0.0891 0.099
Loa Loa (eye worm) hypothetical protein 0.029 0.3914 0.4451
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.009 0.0985 0.2985
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.029 0.3914 0.3914
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0203 0.1221
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0031 0.0121 0.0967
Loa Loa (eye worm) hypothetical protein 0.0325 0.4424 0.5045
Brugia malayi RNase H family protein 0.005 0.0401 0.0424
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0031 0.0121 0.0113
Brugia malayi ecdysteroid receptor 0.0615 0.8675 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0615 0.8675 0.8675
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0615 0.8675 0.8675
Trichomonas vaginalis CAMK family protein kinase 0.01 0.113 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0091 0.0993 0.0993
Brugia malayi Nuclear hormone receptor E75 0.029 0.3914 0.4489
Brugia malayi hypothetical protein 0.0325 0.4424 0.5079
Brugia malayi Thioredoxin reductase 0.009 0.0985 0.1099
Schistosoma mansoni microtubule-associated protein tau 0.0706 1 1
Loa Loa (eye worm) hypothetical protein 0.0615 0.8675 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0722 0.0731
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0031 0.0121 0.0113
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0031 0.0121 0.0967
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0224 0.1893
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0224 0.0151
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0615 0.8675 0.8675
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0615 0.8675 1
Schistosoma mansoni hypothetical protein 0.0034 0.0164 0.0164
Trichomonas vaginalis CAMK family protein kinase 0.01 0.113 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0615 0.8675 0.8675
Echinococcus granulosus thyroid hormone receptor alpha 0.029 0.3914 0.3914
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0615 0.8675 1
Loa Loa (eye worm) nuclear hormone receptor 0.029 0.3914 0.4451
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0224 0.1893
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.029 0.3914 0.4406
Plasmodium vivax glutathione reductase, putative 0.009 0.0985 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0203 0.3104
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0386 0.3289
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0229 0.3016 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0386 1
Brugia malayi Kringle domain containing protein 0.0034 0.0164 0.0149
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0055 0.0464 0.1581
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0031 0.0121 0.0967
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0437 0.0465
Loa Loa (eye worm) hypothetical protein 0.0615 0.8675 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0031 0.0121 0.0113
Brugia malayi glutathione reductase 0.009 0.0985 0.1099
Echinococcus multilocularis FTZ F1 alpha 0.0615 0.8675 0.8675
Loa Loa (eye worm) hypothetical protein 0.029 0.3914 0.4451
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.029 0.3914 0.3914
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0389 0.3368
Trichomonas vaginalis CAMK family protein kinase 0.01 0.113 1
Loa Loa (eye worm) hypothetical protein 0.029 0.3914 0.4451
Brugia malayi nuclear receptor NHR-88 0.029 0.3914 0.4489
Schistosoma mansoni hypothetical protein 0.0036 0.0192 0.0192
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0031 0.0121 0.0121
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0437 0.0399
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0224 0.0224
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0121 0.0967
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0031 0.0121 0.0296
Schistosoma mansoni nuclear receptor 0.029 0.3914 0.3914
Schistosoma mansoni kinase 0.0051 0.0408 0.0408
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0224 0.0218
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0121 0.0967
Onchocerca volvulus Protein ultraspiracle homolog 0.0615 0.8675 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0203 1
Brugia malayi Nuclear hormone receptor-like 1 0.0325 0.4424 0.5079
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0437 0.0465
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0121 0.0967
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0031 0.0121 0.0296
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0615 0.8675 0.8675
Loa Loa (eye worm) nuclear receptor nhr-7B 0.029 0.3914 0.4451
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0203 0.1221
Toxoplasma gondii kringle domain-containing protein 0.0034 0.0164 0.0786
Loa Loa (eye worm) hypothetical protein 0.029 0.3914 0.4451
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0615 0.8675 0.8675
Loa Loa (eye worm) hypothetical protein 0.0053 0.0437 0.0399
Loa Loa (eye worm) hypothetical protein 0.029 0.3914 0.4451
Loa Loa (eye worm) hypothetical protein 0.0037 0.0203 0.0127
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0386 1
Trypanosoma brucei ingi protein (ORF1) 0.0055 0.0464 0.1581
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0192 0.0181
Mycobacterium tuberculosis Probable reductase 0.0206 0.2679 0.8837
Schistosoma mansoni coup transcription factor 0.0615 0.8675 0.8675
Entamoeba histolytica heat shock transcription factor, putative 0.0101 0.1148 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0615 0.8675 0.8675
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0031 0.0121 0.0967
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.113 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.01 0.113 0.1207
Brugia malayi Glycosyl hydrolases family 31 protein 0.0173 0.2194 0.2499
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0386 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0386 0.334
Giardia lamblia Ribonuclease H 0.005 0.0401 0.2781
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0031 0.0121 0.0296
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0325 0.4424 0.4424
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0031 0.0121 0.0967
Treponema pallidum ribonuclease H (rnhA) 0.005 0.0401 1
Plasmodium falciparum thioredoxin reductase 0.009 0.0985 1
Onchocerca volvulus Bile acid receptor homolog 0.0615 0.8675 1
Schistosoma mansoni nuclear hormone receptor 0.029 0.3914 0.3914
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0031 0.0121 0.0099
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0201 0.0201
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.029 0.3914 0.3914
Echinococcus multilocularis ribonuclease H1 0.005 0.0401 0.0401
Echinococcus multilocularis tissue type plasminogen activator 0.0034 0.0164 0.0164
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0031 0.0121 0.0967
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.01 0.113 0.113
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0615 0.8675 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0229 0.3016 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0224 0.1458
Trypanosoma cruzi ribonuclease H1, putative 0.005 0.0401 0.3479
Loa Loa (eye worm) hypothetical protein 0.0615 0.8675 1
Loa Loa (eye worm) hypothetical protein 0.029 0.3914 0.4451
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0615 0.8675 0.8675
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0121 0.0967
Loa Loa (eye worm) hypothetical protein 0.0042 0.0273 0.0208
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0615 0.8675 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0386 0.0916
Echinococcus multilocularis geminin 0.0173 0.2201 0.2201
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0615 0.8675 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.029 0.3914 0.3914
Brugia malayi nuclear hormone receptor 0.029 0.3914 0.4489
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0615 0.8675 0.8675
Loa Loa (eye worm) hypothetical protein 0.0049 0.0386 0.034
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0224 0.1893
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0031 0.0121 0.0121
Toxoplasma gondii thioredoxin reductase 0.009 0.0985 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0615 0.8675 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0615 0.8675 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0206 0.2679 0.8837
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0615 0.8675 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.01 0.113 0.113
Echinococcus granulosus ecdysone induced protein 78C 0.0615 0.8675 0.8675
Echinococcus multilocularis thioredoxin glutathione reductase 0.0091 0.0993 0.0993
Loa Loa (eye worm) hypothetical protein 0.0049 0.0386 0.034
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0224 0.1864
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0173 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0615 0.8675 1
Trypanosoma cruzi trypanothione reductase, putative 0.0031 0.0121 0.0967
Echinococcus granulosus tissue type plasminogen activator 0.0034 0.0164 0.0164
Echinococcus granulosus Nuclear hormone receptor HR96 0.029 0.3914 0.3914
Brugia malayi Steroid receptor seven-up type 2 0.0615 0.8675 1
Plasmodium vivax thioredoxin reductase, putative 0.009 0.0985 1
Brugia malayi nuclear receptor NHR-88 0.0615 0.8675 1
Onchocerca volvulus Ribonuclease H1 homolog 0.005 0.0401 0.0279
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0037 0.0198 0.0198
Brugia malayi hypothetical protein 0.0325 0.4424 0.5079
Schistosoma mansoni hypothetical protein 0.0315 0.4274 0.4274
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0386 0.334
Brugia malayi steroid hormone receptor 0.0615 0.8675 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0615 0.8675 0.8675
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0386 0.0406
Loa Loa (eye worm) hypothetical protein 0.0325 0.4424 0.5045
Onchocerca volvulus Serine\/threonine kinase homolog 0.01 0.113 0.1135
Schistosoma mansoni phosphoglucomutase 0.005 0.0401 0.0401
Brugia malayi Nuclear hormone receptor E75 0.029 0.3914 0.4489
Leishmania major hypothetical protein, conserved 0.0034 0.0164 0.1357
Schistosoma mansoni nuclear hormone receptor 0.029 0.3914 0.3914
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0325 0.4424 0.4424
Schistosoma mansoni alpha glucosidase 0.0038 0.0224 0.0224
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0315 0.4274 0.4871
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0615 0.8675 0.8675
Schistosoma mansoni bromodomain containing protein 0.0065 0.061 0.061
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0615 0.8675 0.8675
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.029 0.3914 0.4489
Schistosoma mansoni phosphoglucomutase 0.005 0.0401 0.0401
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0094 0.0094
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0173 0.0182
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0615 0.8675 0.8675
Echinococcus granulosus lysosomal alpha glucosidase 0.0173 0.2194 0.2194
Loa Loa (eye worm) hypothetical protein 0.0039 0.0237 0.0166
Mycobacterium tuberculosis Probable dehydrogenase 0.0206 0.2679 0.8837
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0386 1
Brugia malayi orphan nuclear receptor NR2E1 0.029 0.3914 0.4489
Echinococcus granulosus neuropeptide receptor A26 0.0478 0.6662 0.6662
Schistosoma mansoni alpha-glucosidase 0.0149 0.1842 0.1842
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0325 0.4424 0.4424
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0386 0.0916
Loa Loa (eye worm) thioredoxin reductase 0.009 0.0985 0.1038
Echinococcus multilocularis lysosomal alpha glucosidase 0.0173 0.2194 0.2194
Entamoeba histolytica heat shock transcription factor, putative 0.0101 0.1148 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0615 0.8675 1
Onchocerca volvulus 0.029 0.3914 0.4406
Brugia malayi nuclear hormone receptor family member nhr-6 0.029 0.3914 0.4489
Brugia malayi nuclear receptor RXR 0.029 0.3914 0.4489
Trypanosoma cruzi ribonuclease H1, putative 0.005 0.0401 0.3479
Brugia malayi Nuclear hormone receptor-like 1 0.0615 0.8675 1
Brugia malayi ecdysone receptor 0.029 0.3914 0.4489
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0206 0.2679 0.8837
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0224 0.1864
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0034 0.0164 0.0786
Loa Loa (eye worm) glutathione reductase 0.009 0.0985 0.1038
Loa Loa (eye worm) hypothetical protein 0.0615 0.8675 1
Loa Loa (eye worm) hypothetical protein 0.0615 0.8675 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0386 0.334
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0615 0.8675 1
Schistosoma mansoni serine/threonine protein kinase 0.01 0.113 0.113
Echinococcus multilocularis neuropeptide s receptor 0.0478 0.6662 0.6662
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0615 0.8675 1
Onchocerca volvulus 0.0615 0.8675 1
Trypanosoma brucei trypanothione reductase 0.009 0.0985 0.3807
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0229 0.3016 1
Brugia malayi nuclear receptor RXR 0.0325 0.4424 0.5079
Brugia malayi Protein kinase domain containing protein 0.0034 0.0164 0.0149
Brugia malayi RNase H family protein 0.005 0.0401 0.0424
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0386 0.0406
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0031 0.0121 0.0296
Loa Loa (eye worm) hypothetical protein 0.029 0.3914 0.4451
Echinococcus granulosus FTZ F1 alpha 0.0615 0.8675 0.8675
Plasmodium falciparum glutathione reductase 0.009 0.0985 1
Schistosoma mansoni nuclear hormone receptor 0.0615 0.8675 0.8675
Trypanosoma cruzi trypanothione reductase, putative 0.009 0.0985 0.87
Plasmodium falciparum glutathione reductase 0.0031 0.0121 0.0296
Schistosoma mansoni retinoic acid receptor RXR 0.0615 0.8675 0.8675
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0386 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0031 0.0121 0.0121
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0121 0.0967
Schistosoma mansoni hypothetical protein 0.0189 0.2434 0.2434
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0224 0.1893
Echinococcus multilocularis ecdysone induced protein 78C 0.0615 0.8675 0.8675
Brugia malayi Importin beta-1 subunit 0.0029 0.0094 0.0068
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0615 0.8675 1
Loa Loa (eye worm) hypothetical protein 0.029 0.3914 0.4451
Echinococcus multilocularis lysosomal alpha glucosidase 0.0173 0.2194 0.2194
Trypanosoma brucei glucosidase, putative 0.0038 0.0224 0.0555
Echinococcus multilocularis Nuclear hormone receptor HR96 0.029 0.3914 0.3914
Trichomonas vaginalis ribonuclease H1, putative 0.005 0.0401 0.3479
Schistosoma mansoni thyroid hormone receptor 0.0615 0.8675 0.8675
Echinococcus granulosus geminin 0.0173 0.2201 0.2201
Loa Loa (eye worm) hypothetical protein 0.029 0.3914 0.4451
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0101 0.1148 0.1155
Loa Loa (eye worm) hypothetical protein 0.0049 0.0386 0.034
Onchocerca volvulus 0.01 0.1127 0.1131
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0615 0.8675 0.8675
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0203 0.0284
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0557 0.0557
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0386 0.3289
Loa Loa (eye worm) steroid hormone receptor 0.0615 0.8675 1
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0389 0.3368
Loa Loa (eye worm) hypothetical protein 0.0036 0.0192 0.0114
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.005 0.0401 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0164 0.0082
Loa Loa (eye worm) hypothetical protein 0.029 0.3914 0.4451
Trypanosoma brucei polo-like protein kinase 0.01 0.113 0.4428
Echinococcus granulosus ribonuclease H1 0.005 0.0401 0.0401
Echinococcus multilocularis microtubule associated protein 2 0.0706 1 1
Echinococcus granulosus importin subunit beta 1 0.0029 0.0094 0.0094
Brugia malayi tailless protein 0.029 0.3914 0.4489
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0224 0.1893
Toxoplasma gondii ribonuclease HI protein 0.005 0.0401 0.3449
Loa Loa (eye worm) nuclear receptor NHR-67 0.029 0.3914 0.4451
Loa Loa (eye worm) hypothetical protein 0.0037 0.0203 0.0127
Trichomonas vaginalis CAMK family protein kinase 0.01 0.113 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.029 0.3914 0.3914
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0224 0.1893
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0224 0.1893
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0031 0.0121 0.0296
Leishmania major ribonuclease H1, putative 0.005 0.0401 0.3479
Leishmania major trypanothione reductase 0.009 0.0985 0.87
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0224 0.1893
Trichomonas vaginalis CAMK family protein kinase 0.01 0.113 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0615 0.8675 1
Loa Loa (eye worm) hypothetical protein 0.029 0.3914 0.4451
Schistosoma mansoni nuclear receptor nhr-48 0.029 0.3914 0.3914
Echinococcus granulosus nuclear receptor nhr 48 0.029 0.3914 0.3914
Schistosoma mansoni thyroid hormone receptor 0.0615 0.8675 0.8675
Brugia malayi nuclear hormone receptor family member odr-7 0.029 0.3914 0.4489
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0206 0.2679 0.8837
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0386 0.0406
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0224 0.1893
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.029 0.3914 0.4406
Loa Loa (eye worm) hypothetical protein 0.0325 0.4424 0.5045
Echinococcus multilocularis Nuclear hormone receptor HR96 0.029 0.3914 0.3914
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0173 0.0182
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0557 0.0557
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0615 0.8675 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0615 0.8675 1
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.113 1
Brugia malayi hypothetical protein 0.029 0.3914 0.4489
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0615 0.8675 1
Trichomonas vaginalis CAMK family protein kinase 0.01 0.113 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0203 0.0127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0615 0.8675 1
Trichomonas vaginalis CAMK family protein kinase 0.01 0.113 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0203 0.0127
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0206 0.2679 0.8837
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.01 0.113 1
Echinococcus granulosus neuropeptide s receptor 0.0478 0.6662 0.6662
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0615 0.8675 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0615 0.8675 1
Loa Loa (eye worm) hypothetical protein 0.0615 0.8675 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0206 0.2679 0.872
Trypanosoma brucei ingi protein (ORF1) 0.0055 0.0464 0.1581
Schistosoma mansoni alpha-glucosidase 0.0149 0.1842 0.1842
Loa Loa (eye worm) hypothetical protein 0.0615 0.8675 1
Schistosoma mansoni hypothetical protein 0.0173 0.2201 0.2201
Schistosoma mansoni importin beta-1 0.0029 0.0094 0.0094
Plasmodium falciparum cysteine repeat modular protein 1 0.0034 0.0164 0.0786
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0173 0.2194 0.2447
Loa Loa (eye worm) DR-78 0.029 0.3914 0.4451
Brugia malayi nuclear hormone receptor 0.0615 0.8675 1
Echinococcus multilocularis snurportin 1 0.0315 0.4274 0.4274
Loa Loa (eye worm) hypothetical protein 0.0101 0.1148 0.1228
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0224 0.0224
Trypanosoma brucei RNA helicase, putative 0.0189 0.2434 1
Entamoeba histolytica heat shock transcription factor, putative 0.0101 0.1148 1
Giardia lamblia Kinase, PLK 0.01 0.113 1
Trichomonas vaginalis mercuric reductase, putative 0.0031 0.0121 0.0967
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0615 0.8675 0.8675
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0224 0.1893
Onchocerca volvulus 0.029 0.3914 0.4406
Loa Loa (eye worm) hypothetical protein 0.029 0.3914 0.4451
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0386 0.3289
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.029 0.3914 0.3914
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0615 0.8675 0.8675
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0386 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0325 0.4424 0.5045
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0325 0.4424 0.4424
Loa Loa (eye worm) hypothetical protein 0.0325 0.4424 0.5045
Loa Loa (eye worm) TK/ROR protein kinase 0.0034 0.0164 0.0082
Onchocerca volvulus 0.0049 0.0386 0.026
Toxoplasma gondii NADPH-glutathione reductase 0.0031 0.0121 0.0296
Schistosoma mansoni RAR-like nuclear receptor 0.0615 0.8675 0.8675
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.029 0.3914 0.3914
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0615 0.8675 0.8675
Schistosoma mansoni nuclear receptor 0.029 0.3914 0.3914
Brugia malayi Bromodomain containing protein 0.0077 0.0786 0.0869
Trypanosoma brucei ribonuclease H1 0.005 0.0401 0.1313

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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